Article
Oncology
Gordon P. Watt, Esther M. John, Elisa V. Bandera, Kathleen E. Malone, Charles F. Lynch, Julie R. Palmer, Julia A. Knight, Melissa A. Troester, Jonine L. Bernstein
Summary: A study in the United States found that non-Hispanic Black and Hispanic women have an increased risk of contralateral breast cancer (CBC) compared to non-Hispanic White women, especially among those diagnosed at a younger age. Adjusting for clinical or socioeconomic factors did not explain these associations. Further research with detailed treatment data is needed to address this disparity.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Anath A. Flugelman, Anya Burton, Lital Keinan-Boker, Nili Stein, Dafna Kutner, Lior Shemesh, Norman Boyd
Summary: There is a significant association between breast density and breast cancer incidence, with higher breast density associated with increased cancer risk. Breast density increases with age.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Cheng-Yao Lin, Sheng-Yen Hsiao, Wen-Tsung Huang, Chao-Jung Tsao, Chung-Han Ho, Shih-Bin Su, How-Ran Guo
Summary: A study from the Breast Cancer Health Database in Taiwan showed that the occurrence of second primary malignancies (SPMs) after breast cancer (BC) is an important issue. However, the study found that the use of chemotherapy and/or radiotherapy did not increase the risk of SPM in women with BC. In fact, for patients at stage III/IV, receiving both therapies was associated with a lower risk of SPM.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Monika Cieszynska, Wojciech Kluzniak, Dominika Wokolorczyk, Cezary Cybulski, Tomasz Huzarski, Jacek Gronwald, Michal Falco, Tadeusz Debniak, Anna Jakubowska, Roza Derkacz, Wojciech Marciniak, Marcin Lener, Karolina Woronko, Dominika Mocarz, Piotr Baszuk, Marta Bryskiewicz, Steven A. Narod, Jan Lubinski
Summary: This study aimed to evaluate the risk of developing thyroid cancer after a diagnosis of breast cancer and identify therapeutic and genetic risk factors. The findings showed that women carrying a CHEK2 mutation had a higher risk of thyroid cancer.
Article
Oncology
Danielle D. Durham, Linn A. Abraham, Megan C. Roberts, Carly P. Khan, Robert A. Smith, Karla Kerlikowske, Diana L. Miglioretti
Summary: This study found that women with a first-degree family history of breast cancer diagnosed between 40 and 49 years, who underwent screening between ages 30 and 39 or 40 and 49, had similar 5-year cumulative incidences of breast cancer as women without a family history undergoing screening between 50-59 years of age. In addition, for women with a relative diagnosed at or before age 45, initiating screening 5-8 years earlier than their relative's diagnosis age resulted in a 5-year cumulative incidence of breast cancer similar to that of an average 50-year-old woman.
Article
Oncology
Jianguang Ji, Jan Sundquist, Kristina Sundquist, Guoqiao Zheng
Summary: This study found that the risk of lung cancer (LCa) is similar when a first-degree relative (FDR) is diagnosed with either LCa-1 or LCa-2. The risk is higher when the FDR is diagnosed with LCa-2 within a certain period of time after the first primary cancer. The risk of LCa is also increased for certain types of first primary cancers, such as ovarian, nervous system, upper aerodigestive tract, cervix, and non-Hodgkin lymphoma.
Article
Oncology
Fei Chen, Sungshim L. Park, Lynne R. Wilkens, Peggy Wan, Steven N. Hart, Chunling Hu, Siddhartha Yadav, Fergus J. Couch, David V. Conti, Adam J. de Smith, Christopher A. Haiman
Summary: This multiethnic study found that germline pathogenic variants in BRCA1, BRCA2, and ERCC2 are associated with the development of second primary cancer in breast cancer survivors, providing biological insights and biomarkers for patient monitoring.
Article
Public, Environmental & Occupational Health
Taylor D. Ellington, Jacqueline W. Miller, S. Jane Henley, Reda J. Wilson, Manxia Wu, Lisa C. Richardson
Summary: Breast cancer accounts for 30% of all cancers diagnosed in women. From 1999 to 2018, the incidence of breast cancer among women aged 20 years and older showed a decreasing trend, with the highest decrease seen from 1999 to 2004 and a slight increase from 2004 to 2018. The incidence increased among non-Hispanic Pacific Islander women and women aged 20-39 years, while it decreased among non-Hispanic White women and women aged 50-64 and 75 years and older. In terms of public health practice, biennial mammography screening is currently recommended for women aged 50-74 years, and women aged 20-49 years may benefit from discussing potential breast cancer risk and ways to reduce risk with their healthcare providers.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Article
Multidisciplinary Sciences
Brijesh Kumar, Aditi S. Khatpe, Guanglong Jiang, Katie Batic, Poornima Bhat-Nakshatri, Maggie M. Granatir, Rebekah Joann Addison, Megan Szymanski, Lee Ann Baldridge, Constance J. Temm, George Sandusky, Sandra K. Althouse, Michele L. Cote, Kathy D. Miller, Anna Maria Storniolo, Harikrishna Nakshatri
Summary: This study explores the characteristics and functions of stromal cells that are particularly enriched in breast cancer patients with genetic ancestry. The researchers found that these cells can trans-differentiate into different cell types and can be transformed into metaplastic carcinoma.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Nishwant Swami, Tiffany Nguyen, Edward Christopher Dee, Idalid Franco, Yefri A. Baez, Kaitlyn Lapen, Lora Wang, Neha Goel, Brandon A. Mahal, Oluwadamilola M. Fayanju, Narjust Duma, Fumiko Chino
Summary: This study aimed to examine the differences in breast cancer stage at presentation among the US Hispanic population. The findings showed that when disaggregated by racial subgroup and country of origin, Hispanic women were more likely to present at later-stage primary breast cancer compared to non-Hispanic White women. These disparities may be driven by socioeconomic differences as well as disparities in access and/or differential care.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Chengshi Wang, Kejia Hu, Chuanxu Luo, Lei Deng, Katja Fall, Rulla M. Tamimi, Unnur A. Valdimarsdottir, Fang Fang, Donghao Lu
Summary: The study findings suggest that cancer survivors who develop breast cancer as a second malignancy are at increased risk of cardiovascular mortality, especially pronounced in individuals aged 30-49 years.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Kathryn P. Lowry, Laura Ichikawa, Rebecca A. Hubbard, Diana S. M. Buist, Erin J. A. Bowles, Louise M. Henderson, Karla Kerlikowske, Jennifer M. Specht, Brian L. Sprague, Karen J. Wernli, Janie M. Lee
Summary: In women with previously treated breast cancer, the risk of second breast cancers is higher in those with ER-negative primary cancer during the first 5 years after diagnosis compared to those with ER-positive cancer.
Review
Surgery
Rachel Xue Ning Lee, Maria Joao Cardoso, Kwok-Leung Cheung, Ruth M. Parks
Summary: The uptake of postmastectomy immediate breast reconstruction (PMIBR) in older women is significantly lower than in younger women, and there are definable (and some correctable) barriers to this trend.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
Maria-Eleni Syleouni, Nena Karavasiloglou, Laura Manduchi, Miriam Wanner, Dimitri Korol, Laura Ortelli, Andrea Bordoni, Sabine Rohrmann
Summary: We developed an automated approach to predict the occurrence of any second breast cancer using patient-level data and validated the models with an external dataset. The best-performing model identified key characteristics contributing to a high second breast cancer risk, and a feed-forward neural network showed the best generalizability across different machine learning algorithms.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Chaofan Li, Mengjie Liu, Jia Li, Xixi Zhao, Yusheng Wang, Xi Chen, Weiwei Wang, Shiyu Sun, Cong Feng, Yifan Cai, Fei Wu, Chong Du, Yinbin Zhang, Shuqun Zhang, Jingkun Qu
Summary: Metastasis in breast cancer patients may promote the occurrence of second primary cancers (SPCs) and further increase the risk of cancer-related deaths. Therefore, more attention should be paid to the occurrence of SPCs in patients with metastatic breast cancer (MBC).
FRONTIERS IN ONCOLOGY
(2022)