Article
Spectroscopy
N. Mithun, Jijo Lukose, Ganesh Mohan, Shamee Shastry, Santhosh Chidangil
Summary: Crystalloid fluids have a greater impact on deoxygenation of red blood cells compared to blood plasma, as shown in Raman Tweezers spectroscopy analysis. Additionally, the ability of cells in blood plasma to withstand laser-induced deoxygenation is better than those in crystalloid fluids at higher laser powers. Principal component analysis of Raman spectral data effectively differentiates between cells in plasma and crystalloid fluids, demonstrating the effect of external induced stress on red blood cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Physiology
Arvind Sehgal, Bishal Gauli
Summary: Administration of normal saline boluses may have adverse effects on respiratory physiology in premature infants, including decreased pulmonary compliance and increased respiratory severity.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Emergency Medicine
Ki Hong Kim, Ki Jeong Hong, Sang Do Shin, Kyoung Jun Song, Young Sun Ro, Joo Jeong, Tae Han Kim, Jeong Ho Park, Hyoukjae Lim, Hyun Jeong Kang
Summary: In a porcine cardiac arrest model, the hypertonic crystalloid group demonstrated higher cerebral perfusion pressure values compared to the isotonic crystalloid group by maintaining higher mean arterial pressure and lower intracranial pressure values.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Raphael Vezina-Audette, Marta Kantyka, Giacomo Gianotti, Deborah C. Silverstein
Summary: In this prospective clinical trial, the effect of a bolus of balanced isotonic crystalloid solutions containing acetate buffers on hypotension in anesthetized dogs was studied. The results showed that none of the dogs experienced a paradoxical hypotensive reaction or an increase in blood pressure after receiving a fluid bolus. This study suggests that the use of these solutions is safe and does not exacerbate hypotension in anesthetized dogs.
Article
Computer Science, Interdisciplinary Applications
Michalakis Savva
Summary: A one-compartment model was established to simulate the drug concentration changes after constant rate repetitive intravenous intermittent infusions, with explicit solutions provided for drug concentration and AUC under non steady state conditions. The accuracy of these formulas was verified through mathematical proofs, numerical methods, and the principle of superposition, confirming their validity in calculating drug concentration and AUC.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Health Care Sciences & Services
Agnieszka Wiorek, Piotr K. Mazur, Elzbieta Zurawska, Lukasz J. Krzych
Summary: Prudent administration of fluids helps maintain hemodynamic stability, but may exacerbate existing coagulopathy. A study on healthy volunteers found that both balanced crystalloid and gelatine infusions resulted in decreased coagulation factors and fibrinogen concentration, impaired clot formation, and no effect on clot lysis. However, balanced crystalloid infusion caused less infusion-induced coagulopathy compared to gelatine.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Jason C. Ray, Shuli Cheng, Kirsten Tsan, Hassan Hussain, Richard J. Stark, Manjit S. Matharu, Elspeth Hutton
Summary: Lidocaine and ketamine infusions are found to be effective inpatient treatments for headache disorders, although they may prolong hospital stay and have potential side effects.
FRONTIERS IN NEUROLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Poomagal Shanmugam, Malar Balasubramaniam, Priyadarshini Srirambalaji, Vanitha Sivagaminathan
Summary: This paper introduces a classification algorithm called isotonic separation and proposes a conformal prediction-based approach to improve its classification performance. The author also presents a new non-conformity measure and conducts experiments on two different forms of conformal prediction methods, showing significant results in terms of performance measures.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Review
Critical Care Medicine
David W. Brossier, Lyvonne N. Tume, Anais R. Briant, Corinne Jotterand Chaparro, Clemence Moullet, Shancy Rooze, Sascha C. A. T. Verbruggen, Luise Marino, Fahad Alsohime, Sophie Beldjilali, Fabrizio Chiusolo, Leonardo Costa, Capucine Didier, Stavroula Ilia, Nyandat L. Joram, Martin C. J. Kneyber, Eva Kuhlwein, Jorge Lopez, Jesus Lopez-Herce, Huw F. Mayberry, Fortesa Mehmeti, Magdalena Mierzewska-Schmidt, Maria Minambres Rodriguez, Claire Morice, John Pappachan, Florence Porcheret, Leonor Reis Boto, Luregn J. Schlapbach, Hakan Tekguc, Konstantinos Tziouvas, Jean-Jacques Parienti, Isabelle Goyer, Frederic V. Valla
Summary: Prescribing intravenous maintenance fluid therapy in acute and critically ill children varies greatly among healthcare professionals. The European Society of Pediatric and Neonatal Intensive Care conducted a systematic review to provide up-to-date guidelines. The review found inconsistent outcome reporting and produced a series of recommendations, including the use of isotonic balanced solutions and regular monitoring of electrolyte levels and fluid balance.
INTENSIVE CARE MEDICINE
(2022)
Review
Veterinary Sciences
Elke Rudloff, Kate Hopper
Summary: This manuscript reviews crystalloid and colloid fluids available for intravenous administration, focusing on their electrolyte, acid-base, colligative, and rheological effects and their implications in therapeutically treating animals with critical illness.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Critical Care Medicine
Andrea Crosignani, Stefano Spina, Francesco Marrazzo, Stefania Cimbanassi, Manu L. N. G. Malbrain, Niels Van Regenemortel, Roberto Fumagalli, Thomas Langer
Summary: Patients with acute pancreatitis often require aggressive fluid resuscitation, but there is currently no consensus on the type, rate, volume, and goal of fluid administration. Close monitoring of fluid infusion and balance is important to avoid fluid overload.
ANNALS OF INTENSIVE CARE
(2022)
Review
Biochemistry & Molecular Biology
Klementina Ocskay, Peter Matrai, Peter Hegyi, Andrea Parniczky
Summary: This study analyzed randomized controlled trials and found that lactated Ringer's solution (LR) significantly reduces the risk of moderate-to-severe pancreatitis, mortality, and the need for intensive care compared to normal saline (NS). LR also reduces the risk of systemic and local complications in acute pancreatitis.
Review
Cardiac & Cardiovascular Systems
Jesus Alfonso Catahay, Edgar Theodore Polintan, Michael Casimiro, Kin Israel Notarte, Jacqueline Veronica Velasco, Abbygail Therese Ver, Adriel Pastrana, Imee Macaranas, Gabriel Patarroyo-Aponte, Kevin Bryan Lo
Summary: Current evidence suggests that the use of balanced electrolyte solutions (BES) leads to faster resolution of diabetic ketoacidosis (DKA) compared to isotonic saline (IS). However, further research is needed to provide more robust evidence for the use of BES in DKA.
Article
Economics
Andrii Babii, Rohit Kumar
Summary: This paper examines the estimation and inference of isotonic regression at the boundary point, which is crucial for analyzing monotone regression discontinuity designs. The paper demonstrates that isotonic regression is inconsistent in this context and provides the asymptotic distributions of boundary-corrected estimators. Interestingly, the boundary-corrected estimators can be bootstrapped without subsampling or additional nonparametric smoothing unlike the interior point. Monte Carlo experiments indicate that shape restrictions can significantly enhance the finite-sample performance of unrestricted estimators. Finally, the paper estimates the causal effect of incumbency in U.S. House elections using isotonic regression discontinuity design.
JOURNAL OF ECONOMETRICS
(2023)
Article
Veterinary Sciences
Alicia Inurria, Angelo Santana, Ana B. Casal, Pascual Calabuig, Alejandro Suarez-Perez, Jorge Oros
Summary: This study compares the efficacy and effects on acid-base and electrolyte status of four different crystalloids in stranded sea turtles, and finds that the combination of 0.9% NaCl and lactated Ringer's solutions is the most effective in resolving acid-base and electrolyte abnormalities.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Hematology
Elaine Cavalcante dos Santos, Peter Bakos, Jean-Louis Vincent
Editorial Material
Microbiology
Jean-Louis Vincent
FUTURE MICROBIOLOGY
(2021)
Letter
Critical Care Medicine
Jean-Louis Vincent, Jacques Creteur
INTENSIVE CARE MEDICINE
(2021)
Article
Critical Care Medicine
Wasineenart Mongkolpun, Peter Bakos, Jean-Louis Vincent, Jacques Creteur
Summary: This study included 42 patients with shock, and found that baseline skin blood flow and its early reduction after initiation of fluid removal using CVVH can predict worsened tissue perfusion, reflected by an increase in blood lactate levels.
ANNALS OF INTENSIVE CARE
(2021)
Review
Medicine, General & Internal
Jean-Louis Vincent, Jacques Creteur
Summary: With increasing life expectancy, more elderly patients are being admitted to ICU, representing a unique subgroup with changes in organ function, reduced daily living activities, decreased mobility, and cognitive decline. Ethical decisions regarding intensive care, life-sustaining interventions, life support withdrawal/withholding, and terminal sedation are more common in elderly patients, and should be personalized to consider individual beliefs and wishes.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jean-Louis Vincent
Summary: Intensive care units (ICUs) worldwide have faced significant challenges due to the COVID-19 pandemic, such as resource shortages and ethical dilemmas. Through the discussions prompted by the COVID-19 situation, valuable lessons can be learned about resource allocation, end-of-life decision-making, and staff support.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fabio Silvio Taccone, Fuhong Su, Xinrong He, Lorenzo Peluso, Katia Donadello, Sabino Scolletta, Daniel De Backer, Jean-Louis Vincent
Summary: The effects of correcting hypotension with vasopressors in septic shock may improve cerebral oxygenation but do not reverse the alterations in brain microcirculation or cerebral metabolism.
Review
Virology
Maya Hites, Jean-Louis Vincent
Summary: This article reviews the clinical studies conducted in Belgium on hospitalized patients with COVID-19, showing a limited participation of hospitals, low international collaboration, and a lack of adaptive platform trials.
Article
Neurosciences
Katia Donadello, Fuhong Su, Filippo Annoni, Sabino Scolletta, Xinrong He, Lorenzo Peluso, Leonardo Gottin, Enrico Polati, Jacques Creteur, Olivier De Witte, Jean-Louis Vincent, Daniel De Backer, Fabio Silvio Taccone
Summary: This study investigated the effects of cooling on cerebral microcirculation, oxygenation and metabolism in a healthy swine model. The results showed that during the cooling phase, cerebral functional capillary density and proportion of small-perfused vessels decreased, while oxygenation increased and metabolism decreased. After rewarming, all variables returned to normal values, except for an increased metabolism in the two groups subjected to hypothermia during the rewarming phase compared to the normothermia group.
Review
Biochemistry & Molecular Biology
Jean-Louis Vincent, Tom van der Poll, John C. Marshall
Summary: Sepsis, a life-threatening organ dysfunction caused by an uncontrolled host response to infection, remains a major challenge for clinicians and trialists. The evaluation of therapeutics targeting components of host response anomalies in sepsis patients is complicated by the inability to identify those who are more likely to benefit from a specific intervention. Furthermore, the existence of multiple and diverse host response aberrations in sepsis and limited knowledge of the dysregulated biological organ system or pathway driving sepsis-induced pathology in individual patients further complicate the development of effective therapies.
Article
Infectious Diseases
Jean-Louis Vincent
Summary: Sepsis is an infection associated with organ dysfunction, and early recognition and assessment of severity are crucial.
Correction
Critical Care Medicine
Alberto Fogagnolo, Fabio Silvio Taccone, Jean Louis Vincent, Giulia Benetto, Elaine Cavalcante, Elisabetta Marangoni, Riccardo Ragazzi, Jacques Creteur, Carlo Alberto Volta, Savino Spadaro
Review
Critical Care Medicine
Carlos A. Santacruz, Jean-Louis Vincent, Andres Bader, Luis A. Rincon-Gutierrez, Claudia Dominguez-Curell, David Communi, Fabio S. Taccone
Summary: Studies suggest that altered CSF concentrations of protein biomarkers related to cytoskeletal damage, inflammation, apoptosis, and oxidative stress may predict worse neurological outcomes in patients with acute brain injuries.
Article
Critical Care Medicine
Jean-Louis Vincent, Nicole P. Juffermans, Karen E. A. Burns, V. Marco Ranieri, Chryssa Pourzitaki, Francesca Rubulotta
Summary: There is a significant gender gap in critical care medicine, with women being underrepresented, but gender diversity has beneficial effects. The article discusses the reasons behind gender imbalance and proposes solutions, emphasizing the need to address and eliminate this issue.
Article
Critical Care Medicine
Jean-Louis Vincent, Julia Wendon, Greg S. Martin, Nicole P. Juffermans, Jacques Creteur, Maurizio Cecconi
Summary: The current coronavirus pandemic has heavily impacted ICUs worldwide, putting immense pressure on healthcare systems and staff. It is important to learn from both the positive and negative aspects of the response to improve organization and patient care in the future.