Article
Oncology
Peiyong Li, Ciqiu Yang, Junsheng Zhang, Yitian Chen, Xiaoqi Zhang, Minting Liang, Na Huang, Yilin Chen, Kun Wang
Summary: Sentinel lymph node biopsy can provide survival results equivalent to axillary lymph node dissection for patients with cN0 and T1-2 breast cancer; however, whether it can be performed on patients with T3-4c breast cancer is still controversial.
Article
Oncology
Xunxi Lu, Mengting He, Luoting Yu, Zongchao Gou
Summary: This cohort study found that receiving surgical axillary staging was associated with better survival for patients with ipsilateral breast tumor recurrence, and repeat sentinel lymph node biopsy had a similar long-term survival outcome as axillary lymph node dissection. Therefore, repeat sentinel lymph node biopsy may be considered for surgical axillary staging in patients with ipsilateral breast tumor recurrence after lumpectomy and initial sentinel lymph node biopsy.
Article
Oncology
Jing Si, Rong Guo, Huan Pan, Xiang Lu, Zhiqin Guo, Chao Han, Li Xue, Dan Xing, Wanxin Wu, Caiping Chen
Summary: The aim of this study was to determine whether breast cancer patients with mastectomy and false-negative frozen section in sentinel lymph node biopsy (SLNB) could forgo axillary lymph node dissection (ALND). The study found that SLNB and axillary radiation therapy could effectively replace ALND in selected patients who met specific criteria.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Enver Ozkurt, Stephanie Wong, Esther Rhei, Mehra Golshan, Jane Brock, Thanh U. Barbie
Summary: The study found that patients with T1 tubular carcinoma (TC) have low rates of axillary lymph node (LN) involvement, comparable to patients with ductal carcinoma in situ (DCIS) and lower than other types of ER-positive invasive ductal carcinoma (IDC) patients. There was no significant difference in 5-year and 10-year overall survival rates between TC patients with or without LN involvement. Therefore, tubular histology is independently associated with improved survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
David W. Chang, Mathias Bressel, Carmen Hansen, Prunella Blinman, Penelope Schofield, Boon H. Chua
Summary: This study investigated the preferences of patients with early breast cancer for axillary dissection after positive sentinel node biopsy. Most patients preferred axillary dissection for additional staging information, even though it did not provide a survival benefit.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Surgery
Y. Andersson, L. Bergkvist, J. Frisell, J. de Boniface
Summary: The SENOMIC trial found that omitting axillary lymph node dissection in patients with breast cancer and sentinel node micrometastases had excellent 3-year event-free survival rates. However, patients who underwent mastectomy had worse tumor characteristics and higher risk of recurrence, especially without adjuvant radiotherapy. Long-term follow-up and enrollment of mastectomy patients are crucial.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
Toralf Reimer
Summary: The local treatment of axilla in early breast cancer patients without clinically evident lymph node metastases is a subject of debate. Various prospective randomized surgical trials are currently being conducted to evaluate the safety of omitting sentinel lymph node biopsy in upfront breast-conserving surgery and neoadjuvant setting. These trials aim to determine whether it is possible to make therapeutic decisions without pathologic evaluation of nodal status. Additionally, ongoing trials are investigating the possibility of de-escalating surgery based on the response to neoadjuvant systemic therapy.
Article
Oncology
Zhao Bi, Jia-Jian Chen, Peng-Chen Liu, Peng Chen, Wei-Li Wang, Yan-Bing Liu, Chun-Jian Wang, Peng-Fei Qiu, Qing Lv, Jiong Wu, Yong-Sheng Wang
Summary: This study developed a predictive model based on a multi-center retrospective database to accurately predict whether HR+/HER2- patients can undergo genomic tests. Through multivariate logistic regression analysis, imaging abnormal nodes, the number of positive SLNs, the number of negative SLNs, pathological tumor stage, and lympho-vascular invasion were identified as independent predictors for patients having <= 3 total metastatic ALNs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qiufan Zheng, Hanjia Luo, Wen Xia, Qianyi Lu, Kuikui Jiang, Ruoxi Hong, Fei Xu, Shusen Wang
Summary: This study found significant differences in overall survival and breast cancer-specific survival between SLNB and ALND, with SLNB showing a slight survival advantage.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Review
Surgery
Nur Amalina Che Bakri, Richard M. Kwasnicki, Naairah Khan, Omar Ghandour, Alice Lee, Yasmin Grant, Aleksander Dawidziuk, Ara Darzi, Hutan Ashrafian, Daniel R. Leff
Summary: This study evaluated the impact of axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) on upper limb morbidity in breast cancer patients. The results showed that ALND patients had higher prevalence of lymphedema, pain, reduced strength, and range of motion compared with SLNB patients. These findings support the continued de-escalation of axillary surgery.
Article
Oncology
Maria Cristina Leonardi, Camilla Arrobbio, Sara Gandini, Stefania Volpe, Francesca Colombo, Eliana La Rocca, Viviana Galimberti, Sabrina Kahler-Ribeiro-Fontana, Cristiana Fodor, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Emilia Montagna, Marco Colleoni, Giovanni Mazzarol, Laura Lavinia Travaini, Mattia Zaffaroni, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: This study aimed to evaluate the rate of positive non-sentinel lymph nodes in breast cancer patients after neoadjuvant systemic therapy following positive sentinel lymph node biopsy. Positive non-SLNs were found in 62.3% of cases and were significantly associated with older age, clinically positive lymph nodes, SLN extracapsular extension, and a higher ratio of positive SLNs/total SLNs. ECE and higher nodal ratio were independent predictors of III axillary level positivity.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Ji Young You, Eun Sook Lee, Siew Kuan Lim, Youngmee Kwon, So-Youn Jung
Summary: According to the study, performing sentinel lymph node biopsy (SLNB) without axillary lymph node dissection (ALND) may be a reasonable treatment option for patients with positive lymph nodes after breast cancer surgery. There was no significant difference in the loco-regional recurrence rates between SLNB with ALND and SLNB alone.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ian Campbell, Neil Wetzig, Owen Ung, David Espinoza, Gelareh Farshid, John Collins, James Kollias, Val Gebski, Rebecca Mister, R. John Simes, Martin R. Stockler, Grantley Gill
Summary: For early breast cancer patients who are clinically node-negative, sentinel node-based management (SNBM) is the international standard of care. In the SNAC1 study, we report the rates of axillary recurrence, overall survival, and breast cancer-specific survival at 10 years.
Article
Oncology
Sophie H. H. Chung, Susanna W. L. de Geus, Grant Shewmaker, Kelsey S. S. Romatoski, Frederick T. T. Drake, Naomi Y. Y. Ko, Andrea L. L. Merrill, Ariel E. E. Hirsch, Jennifer F. F. Tseng, Teviah E. E. Sachs, Michael R. R. Cassidy
Summary: This study compared the survival outcomes of men with positive sentinel lymph nodes after either sentinel lymph node biopsy (SLNB) alone or complete axillary dissection (ALND) in breast cancer. The results showed that ALND was associated with superior survival compared to SLNB alone in early-stage male breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Daniela Cocco, Chirag Shah, Wei Wei, Avia Wilkerson, Stephen R. Grobmyer, Zahraa Al-Hilli
Summary: This study investigated the survival outcomes of patients with limited nodal burden in breast cancer. The data suggest that upfront SLNB and RNI for cN+ T1-2 tumors can provide favorable survival outcomes comparable to ALND with or without RNI.
BRITISH JOURNAL OF SURGERY
(2022)
Review
Cell Biology
Maria P. P. Foschini, Rieko Nishimura, Viscardo Paolo Fabbri, Zsuzsanna Varga, Handan Kaya, Gabor Cserni
Summary: Myoepithelial cells (MECs) form a continuous layer surrounding the breast glands, acting as a barrier during neoplastic transformation. They can undergo various changes and give rise to a wide spectrum of morphological pictures seen in benign and malignant breast tumors. This study aims to provide a review of MECs lesions and their correlation to prognosis, as these tumors are relatively rare.
Letter
Pathology
Jasna Metovic, Anna Sapino, Isabella Castellano
Review
Nutrition & Dietetics
Marianna Pellegrini, Fabio Dario Merlo, Elena Agnello, Taira Monge, Andrea Devecchi, Valentina Casalone, Filippo Montemurro, Ezio Ghigo, Anna Sapino, Simona Bo
Summary: Breast cancer is a common global cancer and chemotherapy, while essential for treatment, often leads to side effects such as taste alterations. Dysgeusia, although underestimated by clinicians, greatly affects the physical and psychological health of cancer patients, with profound impacts on their quality of life. Strategies for managing dysgeusia in breast cancer patients receiving chemotherapy have been proposed, but the literature on this topic is limited and heterogeneous, making it challenging to obtain definitive results and clinical recommendations.
Article
Medicine, General & Internal
Marco Rubatto, Franco Picciotto, Giovenale Moirano, Enrico Fruttero, Virginia Caliendo, Silvia Borriello, Nadia Sciamarrelli, Paolo Fava, Rebecca Senetta, Adriana Lesca, Anna Sapino, Desiree Deandreis, Simone Ribero, Pietro Quaglino
Summary: This study evaluated the characteristics of patients with head and neck melanoma who underwent sentinel lymph node biopsy and found that scalp melanomas are more aggressive than non-scalp melanomas. The status of the sentinel lymph node is the strongest predictor for recurrence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Oncology
Giancarlo Pruneri, Daniele Lorenzini, Mauro G. Mastropasqua, Giuseppe Perrone, Antonio Rizzo, Donatella Santini, Chiara C. Volpi, Saverio Cinieri, Alberto Zambelli, Anna Sapino, Isabella Castellano
Summary: Multigenic tests are crucial for selecting adjuvant therapy in ER+/HER2- breast cancer. The workload generated by these tests is often underestimated, affecting timely therapy initiation. This article discusses the evolving role of pathology laboratories in using multigenic tests and proposes a reflex testing model to optimize turnaround time and therapy intervention.
Editorial Material
Oncology
F. Munck, N. Kroman, T. H. F. Tvedskov
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Frederikke Munck, Inge S. Andersen, Ilse Vejborg, Maria K. Gerlach, Charlotte Lanng, Niels T. Kroman, Tove H. F. Tvedskov
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Frederikke Munck, Inge S. Andersen, Ilse Vejborg, Maria K. Gerlach, Charlotte Lanng, Niels T. Kroman, Tove H. F. Tvedskov
Summary: Targeted axillary dissection (TAD) with I-125 seed marking before neoadjuvant chemotherapy (NACT) is feasible and provides accurate axillary staging for breast cancer patients. This method reduces the need for re-marking before surgery and has a high identification rate (IR) of the marked lymph node (MLN) and sentinel lymph node (SLNB).
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Carl Sars, Helena Sackey, Jan Frisell, Paul W. Dickman, Fredrik Karlsson, Isabelle Kindts, Gustavo Nader Marta, Ruffo Freitas-Junior, Tove Filtenborg Tvedskov, Loay Kassem, Ahmed S. Ali, Hanna Ihalainen, Mathias Neron, Michalis Kontos, Orit Kaidar-Person, Icro Meattini, Anne Brecht Francken, Frederieke van Duijnhoven, Ingvild Ona Moberg, Tanja Marinko, Attila Kollar, Mahbubl Ahmed, Dennis Remoundos, Jenny Banks, Reshma Jagsi, Lesly A. Dossett, Ebba K. Lindqvist
Summary: Phyllodes tumors of the breast are rare fibroepithelial lesions classified as benign, borderline or malignant. Current clinical practice in managing these tumors shows considerable variation, indicating a need for education and further research to establish appropriate surgical margins, follow-up time, and a multidisciplinary approach.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Oncology
Christina M. S. Hassing, Dorte Lisbet Nielsen, Ann Soegaard Knoop, Tove Holst Filtenborg Tvedskov, Niels Kroman, Anne-Vibeke Laenkholm, Carsten Bogh Juhl, Iben Kuemler
Summary: The purpose of this systematic review and meta-analysis was to investigate if adjuvant trastuzumab improves the prognosis in patients with HER2-positive breast tumors <= 10 mm without lymph node involvement. Twelve studies were included, and it was found that adjuvant trastuzumab and chemotherapy significantly improved disease-free survival and overall survival.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Oncology
Andrea Ambrosini-Spaltro, Francesco Di Donato, Luca Saragoni, Gabor Cserni, Emad Rakha, Maria Pia Foschini
Summary: This study aimed to examine the prognostic factors of microinvasive breast carcinoma through a systematic review and meta-analysis. The results showed that lymph node status has a significant association with prognosis, while other factors such as estrogen receptor, progesterone receptor, HER2 status, multifocality or grade of microinvasion, and patient's age do not significantly affect prognosis. Therefore, lymph node status is the main prognostic factor of microinvasive breast carcinoma.
Article
Oncology
Balint Cserni, Darren Kilmartin, Mark O'Loughlin, Xavier Andreu, Zsuzsanna Bago-Horvath, Simonetta Bianchi, Ewa Chmielik, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Aniko Kovacs, Paivi Heikkila, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchio, Elena Provenzano, Peter Regitnig, Angelika Reiner, Ales Ryska, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A. Glynn, Rita Bori, Erika Csorgo, Orsolya Olah-Nemeth, Tamas Pancsa, Anita Sejben, Istvan Sejben, Andras Voros, Tamas Zombori, Tibor Nyari, Grace Callagy, Gabor Cserni
Summary: Tumour-infiltrating lymphocytes (TILs) reflect the host's response against tumours, especially in triple-negative breast cancers. ONEST helps in estimating the number of observers required for a more reliable estimation of inter-observer agreement in TIL assessments, which has not been explored previously. This analysis suggests that between six and nine pathologists can provide a good approximation of inter-observer agreement in TIL assessments.
Article
Surgery
Elisabeth Lauritzen, Rikke Bredgaard, Cecilie Mullerup Laustsen -Kiel, Laura Hansen, Tove Tvedskov, Tine Engberg Damsgaard
Summary: This prospective trial investigated the use of ICG-A in OBCS, specifically in volume displacement and replacement procedures. ICG-A accurately located perforators and assessed tissue perfusion. The results were consistent with the surgeons' clinical assessment. One patient had postoperative infection and seroma, but was successfully treated conservatively. No complications such as necrosis, loss of reconstruction, or lymphedema were observed. Scar assessments showed significant improvements over time, and quality of life also improved. Adjuvant treatment was administered timely in all cases.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Cell Biology
Esther Diana Rossi, Zubair Baloch, Guliz Barkan, Maria Pia Foschini, Daniel Kurtycz, Marc Pusztaszeri, Philippe Vielh, William C. Faquin
Summary: The use of standardised reporting systems for non-gynaecologic cytopathology has gained popularity in various areas, including thyroid fine-needle aspiration and urine cytology. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) provides a defined risk assessment and clinical management algorithm for diagnosing salivary gland lesions. The MSRSGC has been widely accepted and its second edition includes updated risk assessments and advancements in imaging and ancillary testing.