Issues on fit-for-purpose validation of a panel of ELISAs for application as biomarkers in clinical trials of anti-Angiogenic drugs

Quantifying Antivascular Effects of Monoclonal Antibodies to Vascular Endothelial Growth Factor: Insights from Imaging

(2009) J. P.B. O'Connor et al.   CLINICAL CANCER RESEARCH

Effects of pH and Arginine on the Solubility and Stability of a Therapeutic Protein (Fibroblast Growth Factor 20): Relationship between Solubility and Stability

(2009) Haripada Maity et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Increased Protein Stability of FGF1 Can Compensate for Its Reduced Affinity for Heparin

(2009) Malgorzata Zakrzewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Patterns of Cytokine and Angiogenic Factor Modulation and Markers of Benefit for Vandetanib and/or Chemotherapy in Patients With Non–Small-Cell Lung Cancer

(2009) Emer O. Hanrahan et al.   JOURNAL OF CLINICAL ONCOLOGY

‘Fit-for-purpose’ validation of SearchLight multiplex ELISAs of angiogenesis for clinical trial use

(2009) A.C. Backen et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Biomarkers of response and resistance to antiangiogenic therapy

(2009) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Anticancer strategies involving the vasculature

(2009) Victoria L. Heath et al.   Nature Reviews Clinical Oncology

A Compartment Model of VEGF Distribution in Humans in the Presence of Soluble VEGF Receptor-1 Acting as a Ligand Trap

(2009) Florence T. H. Wu et al.   PLoS One

The transport of high amounts of vascular endothelial growth factor by blood platelets underlines their potential contribution in systemic sclerosis angiogenesis

(2009) A. Solanilla et al.   RHEUMATOLOGY

Platelets actively sequester angiogenesis regulators

(2008) G. Lakka Klement et al.   BLOOD

Biologic Markers of Angiogenesis: Circulating Endothelial Cells in Patients with Advanced Malignancies Treated on Phase I Protocol with Metronomic Chemotherapy and Celecoxib

(2008) Przemyslaw W. Twardowski et al.   CANCER INVESTIGATION

Impact of different anticancer regimens on biomarkers of angiogenesis in patients with advanced hepatocellular cancer

(2008) G. Treiber et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Some important considerations for validation of ligand-binding assays

(2008) John W.A. Findlay   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Validation and comparison of two multiplex technologies, Luminex® and Mesoscale Discovery, for human cytokine profiling

(2008) Ferdousi Chowdhury et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Protein aggregation: Pathways, induction factors and analysis

(2008) Hanns-Christian Mahler et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations?

(2008) Cristiana Sessa et al.   Nature clinical practice. Oncology

Biomarker method validation in anticancer drug development

(2007) J Cummings et al.   BRITISH JOURNAL OF PHARMACOLOGY