Article
Oncology
B. Liu, L. Liu, J. Ran, N. Xie, J. Li, H. Xiao, X. Yang, C. Tian, H. Wu, J. Lu, J. Gao, X. Hu, M. Cao, Z. Shui, Z. -y. Hu, Q. Ouyang
Summary: This study compared the efficacy and safety of eribulin plus anlotinib versus eribulin monotherapy in patients with locally recurrent or metastatic breast cancer. The results showed that the combination therapy significantly improved progression-free survival and had higher rates of local control and objective response compared to eribulin alone, making it a viable treatment option for HER2-negative locally advanced or metastatic breast cancer.
Review
Medicine, Research & Experimental
Youkabed Kazemi, Sadegh Dehghani, Rahim Nosrati, Seyed Mohammad Taghdisi, Khalil Abnous, Mona Alibolandi, Mohammad Ramezani
Summary: CD44, as a cancer-related biomarker, plays an important role in the invasion and metastasis of cancer. The detection and quantification of CD44 using sensitive and specific biosensors can provide essential information for clinical cancer diagnosis. Recently, the combination of aptamers and nanoparticles in biosensor systems has led to the development of innovative CD44 detection methods with substantially improved detection limits.
Article
Oncology
Birgitte V. Offersen, Jan Alsner, Hanne M. Nielsen, Erik H. Jakobsen, Mette H. Nielsen, Lars Stenbygaard, Anders N. Pedersen, Mette S. Thomsen, Esben Yates, Martin Berg, Ebbe L. Lorenzen, Ingelise Jensen, Mirjana Josipovic, Maj-Britt Jensen, Jens Overgaard
Summary: External-beam PBI is noninferior to WBI in terms of breast induration for patients with low-risk breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anupama Vadhan, Ming-Feng Hou, Priya Vijayaraghavan, Yi-Chia Wu, Stephen Chu-Sung Hu, Yun-Ming Wang, Tian-Lu Cheng, Yen-Yun Wang, Shyng-Shiou F. Yuan
Summary: CD44 plays a key role in breast cancer metastasis by downregulating nuclear FOXA2.
Article
Oncology
Abdel-Rahman N. Zekri, Abeer Bahnassy, Magda Mourad, Ibrahim Malash, Ola Ahmed, Mona S. Abdellateif
Summary: This study characterized breast cancer stem cells (BCSCs) through genetic profiling, revealing specific molecular profiles that differ according to their phenotypes. These profiles could potentially impact patients' prognosis and outcome.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Thomas Bachelot, Thomas Filleron, Ivan Bieche, Monica Arnedos, Mario Campone, Florence Dalenc, Florence Coussy, Marie-Paule Sablin, Marc Debled, Claudia Lefeuvre-Plesse, Anthony Goncalves, Marie-Ange Mouret Reynier, William Jacot, Benoit You, Philippe Barthelemy, Benjamin Verret, Nicolas Isambert, Xavier Tchiknavorian, Christelle Levy, Jean-Christophe Thery, Tifenn L'Haridon, Jean-Marc Ferrero, Alice Mege, Francesco Del Piano, Etienne Rouleau, Alicia Tran-Dien, Julien Adam, Amelie Lusque, Marta Jimenez, Alexandra Jacquet, Ingrid Garberis, Fabrice Andre
Summary: The study found that single-agent antibodies against PD-L1 as maintenance therapy did not significantly benefit the overall population with metastatic breast cancer, but showed improved overall survival in patients with triple-negative breast cancer. Durvalumab may have better sensitivity in patients with CD274 amplification. Analysis of lymphocyte infiltration and homologous recombination deficiency did not predict sensitivity to durvalumab, warranting further research. Maintenance chemotherapy was more effective than durvalumab in patients with hormone receptor-positive and Her2-negative disease.
Article
Engineering, Biomedical
Ana M. Carvalho, Diana Soares da Costa, Rui L. Reis, Iva Pashkuleva
Summary: This study reveals the altered expression of hyaluronan (HA) receptors CD44 and RHAMM in the tumor microenvironment, which are associated with poor prognosis and treatment outcomes. The study also demonstrates the bi-directional communication between HA and breast cancer cell lines with different surface expression of CD44 and RHAMM. These findings are significant for the development of therapies targeting HA signaling in the tumor microenvironment.
ACTA BIOMATERIALIA
(2022)
Article
Oncology
Shi-Qian Lin, Chih-Ming Su, Hsueh-Chi Wu, Yun-Yun Chou, Yu-Chun Yen, Ka-Wai Tam
Summary: PDAs did not assist patients with breast cancer in making surgical treatment decisions, highlighting the need for clinicians to focus on evidence-based medicine and help patients consider their individual preferences in shared decision-making.
Article
Biochemistry & Molecular Biology
Natalia Izycka, Marcin Rucinski, Malgorzata Andrzejewska, Sebastian Szubert, Ewa Nowak-Markwitz, Karolina Sterzynska
Summary: Recurrent disease and treatment-associated chemoresistance are major contributors to poor clinical outcomes in ovarian cancer patients. This study investigated the expression of CSC-associated markers ALDH1A, CD44, and CD133 to predict patient prognosis. ALDH1A1-positive patients had significantly shorter overall survival (OS) and progression-free survival (PFS). Multivariate analysis revealed that ALDH1A1 expression, FIGO stage III-IV, and residual disease were associated with shorter OS. Targeting ALDH1A1-positive cancer cells may be a promising therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Qian Guo, Yiwen Liu, Yiqing He, Yan Du, Guoliang Zhang, Cuixia Yang, Feng Gao
Summary: This study identified a subset of BCa cells characterized by high expression of CD44v10, which displayed significantly higher proliferation capacity. Mechanistic analysis revealed that CD44v10 facilitated cell proliferation via activation of ERK/p38 MAPK and AKT/mTOR signaling pathways. Knockdown of CD44v10 expression downregulated the phosphorylation of ERK, AKT and mTOR, suggesting CD44v10 as a potential therapeutic target for BCa.
Review
Biochemistry & Molecular Biology
Cornelia Tolg, Britney Jodi-Ann Messam, James Benjamin McCarthy, Andrew Cook Nelson, Eva Ann Turley
Summary: Signaling from actively remodeling extracellular matrix, particularly involving hyaluronan, plays a critical role in tissue repair and disease progression, such as metastatic cancer. This review discusses the multifunctional nature of hyaluronan and its receptors in wound healing, as well as the deregulation of HA metabolism in malignant progression and the potential for targeting HA in breast cancer management.
Article
Biochemistry & Molecular Biology
Martha B. Alvarez-Elizondo, Daphne Weihs
Summary: In this study, the invasiveness of CD44(+)ALDH(+) cancer stem-like cells (CSCs) was investigated using a rapid mechanobiology-based assay. It was found that CD44(+)ALDH(+) cells showed higher invasiveness and migratory capacity, suggesting their potential role in disease progression and as prognostic markers for recurrence and metastasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nouralhuda Alateyah, Ishita Gupta, Radoslaw Stefan Rusyniak, Allal Ouhtit
Summary: This review focuses on the oncogenic potential of SOD2 in breast cancer and the underlying mechanisms associated with the onset and progression of cancer.
Article
Oncology
Christina M. Dieli-Conwright, Maura Harrigan, Brenda Cartmel, Anees Chagpar, Yalai Bai, Fang-yong Li, David L. Rimm, Lajos Pusztai, Lingeng Lu, Tara Sanft, Melinda L. Irwin
Summary: This study examined the impact of a 6-month weight loss intervention on breast tissue and serum biomarkers in women with breast cancer, and found that weight loss had favorable effects on metabolic and inflammatory markers associated with breast cancer.
Article
Multidisciplinary Sciences
Eun-Ok Im, Wonshik Chee, Sudeshna Paul, Mi-Young Choi, Seo Yun Kim, Janet A. Deatrick, Jillian Inouye, Grace Ma, Salimah Meghani, Giang T. Nguyen, Marilyn M. Schapira, Connie M. Ulrich, SeonAe Yeo, Ting Bao, David Shin, Jun J. Mao
Summary: This study demonstrates that a culturally tailored virtual program can improve the survivorship experience of Asian American women breast cancer survivors. The intervention group showed significant reductions in their needs and improvements in their symptoms and quality of life compared to the control group.
NATURE COMMUNICATIONS
(2023)
Article
Pathology
Jeong Won Kim, Joon-Yong Chung, Kris Ylaya, Yoonho Park, Sun-Young Jun, Seung-Mo Hong, Stephen M. Hewitt
Summary: The study revealed that high expression of SOX2 in patients with small intestinal adenocarcinomas is associated with shorter overall survival and has the potential to predict clinical outcomes.
Article
Oncology
Gregor Manukian, Charles Kivolowitz, Tiziana DeAngelis, Anuradha A. Shastri, Jason E. Savage, Kevin Camphausen, Ulrich Rodeck, Jelani C. Zarif, Nicole L. Simone
Summary: Combining caloric restriction with radiation therapy can reduce intratumoral Tregs, increase the CD8:Treg ratio, and increase PD-1 expression through a process dependent on CD8 T cells. Breast cancer patients undergoing caloric restriction concurrently with radiation therapy also experienced significant reductions in immunosuppressive cytokine levels.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Tu Dan, Anuradha A. Shastri, Ajay Palagani, Simone Buraschi, Thomas Neill, Jason E. Savage, Aastha Kapoor, Tiziana DeAngelis, Sankar Addya, Kevin Camphausen, Renato Iozzo, Nicole L. Simone
Summary: Research has shown that miR-21 plays a crucial role in the development and treatment of breast cancer, with its knockout inhibiting tumor growth and metastasis, and increasing tumor sensitivity to radiotherapy and chemotherapy.
Article
Oncology
Gabriella C. Squeo, Courtney M. Lattimore, Nicole L. Simone, Greg Suralik, Sunil W. Dutta, Michael D. Schad, Lucy Su, Bruce Libby, Einsley-Marie Janowski, Shayna L. Showalter, Jennifer M. Lobo, Timothy N. Showalter
Summary: This study compares the costs of precision breast intraoperative radiation therapy (PB-IORT) between a distributed facility and an integrated brachytherapy suite. The results show that PB-IORT costs less at a distributed facility, with consumable supplies being the largest source of costs.
Review
Biochemistry & Molecular Biology
Nicolas Nelson, Joseph Lombardo, Lauren Matlack, Alexandria Smith, Kamryn Hines, Wenyin Shi, Nicole L. Simone
Summary: Disruption of circadian rhythms is linked to the development and radiation response of breast cancer. Molecular alterations in circadian clock regulators may influence cancer phenotypes, outcomes, and radiation response. Exploiting circadian mechanisms can improve the effectiveness of radiation therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anuradha A. Shastri, Joseph Lombardo, Samantha C. Okere, Stephanie Higgins, Brittany C. Smith, Tiziana DeAngelis, Ajay Palagani, Kamryn Hines, Daniel A. Monti, Stella Volpe, Edith P. Mitchell, Nicole L. Simone
Summary: Understanding the metabolic and immune regulations inherent to patient populations is crucial to improving radiation response. Patients with poor response to radiation, such as African Americans, obese individuals, or elderly oncology patients, may benefit from concurrent therapies to enhance response. Nutrient deficiencies in these populations should be corrected to optimize the therapeutic index of radiation therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Brenton A. Maisel, Misung Yi, Amy R. Peck, Yunguang Sun, Jeffrey A. Hooke, Albert J. Kovatich, Craig D. Shriver, Hai Hu, Marja T. Nevalainen, Takemi Tanaka, Nicole Simone, Li Lily Wang, Hallgeir Rui, Inna Chervoneva
Summary: The density and spatial relationship of CD163(+) TAMs in tumor tissue are associated with unfavorable prognosis in breast cancer.
Article
Medicine, Research & Experimental
Candace C. Liu, Marc Bosse, Alex Kong, Adam Kagel, Robert Kinders, Stephen M. Hewitt, Sushama Varma, Matt van de Rijn, Stanislaw H. Nowak, Sean C. Bendall, Michael Angelo
Summary: The study validated the use of MIBI-TOF for imaging proteins in human tissue and compared it to traditional immunohistochemistry methods. The results showed that MIBI-TOF can generate consistent and quantitative annotations of clinically relevant cell states and provide a scalable benchmark for multiplexed immunohistochemistry approaches.
LABORATORY INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Sandeep K. Singhal, Jung S. Byun, Tingfen Yan, Ryan Yancey, Ambar Caban, Sara Gil Hernandez, Sediqua Bufford, Stephen M. Hewitt, Joy Winfield, Jaya Pradhan, Vesco Mustkov, Jasmine A. McDonald, Eliseo J. Perez-Stable, Anna Maria Napoles, Nasreen Vohra, Adriana De Siervi, Clayton Yates, Melissa B. Davis, Mei Yang, Yien Che Tsai, Allan M. Weissman, Kevin Gardner
Summary: Women of African ancestry have higher rates of breast cancer mortality, and differences in tumor biology may play a role in these disparities. The protein gp78, found in patient breast cancer cells, is associated with poor survival outcomes in both ER+ and ER- tumors. Breast cancers with high levels of gp78 are enriched in gene expression pathways related to cell cycle, metabolism, signaling, and stress response. Gp78 protein is an independent predictor of poor outcomes in women of African ancestry, and gene expression signatures stratified by gp78 expression are strong predictors of recurrence and treatment response.
Article
Oncology
Sherry X. Yang, Stephen M. Hewitt, John Yu
Summary: The role of lymph node involvement and tumor size in metastatic disease, including breast cancer, is examined in this study. The findings suggest that nodal involvement and T stage are independent risk factors for mortality in patients with de novo metastatic breast cancer. The study also highlights the significance of positive lymph node count, tumor size, and chest wall involvement in breast cancer-specific mortality. These findings have important implications for the management and treatment of metastatic breast cancer patients.
NPJ PRECISION ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Olivia Z. Horgan, Nicole T. Crane, Evan M. Forman, Brandy-Joe Milliron, Nicole L. Simone, Fengqing Zhang, Meghan L. Butryn
Summary: This study aims to assess the feasibility and effectiveness of intervention components designed to improve adherence to dietary guidelines for cancer prevention. The study combines mHealth and traditional methods to promote healthy grocery choices by emphasizing the importance of dietary goals, enhancing motivation, and increasing household support. The results of this study will inform the development of scalable interventions aimed at lowering cancer risk through dietary changes.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Cell Biology
Kyungeun Kim, Kris Ylaya, Candice Perry, Mi-Yeon Lee, Jeong Won Kim, Joon-Yong Chung, Stephen M. Hewitt
Summary: Water is a crucial factor for protein and RNA degradation in stored tissue sections, and storage conditions can affect the expression of certain key proteins and RNA integrity in breast tissue.
BIOPRESERVATION AND BIOBANKING
(2023)
Article
Multidisciplinary Sciences
Lichun Ma, Sophia Heinrich, Limin Wang, Friederike L. Keggenhoff, Subreen Khatib, Marshonna Forgues, Michael Kelly, Stephen M. Hewitt, Areeba Saif, Jonathan M. Hernandez, Donna Mabry, Roman Kloeckner, Tim F. Greten, Jittiporn Chaisaingmongkol, Mathuros Ruchirawat, Jens U. Marquardt, Xin Wei Wang
Summary: Intratumor heterogeneity arises from the evolution of tumor cells and their interactions with the tumor microenvironment. This study uses single-cell RNA sequencing to analyze liver cancer patients, identifying cellular dynamics and communication networks between malignant cells and tumor-associated immune cells. The findings validate the stable molecular networks of malignant ecosystems and potentially open up new therapeutic opportunities.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Nicolas G. G. Nelson, Joseph F. F. Lombardo, Ayako Shimada, Marissa L. L. Ruggiero, Alexandria P. P. Smith, Kevin Ko, Amy E. E. Leader, Edith P. P. Mitchell, Nicole L. L. Simone
Summary: The LGBTQ+ community faces disparities in cancer screening due to various factors, such as lower screening rates and health literacy gaps caused by systemic barriers. A survey was conducted to understand healthcare providers' experiences, perceptions, and knowledge regarding cancer screening for LGBTQ+ patients. The results showed that despite a lack of formal training, most providers recognized the unique health needs of LGBTQ+ patients. However, there was a lack of consensus among respondents regarding cancer screenings for lesbian and transgender patients, highlighting the need for clearer screening standards and educational programs for LGBTQ+ subpopulations.
Article
Hematology
Elizabeth Ren Zhang-Velten, David Parsons, Pam Lee, Eric Chambers, Ramzi Abdulrahman, Neil B. Desai, Tu Dan, Zabi Wardak, Robert Timmerman, Madhuri Vusirikala, Prapti Patel, Tiffany Simms-Waldrip, Victor Aquino, Andrew Koh, Jun Tan, Zohaib Iqbal, You Zhang, Robert Reynolds, Tsuicheng Chiu, Mindy Joo, Brian Hrycushko, Luo Ouyang, Richard Lamphier, Yulong Yan, Steve B. Jiang, Kiran A. Kumar, Xuejun Gu
Summary: This study reports our six-year clinical experience and outcomes analysis of using VMAT-TBI to treat patients. The results showed that VMAT-TBI is relatively safe and effective in treatment strategy and toxicities, serving as an alternative to cTBI.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)