Journal
BRITISH JOURNAL OF CANCER
Volume 98, Issue 3, Pages 664-667Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604202
Keywords
infant acute leukaemia; intrauterine factors; birth weight; MLL rearrangements
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In this paper, we compared the birth weight distribution among 201 infant leukaemia (IL) cases with that of 440 noncancer controls enrolled in Brazil in 1999-2005. Compared with the general population and the stratum 2500-2999 g as reference, IL cases weighing 3000-3999 g presented an odds ratio (OR) of 1.68 (95% CI: 1.03-2.76), and those of 4000 g or more, an OR of 2.28 (95% CI: 1.08-4.75), P-trend < 0.01. Using hospital-based controls, the OR for 4000 g or more, compared to 2500-2999 g, was 1.30 (95% CI: 1.02-1.43) after adjusting for confounders (gender, income, maternal age, pesticide and hormonal exposure during pregnancy). The results suggest that high birth weight is associated with increased risk of IL.
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