Journal
BRITISH JOURNAL OF CANCER
Volume 99, Issue 9, Pages 1534-1538Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604687
Keywords
breast cancer; CYP1A2; coffee; breast volume; BRCA1/2; oral contraceptive
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Funding
- Swedish Research Council [K2001-27GX-14120-01A, K2008-68X-20802-01-3]
- Medical Faculty in Lund
- Mrs. Berta Kamprad's Foundation
- Gunnar Nilsson Foundation
- South Swedish Health Care Region (Region Ska ne)
- Lund Hospital Fund and the Swedish Cancer Society
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As breast volume may be associated with heart cancer risk, we studied the relationship between breast volume, CYP1A2*1F and coffee intake. Among healthy premenopausal non-hormone users, 3+ cups per day was associated with lower volume only in C-allele carriers (P-interaction = 0.02), which is consistent with reports that coffee protects only C-allele carriers against breast cancer.
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