Article
Medicine, General & Internal
Hao-Wen Chuang, Jyh-Seng Wang, Jen-Wei Tsai, Chao-Tien Hsu, Kai-Jen Lin
Summary: This study assessed the diagnostic value of various immunohistochemical markers for differentiating among benign follicular nodules, noninvasive follicular thyroid neoplasms, noninvasive encapsulated follicular variants of papillary thyroid carcinoma, and infiltrative FVPTC. Results showed specific markers with high sensitivity and specificity in distinguishing different types of lesions, with various combinations enhancing diagnostic accuracy. The similar IHC profiles of NIFTP and NEFVPTC suggest a reliable NIFTP diagnosis and a possible spectrum of progressing neoplasia.
MEDICINA-LITHUANIA
(2021)
Article
Endocrinology & Metabolism
Stephen Halada, Julia A. Baran, Andrew J. Bauer, Julio C. Ricarte-Filho, Amber Isaza, Tasleema Patel, Aime T. Franco, Sogol Mostoufi-Moab, N. Scott Adzick, Ken Kazahaya, Tricia R. Bhatti, Zubair Baloch, Lea F. Surrey
Summary: This study retrospectively reviewed the clinical and histological features of pediatric cases with follicular patterned thyroid nodules with nuclear features of papillary thyroid carcinoma (PTC), focusing on the invasive encapsulated follicular variant of PTC (Ienc-fvPTC) and infiltrative fvPTC (inf-fvPTC) subtypes. The study found that pediatric NIFTP and fvPTC subtypes demonstrate alignment between clinical and histological risk stratification, with indolent behavior in Ienc-fvPTC and invasive features in inf-fvPTC tumors.
Article
Endocrinology & Metabolism
Dongdong Huang, Huifang Zhang, Lu Li, Weigang Ge, Wei Liu, Zhen Dong, Jinlong Gao, Nan Yao, Wenxin Fu, Lingling Huang, Tiannan Guo, Yaoting Sun, Xiaodong Teng
Summary: This study investigated the molecular differences among follicular-patterned thyroid tumors through proteomic analysis. The results identified differentially regulated proteins that can differentiate between different types of thyroid tumors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Bing Zhang, Wenming Wu, Jinjing Liu, Zhou Liang, Liang Zong
Summary: This cohort study examined the impact of different treatments on the prognosis of follicular variant papillary thyroid carcinoma (FVPTC) and classical papillary thyroid carcinoma (CPTC) patients. The findings suggest that combination therapy is associated with a decreased risk of 5-year mortality in CPTC and FVPTC patients.
HORMONE AND METABOLIC RESEARCH
(2023)
Article
Cell Biology
Tyler Janovitz, Drew F. K. Williamson, Kristine S. Wong, Fei Dong, Justine A. Barletta
Summary: Columnar cell variant (CCV) is primarily a BRAF-driven tumor, with most cases also harboring secondary oncogenic mutations and multiple chromosomal gains and losses. Molecular analysis could potentially help risk stratify CCV.
Article
Oncology
Haruhiko Yamazaki, Ryohei Katoh, Kiminori Sugino, Kenichi Matsuzu, Chie Masaki, Junko Akaishi, Kiyomi Yamada Hames, Chisato Tomoda, Akifumi Suzuki, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Yasushi Rino, Koichi Ito
Summary: This study found a correlation between the extent of invasion and prognosis in patients with encapsulated angioinvasive follicular thyroid carcinoma. Patients with two or more foci of vascular invasion, especially those aged 55 years and above, should be closely monitored.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Dilara Akbulut, Ezgi Dicle Kuz, Nazmiye Kursun, Serpil Dizbay Sak
Summary: Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with some tumors being totally or partially encapsulated known as encapsulated (conventional) variant. Clinicopathological features of encapsulated PTC were compared with non-encapsulated conventional type, showing no significant differences except for prominent cystic changes. Evaluation of capsular invasion status is recommended for predicting lymph node metastasis in encapsulated PTC.
ENDOCRINE PATHOLOGY
(2021)
Article
Medicine, General & Internal
Qingshan Huang, Lijun Xie, Liyan Huang, Weili Wei, Haiying Li, Yunfang Zhuang, Xinxiu Liu, Shuqiang Chen, Sufang Zhang
Summary: Using LASSO regression analysis, this study identified 10 clinical and ultrasonic features to construct an ultrasonic diagnostic model for distinguishing FTC from FA, which demonstrated high accuracy and good performance in the validation group.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Michiyo Hayakawa, J. Nicholas Taylor, Ryuta Nakao, Kentaro Mochizuki, Yuki Sawai, Kosuke Hashimoto, Koji Tabata, Yasuaki Kumamoto, Katsumasa Fujita, Eiichi Konishi, Shigeru Hirano, Hideo Tanaka, Tamiki Komatsuzaki, Yoshinori Harada
Summary: This study evaluated the accumulation of lipid droplets and the expression of adipophilin in follicular thyroid carcinoma (FTC) cells. It was found that FTC cells had abundant lipid droplets and adipophilin expression, while follicular thyroid adenoma (FTA) had less. Therefore, assessing adipophilin expression can help differentiate FTC from FTA in surgical specimens.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Xiaomei Li, Min Lin, Juan Xu, Yu Pang, Hongzhi Chen, Peng Sun, Gang Hou
Summary: This article describes a case of invasive lobular carcinoma with solid and encapsulated papillary carcinoma growth pattern, which may present a diagnostic challenge, but the diagnosis was ultimately confirmed through immunohistochemistry and next-generation sequencing. Immunohistochemical analysis is crucial for differential diagnosis. The understanding of this newly discovered variant expands the morphological spectrum of invasive lobular carcinoma and helps to prevent misdiagnosis.
Article
Oncology
Wen Li, Qing Song, Yu Lan, Jie Li, Ying Zhang, Lin Yan, Yingying Li, Yan Zhang, Yukun Luo
Summary: The study aimed to explore the sonographic features of follicular thyroid carcinoma (FTC) and differentiate it from follicular thyroid adenoma (FTA). Results showed that an interrupted halo and satellite nodule(s) with or without halo ring are specific sonographic features for FTC. Sonography could play a role in distinguishing FTC from FTA.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Oncology
Henry Crayton, Katherine Wu, David Leong, Nazim Bhimani, Matti Gild, Anthony Glover
Summary: Diffuse sclerosing variant (DSV) of papillary thyroid carcinoma, a rare and aggressive form of thyroid cancer, has a worse prognosis compared to classical papillary thyroid carcinoma (c-PTC). DSV is often driven by fusion events and carries a higher risk of recurrent disease and distant metastasis.
ENDOCRINE-RELATED CANCER
(2023)
Article
Endocrinology & Metabolism
Anello Marcello Poma, Elisabetta Macerola, Agnese Proietti, Paola Vignali, Rebecca Sparavelli, Liborio Torregrossa, Antonio Matrone, Alessio Basolo, Rossella Elisei, Ferruccio Santini, Clara Ugolini
Summary: This study evaluated the differences between papillary thyroid carcinoma (PTC) with different proportions of hobnail features and hobnail variant (HVPTC), finding that tumors with more than 30% hobnail areas are more likely to have distant metastasis and structural persistence, indicating the need for special attention.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Anna C. Beck, Anand Rajan, Shannon Landers, Sarah Kelley, Andrew M. Bellizzi, Geeta Lal, Sonia L. Sugg, James R. Howe, Carlos H. Chan, Ronald J. Weigel
Summary: The study showed that the tall cell variant of papillary thyroid carcinoma has increased expression of cancer stem cell markers compared to classic papillary thyroid carcinoma. A gene signature similar to the tall cell variant identified a subtype of classic papillary thyroid carcinoma with worse recurrence-free survival.
Article
Cell Biology
Bin Xu, Kartik Viswanathan, Lingxin Zhang, Liz N. Edmund, Olivia Ganly, R. Michael Tuttle, Daniel Lubin, Ronald A. Ghossein
Summary: This study investigated the prognostic factors and appropriate STI cutoff for papillary thyroid carcinoma, solid variant (PTC-SV) through a multi-institutional study. The results suggest that the determining factor for nodal metastasis and disease-free survival (DFS) in PTC-SV is the encapsulation/infiltration status rather than the percentage of solid/trabecular/insular growth (STI).
