Review
Immunology
Minghui Zheng, Jing Li, Weizhen Fang, Ling Luo, Rui Ding, Hua Zeng, Hong Luo, Xianghua Lin, Chaohui Duan
Summary: A meta-analysis explored the association between specific polymorphisms in the IFN-γ and TNF-α genes and the incidence of LC. The results showed that rs361525 is associated with LC in alcoholic liver cirrhosis and HBV-related cirrhosis, while rs2430561 is associated with LC in the Asian population and in the context of HBV-related cirrhosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jiebing Gu, Jing Sun, Yingyu Zhang, Xiaoshuang Wang, Lingling Fu, Linfang Li, Di Wang, Xiuting Wang, Le Yu, Xuemei Han
Summary: This meta-analysis found a marginally significant association between the IFNG +874AT genotype and high risk of MS, but no significant association between TNFA and TNFB gene polymorphisms and MS risk. Further studies with larger samples are needed for more conclusive results about the contribution of other polymorphisms to the risk of MS.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Review
Multidisciplinary Sciences
Sepehr Sadafi, Ali Ebrahimi, Masoud Sadeghi, Omid Emami Aleagha
Summary: This study examined the relationship between tumor necrosis factor-alpha (TNF-a) polymorphisms and the risk of psoriasis. The results showed that the -238 G/A rs361525 polymorphism and the -857C/T rs1799724 polymorphism were associated with an increased risk of psoriasis. The study recommends future well-designed studies with larger sample sizes to confirm these results.
Article
Clinical Neurology
Nour Hamad, Karem H. Alzoubi, Samer F. Swedan, Omar F. Khabour, Khalid El-Salem
Summary: The study found a significant association between rs1800629 and rs1799724 variants in the TNF alpha gene and migraine in the Jordanian population. The A allele in rs1800629 was associated with a higher risk of migraine in both male and female subjects.
NEUROLOGICAL SCIENCES
(2021)
Article
Genetics & Heredity
Yinhao Wei, Zhongyi Zhao, Zhonghao Wang, Keyi Zhang, Zhuoyun Tang, Chuanmin Tao
Summary: The study identified associations between IL-1 beta, TNF-alpha gene polymorphisms and HBV infection, with IL-1 beta rs1143634, TNF-alpha rs1799724, and rs1799964 potentially serving as genetic biomarkers in HBV infection.
Review
Clinical Neurology
Baotian Wang, Fan Wang, De Wu, Xiaoyan Xu, Li Yang, Jing Zhu, Jinjing Yuan, Jiulai Tang
Summary: The meta-analysis found an association between blood TNF-alpha levels and the risk of cerebral palsy in children, confirming the correlation between the two. Further investigation is needed to explore the exact relationship between TNF-alpha and cerebral palsy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
P. Zhu, X. Wu, J. Zhou, K. Wie, Y. Lu
Summary: This meta-analysis suggests that TNF-alpha rs1800629, IL-1A rs1800587, IL-6 rs1800795 and IL-6 rs1800796 polymorphisms may influence the risk of Graves' disease in overall population. Moreover, TNF-alpha rs1800629 and IL-6 rs1800795 polymorphisms may influence the risk of Graves' disease in Caucasians, while IL-1A rs1800587, IL-1B rs16944, IL-6 rs1800795 and IL-6 rs1800796 polymorphisms may influence the risk of Graves' disease in Asians.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Agnieszka Jablonska, Branislav Zagrapan, Christoph Neumayer, Wolf Eilenberg, Andreas Scheuba, Christine Brostjan, Svitlana Demyanets, Markus Klinger, Josif Nanobachvili, Ihor Huk
Summary: The study found that mutations in IL-6 -174G/C genotype were associated with an increased risk of AAA occurrence, while heterozygous carriers of TNF-α -308G/A genotype also showed an increased risk of AAA incidence. The wild-type genotypes of IL-6 -174G/C and TNF-α -308G/A appeared more frequently in healthy subjects, and were associated with a decreased risk of AAA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chih-Wei Lin, Chung-Hwan Chen, Meng-Hsing Wu, Fong-Ming Chang, Lin Kang
Summary: This study investigated the association between two promoter polymorphisms in the TNF genes and preeclampsia (PE). It found that the polymorphism at the -308 position in the TNF-a gene promoter region is associated with severe PE in Taiwanese Han populations.
Article
Multidisciplinary Sciences
Aongart Mahittikorn, Wanida Mala, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui, Polrat Wilairatana, Manas Kotepui
Summary: This study evaluated the differences in IFN-gamma levels between patients with severe and uncomplicated malaria using qualitative and quantitative approaches. The qualitative synthesis showed that most studies found no statistically significant difference in IFN-gamma levels, while some studies reported higher levels in severe malaria patients. The meta-analysis confirmed that patients with severe malaria had higher mean IFN-gamma levels than those with uncomplicated malaria.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Leili Daiane Hausmann, Bibiana Sgorla de Almeida, Iliada Rainha de Souza, Manuela Nunes Drehmer, Braulio Leal Fernandes, Renato Salerno Wilkens, Daniella Serafin Couto Vieira, Sara Emelie Lofgren, Juliana Dal-Ri Lindenau, Guilherme de Toledo e Silva, Yara Costa Netto Muniz
Summary: This study aimed to verify the association of TNFRSF1A and IFNLR1 genes with breast cancer susceptibility in a Brazilian population. Results showed that the AA genotype and A allele of IFNLR1 were significantly associated with a lower risk of developing BC, while TNFRSF1A did not show significant results. Factors such as age, smoking habits, and body mass index were found to be associated with the risk of developing the disease.
BIOCHEMICAL GENETICS
(2021)
Review
Oncology
Christina M. Alymatiri, Georgia T. Gkegka, Maria Gavriatopoulou, Evangelos Terpos, Meletios A. Dimopoulos, Theodoros N. Sergentanis, Theodora Psaltopoulou
Summary: This study investigated the association between two TNF-alpha gene polymorphisms and the risk and survival of multiple myeloma (MM). The results showed no association between the two polymorphisms and MM susceptibility or survival.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Article
Clinical Neurology
Xiao-Yan Chen, Ko Ling Chan, Camilla K. M. Lo, Frederick K. Ho, Wing Cheong Leung, Patrick Ip
Summary: This meta-analysis examined the association between childhood and adulthood victimization and inflammation, highlighting a significant positive correlation. The effect size was found to be small, with childhood victimization showing a stronger effect on inflammation compared to adulthood victimization. Prevention of childhood victimization may be necessary to reduce inflammatory responses.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Woorim Kim, Soo Jin Oh, Nga Thi Trinh, Jin Yeon Gil, In Ah Choi, Ji Hyoun Kim, Joo Hee Kim, Ju-Yang Jung, Jinhyun Kim, Hyoun-Ah Kim, Kyung Eun Lee
Summary: This study aimed to investigate the effects of genetic polymorphisms in RETN on the remission of RA patients receiving TNF-alpha inhibitors, and use machine learning algorithms to predict remission. The results showed that the most significant features associated with the efficacy of TNF-alpha inhibitors included sex, age, hypertension, sulfasalazine, and several genetic polymorphisms. The elastic net algorithm was found to be the best method for predicting remission in RA patients treated with TNF-alpha inhibitors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Dermatology
Lijuan Wang, Hongying Zhou
Summary: This meta-analysis revealed significant associations between specific TNF-alpha polymorphisms and psoriasis, especially in high-risk Caucasian and East Asian populations.