Review
Cell Biology
Juntao Fang, Alain de Bruin, Andreas Villunger, Raymond Schiffelers, Zhiyong Lei, Joost P. G. Sluijter
Summary: Polyploid cells, containing more than one set of chromosome pairs, are common in nature. They provide cells with several advantages, including increased cell size, organ growth, tissue homeostasis, and enhanced tolerance to genomic stress and apoptotic signals. This article focuses on the reasons for polyploidy, the stress responses and molecular signals involved, as well as its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.
Article
Engineering, Multidisciplinary
Jian Tang, Siddhant Kumar, Laura De Lorenzis, Ehsan Hosseini
Summary: We propose Neural Cellular Automata (NCA) for simulating microstructure development in the solidification process of metals. NCA, based on convolutional neural networks, can learn essential features of solidification and are much faster than conventional Cellular Automata (CA). Notably, NCA can make reliable predictions beyond their training range, indicating their understanding of the physics of solidification. While CA data is used for training in this study, NCA can be trained on any microstructural simulation data, such as phase-field models.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Review
Physics, Multidisciplinary
Jonas Pleyer, Christian Fleck
Summary: This mini-review discusses agent-based models as modeling techniques for studying pattern formation of multi-cellular systems in biology. We introduce and compare different agent-based model frameworks with respect to spatial representation, microenvironment, intracellular and extracellular reactions, cellular properties, implementation, and practical use. The guiding criteria for the considered selection of agent-based model frameworks are that they are actively maintained, well documented, and provide a model development workflow.
FRONTIERS IN PHYSICS
(2023)
Article
Computer Science, Artificial Intelligence
Joao B. Florindo, Konradin Metze
Summary: The proposed method combines cellular automata with local descriptors for texture recognition, achieving good results by introducing a new transition function and controlled deterministic chaos concept. The approach shows great potential in plant species texture recognition.
EXPERT SYSTEMS WITH APPLICATIONS
(2021)
Article
Computer Science, Artificial Intelligence
Runhe Zhu, Burcin Becerik-Gerber, Jing Lin, Nan Li
Summary: This study predicts the impact of social and environmental factors on individual wayfinding behavior using machine learning and discrete choice models, and applies them to evaluate crowd evacuation performance under different building design scenarios in evacuation simulations. The results show that different building attributes collectively influence occupant behavior, and the discrete choice model has better interpretability. The study also finds significant differences in agent responses to different building designs and identifies critical factors for the applicability of evacuation models.
ADVANCED ENGINEERING INFORMATICS
(2023)
Article
Materials Science, Multidisciplinary
Jing Wang, Chunxiang Feng, Yunpeng Zhu, Zhixian Wang, Xiang Ren, Xing Li, Yisheng Ying, Yiqun Tian, Kai Yu, Shiliang Liu, Chang Liu, Xiaoyong Zeng
Summary: Bladder tissue engineering using adipose tissue extract (ATE) shows potential for promoting pluripotent marker proteins in stem cells and enhancing proliferation, migration, and angiogenesis in endothelial cells. The integration of electrospun nanofibers and hyaluronic acid colloidal solution in a patch demonstrates feasibility and effectiveness in repairing bladder defects in a rat model, highlighting its potential for tissue engineering and regenerative medicine.
MATERIALS & DESIGN
(2022)
Review
Materials Science, Multidisciplinary
Jung-Hwan Lee, Prakash Parthiban, Guang-Zhen Jin, Jonathan C. Knowles, Hae-Won Kim
Summary: This article discusses the importance of proangiogenic efforts in tissue repair and regeneration, focusing on the pivotal roles of engineered matrices in stimulating angiogenesis processes. The design and tuning of matrices for the proper presentation of growth factors and the sustained release of angiogenic molecules are crucial for tissue repair therapies.
PROGRESS IN MATERIALS SCIENCE
(2021)
Article
Computer Science, Interdisciplinary Applications
Pablo Concha-Vega, Eric Goles, Pedro Montealegre, Martin Rios-Wilson, Julio Santivanez
Summary: This paper introduces the concept of sub-rule for elementary cellular automata, explores the relationships between cellular automata, compares rules and sub-rules using statistical measures, and investigates the potential similarities in the dynamics of rules and their sub-rules.
INTERNATIONAL JOURNAL OF MODERN PHYSICS C
(2022)
Article
Mathematics, Interdisciplinary Applications
Sounak Sadhukhan, P. K. Mishra
Summary: This paper develops a cellular automata-based model to simulate tumor angiogenesis and studies the effects of biological factors on the formation of capillary sprouts. The model successfully captures various phenomena in capillary blood vessels, including morphological changes and fractal characteristics.
CHAOS SOLITONS & FRACTALS
(2022)
Article
Chemistry, Multidisciplinary
Kangqiang Liang, Yumeng Xue, Bin Zhao, Mengyao Wen, Ziqi Xu, Gleb Sukhorukov, Lianbing Zhang, Li Shang
Summary: By functionalizing MoS2 quantum dots (QDs) with l-/d-penicillamine, we found that d-MoS2 QDs exhibited a positive effect in promoting the growth, proliferation, and migration of human umbilical vein endothelial cells. This distinct phenomenon was largely attributed to the higher internalization efficiency of d-MoS2 QDs than l-MoS2 QDs and chirality-dependent nano-bio interactions. In vivo angiogenic assay demonstrated that the expression level of angiogenic markers in newly-formed skin tissues of the d-MoS2 QDs group was higher than that in the l-MoS2 QDs group, leading to accelerated re-epithelialization and improved skin regeneration.
Article
Engineering, Biomedical
Hang Xue, Zhenhe Zhang, Ze Lin, Jin Su, Adriana C. Panayi, Yuan Xiong, Liangcong Hu, Yiqiang Hu, Lang Chen, Chenchen Yan, Xudong Xie, Yusheng Shi, Wu Zhou, Bobin Mi, Guohui Liu
Summary: In this study, multifaceted nanohybrids 5QCS-1GO-PDA were synthesized and showed excellent biocompatibility and enhanced healing ability. These nanohybrids can promote angiogenesis, bone regeneration, and macrophage polarization through multiple signaling pathways, providing a promising method for effectively treating tissue defects.
BIOACTIVE MATERIALS
(2022)
Review
Engineering, Biomedical
Elia Bosch-Rue, Leire Diez-Tercero, Jenifer Olmos Buitrago, Emilio Castro, Roman A. Perez
Summary: Bone has the ability to self-regenerate, but extensive damage can hinder the natural regeneration process. Bone tissue engineering aims to mimic the extracellular matrix and promote the physiological regeneration process by stimulating osteogenesis and angiogenesis.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Rui Zhang, Yuwei Gong, Zhuoyan Cai, Yan Deng, Xingyan Shi, Hongyue Pan, Lihua Xu, Hualin Zhang
Summary: In this study, PLGA/wool keratin composite GTR membranes with specific surface topographical morphologies were prepared and their effects on cellular behaviors were examined. The 2 pm pit-structured membrane showed the best promotion of cell proliferation, while the 10 pm groove-structured membrane was the most effective in inducing osteogenic differentiation. Furthermore, the combination of the 10 pm groove-structured membrane and cell sheet demonstrated improved bone and periodontal tissue regeneration.
ACTA BIOMATERIALIA
(2023)
Article
Computer Science, Theory & Methods
Andrea Giordano, Alessio De Rango, Rocco Rongo, Donato D'Ambrosio, William Spataro
Summary: This article focuses on load balancing issues in parallel execution of spatial-related applications and proposes a method for dynamically computing optimal workload assignment. Experimental results demonstrate the performance improvement of this approach compared to the unbalanced version.
IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS
(2021)
Article
Biology
Eleni Chrysostomou, Hakima Flici, Sebastian G. Gornik, Miguel Salinas-Saavedra, James M. Gahan, Emma T. McMahon, Kerry Thompson, Shirley Hanley, Michelle Kincoyne, Christine E. Schnitzler, Paul Gonzalez, Andreas D. Baxevanis, Uri Frank, Marianne E. Bronner
Summary: This study provides a comprehensive molecular and cellular analysis of neurogenesis in the early-branching phylum Cnidaria, using the Hydractinia symbiolongicarpus as a model. The study reveals the sequential roles of SoxB genes and their impact on embryonic neurogenesis. Furthermore, the influence of cell migration and microenvironments on fate determination of neural cells in Hydractinia remains unclear.