Article
Endocrinology & Metabolism
Mauro Chivite, Rosa M. Ceinos, Jose M. Cerda-Reverter, Jose L. Soengas, Manuel Aldegunde, Marcos A. Lopez-Patino, Jesus M. Miguez
Summary: This study investigated changes in brain serotonin content, activity, and hypothalamic neuropeptide mRNA abundance during feeding time in rainbow trout, as well as the effects of fasting. The results showed that serotonin increased during feeding and remained elevated during the postprandial period. This increase was associated with higher levels of pomca1 mRNA, suggesting that serotonin may promote satiety by acting on neuropeptides. However, further research is needed to better understand the interaction between serotonin and brain centers involved in processing food-related signals.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Fisheries
Sara Comesan, Cristina Velasco, Jose L. Soengas
Summary: Results from an in vitro study suggest that rainbow trout hypothalamus responds to changes in leucine levels in a similar way to in vivo observations, activating amino acid sensing systems and GCN2 kinase. However, the activation of mTOR signaling pathway by leucine observed in vivo appears to be indirect, potentially due to the lack of connections between hypothalamus and other brain areas or changes in hormone levels such as insulin.
Article
Biology
Cristina Velasco, Marta Conde-Sieira, Sara Comesana, Mauro Chivite, Jesus M. Miguez, Jose L. Soengas
Summary: In this study using rainbow trout as a model, the G protein-coupled receptors GPR84 and GPR119 were investigated for their roles in food intake regulation. The treatment with agonists for these receptors induced an anorectic response in the fish, leading to changes in mRNA abundance of neuropeptides and related transcription factors. These changes were associated with phosphorylation status of FOXO1, AMPKa, and Akt, as well as signaling pathways related to PLC beta and IP3.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Neurosciences
Adrian Diaz-Rua, Mauro Chivite, Cristina Velasco, Sara Comesana, Jose L. Soengas, Marta Conde-Sieira
Summary: This study evaluated the main components of the cannabinoid system related to feeding conditions in fish. The results suggest a potential role of the endocannabinoid system in the regulation of food intake in fish, but further research is needed.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Environmental Sciences
Gilles Tinant, Ineke Neefs, Krishna Das, Jean-Francois Rees, Yvan Larondelle, Cathy Debier
Summary: The study found that MeHg affects lipid metabolism in rainbow trout adipocytes, leading to intracellular accumulation of neutral lipids and up-regulation of adipocyte-specific and lipid-related genes.
Article
Fisheries
Lianqun Sun, Carole R. Engle, Ganesh Kumar, Jonathan van Senten
Summary: This study examines the retail sales of farm-raised trout in the United States from 2016 to 2021. The results show that sales increased steadily during this period, with the fastest growth observed in the West North Central region. The top market regions for trout sales were Seattle/Tacoma and Portland Oregon.
AQUACULTURE REPORTS
(2023)
Article
Engineering, Environmental
Amelie Kierkegaard, Marcus Sundbom, Bo Yuan, James M. Armitage, Jon A. Arnot, Steven T. J. Droge, Michael S. McLachlan
Summary: For alkylamines, the bioconcentration increases with chain length (<= C-14) and is influenced by pH value in water. In contrast, quaternary ammonium compounds show minimal pH dependence and have lower bioconcentration levels compared to alkylamines of the same chain length at pH 7.6.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Fisheries
Rebecca A. Dupre, Ryan Ardoin, Jesse Trushenski, Chris Jackson, Casey Grimm, Brennan Smith
Summary: The present research demonstrates that dietary exposure is an alternative route of geosmin uptake in Rainbow Trout fillets, leading to a significant increase in geosmin concentrations. This finding is important for further investigation of sensory quality and off-flavor mitigation strategies for farm-raised fish.
Article
Environmental Sciences
Parastoo Razmara, Jacob J. Imbery, Emily Koide, Caren C. Helbing, Steve B. Wiseman, Patrick T. Gauthier, Douglas F. Bray, Maurice Needham, Travis Haight, Athanasios Zovoilis, Gregory G. Pyle
Summary: The study found that CuNPs are bioavailable to olfactory mucosal cells and have different effects on rainbow trout compared to Cu2+. RNA-seq analysis revealed distinct mechanisms of action between the two contaminants, with CuNPs affecting olfactory signal transduction, calcium homeostasis, and synaptic vesicular signaling in OSNs. CuNPs also impacted neuroregenerative pathways and suppressed inflammatory signaling, without inducing oxidative stress or apoptosis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Fisheries
Felix Docando, Paula Arense, Alba Martin-Martin, Tiehui Wang, Carolina Tafalla, Patricia Diaz-Rosales
Summary: Disease prevention through vaccination is the most appropriate method for pathogen control in aquaculture, but oral vaccines face technical problems in aquatic animals. This study explores different molecules as oral adjuvants and finds that LPS shows strong immunostimulatory potential and could be safely used as a mucosal adjuvant in rainbow trout.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kamil Uney, Duygu Durna Corum, Ertugrul Terzi, Orhan Corum
Summary: This study investigated the pharmacokinetics of carprofen in rainbow trout broodstock via intravenous, intramuscular, and oral routes, showing favorable properties such as good bioavailability and long elimination half-life for the drug when administered via intramuscular and oral routes.
Article
Fisheries
Manuel Gesto, Alfred Jokumsen
Summary: Environmental enrichment is a promising strategy to improve the welfare of fish in captivity, but its effects in terms of shelter type on rainbow trout juveniles are not significant when it comes to reducing overall stress levels. Further research is needed to optimize shelter design and application timing.
Article
Biology
Veronica Chico, Maria Elizabhet Salvador-Mira, Ivan Nombela, Sara Puente-Marin, Luis Perez, Luis Mercado, Maria del Mar Ortega-Villaizan
Summary: NKEF, an antioxidant protein, has been found to inhibit VHSV replication in rainbow trout red blood cells but not in cell lines. Silencing of the nkef gene led to increased VHSV replication and decreased expression of genes related to the IFN1 pathway. Overexpression of NKEF reduced VHSV infectivity, suggesting its potential as a therapeutic target against viral infections.
Article
Chemistry, Multidisciplinary
Joelle Auclair, Patrice Turcotte, Christian Gagnon, Caroline Peyrot, Kevin James Wilkinson, Francois Gagne
Summary: The study examined the sub-lethal toxicity of low concentrations of selected nanoparticles alone and in mixtures in juvenile trout. The results showed that the nanoparticles were bioavailable for fish, with different levels of toxicity for different nanoparticles and antagonistic effects in the mixtures. In conclusion, the bioavailability and toxicity of these nanoparticles are influenced by mixtures of nanoparticles, which is likely to occur in contaminated environments.
Article
Fisheries
Turid Synnove Aas, Torbjorn asgard, Trine Ytrestoyl
Summary: This paper is a documentation of the feed utilization in rainbow trout farming in Norway in 2020. A total of 89,667 tonnes of rainbow trout were produced, and the feed ingredients used included marine protein sources, vegetable protein sources, and micro ingredients, with a small portion of salmon feed also used. Norwegian fish meal and fish oil accounted for 8.8% of the ingredients, while the remaining ingredients were imported.
AQUACULTURE REPORTS
(2022)
Article
Neurosciences
Adrian Diaz-Rua, Mauro Chivite, Cristina Velasco, Sara Comesana, Jose L. Soengas, Marta Conde-Sieira
Summary: This study evaluated the main components of the cannabinoid system related to feeding conditions in fish. The results suggest a potential role of the endocannabinoid system in the regulation of food intake in fish, but further research is needed.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Nuria Saiz, Lisbeth Herrera-Castillo, Esther Isorna, Maria Jesus Delgado, Marta Conde-Sieira, Jose Luis Soengas, Nuria de Pedro
Summary: This study demonstrates, for the first time in fish, the effects of REV-ERB alpha activation via SR9009, promoting a negative energy balance by reducing energetic inputs and regulating lipid and glucose metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Adrian Diaz-Rua, Mauro Chivite, Sara Comesana, Marta Conde-Sieira, Jose L. Soengas
Summary: We investigated the role of the opioid system in the regulation of food intake in rainbow trout. Our results suggest that the opioid system is not critical for the homeostatic regulation of food intake, but it may play a role in the hedonic regulation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Antia Verde, Jesus M. Miguez, Mercedes Gallardo
Summary: The role of melatonin during the growth and ripening of apple fruit was studied using local varieties. It was found that melatonin stimulates fruit ripening through the induction of ethylene synthesis, and melatonin treatments before ripening improve the final fruit quality.
Article
Fisheries
Ana Basto, Luisa M. P. Valente, Jose L. Soengas, Marta Conde-Sieira
Summary: Understanding the regulation of food intake in fish is crucial for formulating aquafeeds. This study evaluated the short- and mid-term response of European sea bass fed diets with partial and total fishmeal replacement by defatted Tenebrio molitor larvae meal (dTM). The results showed that dTM replacement did not affect food intake regulation in sea bass, but may lead to long-term changes in intermediary metabolism.
Article
Fisheries
Sara Comesana, Mauro Chivite, Ayelen M. Blanco, Maria Alborja-Valado, Jessica Calo, Marta Conde-Sieira, Jose L. Soengas
Summary: This study clarifies the importance of mTOR in the central orexigenic effect of valine in fish. The activation of mTOR is associated with increased feed intake levels, but the precise mechanisms are still unclear.
AQUACULTURE NUTRITION
(2022)
Article
Fisheries
Jessica Calo, Marta Conde-Sieira, Sara Comesana, Jose L. Soengas, Ayelen M. Blanco
Summary: This study demonstrates the presence of a gut-brain axis in fish, as different types and lengths of fatty acids impact feed intake and appetite-regulatory centers in rainbow trout. The findings have important implications for aquaculture due to variations in fatty acid composition in aquafeeds.
Article
Behavioral Sciences
Mauro Chivite, Sara Comesana, Jessica Calo, Jose L. Soengas, Marta Conde-Sieira
Summary: This study demonstrated the presence of a rewarding response mediated by the endocannabinoid system (ECs) in rainbow trout fed a lipid-enriched diet. The agonists of ECs had a bimodal effect on feed intake, and the involvement of specific receptors of ECs in this response was assessed using receptor antagonists.
HORMONES AND BEHAVIOR
(2022)
Article
Fisheries
Jessica Calo, Jose L. Soengas, Jose J. Pastor, Ayelen M. Blanco, Sofia Morais
Summary: This study aimed to investigate the amino acid sensing capacity and hormone production in the gastrointestinal tract (GIT) of rainbow trout in response to proline, fishmeal amino acids, and fishmeal aqueous extract. The results showed that the presence of proline in the GIT led to changes in amino acid sensing systems and hormone production, especially in the proximal regions, accompanied by anorectic response in the hypothalamus. Both the fishmeal aqueous extract and the fishmeal amino acids induced anorectic responses in the hypothalamus, accompanied by increased production of anorectic hormones in the intestine.
Article
Fisheries
F. Lai, S. Comesana, A. S. Gomes, D. Flatejord, I. Tolas, M. Espe, C. De Santis, M. B. Hartviksen, T. Verri, J. L. Soengas, I. Ronnestad
Summary: This study found that high leucine diets reduce feed intake, growth, and hepatosomatic index in Atlantic salmon. It was also found that high leucine diets activate amino acid sensing mechanisms in the brain, which further affects the expression of genes related to appetite control.
Article
Biochemistry & Molecular Biology
Jessica Calo, Sara Comesana, Angel L. Alonso-Gomez, Jose L. Soengas, Ayelen M. Blanco
Summary: This study provides the first evidence of fatty acid sensing mechanisms in the gastrointestinal tract (GIT) of fish and identifies differences in these mechanisms between rainbow trout and mammals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Daniela Resende, Ricardo Pereira, David Dominguez, Miguel Pereira, Carlos Pereira, Manuela Pintado, Luisa M. P. Valente, Cristina Velasco
Summary: To improve fish welfare, aquafeeds should be designed to help fish cope with the stressful conditions of fish farms. One effective strategy is to supplement the diet with bioactive hydrolysates. This study investigated the supplementation of European seabass diet with swine blood hydrolysates to modulate oxidative stress and found that nanofiltration-treated hydrolysates may reduce oxidative stress in fish.
AQUACULTURE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Nuria Saiz, Cristina Velasco, Nuria de Pedro, Jose Luis Soengas, Esther Isorna
Summary: This study aimed to investigate the potential role of insulin as an intake signal mediating liver entrainment in fish. The experiments showed that the presence of insulin directly increased the abundance of per1a and per2 transcripts in the fish liver. It was found that the involvement of the PI3K/AKT pathway is crucial for insulin-mediated liver entrainment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alejandra Godino-Gimeno, Per-Ove Thornqvist, Mauro Chivite, Jesus M. Miguez, Svante Winberg, Jose Miguel Cerda-Reverter
Summary: In the past decade, the zebrafish has become an important model organism for studying behavior, neurological disorders, and metabolic diseases. This study used the zebrafish model to investigate how obesity induced by overfeeding affects emotional and cognitive processes. The results showed that obesity impaired short-term memory in zebrafish, but had no effect on anxiety-like behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Ana Basto, Luisa M. P. Valente, Vera Sousa, Marta Conde-Sieira, Jose L. Soengas
Summary: This study evaluated the impact of partial and total fishmeal replacement by insect meal on intermediary metabolism of European sea bass. The results showed that the selected insect meal can replace 50% of fishmeal without adversely affecting liver health or intermediary metabolism. However, total fishmeal replacement may compromise fish health in the long-term.
JOURNAL OF ANIMAL SCIENCE
(2023)