Journal
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
Volume 201, Issue 9, Pages 895-909Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00359-015-1010-y
Keywords
Drosophila; Behavior; Circuit mapping; Intersection; FINGR
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Funding
- National Science Foundation (NSF) [IOS-1025556, DBI-1126578, IOS-1354609]
- National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS) [RO1-NS060878]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1354609] Funding Source: National Science Foundation
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Understanding behavior requires unraveling the mysteries of neurons, glia, and their extensive connectivity. Drosophila has emerged as an excellent organism for studying the neural basis of behavior. This can be largely attributed to the extensive effort of the fly community to develop numerous sophisticated genetic tools for visualizing, mapping, and manipulating behavioral circuits. Here, we attempt to highlight some of the new reagents, techniques and approaches available for dissecting behavioral circuits in Drosophila. We focus on detailing intersectional strategies such as the Flippase-induced intersectional Gal80/Gal4 repression (FINGR), because of the tremendous potential they possess for mapping the minimal number of cells required for a particular behavior. The logic and strategies outlined in this review should have broad applications for other genetic model organisms.
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