Article
Medicine, General & Internal
Nik Izyan Syaizana Nik Mat, Chih Nie Yeoh, Muhammad Maaya, Jaafar Md Zain, Joanna Su Min Ooi
Summary: Sugammadex has a lower incidence of postoperative nausea and vomiting (PONV) within the first 6 hours post-reversal compared to neostigmine-atropine mixture.
FRONTIERS IN MEDICINE
(2022)
Article
Anesthesiology
Marc Schmidt, Julian Rossler, Jack Brooker, Valentina Lara-Erazo, Elyad Ekrami, Xuan Pu, Alparslan Turan, Daniel I. Sessler, Kurt Ruetzler
Summary: This study aimed to compare the postoperative lung function of patients undergoing neuromuscular block reversal using sugammadex versus neostigmine. The results showed similar lung function with both methods, but patients given sugammadex had more minor pulmonary complications.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Anesthesiology
Thomas Ledowski, Zoltan Szabo-Maak, Pui San Loh, Berwin A. Turlach, Hong Seuk Yang, Hans D. de Boer, Laszlo Asztalos, Ina Ismiarti Shariffuddin, Lucy Chan, Bela Fulesdi
Summary: In high-risk older patients, reversing rocuronium neuromuscular block with sugammadex may result in a reduced risk of postoperative pulmonary complications on Day 7.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Anesthesiology
Jia-Feng Wang, Zhen-Zhen Zhao, Zheng-Yu Jiang, Hui-Xing Liu, Xiao-Ming Deng
Summary: A meta-analysis found that using sugammadex to reverse NMB was associated with a lower risk of postoperative pulmonary complications, specifically a lower incidence of postoperative respiratory failure.
PERIOPERATIVE MEDICINE
(2021)
Article
Anesthesiology
Roland Kaddoum, Said Tarraf, Fadia M. Shebbo, Arwa Bou Ali, Cynthia Karam, Carol Abi Shadid, Joanna Bouez, Marie T. Aouad
Summary: Nonoperative time (NOT) is a crucial factor in the operating room that can greatly impact efficiency and satisfaction. Parallel processing and the use of sugammadex can effectively reduce NOT and improve surgeon satisfaction.
ANESTHESIA AND ANALGESIA
(2022)
Article
Anesthesiology
Luca J. Wachtendorf, Tim M. Tartler, Elena Ahrens, Annika S. Witt, Omid Azimaraghi, Philipp Fassbender, Aiman Suleiman, Felix C. Linhardt, Michael Blank, Sarah Y. Nabel, Jerry Y. Chao, Pavel Goriacko, Parsa Mirhaji, Timothy T. Houle, Maximilian S. Schaefer, Matthias Eikermann
Summary: This study evaluated the effects of sugammadex on hospital costs and found that it was associated with lower direct costs compared to neostigmine. However, in high-risk patients, sugammadex was associated with higher total costs.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Medicine, General & Internal
Juan Fiorda Diaz, Marco Echeverria-Villalobos, Alan Esparza Gutierrez, Olufunke Dada, Nicoleta Stoicea, Wiebke Ackermann, Mahmoud Abdel-Rasoul, Jarrett Heard, Alberto Uribe, Sergio D. D. Bergese
Summary: This study compared the effectiveness and cost-effectiveness of sugammadex and neostigmine for moderate neuromuscular blockade reversal. The results showed that sugammadex achieved faster reversal without increasing perioperative costs.
FRONTIERS IN MEDICINE
(2022)
Article
Anesthesiology
Omid Azimaraghi, Elena Ahrens, Karuna Wongtangman, Annika S. Witt, Samuel Rupp, Aiman Suleiman, Tim M. Tartler, Luca J. Wachtendorf, Philipp Fassbender, Curtis Choice, Timothy T. Houle, Matthias Eikermann, Maximilian S. Schaefer
Summary: The use of sugammadex in ambulatory surgery can reverse neuromuscular block faster and reduce post-operative length of stay and costs compared to neostigmine, especially in older and high-risk patients.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Yulong Yu, Huijun Wang, Qianqian Bao, Tao Zhang, Beini Chen, Jinfeng Ding
Summary: This study compared the effects of sugammadex and neostigmine on the reversal of neuromuscular block and the incidence of post-operative pulmonary complications in lung cancer resection patients. The results showed that sugammadex provided faster recovery of neuromuscular block and reduced the incidence of postoperative lung complications and duration of hospital stay.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Anesthesiology
Olivier Duranteau, Wendy Fernandez, Turgay Tuna, Edgard Engelman, Luc Van Obbergh, Ionut Tabolcea
Summary: There was no significant difference in recovery time between injecting sugammadex at TOF1 or TOF2, but different dosages resulted in varied outcomes, consistent with other studies.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2021)
Article
Medicine, General & Internal
Haibei Liu, Rong Luo, Shuangjiao Cao, Bixing Zheng, Ling Ye, Wensheng Zhang
Summary: This meta-analysis examined the difference between sugammadex and neostigmine in reducing postoperative pulmonary complications. The results showed that using sugammadex to reverse neuromuscular blockade can reduce the risk of compound postoperative pulmonary complications, pneumonia, and respiratory failure. However, the evidence is limited by confounding factors and small-scale randomized controlled trials.
CHINESE MEDICAL JOURNAL
(2023)
Article
Anesthesiology
M. Carron, G. Andreatta, E. Pesenti, A. De Cassai, P. Feltracco, F. Linassi, M. Sergi, C. Di Bella, M. Di Bello, F. Neri, C. Silvestre, L. Furian, P. Navalesi
Summary: This retrospective cohort case-control study aimed to compare the effects of sugammadex and neostigmine in reversing neuromuscular block (NMB) in patients undergoing kidney transplantation. The results showed that the sugammadex group had better postoperative kidney function, lower incidence of severe hypoxemia, shorter post-anesthesia care unit stay, and reduced intensive care unit admissions compared to the neostigmine group.
PERIOPERATIVE MEDICINE
(2022)
Article
Anesthesiology
T. Andrew Bowdle, Kishanee J. Haththotuwegama, Srdjan Jelacic, Sharon T. Nguyen, Kei Togashi, Kelly E. Michaelsen
Summary: Sugammadex dose titration is necessary for effective reversal of neuromuscular blockade after rocuronium administration. Most patients require less than the recommended dose, but some may need more, and recurrent paralysis can occur.
Article
Chemistry, Medicinal
Dizhou Zhao, Jieyu Fang, Wei Xiong, Jun Lin, Wanmei Chen, Chujun Wu
Summary: Sugammadex transiently prolonged coagulation parameters in patients undergoing thyroidectomy, while neostigmine did not alter coagulation function.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Medicine, General & Internal
Andrea Calef, Rashel Castelgrande, Kristin Crawley, Sara Dorris, Joanna Durham, Kaitlin Lee, Jen Paras, Kristen Piazza, Abigail Race, Laura Rider, Michael Shelley, Emily Stewart, Miranda Tamok, Jennifer Tate, Jeffrey M. Dodd-o
Summary: This study aimed to investigate the consequences of not using residual neuromuscular blockade (RNB) analysis to guide the administration of neuromuscular blockade reversal in the postsurgical ICU. The results showed that there may be a risk of residual neuromuscular blockade in patients who did not undergo RNB analysis before receiving neuromuscular blockade reversal agents. Therefore, careful assessment and monitoring of residual neuromuscular blockade in patients in the postsurgical ICU is necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)