Article
Geriatrics & Gerontology
Xiaolan Lian, Mingyi Zhao, Ji Xia, Yulei He, Lina Zhang
Summary: The study found that both well-known mRNA splicing genes and rarely reported mRNA splicing relevant genes were significantly down-regulated during the aging process of HSPCs. This research enhanced our understanding of the role of mRNA splicing in HSPC aging.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Biology
Hussain Ali, Javaid Iqbal, Hael S. Raweh, Abdulaziz S. Alqarni
Summary: This study compared the response of different honey bee species to three sugar types at different concentrations, indicating that native species are better adapted than A. mellifera under local climate conditions.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Jialiang Li, Rui Yang, Yonglei Jiang, Shubin Sun, Junying Li, Hao Gu, Ying Lin, Xianxue Luo, Chenggang He, Yi Chen
Summary: This study provides insights into the responses of tobacco roots to different soil types, showing that red soil promotes the coordination of chemical composition of tobacco leaves and the growth and activity of the root system, while limestone soil and paddy soil have relatively weaker effects.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Toxicology
Wei Zhang, Ruiguo Wang, John P. Giesy, Su Zhang, Shulin Wei, Peilong Wang
Summary: In this study, the effects of TDCIPP on immune cells were investigated using iTRAQ-based proteomic techniques. A total of 180 differentially expressed proteins were identified, with some found to be involved in pathways related to apoptosis, DNA damage, cell cycle arrest, immune-toxicity, and signaling pathways. The study also suggested that the collapse of MMP may play a role in TDCIPP induced apoptosis.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Fisheries
Yufeng Zhai, Ruihang Xu, Peimin He, Rui Jia
Summary: The study confirms the phenomenon of immune priming in shrimp P. vannamei, showing that the initial stimulation with trans-vp28 gene Synechocystis sp. PCC6803 can enhance shrimp's immune protection against secondary stimulation. The analysis identified differentially expressed proteins and signaling pathways involved in the immune response, providing insights into the mechanisms of immune priming in shrimp. These findings suggest the potential for enhancing shrimp immunity through immuno-priming strategies.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Caiye Zhu, Heping Cheng, Na Li, Tiaoguo Liu, Youji Ma
Summary: Differentiated proteins related to fat deposition and metabolism in the tails of Altay sheep and Tibetan sheep were identified using iTRAQ and LC-MS/MS technologies. Genes such as APOA2, GALK1, ADIPOQ, and NDUFS4 may play roles in fat formation and metabolism in sheep tails, providing a basis for breeding thin-tailed sheep.
FRONTIERS IN GENETICS
(2021)
Article
Microbiology
Jiatian Wang, Peiyang Fan, Yong Wei, Jiaqi Wang, Weihao Zou, Guofa Zhou, Daibin Zhong, Xueli Zheng
Summary: This study used iTRAQ-based proteomic analysis to investigate the changes in protein expression in the midgut of Ae. albopictus during DENV infection. The results revealed differential upregulation or downregulation of certain proteins in response to DENV infection, with enrichment in pathways related to ubiquitin ligase complex, cuticle structure, carbohydrate metabolism, and lipid metabolism. Additionally, a putative pupal cuticle (PC) protein and ubiquitin carboxyl-terminal hydrolase (UCH) protein were found to potentially play important roles in the antiviral response.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Neurosciences
Zhifeng Qi, Shuhua Yuan, Xixi Zhou, Xunming Ji, Ke Jian Liu
Summary: This study identified potential serum biomarkers for predicting hemorrhagic transformation (HT) after ischemic stroke by analyzing differences in protein levels in 37 acute ischemic stroke patients. Further analysis indicated that these differentially expressed proteins may interact to contribute to the development of HT.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Preethi Balan, Yap S. Chong, Qingsong Lin, Teck Kwang Lim, Huihua Li, Mun L. Wong, Violeta Lopez, Hong Gu He, Chaminda Jayampath Seneviratne
Summary: The study found that pathways associated with neutrophil-mediated immune response and antioxidant defense mechanism were significantly increased in pregnant women with gingivitis. However, the abundance of salivary cystatins and antimicrobial proteins decreased in both pregnant women with and without gingivitis. This may predispose healthy pregnant women to pregnancy gingivitis and cause persistence of inflammation in pregnant women with gingivitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Plant Sciences
Salvador Gonzalez-Gordo, Jose M. Palma, Francisco J. Corpas
Summary: The proteomic composition of peroxisomes in sweet pepper fruits was analyzed, revealing significant differences in peroxisomal proteins involved in antioxidant metabolism and beta-oxidation pathway. These findings provide new insights into the metabolic functions of peroxisomes during fruit ripening.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Entomology
M. Choppin, L. Lach
Summary: Organisms with the ability to detect parasites are more likely to avoid them. Asian honey bee, Apis cerana, is more likely to avoid higher concentrations of N. ceranae spores compared to western honey bee, Apis mellifera. However, neither species avoids lower concentrations of the parasite spores.
Article
Chemistry, Analytical
Jonghyun Kim, Dongtan Yin, Jua Lee, Hyun Joo An, Tae-Young Kim
Summary: A new relative quantification strategy for glycomics, DOLGOReQ, has been developed based on partial metabolic D2O labeling, showing high accuracy and potential for universal quantification in large-scale comparative glycomic experiments. The method accurately quantifies the ratio of mixed glycans and demonstrates good quantification capabilities across a wide range of mixing ratios.
ANALYTICAL CHEMISTRY
(2021)
Article
Biology
Bin Han, Qiaohong Wei, Fan Wu, Han Hu, Chuan Ma, Lifeng Meng, Xufeng Zhang, Mao Feng, Yu Fang, Olav Rueppell, Jianke Li
Summary: Behavioral specialization is crucial for the success of social insects, and honeybee workers show different response thresholds to task-specific stimuli corresponding to their behavioral phenotypes. Tachykinin signaling plays a functional role in regulating the responsiveness of specialized honeybee workers to specific tasks, suggesting a potential mechanism for controlling behavior in animals.
Article
Biochemistry & Molecular Biology
Lien-Hung Huang, Cheng-Shyuan Rau, Yueh-Wei Liu, Hui-Ping Lin, Yi-Chan Wu, Chia-Wen Tsai, Peng-Chen Chien, Chia-Jung Wu, Chun-Ying Huang, Ting-Min Hsieh, Ching-Hua Hsieh
Summary: This study identified alterations in protein levels within circulating exosomes in patients with hepatocellular carcinoma (HCC). Increased levels of von Willebrand factor and proteasome subunit beta type-2, as well as decreased levels of cathelicidin antimicrobial peptide, were observed. The study also provided evidence that cathelicidin antimicrobial peptide may act as a tumor suppressor in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Xiangyu Wang, Kaina Yan, Muqing Fu, Song Liang, Haiyi Zhao, Changzhu Fu, Lan Yang, Zhihong Song, Dayong Sun, Chengsong Wan
Summary: Using iTRAQ technique, we investigated the pathogenic characteristics of EHEC's EspF in host cells. The study revealed that EspF induced ER stress and apoptosis in intestinal epithelial cells, providing insights into the virulence mechanism of EspF.
FRONTIERS IN MICROBIOLOGY
(2022)
