Article
Medicine, Research & Experimental
Sheng-Kai Hung, Chia-Chi Yeh, Pei-Chi Ting, Cay-Huyen Chen, Ming-Chang Kao
Summary: Although rare, anaphylaxis during anesthesia can be caused by neuromuscular blocking drugs. This case report highlights the potential benefit of using sugammadex as an adjunct treatment option for rocuronium-induced anaphylaxis.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Razvan Bologheanu, Paul Lichtenegger, Mathias Maleczek, Daniel Laxar, Eva Schaden, Oliver Kimberger
Summary: This study retrospectively evaluated the use of Sugammadex in critically ill patients and found that it was well tolerated and could be considered for the reversal of neuromuscular blockade. However, larger prospective studies are needed to determine its safety profile and potential benefits in the critical care setting.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Sang-Hwan Ji, Ki Young Huh, Jaeseong Oh, Hee-Jeong Jeong, Young-Eun Jang, Eun-Hee Kim, Ji-Hyun Lee, Jin-Tae Kim, Hee-Soo Kim
Summary: This study investigated the pharmacokinetics and pharmacodynamics of sugammadex in Korean children. The results showed that the recommended dose of 2 mg/kg of sugammadex could be safely administered for reversing moderate neuromuscular blockade. Some differences in the pharmacokinetics of sugammadex were observed according to age.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Hao-Chen Wang, Cheng-Wei Lu, Tzu-Yu Lin, Ya-Ying Chang
Summary: This case report highlights a patient who experienced prolonged muscle relaxation and poor response to sugammadex when using rocuronium. Perioperative train-of-four (TOF) combined with other neuromuscular monitoring is suggested to optimize the dose of rocuronium.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Anesthesiology
Kohji Uzawa, Hiroyuki Seki, Tomoko Yorozu
Summary: In this case, the recommended dose of sugammadex failed to completely reverse the rocuronium-induced neuromuscular blockade, requiring an additional dose of sugammadex to return to normal levels.
BMC ANESTHESIOLOGY
(2021)
Article
Anesthesiology
Marc T. Schmidt, Stephania Paredes, Julian Rossler, Rupashi Mukhia, Xuan Pu, Guangmei Mao, Alparslan Turan, Kurt Ruetzler
Summary: This retrospective cohort study analyzed the use of sugammadex and neostigmine in patients undergoing noncardiac surgery. The study found no significant difference in the risk of postoperative transfusion between the two drugs. However, patients receiving sugammadex had a higher likelihood of postoperative ICU admission.
ANESTHESIA AND ANALGESIA
(2023)
Article
Anesthesiology
Amir Hossein Irani, Logan Voss, Nicola Whittle, Jamie W. Sleigh
Summary: Computational molecular dynamics simulations were used to study the interaction between sugammadex and neuromuscular blocking drugs. The results confirmed the binding strength between sugammadex and other drugs, and revealed a potential weak interaction between sugammadex and propofol. Experimental validation showed that the drug encapsulation process occurred in the opposite direction than previously hypothesized.
Article
Anesthesiology
Tatsuo Horiuchi, Tomonori Takazawa, Masaki Orihara, Shinya Sakamoto, Kazuhiro Nagumo, Shigeru Saito
Summary: Perioperative anaphylaxis is a sudden and life-threatening event that requires anesthesiologists to have sufficient knowledge and coping strategies. While studies on this condition are rare in Japan, a recent study analyzed data from 46 patients to identify common causative agents and their associated characteristics. The findings may provide valuable information for anesthesiologists in Japan dealing with perioperative anaphylaxis.
JOURNAL OF ANESTHESIA
(2021)
Article
Allergy
Serdar Yesiltas, Zeynep Nur Orhon, Hasan Cakir, Mahmut Dogru, Melek Gura Celik
Summary: This study shows that allergic inflammatory changes in the lungs of rats caused by rocuronium can be reduced with the use of sugammadex. Sugammadex is effective in alleviating allergic reactions.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2021)
Article
Medicine, Research & Experimental
Jing He, Huan He, Xing Li, Mei Sun, Zhihao Lai, Bo Xu
Summary: The study aimed to determine appropriate doses of sugammadex and neostigmine to reverse residual vecuronium-induced NMB, with sugammadex 0.56 mg/kg possibly being sufficient to reverse residual NMB at a TOF ratio of 0.3; compared to neostigmine, sugammadex may provide a faster and more satisfactory antagonistic effect even in shallow NMB.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, General & Internal
Yingying Jiang, Yujun Zhang, Zhaoqiong Zhu, Yidan Huang, Dachun Zhou, Jingchen Liu, Chaoyu Li, Xiangdong Chen, Dingxin Kang, Shoushi Wang, Jin Liu, Bin Liu, Wensheng Zhang
Summary: This study compared the effectiveness and safety of adamgammadex and sugammadex in reversing rocuronium-induced neuromuscular block. The results showed no significant difference in the recovery time between adamgammadex and sugammadex. Both drugs were associated with adverse events, with incision site pain, hypotension, and emesis being the most common.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
Sakiko Hiramatsu, Katsuyuki Moriwaki, Miwako Nakao, Yasuo M. Tsutsumi
Summary: This case illustrates that rocuronium can lead to prolonged neuromuscular respiratory paralysis that is resistant to sugammadex in patients with CMT1A and impaired respiratory function. Furthermore, restrictive pulmonary impairment and a low nerve conduction velocity of 20 m/s may be predictive factors for prolonged neuromuscular respiratory paralysis that is resistant to sugammadex in CMT1A patients.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Review
Multidisciplinary Sciences
Sheng Zhou, Haiying Hu, Jianfen Ru
Summary: This study conducted a meta-analysis and found that Sug sodium is more effective and safer in reversing rocuronium-induced neuromuscular blockade in children than traditional antagonistic regimens or placebos.
Article
Medicine, General & Internal
Jae-Woo Ju, Nayoung Kim, Seong Mi Yang, Won Ho Kim, Ho-Jin Lee
Summary: The study aimed to investigate the incidence of sugammadex-induced anaphylaxis in a large Korean population. The estimated incidence of sugammadex-induced anaphylaxis was lower than previously reported rates in other countries, suggesting that concerns over anaphylaxis risk should not hinder its use in general anesthesia in Korea.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Paulo A. Germano-Filho, Ismar L. Cavalcanti, Angelo J. Q. R. Micuci, Luis G. C. Velarde, Hans D. de Boer, Nubia Vercosa
Summary: The objective of this study was to test the hypothesis that magnesium sulfate after reversal with sugammadex causes recurarization. The study was designed as a single-center, prospective, randomized, double-blind, controlled trial. The results showed that in the magnesium sulfate group, 64% of patients with deep blockade and 73% of patients with moderate blockade experienced recurarization, while in the placebo group, only 7% and 0% of patients experienced recurarization, respectively. This study demonstrated that a single dose of magnesium sulfate led to recurarization in patients who had recovered from rocuronium-induced deep and moderate neuromuscular blockade using sugammadex, and additional sugammadex could reverse prolonged recurarization.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
