Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 148, Issue 1, Pages 117-123Publisher
SPRINGER
DOI: 10.1007/s10549-014-3143-z
Keywords
Oncotype DX; Oncotype DX recurrence score; Breast imaging; Ultrasound; Mammography; Imaging correlation
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To determine whether mammographic or sonographic features can predict the Oncotype DX (TM) recurrence scores (RS) in patients with TI-II, hormone receptor (HR) positive, HER2/neu negative and node negative breast cancers. Institutional board review was obtained and informed consent was waived for this retrospective study. Seventy-eight patients with stage I-II invasive breast cancer that was HR positive, HER2 negative, and lymph node negative for whom mammographic and or sonographic imaging and Oncotype DX (TM) assay scores were available were included in the study Four breast dedicated radiologists blinded to the RS retrospectively described the lesions according to BI-RADS lexicon descriptors. Multivariable logistic regression was used to test for significant independent predictors of low (< 18) versus intermediate to high range (a parts per thousand yen18). Two imaging features reached statistical significance in predicting low from intermediate or high risk RS: pleomorphic microcalcifications within a mass (P = 0.017); OR 8.37, 95 % CI (1.47-47.79) on mammography and posterior acoustic enhancement in a mass on ultrasound (P = 0.048); OR 4.35, 95 % CI (1.01-18.73) on multivariable logistic regression. A mass with pleomorphic microcalcifications on mammography or the presence of posterior acoustic enhancement on ultrasound may predict an intermediate to high RS as determined by the Oncotype DXTM assay in patients with stage I-II HR positive, HER2 negative, and lymph node negative invasive breast cancer.
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