Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care

Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts

(2013) Inna Y. Gong et al.   BREAST CANCER RESEARCH AND TREATMENT

Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials

(2013)   LANCET

Endoxifen’s Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens

(2013) John R. Hawse et al.   PLoS One

Potential of Selective Estrogen Receptor Modulators as Treatments and Preventives of Breast Cancer

(2012) Jing Peng et al.   Anti-Cancer Agents in Medicinal Chemistry

Importance of highly selective LC–MS/MS analysis for the accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen

(2012) N. G. L. Jager et al.   BREAST CANCER RESEARCH AND TREATMENT

Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?

(2012) Karin Beelen et al.   Nature Reviews Clinical Oncology

Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer

(2011) Wenjie Jessie Lu et al.   BREAST CANCER RESEARCH AND TREATMENT

Increasing Tamoxifen Dose in Breast Cancer Patients Based on CYP2D6 Genotypes and Endoxifen Levels: Effect on Active Metabolite Isomers and the Antiestrogenic Activity Score

(2011) M F Barginear et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma

(2011) T E Mürdter et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Tamoxifen Metabolite Concentrations, CYP2D6 Genotype, and Breast Cancer Outcomes

(2011) L Madlensky et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry

(2011) S.F. Teunissen et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Genotype-Guided Tamoxifen Dosing Increases Active Metabolite Exposure in Women With Reduced CYP2D6 Metabolism: A Multicenter Study

(2011) William J. Irvin et al.   JOURNAL OF CLINICAL ONCOLOGY

Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques

(2011) S.F. Teunissen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The Tamoxifen Metabolite, Endoxifen, Is a Potent Antiestrogen that Targets Estrogen Receptor   for Degradation in Breast Cancer Cells

(2009) X. Wu et al.   CANCER RESEARCH