Article
Biochemistry & Molecular Biology
Amrita Bhat, Gh. Rasool Bhat, Sonali Verma, Bhanu Sharma, Divya Bakshi, Deepak Abrol, Supinder Singh, Raies Ahmed Qadri, Ruchi Shah, Rakesh Kumar
Summary: The study found significant associations between 5 genetic variants and increased risk of leukemia in the northern Indian population, including TERT, PSCA, BRIP1, TNKS, and TCF21.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Obstetrics & Gynecology
Z. Yang, J. Liu, J. Fu, S. Li, Z. Chai, Y. Sun
Summary: The study found that LRP5 gene polymorphisms (rs2291467, rs11228240, and rs12272917) were significantly associated with a decreased risk of osteoporosis, especially in the subgroup with a body mass index (BMI) <= 24. In contrast, individuals carrying a heterozygote genotype of WNT16 gene polymorphisms had a higher risk of osteoporosis in the subgroup with BMI > 24. Additionally, two haplotypes were identified, with only certain combinations showing a strong association with decreased osteoporosis risk.
Article
Agriculture, Dairy & Animal Science
Qixin Guo, Lan Huang, Yong Jiang, Zhixiu Wang, Yulin Bi, Guohong Chen, Hao Bai, Guobin Chang
Summary: Good feed efficiency is crucial for the economic output of the livestock and poultry industries. This study conducted a genome-wide association study to identify potential variants and genes associated with seven feed efficiency measures in ducks. The findings provide insights into the genetic mechanisms and genes involved in feed efficiency-related traits in ducks. Further investigations are warranted to validate these findings.
Article
Plant Sciences
Huilong Hong, Mei Li, Yijie Chen, Haorang Wang, Jun Wang, Bingfu Guo, Huawei Gao, Honglei Ren, Ming Yuan, Yingpeng Han, Lijuan Qiu
Summary: This study analyzed the phenotypic diversity and genetic basis of epicotyl length (EL) in soybean using 951 cultivars and landraces from different regions. The study identified 180 QTNs and QEIs associated with EL, and predicted 10 candidate genes that may be involved in seed germination and seedling development.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Immunology
Shou-En Wu, Wei Liang Chen
Summary: The study investigated sarcopenia-related SNPs in Asian older adults and created a genotype score to test the combined effect of these SNPs on sarcopenia risk. Results revealed significant associations between SNPs and sarcopenic indices, with higher genotype scores linked to increased sarcopenia risk.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Veterinary Sciences
Keon Kim, Jung Eun Song, Jae Beom Joo, Hyeon A. Park, Chang Hyeon Choi, Chang Yun Je, Ock Kyu Kim, Sin Wook Park, Yoon Jung Do, Tai-Young Hur, Sang-Ik Park, Chang-Min Lee
Summary: This study conducted a GWAS analysis to investigate the genetic predisposition to mammary gland tumors (MGT) in Maltese dogs. Several significant SNPs associated with MGT phenotype were identified, providing a basis for further research on the genetic predisposition to MGTs in Maltese dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Plant Sciences
Narayana Bhat Devate, Hari Krishna, Sunil Kumar V. Parmeshwarappa, Karthik Kumar Manjunath, Divya Chauhan, Shweta Singh, Jang Bahadur Singh, Monu Kumar, Ravindra Patil, Hanif Khan, Neelu Jain, Gyanendra Pratap Singh, Pradeep Kumar Singh
Summary: This study conducted a genome-wide association study to identify markers associated with traits under heat and drought stress in bread wheat. The results provide valuable markers that can be used for marker-assisted breeding to develop climate-resilient cultivars.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Fisheries
W. K. M. Omeka, D. S. Liyanage, Sukkyoung Lee, Chaehyeon Lim, Hyerim Yang, W. M. Gayashani Sandamalika, H. M. V. Udayantha, Gaeun Kim, Subothini Ganeshalingam, Taehyug Jeong, Seong-Rip Oh, Seung-Hwan Won, Hyoung-Bum Koh, Mun-Kwan Kim, David B. Jones, Cecile Massault, Dean R. Jerry, Jehee Lee
Summary: Traits linked to growth performance in farmed fish are important for profitability in aquaculture. A genome-wide association study (GWAS) on olive flounder identified several single nucleotide polymorphisms (SNPs) associated with growth traits. These findings contribute to understanding the molecular basis of growth regulation and promote the use of SNP-based genomic selection in flounder culture.
Article
Dentistry, Oral Surgery & Medicine
Liwen Fan, Lan Ma, Guirong Zhu, Siyue Yao, Xiaofeng Li, Xin Yu, Yongchu Pan, Lin Wang
Summary: Our GWAS study identified chromosome 2 variants, including rs147680216, as well as three novel susceptibility loci, associated with the risk of premolar agenesis in the Chinese population.
Article
Agriculture, Dairy & Animal Science
Bowen Gu, Ruifan Sun, Xingqiang Fang, Jipan Zhang, Zhongquan Zhao, Deli Huang, Yuanping Zhao, Yongju Zhao
Summary: This study conducted a genome-wide association study on a Chinese indigenous goat breed, Dazu black goats, to identify the genetic variants associated with body conformation traits. A total of 53 significant single nucleotide polymorphisms and 42 candidate genes were detected. These findings have practical applications for genetic improvement and economic benefits in the goat meat industry.
Article
Biotechnology & Applied Microbiology
Charlotte E. Vollenbrock, Delnaz Roshandel, Melanie M. van der Klauw, Bruce H. R. Wolffenbuttel, Andrew D. Paterson
Summary: This study found that skin autofluorescence (SAF) has a high heritability and identified genetic variants associated with SAF through genome-wide association studies (GWAS). Further investigating the genetic architecture of SAF can improve its utility as a tool for screening and early detection of diseases.
Article
Biochemical Research Methods
Cheng-Hong Yang, Hsiu-Chen Huang, Ming-Feng Hou, Li-Yeh Chuang, Yu-Da Lin
Summary: In this study, an empirical fuzzy MOMDR (EFMOMDR) was proposed to address the limitations of binary classification in epistasis detection. Simulation studies showed that EFMOMDR had a higher detection success rate than MOMDR, indicating successful improvement of the limitations. EFMOMDR was also applied to analyze coronary artery disease.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2023)
Article
Medicine, General & Internal
Hyun-Ju An, Jae-Hwa Kim, Siyeong Yoon, Junwon Choi, Jeongmo Koo, Soonchul Lee
Summary: This study aimed to identify specific genes or genetic variants associated with rotator cuff tears through a genome-wide association study. More than 20 significantly associated SNPs were found. However, the study was limited by the small sample size and requires further validation. Nevertheless, the identification of potential genetic variants related to rotator cuff injury would aid in the early detection of individuals at risk and provide insight into future gene therapies.
Article
Obstetrics & Gynecology
Jianqiong Liu, Qiong Dai, Wei Li, Yan Guo, Anna Dai, Yanqing Wang, Mengyao Deng, Zhao Tang, Lu She, Xiaohong Chen, Mei Yang
Summary: In this study, VDR gene SNPs rs154410, rs7975232, rs731236, rs2228570 and rs739837 showed no significant associations or gene-gene interactions with GDM in Wuhan, China.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Medicine, Research & Experimental
Ching-Lung Ko, Wei-Zhi Lin, Meng-Ting Lee, Yu-Tien Chang, Hung-Che Lin, Yi-Syuan Wu, Jun-Fu Lin, Ke-Ting Pan, Yu-Chuan Chang, Ko-Han Lee, Yi-Lun Lee, Tsung-Ting Hsieh, Jia-Hsin Huang, Chih-Hung Wang, Sung-Sen Yang, Hsiang-Cheng Chen, Chi-Ming Chu
Summary: This study explored the race-specific SNP susceptibility of AS in Taiwanese individuals and found an association between HLA-B27 and AS susceptibility SNPs. The study also found differences in AS SNPs between Taiwanese individuals and other races, and that Taiwanese individuals with HLA-B27 positivity had a higher proportion of minor alleles. Additionally, AS polygenic risk score models were developed and individuals with high polygenic risk had a fivefold increased risk of developing AS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Letter
Urology & Nephrology
Hua-Jun Jiang, Hui Tang, Fei Xiong, Wen-Li Chen, Jian-Bo Tian, Jing Sun, Jun-Wu Dong, Xiao-Hui Wang, Xiao-Fei Jin, Yan-Qiong Ding, Li Xu, Xiao-Ping Miao, Chun Zhang
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jianbo Tian, Yimin Cai, Yue Li, Zequn Lu, Jinyu Huang, Yao Deng, Nan Yang, Xiaoyang Wang, Pingting Ying, Shanshan Zhang, Ying Zhu, Huilan Zhang, Rong Zhong, Jiang Chang, Xiaoping Miao
Summary: Genetic variants have been shown to impact tumor-infiltrating immune cells, emphasizing the importance of identifying immunQTLs to fully understand the contribution of genetic variants in tumor development. A computational pipeline was developed to identify 913 immunQTLs in 33 cancer types, and a user-friendly database, CancerImmunityQTL, was constructed to provide a valuable resource for studying the genetic determinants of immune infiltration in human cancer.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Toxicology
Pingting Ying, Yao Li, Nan Yang, Xiaoyang Wang, Haoxue Wang, Heng He, Bin Li, Xiating Peng, Danyi Zou, Ying Zhu, Rong Zhong, Xiaoping Miao, Jianbo Tian, Jiang Chang
Summary: The study revealed that the rs7495 gene is significantly associated with an increased risk of PDAC, with the G allele promoting the expression of hnRNPC and thus the risk of disease. This provides new insights into the critical role of m(6)A modification in tumorigenesis.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Immunology
Jianbo Tian, Ming Zhang, Meng Jin, Fengqin Zhang, Qian Chu, Xiaoyang Wang, Can Chen, Huihui Yue, Li Zhang, Ronghui Du, Dong Zhao, Zhaofu Zeng, Yang Zhao, Kui Liu, Mengmei Wang, Ke Hu, Xiaoping Miao, Huilan Zhang
Summary: This study found that tocilizumab treatment in COVID-19 patients can lower the risk of in-hospital death and acute respiratory distress syndrome. Patients had heightened inflammation and dysregulated immune cells before treatment, but these indicators improved after tocilizumab administration.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Pei Ji, Jiang Chang, Xiaoyu Wei, Xueyao Song, Hua Yuan, Linnan Gong, Yuancheng Li, Dongsheng Ding, Erbao Zhang, Caiwang Yan, Meng Zhu, Xiaoping Miao, Chen Wu, Guangfu Jin, Zhibin Hu, Hongbing Shen, Hongxia Ma
Summary: This study identified three novel genetic variants associated with SCCHN risk. Functional analysis revealed that one variant could modulate TCF19 expression by regulating the binding affinity of SREBF1 to the promoter of TCF19. These findings suggest that TCF19 may serve as a susceptibility gene for SCCHN.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Weiwei Jin, Guanghui Jiang, Yanbo Yang, Jianye Yang, Wenqian Yang, Dongyang Wang, Xiaohui Niu, Rong Zhong, Zhao Zhang, Jing Gong
Summary: Enhancer RNAs (eRNAs) are non-coding RNAs transcribed from enhancers, playing important roles in gene regulation as markers of active enhancers. The Animal-eRNAdb is a user-friendly database that facilitates the exploration of eRNA functions and mechanisms in different species' tissues.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Urology & Nephrology
Hui Tang, Can Tu, Fei Xiong, Xin Sun, Jian-Bo Tian, Jun-Wu Dong, Xiao-Hui Wang, Chun-Tao Lei, Jing Liu, Zheng Zhao, Yang Qiu, Xiao-Ping Miao, Chun Zhang
Summary: Maintenance hemodialysis patients are at increased risk of mortality and prolonged virus shedding period in the ongoing COVID-19 pandemic. Advanced age, decreased oxygen saturation, low diastolic blood pressure on admission, and complications like acute cardiac injury are independently associated with poor prognosis.
SEMINARS IN DIALYSIS
(2022)
Article
Environmental Sciences
Heng He, Yao Deng, Hao Wan, Na Shen, Jiaoyuan Li, Qiang Zeng, Jiang Chang, Qing Lu, Xiaoping Miao, Jianbo Tian, Rong Zhong
Summary: The study found that breast cancer patients had significantly higher urinary BPA concentrations than healthy individuals, with a 54% increased risk of breast cancer for every 1-unit increase in log-transformed urinary BPA. Individuals with the CYP19A1 rs1902580 GA + AA genotype had a significantly higher risk of breast cancer than those with the GG genotype. The interaction between BPA and CYP17A1 rs743572 was associated with a higher risk of breast cancer.
Article
Environmental Sciences
Rong Zhong, Heng He, Meng Jin, Zequn Lu, Yao Deng, Chong Liu, Na Shen, Jiaoyuan Li, Haoxue Wang, Pingting Ying, Bin Li, Qiang Zeng, Qing Lu, Liming Cheng, Ying Zhu, Xiaoping Miao, Jianbo Tian
Summary: This study in a Chinese population found a positive association between bisphenols, triclosan and oxidative stress markers. Significant interactions between genetic variants and endocrine disruptors were identified, indicating that endocrine disruptors may modify the effect of genetic variants on oxidative stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Oncology
Bin Li, Xiang Cheng, Ying Zhu, Hao Wan, Zequn Lu, Yimin Cai, Wenhui Li, Pengfei Yi, Li Liu, Jiang Chang, Xiaoping Miao, Jianbo Tian, Rong Zhong
Summary: The study revealed that the regulatory variant rs7160774 was associated with a decreased risk of breast cancer. Biological experiments demonstrated that the rs7160774[A] allele down-regulated FOXA1 expression by affecting transcription factor binding affinity, suggesting a crucial role in breast cancer development.
Article
Critical Care Medicine
Heng He, Ming-Ming He, Haoxue Wang, Weihong Qiu, Lei Liu, Lu Long, Qian Shen, Shanshan Zhang, Shifan Qin, Zequn Lu, Yimin Cai, Ming Zhang, Siyuan Niu, Jiaoyuan Li, Na Shen, Ying Zhu, Jianbo Tian, Jiang Chang, Xiaoping Miao, Rong Zhong
Summary: This study found that in utero tobacco exposure significantly increased the risk of lung cancer, and early smoking initiation in adulthood, adolescence, and childhood also increased the risk. Additionally, individuals with high polygenic risk scores (PRSs) and in utero tobacco exposure had a higher risk of lung cancer incidence and mortality, as did those with high PRSs and smoking initiation in childhood.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Kota Arima, Rong Zhong, Tomotaka Ugai, Melissa Zhao, Koichiro Haruki, Naohiko Akimoto, Mai Chan Lau, Kazuo Okadome, Raaj S. Mehta, Juha P. Vayrynen, Junko Kishikawa, Tyler S. Twombly, Shanshan Shi, Kenji Fujiyoshi, Keisuke Kosumi, Yoko Ogata, Hideo Baba, Fenglei Wang, Kana Wu, Mingyang Song, Xuehong Zhang, Charles S. Fuchs, Cynthia L. Sears, Walter C. Willett, Edward L. Giovannucci, Jeffrey A. Meyerhardt, Wendy S. Garrett, Curtis Huttenhower, Andrew T. Chan, Jonathan A. Nowak, Marios Giannakis, Shuji Ogino
Summary: This study found that a Western-style diet is associated with a higher incidence of colorectal cancer containing abundant pks(+) E coli, providing further support for a potential link between diet, the intestinal microbiota, and colorectal carcinogenesis.