Estrogen receptor (ER) α mutations in breast cancer: hidden in plain sight

42O_PR * ASSESSMENT OF GENETIC ALTERATIONS IN POSTMENOPAUSAL WOMEN WITH HORMONE RECEPTOR-POSITIVE, HER2-NEGATIVE ADVANCED BREAST CANCER FROM THE BOLERO-2 TRIAL BY NEXT-GENERATION SEQUENCING

(2013) M. Piccart et al.   ANNALS OF ONCOLOGY

Nuclear Receptor Coactivators: Master Regulators of Human Health and Disease

(2013) Subhamoy Dasgupta et al.   Annual Review of Medicine

D538G Mutation in Estrogen Receptor- : A Novel Mechanism for Acquired Endocrine Resistance in Breast Cancer

(2013) K. Merenbakh-Lamin et al.   CANCER RESEARCH

Multicenter Phase II Study of Neoadjuvant Lapatinib and Trastuzumab With Hormonal Therapy and Without Chemotherapy in Patients With Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer: TBCRC 006

(2013) Mothaffar F. Rimawi et al.   JOURNAL OF CLINICAL ONCOLOGY

Final Overall Survival: Fulvestrant 500 mg vs 250 mg in the Randomized CONFIRM Trial

(2013) A. D. Leo et al.   JNCI-Journal of the National Cancer Institute

Somatic Mutation Profiling and Associations With Prognosis and Trastuzumab Benefit in Early Breast Cancer

(2013) Sherene Loi et al.   JNCI-Journal of the National Cancer Institute

Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials

(2013)   LANCET

Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib

(2013) Oliver Gautschi et al.   LUNG CANCER

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

(2013) Weiyi Toy et al.   NATURE GENETICS

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

(2013) Dan R Robinson et al.   NATURE GENETICS

Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

(2013) Shunqiang Li et al.   Cell Reports

Leptin Mediates Tumor-Stromal Interactions That Promote the Invasive Growth of Breast Cancer Cells

(2012) I. Barone et al.   CANCER RESEARCH

The Life History of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

ERα Phosphorylation at Y537 by Src Triggers E6-AP-ERα Binding, ERα Ubiquitylation, Promoter Occupancy, and Target Gene Expression

(2012) Jun Sun et al.   MOLECULAR ENDOCRINOLOGY

Tamoxifen regulates cell fate through mitochondrial estrogen receptor beta in breast cancer

(2012) M Razandi et al.   ONCOGENE

Cracking the Estrogen Receptor's Posttranslational Code in Breast Tumors

(2011) Muriel Le Romancer et al.   ENDOCRINE REVIEWS

Phosphorylation of Estrogen Receptor α at Serine 118 Directs Recruitment of Promoter Complexes and Gene-Specific Transcription

(2011) Tamika T. Duplessis et al.   ENDOCRINOLOGY

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Estrogen Receptor Mutations and Changes in Downstream Gene Expression and Signaling

(2010) I. Barone et al.   CLINICAL CANCER RESEARCH

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

Phosphorylation of the mutant K303R estrogen receptor α at serine 305 affects aromatase inhibitor sensitivity

(2010) I Barone et al.   ONCOGENE

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

(2010) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen Receptor Alpha Phosphorylated at Tyrosine 537 is Associated with Poor Clinical Outcome in Breast Cancer Patients Treated with Tamoxifen

(2010) Georgios P. Skliris et al.   Hormones & Cancer

A hypersensitive estrogen receptor α mutation that alters dynamic protein interactions

(2009) Matthew H. Herynk et al.   BREAST CANCER RESEARCH AND TREATMENT

Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor α and its phosphorylation at serine 305

(2009) Cinzia Giordano et al.   BREAST CANCER RESEARCH AND TREATMENT

Expression of the K303R Estrogen Receptor-  Breast Cancer Mutation Induces Resistance to an Aromatase Inhibitor via Addiction to the PI3K/Akt Kinase Pathway

(2009) I. Barone et al.   CANCER RESEARCH

BRCA1 Regulates Acetylation and Ubiquitination of Estrogen Receptor-α

(2009) Yongxian Ma et al.   MOLECULAR ENDOCRINOLOGY

Accelerated mammary maturation and differentiation and delayed MMTVneu-induced tumorigenesis of K303R mutant ERα transgenic mice

(2009) M H Herynk et al.   ONCOGENE

Regulation of Estrogen Receptor α by the SET7 Lysine Methyltransferase

(2008) Krithika Subramanian et al.   MOLECULAR CELL