Review
Oncology
Ke Zhu, Aiqun Xu, Wanli Xia, Pulin Li, Binbin Zhang, Huihui Jiang, Sijing Zhou, Ran Wang
Summary: The NAT2 slow + intermediate phenotype is significantly associated with an increased risk of lung cancer, while the NAT2 rapid phenotype is associated with a reduced risk of lung cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Babatunde Adedokun, Zhaohui Du, Guimin Gao, Thomas U. Ahearn, Kathryn L. Lunetta, Gary Zirpoli, Jonine Figueroa, Esther M. John, Leslie Bernstein, Wei Zheng, Jennifer J. Hu, Regina G. Ziegler, Sarah Nyante, Elisa Bandera, Sue A. Ingles, Michael F. Press, Sandra L. Deming-Halverson, Jorge L. Rodriguez-Gil, Song Yao, Temidayo O. Ogundiran, Oladosu Ojengbede, William Blot, Melissa A. Troester, Katherine L. Nathanson, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Peter N. Fiorica, Lara E. Sucheston-Campbell, Jeannette T. Bensen, Lawrence H. Kushi, Gabriela Torres-Mejia, Donglei Hu, Laura Fejerman, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Kyriaki Michailidou, Paul D. P. Pharoah, Qin Wang, Dale P. Sandler, Jack A. Taylor, Katie M. O'Brien, Cari M. Kitahara, Adeyinka G. Falusi, Chinedum Babalola, Joel Yarney, Baffour Awuah, Beatrice Addai-Wiafe, Stephen J. Chanock, Andrew F. Olshan, Christine B. Ambrosone, David Conti, Elad Ziv, Olufunmilayo Olopade, Montserrat Garcia-Closas, Julie R. Palmer, Christopher A. Haiman, Dezheng Huo
Summary: Using a cross-ancestry approach, the study identified seven new variants associated with breast cancer risk among women of African ancestry, shedding light on the genetic basis of breast cancer in different populations and emphasizing the importance of replication across multiple ancestry populations to identify causal variants.
NATURE COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Yingying Yuan, Yachun Wang, Xiaodong Niu, Yungang Han, Wenbo Li, Meijin Cheng, Zheng Li, Jiao Tan, Yue Zhao, Wei Wang
Summary: This study provides a more precise estimation of the relationship between lncRNA H19 polymorphisms and cancer risk based on a meta-analysis of 53 studies. The results suggest that the rs2839698 polymorphism in H19 is associated with increased cancer risk in all participants. Stratification analysis reveals that certain mutations are linked to specific cancer types.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Shilin Xue, Wenya Shen, Jianning Cai, Jinhai Jia, Dan Zhao, Shan Zhang, Xiujun Zhao, Ning Ma, Wenjuan Wang, Bingshuang Wang, Xiaolin Zhang, Xuehui Liu
Summary: This meta-analysis aimed to examine the association between rs735482 polymorphism and cancer risk. The results showed that there is no significant association between rs735482 polymorphism and susceptibility to various cancers overall. However, stratified analysis by ethnicity indicated that rs735482 is associated with an increased risk of cancer in the Chinese population and a decreased risk in the Italian population.
Review
Oncology
Maoquan Yang, Mingwei Zhang, Qiong Wang, Xiaojing Guo, Peizhen Geng, Jinhua Gu, Wansheng Ji, Li Zhang
Summary: In this meta-analysis, a significant association was found between H19 gene polymorphisms and cancer susceptibility. Specifically, the rs2107425 variation was related to decreased cancer risk among Caucasians, while the rs217727 polymorphism was associated with increased risk of lung cancer, hepatocellular carcinoma, and oral squamous cell carcinoma. Moreover, the rs2839698 polymorphism was linked to increased cancer risk among Asians and in different cancer types (such as gastric cancer and hepatocellular carcinoma) and larger study populations. Overall, H19 SNPs were found to be significantly correlated with cancer risk.
Review
Genetics & Heredity
Lin Zhao, Xiang-Xiongyi Yin, Jun Qin, Wei Wang, Xiao-Feng He
Summary: Based on a comprehensive analysis of a large number of studies, this meta-analysis found no significant association between TP53 codons 72, IVS3 16 bp, and IVS6+62A > G polymorphisms and breast cancer risk. The previous results suggesting an association may be false-positive results due to confounding factors.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Pranoti Pradhan, Guochong Jia, Nikhil K. Khankari, Wei Zheng
Summary: Tobacco smoking is strongly associated with bladder cancer risk, and this study found that the interaction between tobacco smoking and NAT2 genotypes and polygenic risk score (PRS) significantly increased the risk of developing bladder cancer. The study highlights the importance of considering both genetic and lifestyle risk factors in preventing bladder cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Medicine, General & Internal
Maoquan Yang, Wansheng Ji, Ning Xu, Chuanju Zong, Jinhua Gu, Xiaojing Guo, Li Zhang
Summary: In this meta-analysis, VDR gene polymorphisms including Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI were found to be significantly associated with colorectal cancer (CRC) risk. Specifically, the BsmI variant was associated with a lower risk of CRC in Caucasian population, the FokI polymorphism was associated with colon cancer risk, and the Cdx-2 polymorphism was associated with decreased CRC risk among Africans.
Review
Oncology
Yujing He, Yuexiu Si, Xiangyuan Li, Jiaze Hong, Chiyuan Yu, Ning He
Summary: The study revealed that smoking (both active and passive) increased the risk of breast cancer in women, especially in premenopausal breast cancer patients. The effect of smoking on breast cancer risk is influenced by smoking-related factors, population-related factors, and breast cancer subtypes.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Gaoming Li, Jingfu Ma, Ning Zhang, Xiaogang Li, Fangfang Li, Yuxing Jiang
Summary: This meta-analysis examined the associations between interleukin-17 (IL-17) polymorphisms and colorectal cancer susceptibility. The results showed that the IL-17A rs2275913 polymorphism was significantly associated with increased colorectal cancer susceptibility, while the IL-17F rs763780 polymorphism was not. These findings provide important evidence for the genetic risk of colorectal cancer and suggest potential targets for future research.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Liwei Cheng, Fan Zhang, Ying Wang, Jing Chen, Xiaoping Yuan
Summary: This meta-analysis study found an association between IFNGR1 gene polymorphisms and tuberculosis susceptibility. The rs2234711 polymorphism was associated with increased tuberculosis susceptibility in Africans and decreased susceptibility in Asians. Additionally, the rs7749390 polymorphism was associated with decreased tuberculosis susceptibility in Africans.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Heran Wang, Robert J. MacInnis, Shuai Li
Summary: A systematic review found that Asian women with a family history of breast cancer have approximately double the risk compared to those without a family history, similar to women of European ancestry.
Article
Infectious Diseases
Yapeng Li, Lanlan Wei, Lanye He, Jiahui Sun, Nanyang Liu
Summary: The meta-analysis suggests an association between IFITM3 rs12252 gene polymorphisms and COVID-19 susceptibility, with the rs12252-C variant being particularly critical for severity.
JOURNAL OF INFECTION
(2022)
Article
Biochemistry & Molecular Biology
Na Li, Zhigang Cui, Min Gao, Sixuan Li, Mingyang Song, Ying Wang, Lianwei Tong, Yanhong Bi, Ziwei Zhang, Shengli Wang, Baosen Zhou, Zhihua Yin
Summary: rs13252298 and rs1456315 in PRNCR1 may be genetic susceptibility factors for lung cancer in Chinese population. These results need to be confirmed by further studies.
DNA AND CELL BIOLOGY
(2021)
Article
Genetics & Heredity
Ayatun Nesa, Md. Mostafijur Rahman, Md Tahminur Rahman, Yearul Kabir
Summary: This study aimed to investigate the association of NAT2, GSTT1, and GSTM1 gene polymorphisms with prostate cancer risk in the Bangladeshi population. The results showed a higher frequency of mutant NAT2*5A, NAT2*6A, and NAT2*7A in prostate cancer cases compared to controls. The presence of NAT2 slow genotypes, GSTT1 genotype, and GSTM1 genotype significantly increased the risk of prostate cancer.