Review
Oncology
Katyana Amilca-Seba, Michele Sabbah, Annette K. Larsen, Jerome A. Denis
Summary: The mortality of colorectal cancer is linked to metastatic disease and undetectable micro-metastasis growth. Therapeutic strategies are efficient for locally advanced cancer but struggle to cure metastatic disease due to drug resistance and aggressive phenotype. Osteopontin is emerging as a valuable biomarker in various cancer types, including CRC, and shows potential as a therapeutic target.
Article
Oncology
Jiro Kimura, Kenta Sui, Takahiro Murokawa, Motoyasu Tabuchi, Shinya Sakamoto, Jun Iwata, Tatsuo Iiyama, Takehiro Okabayashi
Summary: It remains unclear which patients with recurrence after a second hepatectomy will benefit from a third hepatectomy. Factors such as tumor size and CA 19-9 level can affect long-term outcomes.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Hou-Ying Cheng, Kai-Wen Huang, Jin-Tung Liang, Been-Ren Lin, John Huang, Ji-Shiang Hung, Chi-Ling Chen
Summary: Multi-RFA and hepatectomy provide similar survival benefits for resectable colorectal cancer liver metastases patients, while systemic treatment has inferior outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Fumitoshi Hirokawa, Masaki Ueno, Takuya Nakai, Masaki Kaibori, Takeo Nomi, Hiroya Iida, Shogo Tanaka, Koji Komeda, Shinya Hayami, Hisashi Kosaka, Daisuke Hokuto, Shoji Kubo, Kazuhisa Uchiyama
Summary: This study compared the effectiveness of neoadjuvant chemotherapy and upfront surgery for resectable colorectal liver metastasis patients and found that upfront surgery group had a higher overall survival rate, thus suggesting that these patients should undergo upfront surgery.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Oncology
Jie-ying Liang, Hao-cheng Lin, Jingwen Liu, De-shen Wang, Yun-fei Yuan, Bin-kui Li, Yun Zheng, Xiao-jun Wu, Gong Chen, Feng-hua Wang, Zhi-qiang Wang, Zhi-zhong Pan, De-sen Wan, Rui-hua Xu, Yu-hong Li
Summary: The study aimed to construct a nomogram to predict personalized post-recurrence survival among colorectal cancer liver metastasis patients with post-hepatectomy recurrence. The nomogram displayed good discrimination and calibration, successfully grouping patients into three risk groups to assist physicians in decision-making.
Review
Biochemistry & Molecular Biology
Stephanos Pericleous, Ricky H. Bhogal, Vasileios K. Mavroeidis
Summary: Colorectal cancer is the fourth most commonly diagnosed cancer worldwide, with the third highest mortality rate. Liver resection may be a suitable treatment option for patients with oligometastatic disease. Advances in perioperative management and surgical techniques have increased the number of patients eligible for hepatectomy. Early detection and treatment of tumors, including recurrence, is crucial for improved outcomes. Current tumor biomarkers, such as Carcinoembryonic Antigen (CEA), have limitations, highlighting the need for novel biomarkers. This study reviews the current status and role of circulating biomarkers in patients post hepatectomy for colorectal cancer metastasis, including alternative cancer antigens to CEA, extracellular vesicles, circulating microRNA, circulating tumor cells, and circulating tumor DNA.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Oncology
Yu-Ming Su, Wei Liu, Xiao-Luan Yan, Li-Jun Wang, Ming Liu, Hong-Wei Wang, Ke-Min Jin, Quan Bao, Kun Wang, Juan Li, Da Xu, Bao-Cai Xing
Summary: This study analyzed long-term recurrence and cure rates of colorectal cancer liver metastases patients in the Chinese population who underwent liver resection. A prediction model was established and it was found that about one quarter of patients achieved potential cure with no recurrence after 5 years. Late recurrence and lung relapse were identified as significant factors for improved long-term survival.
Article
Surgery
Wong Hoi She, Tan To Cheung, Simon H. Y. Tsang, Wing Chiu Dai, Ka On Lam, Albert C. Y. Chan, Chung Mau Lo
Summary: This retrospective study examined factors for long-term survival in patients with colorectal liver metastasis (CRLM) who underwent liver resection. The study found that patients who survived for more than 10 years tended to have normal preoperative hemoglobin levels, involvement of only one liver lobe, fewer tumor nodules, and received adjuvant chemotherapy. Adjuvant chemotherapy was found to positively affect the long-term survival of CRLM patients.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Review
Oncology
Luigi Marongiu, Heike Allgayer
Summary: Evidence suggests that microorganisms, including specific viruses and bacteriophages, may play a significant role in the oncogenesis and progression of colorectal cancer. However, the mechanisms underlying these associations are not fully understood. Various viruses, such as EBV, HPV, JCV, and CMV, have been linked to CRC, along with bacteriophages. The complex interplay between different species within the microbiome and their impact on colorectal cells and the microenvironment may explain the challenges in establishing clear causal links between specific viral infections and CRC.
MOLECULAR ONCOLOGY
(2022)
Review
Oncology
Thomas M. Diehl, Daniel E. Abbott
Summary: Treatment for metastatic colorectal cancer has significantly improved with the evolution of cytotoxic and targeted chemotherapies and the standardization of resection of colorectal liver metastases for eligible patients. Personalized approaches using genetic profiles for risk stratification are crucial, as clinical risk scores do not perfectly predict outcomes. The decision to operate should be individualized based on patient condition, tumor biology, and technical resectability.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Article
Oncology
Feng-Lin Chen, Yan-Yan Wang, Wei Liu, Bao-Cai Xing
Summary: The study revealed that prognostic factors varied among colorectal liver metastases patients with different numbers of liver metastases, with RAS mutation being the only consistent risk factor across all subgroups. Building prediction models based on different prognostic factors can improve patient stratification.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Yun Wang, Xiuxing Chen, Haocheng Lin, Xiaoqiang Sun, William Pat Fong, Xiaojun Wu, Zhizhong Pan, Yunfei Yuan, Jieying Liang, Deshen Wang, Ziming Du, Baocai Xing, Yuhong Li
Summary: Exosomal miRNA signature developed in this study can predict prognosis and guide adjuvant chemotherapy decisions after hepatectomy in CRLM patients. The signature showed good predictive performance for patient outcome, helping to improve the accuracy of the current CRLM predictive model system.
Article
Agriculture, Dairy & Animal Science
Caroline Grisoni Sanchez, Marxa Leao Figueiredo, Laiza de Sartori Camargo, Luiz Guilherme Dercore Benevenuto, Zara Alves Lacerda, Carlos Eduardo Fonseca-Alves
Summary: Osteopontin (OPN) expression was investigated in canine mammary gland tumors (MGTs) and prostate cancer (PC) samples, and its association with bone metastasis was explored. Higher OPN expression was detected in primary tumor samples from animals with bone metastasis. In MGT samples, patients with higher OPN expression had significantly lower survival rates. Although not statistically significant, animals with positive OPN expression in PC samples showed a trend toward lower survival. These findings suggest that OPN may be a promising target for future studies on MGTs and PC due to its role in enhancing cell invasion and metastasis.
Article
Oncology
Mizuki Ninomiya, Yasunori Emi, Takashi Motomura, Takahiro Tomino, Tomohiro Iguchi, Hiroto Kayashima, Noboru Harada, Hideaki Uchiyama, Takashi Nishizaki, Hidefumi Higashi, Hiroyuki Kuwano
Summary: The study suggests that patients with synchronous and Grade B/C colorectal liver metastases may benefit from neoadjuvant chemotherapy before surgery.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Nozomu Sakai, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Masayuki Ohtsuka
Summary: This study found that KRAS mutation is an independent prognostic factor in patients with synchronous CRLM, but not in patients with metachronous CRLM.
Review
Biotechnology & Applied Microbiology
Nitin Bharat Charbe, Murtaza Tambuwala, Sushesh Srivatsa Palakurthi, Amol Warokar, Altijana HronniC-JahjefendiC, Hamid Bakshi, Flavia Zacconi, Vijay Mishra, Saurabh Khadse, Alaa A. Aljabali, Mohamed El-Tanani, Angel Serrano-Aroca, Srinath Palakurthi
Summary: This article provides an overview of the latest development and application of 3D bioprinting in regenerating skeletal muscle tissues and restoring the functional abilities of damaged craniofacial tissue. It discusses the limitations of traditional surgical repair and highlights the potential of 3D bioprinting in producing patient-specific functional implants.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Nighat Gull, Fareeha Arshad, Gowhar A. Naikoo, Israr Ul Hassan, Mona Zamani Pedram, Arif Ahmad, Alaa A. A. Aljabali, Vijay Mishra, Saurabh Satija, Nitin Charbe, Poonam Negi, Rohit Goyal, Angel Serrano-Aroca, Mazhar S. Al Zoubi, Mohamed El-Tanani, Murtaza M. Tambuwala
Summary: This article introduces hepatocellular carcinoma (HCC) as the fifth most common cancer worldwide and discusses the potential of curcumin as a multifunctional active ingredient in anticancer treatment. The article summarizes the anticancer properties and molecular targets of curcumin in HCC, and discusses the challenges and future prospects of novel plant extracts from Curcuma longa in cancer treatment.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Review
Biochemistry & Molecular Biology
Alaa A. Aljabali, Mohammad A. Obeid, Rasha M. Bashatwah, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Mohamed El-Tanani, Altijana Hromic-Jahjefendic, Deepak N. Kapoor, Rohit Goyal, Gowhar A. Naikoo, Murtaza M. Tambuwala
Summary: Nanomaterials have been extensively studied in the medical and industrial sectors, but their potential toxicities have raised concerns. Researchers are interested in how nanoparticles interact with the immune system and their biomolecules. This review examines literature on the immunostimulatory and immunosuppressive effects of nanomaterials and their interactions with immune cells, as well as the possibility of creating stealth nanomaterials that evade the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mohamed El-Tanani, Hamdi Nsairat, Vijay Mishra, Yachana Mishra, Alaa A. A. Aljabali, Angel Serrano-Aroca, Murtaza M. Tambuwala
Summary: Ran is a member of the Ras superfamily of proteins, regulating nucleocytoplasmic trafficking and mitosis by regulating spindle formation and nuclear envelope reassembly. Aberrant Ran expression in cancer is due to upstream dysregulation and abnormal activation of signaling pathways. Overexpression of Ran affects cell phenotype and has been found in various cancers, correlating with tumor grade and metastasis. Increased dependence on Ran for spindle formation and mitosis, as well as dysregulation of nucleocytoplasmic transport, contribute to the increased malignancy and invasiveness associated with Ran overexpression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
Jack Wallace, Saeed Hamid, Rosmawati Mohamed, Tzu Wong
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Surgery
Mauro Podda, Gianluca Pellino, Salomone Di Saverio, Federico Coccolini, Daniela Pacella, Stefano Piero Bernardo Cloffi, Francesco Vlrdis, Andrea Balla, Benedetto Ielpo, Francesco Pata, Gaetano Poillucci, Monica Ortenzi, Dimitrios Damaskos, Belinda De Simone, Massimo Sartelli, Ari Leppaniemi, Kumar Jayant, Fausto Catena, Antonio Giuliani, Marcello Di Martino, Adolfo Pisanu
Summary: The identification of high-risk patients is crucial in the early stages of infected pancreatic necrosis (IPN) to determine appropriate management strategies. This study found that history of uncontrolled arterial hypertension, qSOFA score, renal failure, haemodynamic failure were independent predictors of mortality in IPN patients. Cholangitis, abdominal compartment syndrome, and gastrointestinal/intra-abdominal bleeding were associated with increased risk of mortality. Upfront open surgical necrosectomy was strongly associated with higher mortality risk, while endoscopic drainage of pancreatic necrosis and enteral nutrition were protective factors.
UPDATES IN SURGERY
(2023)
Article
Chemistry, Medicinal
Mohamed El-Tanani, Khaled Abdul-Aziz Ahmed, Ashok K. Shakya, Wesam G. Ammari, Abdel-Elah Al-Shudifat
Summary: This study evaluated the clinical efficacy and safety of mebendazole as an adjuvant therapy for COVID-19 outpatients. The results showed that the mebendazole group had lower C-reactive protein levels and higher cycle threshold levels on the third day. Mebendazole therapy increased innate immunity and returned inflammation to normal levels faster than placebo.
Review
Multidisciplinary Sciences
Heather Waddell, Tyler J. Stevenson, Damian J. Mole
Summary: Circadian rhythms play an important role in regulating various physiological processes, and dysregulation of these rhythms can occur in critical illnesses such as acute pancreatitis (AP). Evidence suggests that the timing of disease onset and peripheral inflammation can impact circadian rhythms in both the central pacemaker and peripheral tissues, leading to disruption in immune cell release and gene expression. This disruption may contribute to increased pancreatic injury, tissue damage, and the development of systemic inflammation and multiple organ failure.
Review
Biochemistry & Molecular Biology
Fareeha Arshad, Gowhar A. Naikoo, Israr U. Hassan, Sai Raghuveer Chava, Mohamed El-Tanani, Alaa A. Aljabali, Murtaza M. Tambuwala
Summary: Silver nanoparticles (AgNPs) possess unique properties as antimicrobial, antifungal, antiviral, and anticancer agents. The green synthesis method of AgNPs has advantages such as low cost and eco-friendly production, which attract attention.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Correction
Medicine, Research & Experimental
Mohamed El-Tanani, Angela Platt-Higgins, Hamdi Nsairat, Ismail I. Matalka, Khaled Abdul-Aziz Ahmed, Shu-Dong Zhang, Walhan Alshaer, Abdalla Awidi, Kyle B. Matchett, Alaa A. Aljabali, Vijay Mishra, Angel Serrano-Aroca, Murtaza M. Tambuwala, Philip S. Rudland
Article
Biochemical Research Methods
Hamdi Nsairat, Walhan Alshaer, Zainab Lafi, Somaya Ahmad, Alaa Al-Sanabrah, Mohamed El-Tanani
Summary: This study developed and validated an HPLC technique for the determination of fulvestrant and disulfiram in liposomes. The method showed specificity, linearity, precision, and accuracy, making it suitable for simultaneous determination of the two drugs. The study also found high encapsulation efficiencies, indicating improved anticancer potential.
Article
Cell Biology
Alastair J. Hayes, Xiaozhong Zheng, James O'Kelly, Lucile P. A. Neyton, Natalia A. Bochkina, Iain Uings, John Liddle, J. Kenneth Baillie, George Just, Margaret Binnie, Natalie Z. M. Homer, Toby B. J. Murray, James Baily, Kris McGuire, Christos Skouras, O. James Garden, Scott P. Webster, John P. Iredale, Sarah E. M. Howie, Damian J. Mole
Summary: Blocking KMO protects against organ failure in acute pancreatitis by reducing systemic inflammation. The KMO product 3-hydroxykynurenine enhances innate immune signaling and inflammatory gene transcription. Elevated 3-hydroxykynurenine levels lead to increased apoptosis and mortality, but treatment with a selective KMO inhibitor rescues the phenotype.
Article
Cell Biology
Hamid A. Bakshi, Michella Mkhael, Hakkim L. Faruck, Asad Ullah Khan, Alaa A. A. Aljabali, Vijay Mishra, Mohamed El-Tanani, Nitin B. Charbe, Murtaza M. Tambuwala
Summary: The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability and biomass. Recent studies have shown that hypoxic cancer cells, which heavily rely on glucose, can utilize alternative energy sources such as mannose and maltose. This review comprehensively examines the hypoxic cancer microenvironment, its association with drug resistance, and potential therapeutic strategies for targeting this unique niche.
CELLULAR SIGNALLING
(2024)
Article
Environmental Sciences
Sadia Aziz, Bushra Uzair, Muhammad Ishtiaq Ali, Sundas Anbreen, Fatiha Umber, Muneeba Khalid, Alaa AA. Aljabali, Yachana Mishra, Vijay Mishra, Angel Serrano-Aroca, Gowhar A. Naikoo, Mohamed El-Tanani, Shafiul Haque, Abdulmajeed G. Almutary, Murtaza M. Tambuwala
Summary: This study investigates the potential of nanobiochar synthesized through ultrasonication and centrifugation for the removal of dyes from water. The results show that nanobiochar has a high adsorption capacity for dyes and can effectively remove them. The optimal removal efficiency is achieved at higher nanobiochar concentration, high temperature, and neutral pH.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Yachana Mishra, Vijay Mishra, Aditi Chattaraj, Alaa A. A. Aljabali, Mohamed El-Tanani, Marzieh Ramezani Farani, Yun Suk Huh, Angel Serrano-Aroca, Murtaza M. Tambuwala
Summary: Water treatment plays a crucial role in addressing global water shortages. Carbon nanotubes (CNTs) show great potential in environmental applications due to their unique physical and chemical characteristics. The utilization of functionalized CNTs and nanocomposites can effectively eliminate contaminants, although their high costs still limit their widespread implementation in water treatment.
ENVIRONMENTAL RESEARCH
(2023)
