Article
Oncology
Ji Wang, Hongtao Fu, Zhaoyun Zhong, Yunshan Jiang, Hong Pan, Xiaowei Sun, Weiwei Xu, Xinyu Tang, Wenbin Zhou, Shui Wang
Summary: The study aims to determine whether local and systemic therapy can be safely de-escalated in elderly breast cancer patients. The results showed that unnecessary local or systemic treatments can be reduced in HR+/HER2- subtype.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Sin-Hye Park, Tung Hoang, Jeongseon Kim
Summary: This study examines the relationship between dietary factors and breast cancer prognosis among breast cancer survivors through systematic review and meta-analysis. It finds that unhealthy dietary patterns such as beer and saturated fat intake may worsen breast cancer prognosis, while supplementation of most vitamins is beneficial. The study suggests that developing dietary guidelines based on these findings could improve the prognosis for breast cancer survivors.
Article
Cardiac & Cardiovascular Systems
Dong D. Wang, Yanping Li, Shilpa N. Bhupathiraju, Bernard A. Rosner, Qi Sun, Edward L. Giovannucci, Eric B. Rimm, JoAnn E. Manson, Walter C. Willett, Meir J. Stampfer, Frank B. Hu
Summary: The study found that consuming approximately 5 servings of fruits and vegetables per day was associated with lower total mortality and mortality from cancer, cardiovascular disease, and respiratory disease. Higher intake beyond this level did not provide additional risk reduction.
Article
Hematology
Trine Trab, Joachim Baech, Lasse Hjort Jakobsen, Simon Husby, Marianne Tang Severinsen, Sandra Eloranta, Jette S. Gorlov, Judit M. Jorgensen, Sif Gudbrandsdottir, Thomas Stauffer Larsen, Peter Brown, Kirsten Gronbaek, Karin E. Smedby, Tarec C. El-Galaly
Summary: This study aimed to investigate the risk of second primary malignancies (SPMs) in lymphoma patients treated with high-dose chemotherapy and autologous haematopoietic stem-cell transplantation (HSCT). The findings showed that patients receiving this treatment had a higher incidence of SPMs compared to the general population, with a significantly increased risk of non-melanoma skin cancer and myelodysplastic syndrome or acute myeloid leukaemia (AML).
LANCET HAEMATOLOGY
(2023)
Article
Oncology
Zhengyi Deng, Miranda R. Jones, Mei-Cheng Wang, Kala Visvanathan
Summary: Limited information exists about survival outcomes after second primary cancers among breast cancer survivors. Studies suggest that mortality after certain second primary cancers may be higher than mortality after first primary cancers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Emily B. Ambinder, Emerson Lee, Derek L. Nguyen, Anna J. Gong, Orli J. Haken, Kale Visvanathan
Summary: This study reviewed mammographic screening data and found that the sensitivity for early-stage breast cancer detection was high. However, some interval breast cancers were missed. Interval breast cancers were more likely to occur in patients with dense breast tissue, higher stage, and unfavorable molecular features.
ACADEMIC RADIOLOGY
(2023)
Article
Oncology
Yan Wang, Jialong Li, Shuai Chag, Yingxian Dong, Guowei Che
Summary: This study found that differentiation status and pTNM stage were independent prognostic factors in operated breast cancer patients with second primary lung cancer. The prognosis of these patients was worse than single primary lung cancer patients, indicating that the medical history of breast cancer was also a prognostic risk factor for female lung cancer patients.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Javier Antonanzas, Ana Morello-Vicente, Gloria Maria Garnacho-Saucedo, Pedro Redondo, Leyre Aguado-Gil, Rafael Salido-Vallejo
Summary: This study evaluates the occurrence of second primary neoplasms (SPNs) in individuals with a history of melanoma (MM) and identifies factors that increase the risk in our population. The estimated probability of developing SPNs after MM diagnosis was found to increase over time, reaching 4.1% at 1 year, 11% at 5 years, and 19% at 10 years. Several factors were significantly associated with a higher risk of SPNs, including older age, primary MM location on the face or neck, and the histologic subtype of lentigo maligna MM. Understanding these risk factors can assist in developing MM guidelines that provide specific follow-up recommendations for individuals at the highest risk.
Article
Oncology
Zhangheng Huang, Xin Zhou, Yuexin Tong, Lujian Zhu, Ruhan Zhao, Xiaohui Huang
Summary: Surgery for the primary tumor in breast cancer patients with bone metastases can significantly improve overall survival. Prognostic nomograms developed in this study can accurately assess long-term prognosis and assist clinicians in developing personalized treatment strategies.
Article
Oncology
Yuxin Xie, Yingjie Zhang, Keqi Xie, Xiaorong Zhong, Hong Zheng, Qiheng Gou
Summary: The optimal timing for postoperative radiotherapy (TTR) in breast cancer patients after neoadjuvant chemotherapy (NAC) and surgery remains unclear. This study found that patients with TTRs of 8 to 16 weeks had lower risks of breast cancer-specific mortality (BCSM) and all-cause mortality (ACM) compared to patients with TTRs exceeding 16 weeks. Furthermore, each additional week of TTR beyond 16 weeks was associated with a higher risk of BCSM and ACM.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Hyeong In Ha, Eun-Gyeong Lee, Jiwon Lim, So-Youn Jung, Yoon Jung Chang, Young-Joo Won, Myong Cheol Lim
Summary: The incidence of secondary primary POFT cancer after breast cancer increased in Korea between 1999 and 2017. Second primary POFT cancer patients were diagnosed at older ages and had more serous histology.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Immunology
Hongxia Lin, Lili Yang, Jie Fang, Yulian Gao, Haixing Zhu, Shengxiong Zhang, Hanssa Dwarka Summah, Guochao Shi, Jingyong Sun, Lei Ni, Yun Feng
Summary: This study assessed the independent risk factors of mortality in immunosuppressed patients with bloodstream infection. Age and PCT were identified as key factors associated with mortality in immunosuppressive states.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Ruohan Yang, Lin Jia, Guanyu Lu, Zheng Lv, Jiuwei Cui
Summary: Symptomatic bone marrow metastasis in breast cancer is rare and has a poor prognosis. Chemotherapy is the primary treatment, but its efficacy is limited, resulting in dose reduction and decreased quality of life. This study aimed to explore the clinicopathological characteristics, treatment modalities, and prognosis of breast cancer patients with bone marrow metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Virology
Qian Wu, Li Deng, Ye Cao, Shixian Lian
Summary: This study aimed to investigate the clinical characteristics and prognosis of breast cancer patients with HIV in China. The findings revealed that breast cancer in patients with HIV reflected a more aggressive nature with a more advanced diagnostic stage and worse prognosis. Moreover, preoperative immune and inflammatory biomarkers might play a role in the prognosis of breast cancer patients with HIV.
Article
Radiology, Nuclear Medicine & Medical Imaging
Almir G. Bitencourt, Barbara S. Pires, Vinicius F. Calsavara, Erika M. S. Negrao, Juliana A. Souza, Luciana Graziano, Camila S. Guatelli, Fabiana B. Makdissi, Solange M. Sanches, Monique C. Tavares, Cynthia A. B. T. Osorio, Marina De Brot, Elvira F. Marques, Rubens Chojniak
Summary: The study found that the response evaluation after NAC assessed by both MRI and pathology has an impact on DFS in breast cancer patients. Patients with consistent radiological and pathological responses have a better DFS curve, while those with only MRI or pathology response, or no response, have a higher risk of recurrence.
EUROPEAN RADIOLOGY
(2021)
Article
Genetics & Heredity
Inge M. M. Lakeman, Mar D. M. Rodriguez-Girondo, Andrew Lee, Nandi Celosse, Merel E. Braspenning, Klaartje van Engelen, Irma van de Beek, Annemiek H. van der Hout, Encarna B. Gomez Garcia, Arjen R. Mensenkamp, Margreet G. E. M. Ausems, Maartje J. Hooning, Muriel A. Adank, Antoinette Hollestelle, Marjanka K. Schmidt, Christi J. van Asperen, Peter Devilee
Summary: This study explored the additive impact of a 313-variant-based Polygenic Risk Score (PRS313) in non-BRCA1/2 Dutch breast cancer families. The results showed a significant association between PRS313 and breast cancer, and the PRS313 had a substantial impact on breast cancer screening recommendations. These findings support the application of PRS313 in risk prediction for breast cancer families and families with pathogenic variants in moderate breast cancer risk genes.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Oncology
Delal Akdeniz, Iris Kramer, Carolien H. M. van Deurzen, Bernadette A. M. Heemskerk-Gerritsen, Michael Schaapveld, Pieter J. Westenend, Adri C. Voogd, Agnes Jager, Ewout W. Steyerberg, Stefan Sleijfer, Marjanka K. Schmidt, Maartje J. Hooning
Summary: Lobular and lobular mixed primary breast cancer histology are associated with modestly increased risk of contralateral breast cancer (CBC), and personalized risk assessment needs to consider the histology of the primary cancer as well as the impact of systemic therapy.
Article
Biochemistry & Molecular Biology
Gisella Figlioli, Amandine Billaud, Thomas U. Ahearn, Natalia N. Antonenkova, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Marinus J. Blok, Natalia Bogdanova, Bernardo Bonanni, Barbara Burwinkel, Nicola J. Camp, Archie Campbell, Jose E. Castelao, Melissa H. Cessna, Stephen J. Chanock, Kamila Czene, Peter Devilee, Thilo Doerk, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Anna Gonzalez-Neira, Felix Grassmann, Pascal Guenel, Melanie Gundert, Andreas Hadjisavvas, Eric Hahnen, Per Hall, Ute Hamann, Patricia A. Harrington, Wei He, Peter Hillemanns, Antoinette Hollestelle, Maartje J. Hooning, Reiner Hoppe, Anthony Howell, Keith Humphreys, Agnes Jager, Anna Jakubowska, Elza K. Khusnutdinova, Yon-Dschun Ko, Vessela N. Kristensen, Annika Lindblom, Jolanta Lissowska, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Dimitrios Mavroudis, William G. Newman, Nadia Obi, Mihalis Panayiotidis, Muhammad U. Rashid, Valerie Rhenius, Matti A. Rookus, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Mitul Shah, Reijo Sironen, Melissa C. Southey, Maija Suvanto, Rob A. E. M. Tollenaar, Ian Tomlinson, Therese Truong, Lizet E. van der Kolk, Elke M. van Veen, Barbara Wappenschmidt, Xiaohong R. Yang, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Michael Lush, Kyriaki Michailidou, Paul D. P. Pharoah, Qin Wang, Muriel A. Adank, Marjanka K. Schmidt, Irene L. Andrulis, Jenny Chang-Claude, Heli Nevanlinna, Georgia Chenevix-Trench, D. Gareth Evans, Roger L. Milne, Paolo Radice, Paolo Peterlongo
Summary: Evidence from the BRIDGES study suggests that germline protein truncating variants (PTVs) in FANCM are associated with increased risk of ER-negative and triple-negative breast cancer (TNBC), particularly for those with a family history. This study further investigates the association between FANCM missense variants (MVs) and breast cancer risk using the BRIDGES study, analyzing a total of 689 MVs. The results indicate that FANCM MVs may be low/moderate risk factors for ER-negative and TNBC subtypes of breast cancer.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Genetics & Heredity
Stefanie H. Mueller, Alvina G. Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y. Brucker, Saundra S. Buys, Jose E. Castelao, Tsun L. Chan, Jenny Chang-Claude, Stephen J. Chanock, Ji-Yeob Choi, Wendy K. Chung, Sarah Colonna, Sten Cornelissen, Fergus J. Couch, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dork, Laure Dossus, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, A. Heather Eliassen, Christoph Engel, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Manuela Gago-Dominguez, Yu-Tang Gao, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Jeanine Genkinger, Aleksandra Gentry-Maharaj, Felix Grassmann, Pascal Guenel, Melanie Gundert, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Elaine F. Harkness, Patricia A. Harrington, Jaana M. Hartikainen, Mikael Hartman, Alexander Hein, Weang-Kee Ho, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Dezheng Huo, Abctb Investigators, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Daehee Kang, Elza K. Khusnutdinova, Sung-Won Kim, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka-Sabit, Allison W. Kurian, Ava Kwong, James Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Usha Menon, Kenneth Muir, Rachel A. Murphy, Heli Nevanlinna, William G. Newman, Dieter Niederacher, Katie M. O'Brien, Nadia Obi, Kenneth Offit, Olufunmilayo Olopade, Andrew F. Olshan, Hakan Olsson, Sue K. Park, Alpa Patel, Achal Patel, Charles M. Perou, Julian Peto, Paul D. P. Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Muhammad U. Rashid, Gad Rennert, Atocha Romero, Kathryn J. Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Michael O. Schneider, Christopher Scott, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Harald Surowy, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Soo Hwang Teo, Lauren R. Teras, Amanda E. Toland, Rob A. E. M. Tollenaar, Diana Torres, Gabriela Torres-Mejia, Melissa A. Troester, Therese Truong, Celine M. Vachon, Joseph Vijai, Clarice R. Weinberg, Camilla Wendt, Robert Winqvist, Alicja Wolk, Anna H. Wu, Taiki Yamaji, Xiaohong R. Yang, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M. Dunning, Douglas F. Easton, Harry Hemingway, Ute Hamann, Karoline B. Kuchenbaecker
Summary: This study identified 14 genes associated with breast cancer using gene-based aggregation analysis, including two newly discovered genes FMNL3 and AC058822.1. Furthermore, associations with established candidate genes like ESR1 were found through the collaboration of multi-ancestral cohorts, highlighting the importance of diversifying study cohorts. These findings provide new insights into the development of breast cancer.
Editorial Material
Dermatology
Esther de Vries
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Oncology
Marjanka K. Schmidt, Jennifer E. Kelly, Anne Bredart, David A. Cameron, Jana de Boniface, Douglas F. Easton, Birgitte Offersen, Fiorita Poulakaki, Isabel T. Rubio, Francesco Sardanelli, Rita Schmutzler, Tanja Spanic, Britta Weigelt, Emiel J. T. Rutgers
Summary: After a unilateral breast cancer diagnosis, more and more patients are choosing to have contralateral prophylactic mastectomy (CPM), the removal of the healthy breast. Breast cancer specialists need to provide guidance to women considering CPM. This manifesto discusses the challenges of CPM and offers recommendations to improve outcomes for women with unilateral breast cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Angelica Arango-Gutierrez, Socorro Moreno, Martin Rondon, Lucia Arroyo, Liliana Ardila, Fabian Alexander Leal Arenas, Jose A. Calvache, Esther de Vries
Summary: This study aimed to explore the associations between the level of suffering of cancer patients who died and received care in three Colombian hospitals with patient, tumor, treatment, and care characteristics. The results showed that factors associated with a higher level of suffering include unclear treatment information, procedures inconsistent with the patient's wishes, outpatient palliative care, and a younger age at death.
BMC PALLIATIVE CARE
(2023)
Article
Health Care Sciences & Services
Salvatore Vaccarella, Damien Georges, Freddie Bray, Ophira Ginsburg, Hadrien Charvat, Pekka Martikainen, Henrik Bronnum-Hansen, Patrick Deboosere, Matthias Bopp, Mall Leinsalu, Barbara Artnik, Valentina Lorenzoni, Esther De Vries, Michael Marmot, Paolo Vineis, Johan Mackenbach, Wilma Nusselder
Summary: This study collected and analyzed whole-of-population cancer-specific mortality data by education level and sex across 18 countries in Europe during 1990-2015. The results showed that lower-educated individuals have higher mortality rates for almost all types of cancer compared to their more highly-educated counterparts. The magnitude of inequalities varied greatly by country and over time, and lung cancer was the largest contributor to overall cancer mortality inequalities. These findings highlight the importance of addressing socioeconomic inequalities in cancer in Europe.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Oncology
Lonneke A. van Tuijl, Maartje Basten, Kuan-Yu Pan, Roel Vermeulen, Luetzen Portengen, Alexander de Graeff, Joost Dekker, Mirjam I. Geerlings, Adriaan Hoogendoorn, Femke Lamers, Adri C. Voogd, Jessica Abell, Philip Awadalla, Aartjan T. F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Trynke R. de Jong, Melanie R. Keats, Almar A. L. Kok, Steinar Krokstad, Flora E. van Leeuwen, Annemarie I. Luik, Nolwenn Noisel, N. Charlotte Onland-Moret, Yves Payette, Brenda W. J. H. Penninx, Ina Rissanen, Annelieke M. Roest, Rikje Ruiter, Robert A. Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Emma L. Twait, Alison Teyhan, W. M. Monique Verschuren, Kimberly D. van der Willik, Judith G. M. Rosmalen, Adelita V. Ranchor
Summary: A meta-analysis of individual participant data from 18 cohorts found no associations between depression or anxiety and most types of cancer, except for lung cancer and smoking-related cancers. The associations with lung and smoking-related cancers were attenuated when adjusting for known risk factors.
Article
Oncology
Isaac Chayo, Claudia Janeth Uribe Perez, Esther De Vries, Paulo S. Pinheiro
Summary: Cervical cancer remains a significant cause of death in Colombia. This study investigated the relationship between socioeconomic status and health insurance affiliation with cervical cancer survival in Bucaramanga, Colombia. The results showed that lower socioeconomic status and subsidized health insurance were associated with lower 5-year overall survival rates. These disparities remained even within Colombia's universal healthcare system.
CANCER EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Cindy V. Mendieta, Esther de Vries, Maria Elizabeth Gomez-Neva, Angela Maria Munoz-Escudero, Jose Andres Calvache, Tracey Mcconnell
Summary: This study aims to explore the barriers and facilitators to palliative care for patients with non-curable cancer in Colombia from the perspective of Allied Health and Social Care Professionals (AHSCP). The results showed that there are misconceptions about palliative care, which is mainly due to the lack of inclusion of this area in the educational programs of health professionals and AHSCPs, along with limited supply and access to palliative care, especially in rural areas.
BMC PALLIATIVE CARE
(2023)
Article
Psychology, Multidisciplinary
Socorro Moreno, Mauricio Medina-Rico, Katalina Osorio Clavijo, Nicole A. Rodriguez, Victor M. Vicuna Jimenez, Jose A. Calvache, Esther de Vries
Summary: This research provides limited knowledge about the preferences of Colombian patients with advanced cancer regarding their final moments, place of death, and post-death wishes. The study conducted 23 in-depth interviews with patients of different age groups. The findings showed that while many participants desired a peaceful death, the topic of death itself was largely uncomfortable to discuss. Socioeconomic and geographical factors significantly influenced the wishes and preferences expressed by the participants.
OMEGA-JOURNAL OF DEATH AND DYING
(2023)
Article
Health Care Sciences & Services
Cindy V. Mendieta, Esther de Vries, Jose Andres Calvache, Sam H. Ahmedzai, Gillian Prue, Tracey Mcconnell, Joanne Reid
Summary: This article introduces the implementation strategy workshop for SPARC-Sp in Colombia. Participants identified the need for PC education, clarification, and professional capacity building. They also recognized the need for adaptations to SPARC-Sp to address the low literacy of the population and specificities of the healthcare system in Colombia.
Article
Oncology
Yuwei Wang, Annegien Broeks, Daniele Giardiello, Michael Hauptmann, Katarzyna Jozwiak, Esther A. Koop, Mark Opdam, Sabine Siesling, Gabe S. Sonke, Nikolas Stathonikos, Natalie D. ter Hoeve, Elsken van der Wall, Carolien H. M. van Deurzen, Paul J. van Diest, Adri C. Voogd, Willem Vreuls, Sabine C. Linn, Gwen M. H. E. Dackus, Marjanka K. Schmidt
Summary: This study validated the reliability of the PREDICT breast cancer prognostic model and assessed its clinical utility in young women with node-negative breast cancer. The results showed that PREDICT was not reliable in predicting outcomes for this patient subset and further updates are needed.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristien B. I. M. Keymeulen, Sandra M. E. Geurts, Loes F. S. Kooreman, Lucien E. M. Duijm, Sanne Engelen, Sigrid Vanwetswinkel, Ernest Luiten, Sabine Siesling, Adri C. Voogd, Vivianne C. G. Tjan-Heijnen
Summary: Breast MRI at primary DCIS diagnosis can detect additional synchronous cDCIS and cIBC, and is associated with a higher rate of metachronous cDCIS without decreasing the rate of metachronous cIBC. This finding is most evident in younger patients.
EUROPEAN RADIOLOGY
(2023)
