Article
Oncology
Giulia Turri, Gulser Caliskan, Cristian Conti, Luigi Martinelli, Ernesto De Giulio, Andrea Ruzzenente, Alfredo Guglielmi, Giuseppe Verlato, Corrado Pedrazzani
Summary: As the world population ages, more and more elderly patients will require cancer surgery. This study aimed to evaluate the impact of age and comorbidities on postoperative outcomes and long-term survival, and identify potential age-related survival differences.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Ying Zhang, Fang Wang, Hui Zhang, Yulong Wei, Yanan Deng, Dezhi Wang
Summary: The study compared postoperative complications, overall survival, and recurrence-free survival between patients who received volatile anesthesia and those who received propofol-based total intravenous anesthesia for digestive tract cancer curative surgeries. The results showed that there was no significant difference in postoperative complications, overall survival, or recurrence-free survival between the two groups. Age, comorbidity index, and cancer stage were identified as independent parameters for death of patients during the 3-year follow-up period.
Article
Oncology
Ramakrishnan Ayloor Seshadri, Arya C. Soman, Ajit Aggrawal, Anand Karnawat, Shailesh Patidar, Rajaraman Swaminathan
Summary: Conditional survival provides the probability of additional years survived for patients who have already survived a certain number of years after treatment. This study aimed to investigate the conditional survival of patients with gastric cancer. The analysis included patients who underwent curative intent treatment for gastric cancer between 2007 and 2018, and the probability of surviving additional years was calculated based on the number of years survived. The results showed that the probability of surviving an additional 3 years for patients who had already survived 1, 2, 3, 4, and 5 years after treatment were 64.2%, 74.5%, 81.6%, 83.2%, and 88.2%, respectively.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Ryan Howard, Samantha Hendren, Minal Patel, Vidhya Gunaseelan, Matthew Wixson, Jennifer Waljee, Michael Englesbe, Mark C. Bicket
Summary: This study aimed to evaluate differences in presentation and outcomes of surgery for colorectal cancer. The findings showed that Black non-Hispanic patients were more likely to undergo emergency surgery than White non-Hispanic patients, suggesting barriers to timely screening and evaluation.
Article
Oncology
Ifigenia Konstantinou, Iestyn M. Shapey, Demetris Papamichael, Nicola de Liguori Carino
Summary: Colorectal cancer is more prevalent in older patients, but optimal management for this population remains limited. Age alone should not dictate treatment options, and individualized plans should be made based on physiological reserve, tolerance, and priorities of the patients.
Article
Oncology
Haruhisa Matsuguma, Mingyon Mun, Atsushi Sano, Ichiro Yoshino, Hiroshi Hashimoto, Yasushi Shintani, Tomohiko Iida, Satoshi Shiono, Masayuki Chida, Hiroaki Kuroda, Mitsuo Nakayama, Yuji Shiraishi, Kazuhito Funai, Masafumi Kawamura
Summary: This study developed a new indicator, time to incurable recurrence (TTIR), to evaluate the probability of cure for patients undergoing lung metastasectomy. The results showed that TTIR was similar to the overall survival curve and could be used to analyze prognostic factors associated with cure.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Ryota Nakanishi, Ken'ichi Morooka, Kazuki Omori, Satoshi Toyota, Yasushi Tanaka, Hirofumi Hasuda, Naomichi Koga, Kentaro Nonaka, Qingjiang Hu, Yu Nakaji, Tomonori Nakanoko, Koji Ando, Mitsuhiko Ota, Yasue Kimura, Eiji Oki, Yoshinao Oda, Tomoharu Yoshizumi
Summary: A AI-based model has been developed to predict recurrence after curative resection for colorectal cancer using digitized pathological slides. The model successfully differentiated high-risk patients and could be used to consider the benefits of adjuvant chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Adrian Diaz, Elizabeth Barmash, Rosevine Azap, Anghela Z. Paredes, J. Madison Hyer, Timothy M. Pawlik
Summary: This study aimed to assess the association between county-level vulnerability and the probability of having a non-elective colon resection. The results showed that patients residing in communities with high social vulnerability were more likely to undergo a non-elective colon resection, highlighting the importance of social determinants in healthcare outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Multidisciplinary Sciences
Chien-Yi Yang, Min-Hsuan Yen, Kee-Thai Kiu, Yu-Ting Chen, Tung-Cheng Chang
Summary: This study compared the outcomes of right-sided colon cancer (RCC) and left-sided colon cancer (LCC). The results showed no significant difference in overall survival or time to recurrence between patients with RCC and LCC. However, in stage II colon cancer patients, RCC was associated with shorter time to recurrence.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Malin Ljunggren, Caroline E. Weibull, Gabriella Palmer, Emerik Osterlund, Bengt Glimelius, Anna Martling, Caroline Nordenvall
Summary: This population-based study found that women with synchronous metastatic colorectal cancer (mCRC) were less likely to receive metastatic surgery and had slightly higher all-cause mortality compared to men.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
A. K. Warps, R. A. E. M. Tollenaar, P. J. Tanis, J. W. T. Dekker
Summary: Complications after colorectal cancer surgery can have a significant impact on long-term survival. Non-surgical complications have a greater effect on survival than surgical complications. The impact of surgical complications on survival is still measurable in rectal cancer patients after surviving the first year, but not in colon cancer patients.
Article
Oncology
Antoine El Asmar, Martin Delcourt, Leonel Kamden, Charif Khaled, Ali Bohlok, Michel Moreau, Francesco Sclafani, Vincent Donckier, Gabriel Liberale
Summary: Preoperative serological biomarkers, specifically a higher neutrophil-to-lymphocyte ratio (NLR) and a higher platelet-to-lymphocyte ratio (PLR), can predict the prognosis of patients with peritoneal metastases of colorectal cancer (PMCRC) treated with complete cytoreductive surgery (CRS) +/- HIPEC.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Antoine El Asmar, Martin Delcourt, Leonel Kamden, Charif Khaled, Ali Bohlok, Michel Moreau, Francesco Sclafani, Vincent Donckier, Gabriel Liberale
Summary: This study aimed to evaluate the prognostic value of preoperative serological biomarkers in patients with PMCRC treated with complete CRS +/- HIPEC. The study found that a higher neutrophil-to-lymphocyte ratio (NLR) was associated with poor overall survival (OS), while a higher platelet-to-lymphocyte ratio (PLR) predicted favorable disease-free survival (DFS).
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alessandro Brunelli, Nilanjan Chaudhuri, Manos Kefaloyannis, Richard Milton, Cecilia Pompili, Peter Tcherveniakov, Kostas Papagiannopoulos
Summary: The study aimed to determine if the Eurolung score was linked to long-term survival post-lung cancer resection. Through analyzing data from 1359 patients who underwent lung resection surgeries between 2014 to 2018, it was found that the Eurolung score was significantly associated with overall survival rates. The score categorized patients into four classes, with different classes showing varying levels of long-term overall survival.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Oncology
Maud T. A. Strous, Charlotte J. L. Molenaar, Ruud F. W. Franssen, Frits van Osch, Eric Belgers, Johanne G. Bloemen, Gerrit D. Slooter, Jarno Melenhorst, Jeroen Heemskerk, Adriaan P. de Bruine, Maryska L. G. Janssen-Heijnen, F. Jeroen Vogelaar
Summary: This study aims to investigate whether a prolonged treatment interval in colon cancer treatment is associated with a clinically significant deterioration in overall and cancer-free survival. The results suggest that even a treatment interval over 49 days is non-inferior to the current waiting-time target of <= 35 days in terms of cancer-free survival. However, the results for overall survival are inconclusive.
BRITISH JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Arwa S. Almasaudi, Stephen T. McSorley, Ross D. Dolan, Christine A. Edwards, Donald C. McMillan
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Review
Oncology
Peter G. Alexander, Donald C. McMillan, James H. Park
CANCER TREATMENT REVIEWS
(2020)
Article
Oncology
Louise E. Daly, Ross D. Dolan, Derek G. Power, Eadaoin Ni Bhuachalla, Wei Sim, Samantha J. Cushen, Marie Fallon, Claribel Simmons, Donald C. Mcmillan, Barry J. Laird, Aoife M. Ryan
Review
Oncology
Ross D. Dolan, Donald C. McMillan
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Ross D. Dolan, Muhammed Alwahid, Stephen T. McSorley, James H. Park, Richard P. Stevenson, Campbell S. Roxburgh, Paul G. Horgan, Donald C. McMillan
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Peter G. Alexander, Antonia K. Roseweir, Kathryn A. F. Pennel, Hester C. van Wyk, Arfon G. M. T. Powell, Donald C. McMillan, Paul G. Horgan, Caroline Kelly, Jennifer Hay, Owen Sansom, Andrea Harkin, Campbell S. D. Roxburgh, Janet Graham, David N. Church, Ian Tomlinson, Mark Saunders, Tim J. Iveson, Joanne Edwards, James H. Park
Summary: The Glasgow Microenvironment Score (GMS) is validated as a prognostic tool for patients with stage I-III colorectal cancer, independent of TNM staging, and has the ability to stratify both low- and high-risk disease. Additionally, GMS 0 can be used to identify patients who benefit from FOLFOX over CAPOX chemotherapy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Katrina A. Knight, Ioanna Drami, Donald C. McMillan, Paul G. Horgan, James H. Park, John T. Jenkins, Campbell S. D. Roxburgh
Summary: The study found that calcification of the aortoiliac vessels supplying the rectum (AC) was not associated with NACRT response in the examined cohorts. Larger contemporary cohorts are needed to better assess host determinants of NACRT response and develop predictive models to improve patient selection.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Allan M. Golder, Donald C. McMillan, James H. Park, David Mansouri, Paul G. Horgan, Campbell S. Roxburgh
Summary: This study demonstrates that the pre-operative systemic inflammatory response (SIR) in patients undergoing curative surgery for colon cancer is best evaluated using a Systemic Inflammatory Grade (SIG) combining modified Glasgow Prognostic Score (mGPS) and neutrophil-lymphocyte ratio (NLR). Both mGPS and NLR have a significant impact on survival rates in colon cancer patients, and their combined use can better predict outcomes.
BRITISH JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Josh McGovern, Ross Dolan, Conor Richards, Barry J. Laird, Donald C. McMillan, Donogh Maguire
Summary: The study found that sarcopenia in the presence of obesity was associated with higher 30-day mortality in patients with COVID-19.
JOURNAL OF NUTRITION
(2021)
Article
Oncology
Josh McGovern, Ross D. Dolan, Richard J. Skipworth, Barry J. Laird, Donald C. McMillan
Summary: Cancer cachexia has traditionally been viewed as a nutritional syndrome, but recent research suggests that it may be primarily a manifestation of systemic inflammation. This has important implications for future treatment strategies.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Suad A. K. Shamis, Jean Quinn, Elizabeth E. A. Mallon, Joanne Edwards, Donald C. McMillan
Summary: The prognostic significance of hypoxia markers in estrogen receptor-positive breast cancer patients was investigated. The expression of these markers was associated with clinicopathological parameters and disease-free survival.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Oncology
P. G. Alexander, H. C. van Wyk, K. A. F. Pennel, J. Hay, D. C. McMillan, P. G. Horgan, C. S. D. Roxburgh, J. Edwards, J. H. Park
Summary: The Glasgow Microenvironment Score (GMS) is associated with the location of recurrence in colorectal cancer. Higher GMS categories (GMS 1 and 2) are associated with an increased risk of local and distant recurrence.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Josh McGovern, Ross D. Dolan, Claribel P. L. Simmons, Louise E. Daly, Aoife M. Ryan, Derek G. Power, Donogh Maguire, Marie T. Fallon, Barry J. Laird, Donald C. McMillan
Summary: This study found a relationship between serum LDH level, phenotypic/aetiologic diagnostic GLIM criteria, and survival in patients with advanced cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Bruna M. M. Rocha, Ross D. Dolan, Carlos E. Paiva, Josh McGovern, Bianca S. R. Paiva, Daniel D. Preto, Donald C. McMillan, Yara C. P. Maia, Barry J. Laird
Summary: This study compares prognostic factors in two international cohorts of patients with advanced cancer and establishes a prognostic framework for treatment. The study finds that despite geographical and socio-demographic differences, similar prognostic factors are associated with long-term survival in both the European and Brazilian cohorts.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Review
Oncology
F. Savioli, J. Edwards, D. McMillan, S. Stallard, J. Doughty, L. Romics
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2020)