Article
Oncology
Alpa Patel, Emily Deubler, Lauren R. Teras, Graham A. Colditz, Cari J. Lichtman, William G. Cance, Christina A. Clarke
Summary: In this study, it was found that older age and smoking were the two most important risk factors associated with the relative and absolute 5-year risk of developing any cancer. Other factors such as alcohol intake, family history of cancer, red meat consumption, body mass index, type 2 diabetes, and physical inactivity were also found to be associated with cancer risk.
Article
Oncology
Yohwan Yeo, Dong Wook Shin, Kyungdo Han, Sang Hyun Park, Keun-Hye Jeon, Jungkwon Lee, Junghyun Kim, Aesun Shin
Summary: A personalized lung cancer risk prediction model for Korean adults was developed, aiming to identify high-risk individuals for screening and promote interactions between healthcare providers and examinees. The model showed good discrimination and calibration, effectively predicting lung cancer development and assisting individuals in decision-making and behavior modification.
Article
Psychology, Multidisciplinary
Serena Oliveri, Lucilla Lanzoni, Jorien Veldwijk, G. Ardine de Wit, Serena Petrocchi, Rosanne Janssens, Elise Schoefs, Meredith Y. Smith, Ian Smith, Kristiaan Nackaerts, Marie Vandevelde, Evelyne Louis, Herbert Decaluwe, Paul De Leyn, Hanne Declerck, Francesco Petrella, Monica Casiraghi, Giulia Galli, Marina Chiara Garassino, Charis Girvalaki, Isabelle Huys, Gabriella Pravettoni
Summary: The combination of Immuno-Oncotherapy (IO) and chemotherapy (CT) has been found to be superior to IO or CT alone for the treatment of Non-Small Cell Lung Cancer (NSCLC). This study aimed to quantify patients' preferences for treatment attributes and evaluate their maximum acceptable risk/benefit. An online preference survey using a discrete-choice experiment (DCE) was conducted among NSCLC patients from two hospitals in Italy and Belgium.
FRONTIERS IN PSYCHOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Lilian Calderon-Garciduenas, Alberto Ayala
Summary: A study by Harvard University reveals that fine particulate matter (PM2.5) concentrations exceeding WHO guidelines impact 99% of the global population. The research, published in Nature, provides evidence supporting the hypothesis that inhalation of PM2.5 can increase the risk of lung carcinoma, even without smoking.
Article
Oncology
Runhua Li, Min Zhang, Yongran Cheng, Xiyi Jiang, Huijuan Tang, Liangyou Wang, Tianhui Chen, Bicheng Chen
Summary: The study assessed the long-term survival of lung cancer patients using cancer registry data from Taizhou City, identifying the impact of sex, age, and region on survival rates. Projections showed a 5-year relative survival of 52.7% for lung cancer patients in 2019-2023, with higher rates for women and urban patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Daniel J. Schaid, Jason P. Sinnwell, Anthony Batzler, Shannon K. McDonnell
Summary: This study investigates the age dependency of polygenic risk scores (PRSs) for prostate cancer and finds that genetic relative risks decrease with increasing age. The results suggest that while there is strong evidence of age-dependent genetic relative risk, absolute risk predictions do not differ significantly, simplifying risk discussions in clinical practice.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Geriatrics & Gerontology
Lisa Langsetmo, John T. Schousboe, Brent C. Taylor, Jane A. Cauley, Howard A. Fink, Peggy M. Cawthon, Marcia L. Stefanick, Deborah M. Kado, Allyson M. Kats, Kristine E. Ensrud
Summary: This study evaluated the risks of clinical fracture, hip fracture, and mortality prior to fracture among men aged at least 80 years. The results showed that fall history, hip bone mineral density, and recent fracture were strong predictors of clinical fracture and hip fracture. Age and multimorbidity were strong predictors of mortality before fracture. The study results have important implications for guiding osteoporosis drug treatment decisions.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Simran K. Randhawa, Zhizhou Yang, Deniz B. Morkan, Yan Yan, Su-Hsin Chang, Ramsey R. Hachem, Chad A. Witt, Derek E. Byers, Hrishikesh S. Kulkarni, Rodrigo Vasquez Guillamet, Benjamin D. Kozower, Ruben G. Nava, Bryan F. Meyers, G. Alexander Patterson, Daniel Kreisel, Varun Puri
Summary: This study found that outcomes after lung retransplantation (LRT) are worse compared to primary lung transplantation (PLT). However, higher center volume is associated with better 1-year survival after LRT, particularly within the initial 30 days post-transplantation. These findings suggest that LRT candidates may benefit from being referred to higher-volume centers for surgery.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
M. Malvezzi, C. Santucci, P. Boffetta, G. Collatuzzo, F. Levi, C. La Vecchia, E. Negri
Summary: This study predicts cancer mortality figures for 2023 in the European Union, its five most populous countries, and the UK, with a focus on lung cancer. The results show that the decline in lung cancer mortality reflects advancements in tobacco control, and further efforts are needed to control overweight and obesity, alcohol consumption, infection, and related neoplasms, as well as improve screening, early diagnosis, and treatments. These efforts may achieve a 35% reduction in cancer mortality in the EU by 2035.
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Hsiu-An Lee, Louis R. Chao, Chien-Yeh Hsu
Summary: Lung cancer is the leading cause of death in Taiwan, and a deep neural network prediction model was developed using the NHIRDB to identify diseases and symptoms associated with lung cancer. Thirteen diseases were selected as predicting factors, and the model showed an accuracy of 85.4% with the ability to predict lung cancer risk earlier than traditional methods.
Article
Public, Environmental & Occupational Health
Bernadette Wilhelmina Antonia van der Linden, Nicolas Bovio, Patrick Arveux, Yvan Bergeron, Jean-Luc Bulliard, Evelyne Fournier, Simon Germann, Isabelle Konzelmann, Manuela Maspoli, Elisabetta Rapiti, Arnaud Chiolero, Irina Guseva Canu
Summary: The study aims to estimate the 10-year risk of lung and breast cancer by occupation and smoking status and to create easy to use age-, and sex-specific 10-year risk charts. The results show that the risks of lung and breast cancer increase with age and are the highest for current smokers. There are significant differences in the 10-year risk between occupational categories, and smoking has a greater impact on the risk than occupation. The risk charts can be used as public health indicators and to inform policies to protect workers.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Respiratory System
Gregoire Justeau, Sebastien Bailly, Chloe Gerves-Pinquie, Wojciech Trzepizur, Nicole Meslier, Francois Goupil, Thierry Pigeanne, Sandrine Launois, Laurene Leclair-Visonneau, Philippe Masson, Acya Bizieux-Thaminy, Jean-Louis Racineux, David Gozal, Frederic Gagnadoux
Summary: This study aimed to investigate the association between adherence to continuous positive airway pressure (CPAP) therapy and the incidence of cancer in patients with obstructive sleep apnoea (OSA). The results showed that adherence to CPAP therapy did not significantly reduce the risk of all-cancer incidence. Further evaluation is needed to determine if adherent CPAP therapy for OSA can reduce the risk of specific cancer sites.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Multidisciplinary Sciences
Jiaxin Li, Zijun Zhou, Jianyu Dong, Ying Fu, Yuan Li, Ze Luan, Xin Peng
Summary: This systematic review analyzed current studies on using machine learning to predict the 5-year survival rate of breast cancer patients, finding that most studies utilized decision trees, artificial neural networks, support vector machines, and ensemble learning as common ML methods. The research showed that compared with traditional statistical methods, the performance of ML models does not necessarily show any improvement, and still faces limitations related to a lack of data preprocessing steps, the excessive differences of sample feature selection, and issues related to validation.
Article
Mathematical & Computational Biology
Danping Liu, Emily Wu, Joanna H. H. Shih, Cari M. M. Kitahara, Li C. C. Cheung
Summary: Incomplete cancer registries can result in underreporting of cancers and biased risk estimates. This study proposes a two-step procedure to estimate relative and absolute risk by incorporating individuals' residential history and accounting for unobserved events. Extensive simulation studies show that the proposed method reduces bias and improves efficiency compared to alternative approaches. The method is then applied to a study on first primary lung cancers in the USRT cohort.
STATISTICS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Guoqing Huang, Qiankai Jin, Yushan Mao
Summary: This study investigates the 5-year incidence of NAFLD in the Chinese population and develops a machine learning model to predict the 5-year NAFLD risk. The model can aid in identifying populations at a heightened risk of developing NAFLD and reducing adverse liver prognostic events.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Oncology
Sabine Schmid, Mei Jiang, M. Catherine Brown, Aline Fares, Miguel Garcia, Joelle Soriano, Mei Dong, Sera Thomas, Takashi Kohno, Leticia Ferro Leal, Nancy Diao, Juntao Xie, Zhichao Wang, David Zaridze, Ivana Holcatova, Jolanta Lissowska, Beata Swiatkowska, Dana Mates, Milan Savic, Angela S. Wenzlaff, Curtis C. Harris, Neil E. Caporaso, Hongxia Ma, Guillermo Fernandez-Tardon, Matthew J. Barnett, Gary Goodman, Michael P. A. Davies, Monica Perez-Rios, Fiona Taylor, Eric J. Duell, Ben Schoettker, Hermann Brenner, Angeline Andrew, Angela Cox, Alberto Ruano-Ravina, John K. Field, Loic Le Marchand, Ying Wang, Chu Chen, Adonina Tardon, Sanjay Shete, Matthew B. Schabath, Hongbing Shen, Maria Teresa Landi, Brid M. Ryan, Ann G. Schwartz, Lihong Qi, Lori C. Sakoda, Paul Brennan, Ping Yang, Jie Zhang, David C. Christiani, Rui Manuel Reis, Kouya Shiraishi, Rayjean J. Hung, Wei Xu, Geoffrey Liu
Summary: This study developed and tested pragmatic approaches to account for the missing EGFR-mutation-status in epidemiologic datasets of non-small cell lung cancers (NSCLC). By developing a regression model and using restriction and imputation methods, the study successfully evaluated the clinical impact of EGFR-status on NSCLC.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Wei Hong, Ang Li, Yanhong Liu, Xiangjun Xiao, David C. Christiani, Rayjean J. Hung, James McKay, John Field, Christopher Amos, Chao Cheng
Summary: Analysis of whole-exome sequencing data reveals correlations between clonal hematopoiesis and lung cancer risk factors, identifies genetic variants associated with clonal hematopoiesis, and uncovers numerous potential novel clonal hematopoiesis mutations.
Article
Biochemistry & Molecular Biology
Yafang Li, Xiangjun Xiao, Jianrong Li, Jinyoung Byun, Chao Cheng, Yohan Bosse, James McKay, Demetrios Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Maria T. Landi, Mattias Johansson, Angela Risch, Heike Bickeboeller, H-Erich Wichmann, David C. Christiani, Gad Rennert, Susanne Arnold, Gary Goodman, John K. Field, Michael P. A. Davies, Sanjay S. Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline S. Andrew, Lambertus A. Kiemeney, Hongbing Shen, Ryan Sun, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Dawn M. Teare, Yun-Chul Hong, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Ann G. Schwartz, Ivan Gorlov, Kristen Purrington, Ping Yang, Yanhong Liu, Younghun Han, Joan E. Bailey-Wilson, Susan M. Pinney, Diptasri Mandal, James C. Willey, Colette Gaba, Paul Brennan, Christopher Amos
Summary: Sex differences in lung cancer risk have not been well studied despite the success in lung cancer association studies. By analyzing genotypes from a lung cancer cohort, we identified three low-frequency variants with differential risk effects in men and women. Further analysis suggested that one of the variants affects lung cancer risk through regulation of CXADR gene expression.
HUMAN MOLECULAR GENETICS
(2022)
Article
Oncology
Rudolf M. Huber, Milena Cavic, Anna Kerpel-Fronius, Lucia Viola, John Field, Long Jiang, Ella A. Kazerooni, Coenraad F. N. Koegelenberg, Anant Mohan, Ricardo Sales Dos Santos, Luigi Ventura, Murry Wynes, Dawei Yang, Javier Zulueta, Choon-Taek Lee, Martin C. Tammemagi, Claudia Henschke, Stephen Lam
Summary: This report discusses the importance of global implementation of lung cancer screening and the impact of respiratory infections such as COVID-19 on screening. It highlights the risk of false positive results due to respiratory infections and provides guidance and recommendations for these situations, while also calling for further research and discussions.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Respiratory System
Emma L. O'Dowd, Kevin Ten Haaf, Jaspreet Kaur, Stephen W. Duffy, William Hamilton, Richard B. Hubbard, John K. Field, Matthew Ej Callister, Sam M. Janes, Harry J. de Koning, Janette Rawlinson, David R. Baldwin
Summary: The effectiveness of lung cancer screening for high-risk individuals is well-established. However, applying risk-prediction models directly to primary care data may not yield accurate results. These models, while helping to reduce the number of individuals for screening evaluation, may also result in missing some cases of lung cancer. Further research is needed to improve the performance of these models in primary care settings.
Article
Oncology
Ann Olsson, Neela Guha, Liacine Bouaoun, Hans Kromhout, Susan Peters, Jack Siemiatycki, Vikki Ho, Per Gustavsson, Paolo Boffetta, Roel Vermeulen, Thomas Behrens, Thomas Bruening, Benjamin Kendzia, Pascal Guenel, Daniele Luce, Stefan Karrasch, Heinz-Erich Wichmann, Dario Consonni, Maria Teresa Landi, Neil E. Caporaso, Franco Merletti, Dario Mirabelli, Lorenzo Richiardi, Karl-Heinz Joeckel, Wolfgang Ahrens, Hermann Pohlabeln, Adonina Tardon, David Zaridze, John K. Field, Jolanta Lissowska, Beata Swiatkowska, John R. McLaughlin, Paul A. Demers, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Tamas Pandics, Eleonora Fabianova, Dana Mates, Francesco Forastiere, Bas Bueno-de-Mesquita, Joachim Schuez, Kurt Straif
Summary: This study investigated the association between occupational exposure to PAH and lung cancer risk. The results showed an elevated risk of lung cancer among both men and women with PAH exposure. The study also found joint effects between PAH and smoking. However, more recent studies did not show an increased risk of lung cancer associated with PAH.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Health Care Sciences & Services
Samantha Groves, Grace McCutchan, Samantha L. Quaife, Rachael L. Murray, Jamie S. Ostroff, Kate Brain, Philip A. J. Crosbie, Janelle Yorke, David Baldwin, John K. Field, Lorna McWilliams
Summary: This study explored attitudes and preferences regarding the integration of smoking cessation support within lung cancer screening in the UK. The results showed that the integration of smoking cessation was positively viewed by eligible individuals. Personalized lung health information during screening appointments may increase cessation motivation. Services should support participants with fatalistic views and decreased motivation upon receiving a good screening result. Person-centred services are needed to increase engagement in cessation.
HEALTH EXPECTATIONS
(2022)
Article
Oncology
Ruyang Zhang, Sipeng Shen, Yongyue Wei, Ying Zhu, Yi Li, Jiajin Chen, Jinxing Guan, Zoucheng Pan, Yuzhuo Wang, Meng Zhu, Junxing Xie, Xiangjun Xiao, Dakai Zhu, Yafang Li, Demetrios Albanes, Maria Teresa Landi, Neil E. Caporaso, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeboeller, H-Erich Wichmann, Gadi Rennert, Susanne Arnold, Paul Brennan, James D. McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Annelie Behndig, Mikael Johansson, Angela Cox, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Juncheng Dai, Hongxia Ma, Yang Zhao, Zhibin Hu, Rayjean J. Hung, Christopher Amos, Hongbing Shen, Feng Chen, David C. Christiani
Summary: In this study, important gene-gene interactions that influence the risk of non-small cell lung cancer (NSCLC) were identified and enriched in the 5p15.33 and 6p21.32 regions. These findings have the potential to improve lung cancer screening models.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Genetics & Heredity
Jinyoung Byun, Younghun Han, Yafang Li, Jun Xia, Erping Long, Jiyeon Choi, Xiangjun Xiao, Meng Zhu, Wen Zhou, Ryan Sun, Yohan Bosse, Zhuoyi Song, Ann Schwartz, Christine Lusk, Thorunn Rafnar, Kari Stefansson, Tongwu Zhang, Wei Zhao, Rowland W. Pettit, Yanhong Liu, Xihao Li, Hufeng Zhou, Kyle M. Walsh, Ivan Gorlov, Olga Gorlova, Dakai Zhu, Susan M. Rosenberg, Susan Pinney, Joan E. Bailey-Wilson, Diptasri Mandal, Mariza de Andrade, Colette Gaba, James C. Willey, Ming You, Marshall Anderson, John K. Wiencke, Demetrius Albanes, Stephan Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig Bojeson, Hermann Brenner, Maria Teresa Landi, Stephen J. Chanock, Mattias Johansson, Thomas Muley, Angela Risch, H-Erich Wichmann, Heike Bickeboeller, David C. Christiani, Gad Rennert, Susanne Arnold, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Hongbing Shen, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Angela Cox, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Alpa Patel, Qing Lan, Nathaniel Rothman, Fiona Taylor, Linda Kachuri, John S. Witte, Lori C. Sakoda, Margaret Spitz, Paul Brennan, Xihong Lin, James McKay, Rayjean J. Hung, Christopher Amos
Summary: A genome-wide association meta-analysis of lung cancer among different populations reveals five new susceptibility loci and identifies population-specific effects of common and rare variants. The study also highlights the potential role of genes such as IRF4 and FUBP1 in promoting DNA damage in lung fibroblasts.
Article
Public, Environmental & Occupational Health
Hilary A. Robbins, Karine Alcala, Elham Khodayari Moez, Florence Guida, Sera Thomas, Hana Zahed, Matthew T. Warkentin, Karl Smith-Byrne, Yonathan Brhane, David Muller, Xiaoshuang Feng, Demetrius Albanes, Melinda C. Aldrich, Alan A. Arslan, Julie Bassett, Christine D. Berg, Qiuyin Cai, Chu Chen, Michael P. A. Davies, Brenda Diergaarde, John K. Field, Neal D. Freedman, Wen-Yi Huang, Mikael Johansson, Michael Jones, Woon-Puay Koh, Stephen Lam, Qing Lan, Arnulf Langhammer, Linda M. Liao, Geoffrey Liu, Reza Malekzadeh, Roger L. Milne, Luis M. Montuenga, Thomas Rohan, Howard D. Sesso, Gianluca Severi, Mahdi Sheikh, Rashmi Sinha, Xiao-Ou Shu, Victoria L. Stevens, Martin C. Tammemaegi, Lesley F. Tinker, Kala Visvanathan, Ying Wang, Renwei Wang, Stephanie J. Weinstein, Emily White, David Wilson, Jian-Min Yuan, Xuehong Zhang, Wei Zheng, Christopher I. Amos, Paul Brennan, Mattias Johansson, Rayjean J. Hung
Summary: The INTEGRAL program aims to develop tools for optimizing LDCT lung cancer screening. It includes the Risk Biomarker and Nodule Malignancy projects, which investigate circulating protein markers for identifying individuals likely to benefit from screening and distinguishing benign versus malignant nodules. A total of 1161 and 1078 proteins were measured, and 21 proteins were selected for performance evaluation in the Risk Biomarker and Nodule Malignancy projects.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Oncology
Thomas Behrens, Calvin Ge, Roel Vermeulen, Benjamin Kendzia, Ann Olsson, Joachim Schuez, Hans Kromhout, Beate Pesch, Susan Peters, Luetzen Portengen, Per Gustavsson, Dario Mirabelli, Pascal Guenel, Daniele Luce, Dario Consonni, Neil E. Caporaso, Maria Teresa Landi, John K. Field, Stefan Karrasch, Heinz-Erich Wichmann, Jack Siemiatycki, Marie-Elise Parent, Lorenzo Richiardi, Lorenzo Simonato, Karl-Heinz Joeckel, Wolfgang Ahrens, Hermann Pohlabeln, Guillermo Fernandez-Tardon, David Zaridze, John R. McLaughlin, Paul A. Demers, Beata Swiatkowska, Jolanta Lissowska, Tamas Pandics, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Paolo Boffetta, Bas Bueno-de-Mesquita, Francesco Forastiere, Kurt Straif, Thomas Bruening
Summary: Limited evidence exists regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. This study found that occupational exposure to Cr(VI) and nickel was associated with lung-cancer risks, particularly in men. In men, the highest quartile of cumulative exposure to CR(VI) and nickel were both significantly associated with increased odds ratios for lung cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Respiratory System
John K. Field
Article
Medicine, General & Internal
Michael P. A. Davies, Takahiro Sato, Haitham Ashoor, Liping Hou, Triantafillos Liloglou, Robert Yang, John K. Field
Summary: The study investigated the potential of plasma proteomes for lung cancer prediction and identified differentially expressed proteins and pathways associated with the presence and prediction of lung cancer.
Review
Oncology
Emma L. O'Dowd, Richard W. Lee, Ahsan R. Akram, Emily C. Bartlett, Stephen H. Bradley, Kate Brain, Matthew E. J. Callister, Yan Chen, Anand Devaraj, Sinan R. Eccles, John K. Field, Jesme Fox, Seamus Grundy, Sam M. Janes, Martin Ledson, Melanie MacKean, Anne Mackie, Kieran G. McManus, Rachael L. Murray, Arjun Nair, Samantha L. Quaife, Robert Rintoul, Anne Stevenson, Yvonne Summers, Louise S. Wilkinson, Richard Booton, David R. Baldwint, Philip Crosbie
Summary: Lung cancer screening with low-dose CT has been recommended by the UK National Screening Committee based on trials showing a reduction in lung cancer mortality. The UK has made significant progress in addressing logistical issues and implementing targeted lung cancer screening through clinical trials and the NHS England Targeted Lung Health Check Programme. This Policy Review provides a summary of the consensus and key requirements for effective implementation of a screening programme, and can serve as a valuable resource for countries planning their own lung cancer screenings.
Letter
Health Care Sciences & Services
Stephen W. Duffy, John K. Field
LANCET REGIONAL HEALTH-EUROPE
(2022)
