Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 133, Issue 2, Pages 607-615Publisher
SPRINGER
DOI: 10.1007/s10549-011-1822-6
Keywords
GRB7; Adapter proteins; Triple-negative breast cancer; Tumor cell invasion; Receptor tyrosine kinase signaling
Categories
Funding
- Susan G. Komen for the Cure Foundation [KG091136, KG100888]
- Fundacion Alfonso Martin Escudero
- National Cancer Institute [R01 CA80790]
- SD Ireland Cancer Research Foundation
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Triple-negative breast cancer (TNBC) is a heterogeneous disease that is usually associated with poor prognosis, and frequently associated with the basal-like breast cancer gene expression profile. There are no targeted therapeutic modalities for this disease, and no useful biomarkers. High GRB7 RNA expression levels are associated with an elevated risk of recurrence in patients with operable TNBC treated with standard adjuvant anthracycline and taxane therapy. To determine whether GRB7 is involved in the pathobiology of TNBC, we evaluated the biological effects of GRB7 inhibition in a panel of triple-negative cell lines-MDA-MB-468, MDA-MB-231, HCC70, and T4-2. We found GRB7 inhibition reduced cell motility and invasion of these cell lines and promoted cell death by apoptosis in 3D culture. These data suggest that GRB7 itself, or GRB7-dependent pathways, may prove to be important therapeutic targets in this disease.
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