Article
Endocrinology & Metabolism
Haoli Mao, Huimin Huang, Ren Zhou, Jiao Zhu, Jia Yan, Hong Jiang, Lei Zhang
Summary: This study aimed to identify preoperative blood biomarkers related to the development of delayed neurocognitive recovery (dNCR) following surgery. Preoperative serum levels of oxaloacetate and 2-aminoadipic acid (2-AAA) were found to be associated with the occurrence of postoperative dNCR. High levels of these metabolites were also associated with a decrease in cognitive function after surgery.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Surgery
Yotam Weiss, Lilach Zac, Einat Refaeli, Shimon Ben-Yishai, Alexander Zegerman, Barak Cohen, Idit Matot
Summary: The study aimed to test the hypothesis that in surgical patients >=70 years, preoperative cognitive impairment is independently associated with postoperative delirium. The results showed that one-fifth of elective surgical patients >= 70 years present to surgery with preoperative cognitive impairment, and these patients are at increased risk of postoperative delirium and major adverse outcomes.
Article
Multidisciplinary Sciences
Marinus Fislage, Insa Feinkohl, Friedrich Borchers, Tobias Pischon, Claudia D. Spies, Georg Winterer, Norman Zacharias, BioCog Consortium
Summary: This study aimed to investigate the association between preoperative thalamic volume and both preoperative cognitive impairment (preCI) and postoperative cognitive dysfunction at 3 months (POCD). The results showed that there was no significant association between preoperative thalamic volume and either preCI or POCD.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Marinus Fislage, Insa Feinkohl, Friedrich Borchers, Tobias Pischon, Claudia D. Spies, Georg Winterer, Norman Zacharias
Summary: This study aimed to investigate the relationship between preoperative thalamic volume and preoperative cognitive impairment (preCI) as well as postoperative cognitive dysfunction at 3 months (POCD). The study found that there was no significant association between preoperative thalamic volume and preCI or POCD, independent of age, sex, and intracranial volume, based on the analysis of 301 patients.
SCIENTIFIC REPORTS
(2023)
Article
Orthopedics
Sylvia H. Wilson, Renuka M. George, Jennifer R. Matos, Dulaney A. Wilson, Walter J. Johnson, Shane K. Woolf
Summary: This study aimed to examine the acute postoperative opioid consumption in patients undergoing hip arthroscopy. The results showed that patients who received a preoperative lateral quadratus lumborum block had reduced opioid consumption, indicating that the block can be an effective component of multimodal analgesia in patients undergoing elective hip arthroscopy.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Geriatrics & Gerontology
Xin Ma, Xinchun Mei, Tianyi Tang, Meijuan Wang, Xiaoyi Wei, Hailin Zheng, Jing Cao, Hui Zheng, Kathryn Cody, Lize Xiong, Edward R. Marcantonio, Zhongcong Xie, Yuan Shen
Summary: This study aimed to compare the role of preoperative homocysteine versus postoperative CRP blood concentration in predicting postoperative delirium. The results showed that the postoperative plasma concentration of CRP was associated with the incidence and severity of postoperative delirium. Furthermore, the preoperative plasma concentration of homocysteine modified this association.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Sicong Yu, Yicheng Xiong, Guangtao Lu, Xiangqing Xiong
Summary: Sleep disorders have a significant impact on the recovery and postoperative pain of patients undergoing laparoscopic gynecological surgery under general anesthesia. The degree of sleep disorders is positively correlated with the length of extubation and recovery time, as well as the intensity of postoperative pain. Sleep disorders can also exacerbate inflammatory reactions in the body after surgery.
MEDIATORS OF INFLAMMATION
(2022)
Article
Surgery
Stacie Deiner, Xiaoyu Liu, Hung-Mo Lin, Rachelle Jacoby, Jong Kim, Mark G. Baxter, Frederick Sieber, Kenneth Boockvar, Mary Sano
Summary: Patients with POCD are more likely to experience new disability in activities of daily living after surgery, influenced by factors such as preoperative cognition and function, postoperative depression, and postoperative complications. Therefore, a comprehensive assessment of cognitive and functional status before surgery should be conducted to reduce the risk of new disability after surgery.
Article
Urology & Nephrology
K. R. Seetharam Bhat, Marcio Covas Moschovas, Marco Sandri, Paolo Dell'Oglio, Fikret F. Onol, Travis Rogers, Sunil Reddy, Jonathan Noel, Shannon Roof, Maria Chiara Sighinolfi, Bernardo Rocco, Vipul R. Patel
Summary: The study proposes preoperative and postoperative nomograms to predict potency recovery following robot-assisted radical prostatectomy (RARP). By considering preoperative and postoperative factors, the nomograms accurately predict the probability of potency recovery within 3, 6, 12, and 24 months after surgery.
JOURNAL OF UROLOGY
(2021)
Article
Chemistry, Medicinal
Conghui Hao, Hai Xu, Jingjing Du, Tianyu Zhang, Xiaobao Zhang, Zhibin Zhao, Hengfei Luan
Summary: The quality of recovery was superior in patients receiving opioid-free anesthesia compared to those receiving opioid-based anesthesia after laparoscopic cholecystectomy, with significant differences in postoperative recovery scores and incidence of opioid-related symptoms.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Fumiko Seto, Gaku Kawamura, Keisuke Hosoki, Michiko Ushio, Taisuke Jo, Kanji Uchida
Summary: This study assessed the association between perioperative management and postoperative acute exacerbations in interstitial lung disease patients. It found that one lung ventilation and intraoperative steroid administration were significantly associated with higher rates of acute exacerbations.
SCIENTIFIC REPORTS
(2023)
Article
Geriatrics & Gerontology
Shooka Esmaeeli, Esteban Franco-Garcia, Oluwaseun Akeju, Marilyn Heng, Carmen Zhou, Ruben J. Azocar, Sadeq A. Quraishi
Summary: The study found that preoperative frailty is associated with postoperative delirium (POD) in elderly orthopedic trauma patients, with each unit increase in frailty score associated with a 33% higher likelihood of POD. Future research is needed to determine if perioperative interventions focused on improving frailty can reduce the risk of POD and improve outcomes for this patient population.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Xiangyi Gu, Yufei Zhang, Wenxin Wei, Junchao Zhu
Summary: This study aimed to investigate the effects of preoperative anxiety on postoperative sleep quality and recovery outcomes among patients undergoing laparoscopic gynecological surgery. The results showed that preoperative anxiety was associated with poorer sleep quality, increased postoperative pain, and a higher requirement for analgesia. Additionally, patients with preoperative anxiety had a higher incidence of nausea, vomiting, and dizziness. However, there was no significant difference in the satisfaction rate between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jae Hong Park, Yei Heum Park, Byeongcheol Lee, Sung Hyun Shin, Daeseok Oh, Sung Ho Moon, Myoung Jin Ko
Summary: Preoperative echocardiography does not affect postoperative outcomes, but it has the potential to affect intraoperative anesthetic management such as invasive hemodynamic monitoring during surgery.
Review
Environmental Sciences
Wentao Ji, Chao Sang, Xiaoting Zhang, Keming Zhu, Lulong Bo
Summary: This review examines the relationship between personality traits and preoperative anxiety, as well as their association with postoperative outcomes. Existing research suggests that anxiety may mediate the relationship between personality and postoperative outcomes, with severe anxiety partially explaining the adverse effects of certain personality traits on surgical outcomes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Anesthesiology
George A. Mashour, Robert D. Sanders, UnCheol Lee
Letter
Anesthesiology
Justin G. Wu, Jennifer Taylor, Maggie Parker, David Kunkel, Cameron Rivera, Robert A. Pearce, Richard Lennertz, Robert D. Sanders
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Anesthesiology
Jennifer Taylor, Margaret Parker, Cameron P. Casey, Sean Tanabe, David Kunkel, Cameron Rivera, Henrik Zetterberg, Kaj Blennow, Robert A. Pearce, Richard C. Lennertz, Robert D. Sanders
Summary: This study found that changes in cerebrospinal fluid/plasma albumin ratio and plasma S100B during the perioperative period were associated with the severity of delirium. The breakdown of the blood-brain barrier was identified as a cause of postoperative delirium. Blood loss was also found to be related to the occurrence and severity of delirium.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Anesthesiology
Xiao Yang, Zhifeng Li, Binbin Wang, Yunbao Pan, Chaoyun Jiang, Xingguo Zhang, Yadong Yang, Chenliang Zhou, Chang Hu, Zhijiang Zhang, Haibo Xu, Weijin Liao, Marcela P. Vizcaychipi, Robert D. Sanders, Yirong Li, Daqing Ma, Zhiyong Peng
Summary: Survivors of critical illness from COVID-19 may experience persistent long-term impairments in lung function, although most of the functions are restored to normal by 12 months. These patients still have detectable levels of neutralising antibodies against SARS-CoV-2 and all types of IgG at 12 months, but the antibody levels have declined over time.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Letter
Anesthesiology
Maribel Torres-Velazquez, Margaret Parker, Amber Bo, Marissa White, Sean Tanabe, Robert A. Pearce, Richard Lennertz, Steve Y. Cho, Barbara Bendlin, Sterling C. Johnson, Vivek Prabhakaran, Alan B. McMillan, Robert D. Sanders
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Anesthesiology
Cameron P. Casey, Sean Tanabe, Zahra Farahbakhsh, Margaret Parker, Amber Bo, Marissa White, Tyler Ballweg, Andrew Mcintosh, William Filbey, Yuri Saalmann, Robert A. Pearce, Robert D. Sanders
Summary: This study investigated the neural correlates of sensory disconnection and unconsciousness using a novel serial awakening paradigm. The results showed that occipital delta power could differentiate disconnected and unconscious states. Source localised signatures of sensory disconnection and unconsciousness were identified. These findings could potentially lead to the development of new monitors for the anaesthetic state and provide insights into the biology of arousal.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Psychology, Clinical
Sophia Wang, Ryan Greene, Yiqing Song, Carol Chan, Heidi Lindroth, Sikandar Khan, Gabriel Rios, Robert D. Sanders, Babar Khan
Summary: This study used meta-analysis to identify biomarkers of Alzheimer's and related dementias (ADRD) associated with postoperative delirium (POD). Certain inflammatory and neuronal injury biomarkers were found to be significantly related to POD. Future studies should further investigate these relationships and incorporate amyloid and tau biomarkers to better understand the relationship between POD and ADRD.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Geriatrics & Gerontology
Sean Tanabe, Maggie Parker, Richard Lennertz, Robert A. Pearce, Matthew Banks, Robert D. Sanders
Summary: Delirium is associated with a decrease in cortical complexity as measured by Lempil-Ziv Complexity (LZC), showing reduced brain information processing with increasing delirium severity. The negative correlation between LZC and delirium severity was observed widely across the scalp, while LZC normalized to a phase-shuffled distribution showed weaker correlations primarily in midline posterior regions. The study suggests that peripheral inflammation, as represented by monocyte chemoattractant protein-1, does not fully explain the decreased cortical complexity associated with delirium, indicating additional pathogenic mechanisms may be at play.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Editorial Material
Clinical Neurology
Richard C. Lennertz, Robert D. Sanders
Article
Anesthesiology
Thomas Payne, Jennifer Taylor, Cameron Casey, David Kunkel, Maggie Parker, Kaj Blennow, Henrik Zetterberg, Robert A. Pearce, Richard C. Lennertz, Robert D. Sanders
Summary: The study aimed to investigate the relationship between surgery, delirium, and changes in amyloid pathways. Results showed that the increase in plasma A(3R was not associated with delirium incidence or severity. Additionally, the change in plasma A(3R was not related to intraoperative variables.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Jordan J. Wehrman, Cameron Casey, Sean Tanabe, Sounak Mohanta, William Filbey, Lilian Weber, Matthew I. Banks, Robert A. Pearce, Yuri Saalmann, Robert D. Sanders
Summary: The study found that subanaesthetic dosing of ketamine reduced correlates of predictive coding but did not eliminate them. Prediction errors associated with the transition of one tone to the next were reduced at blood concentrations of 0.2-0.3 mg ml-1, but electroencephalographic activity still showed evidence of prediction errors. Prediction errors related to environmental volatility were observed before and during ketamine administration at the same dose.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Letter
Anesthesiology
Jennifer Taylor, Thomas Payne, Robert D. Sanders, Richard C. Lennertz
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Editorial Material
Anesthesiology
Andrew J. F. Turner, Jordan Wehrman, Robert D. Sanders
Summary: A recent study found that the frequency and content of recalled experiences were similar after non-rapid eye movement sleep and target-controlled infusions of propofol or dexmedetomidine titrated to verbal unresponsiveness. The study suggests that the phenomenological similarities between consciousness during sleep and sedation reflect their physiological similarities. Interestingly, conscious experience did not show a dose-dependent response in this small sample, suggesting that other factors may be important in determining consciousness under sedation.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Editorial Material
Anesthesiology
Elie Matar, Robert D. Sanders
Summary: Postoperative delirium is a significant complication of surgery that is linked to long-term cognitive decline, although the neural mechanisms behind this relationship are not well understood. Neuroimaging studies and network-based approaches are important tools for unraveling the link between delirium and cognitive decline. A recent study using resting state functional MRI revealed reduced global connectivity for up to 3 months after delirium, supporting current models of delirium and providing potential insight into the complex relationship between delirium and dementia.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Richard Lennertz, Kane O. Pryor, Aeyal Raz, Maggie Parker, Vincent Bonhomme, Peter Schuller, Gerhard Schneider, Matt Moore, Mark Coburn, James C. Root, Jacqueline M. Emerson, Alexandra L. Hohmann, Haya Azaria, Neta Golomb, Aline Defresne, Javier Montupil, Stefanie Pilge, David P. Obert, Hanna van Waart, Marta Seretny, Rolf Rossaint, Ana Kowark, Alexander Blair, Bryan Krause, Alex Proekt, Max Kelz, Jamie Sleigh, Amy Gaskell, Robert D. Sanders
Summary: Connected consciousness can occur after tracheal intubation in young adults, with females being at a higher risk. Further research is needed to understand the differences in risk between sexes.
BRITISH JOURNAL OF ANAESTHESIA
(2023)