Article
Oncology
Ju Won Kim, Ah Reum Lim, Ji Young You, Jung Hyun Lee, Sung Eun Song, Nam Kwon Lee, Seung Pil Jung, Kyu Ran Cho, Cheol Yong Kim, Kyong Hwa Park
Summary: The study investigated the correlation between PIK3CA mutations and treatment response or duration in patients with HER2-positive breast cancer. The results showed that patients with activating PIK3CA mutations had lower pathologic complete response rates and shorter progression-free survival with HER2-targeted therapy. Precise targeted therapy is needed to improve survival of patients with HER2+/PIK3CA mutant breast cancer.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Stefania Pianetti, Kathy D. Miller, Hannah H. H. Chen, Sandra Althouse, Sha Cao, Steven J. Michael, Gail E. Sonenshein, Nora D. Mineva
Summary: Breast malignancies are the leading cause of cancer-related death in women. ADAM8 has been identified as a marker of poor survival and a driver of Triple-Negative Breast Cancer growth. A highly specific IHC assay for detecting ADAM8-positive breast tumors has been developed.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Nah Him Kim, Min Ho Park, Sun-Seog Kweon, Namki Cii, Ji Shin Lee
Summary: The study identified high expression of SQLE gene in breast cancer (BC) tissues, which is significantly associated with tumorigenesis and clinical outcome in BC patients. High SQLE expression was observed mainly in ductal carcinoma in situ (DCIS) and BC tissues, suggesting it may serve as a useful biomarker for predicting poor prognosis in BC patients.
Article
Oncology
Kristin Reinhardt, Kathrin Stueckrath, Carolin Hartung, Sandy Kaufhold, Christoph Uleer, Volker Hanf, Tillmann Lantzsch, Susanne Peschel, Jutta John, Marleen Poehler, Marcus Bauer, Friedrich Karl Buerrig, Edith Weigert, Joerg Buchmann, Eva Johanna Kantelhardt, Christoph Thomssen, Martina Vetter
Summary: This study investigated the prevalence of PIK3CA mutations in early stage breast cancer patients and their association with the course of disease. The results showed that PIK3CA mutations were more common in certain types of breast tumors, but did not have a significant association with recurrence-free interval overall. However, in specific subgroups of patients, such as those with hormone receptor-positive breast cancer receiving aromatase inhibitors, PIK3CA mutations were found to have a detrimental impact on prognosis.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Biochemistry & Molecular Biology
Kun Li, Guangqing Tan, Xin Zhang, Weiyu Lu, Jingyi Ren, Yuewen Si, Enoch Appiah Adu-Gyamfi, Fangfang Li, Yingxiong Wang, Biao Xie, Meijiao Wang
Summary: EIF4G1 is identified as a potential prognostic biomarker and therapeutic target for breast cancer, as it may regulate the tumor microenvironment and affect metastasis and overall survival in breast cancer patients.
Article
Oncology
Yuan Li, Hao Huang, Yulan Zhu, Bin Xu, Junjun Chen, Yingting Liu, Xiao Zheng, Lujun Chen
Summary: This study found that METTL3 expression is increased in pancreatic cancer tissues and is associated with the progression and prognosis of the disease. Additionally, METTL3 expression is related to tumor-infiltrating immune cells and m(6)A modification and metabolism in pancreatic cancer tissues.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guanyu Yu, Mengnan Xu, Leqi Zhou, Kuo Zheng, Xiaoming Zhu, Jinke Sui, Cheng Xin, Wenjun Chang, Wei Zhang, Fuao Cao
Summary: This study investigated the expression of phosphorylated Focal adhesion kinase (p-FAK) in colorectal cancer (CRC) and its association with prognosis. The results showed that high p-FAK expression was associated with poor prognosis and poor chemotherapeutic response in CRC. Therefore, the expression level of p-FAK can serve as an independent prognostic biomarker for CRC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Andreas Marx, Lena Koopmann, Doris Haflmayer, Franziska Buescheck, Claudia Hube-Magg, Stefan Steurer, Till Eichenauer, Till S. Clauditz, Waldemar Wilczak, Ronald Simon, Guido Sauter, Jakob R. Izbicki, Hartwig Huland, Hans Heinzer, Markus Graefen, Alexander Haese, Thorsten Schlomm, Christian Bernreuther, Patrick Lebok, Sarah Bonk
Summary: ANO7 protein expression is strongly associated with prostate epithelial cells and its reduced expression is closely linked to adverse tumor features, serving as a strong and independent predictor of poor prognosis in prostate cancer.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shasha Tang, Wenjing Liu, Liyun Yong, Dongyang Liu, Xiaoyan Lin, Yuan Huang, Hui Wang, Fengfeng Cai
Summary: KRT17 expression is closely associated with prognosis in breast cancer, especially in patients with high HER2 expression. KRT17 may be involved in multiple immune pathways and associated with various immune cells. This finding provides a promising biomarker for the diagnosis and prognosis of breast cancer.
Article
Health Care Sciences & Services
Zhijun Li, Yiqun Han, Jiayu Wang, Binghe Xu
Summary: This study aimed to identify prognostic factors for TNBC patients with residual disease after neoadjuvant chemotherapy. The genomic analysis revealed that TP53, PIK3CA, MET, and PTEN alterations occurred commonly. The clinical TNM stage and PIK3CA status were identified as independent prognostic factors for disease-free survival.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mio Yamaguchi, Kiyoshi Takagi, Koki Narita, Yasuhiro Miki, Yoshiaki Onodera, Minoru Miyashita, Hironobu Sasano, Takashi Suzuki
Summary: Chemokines, particularly CCL5, secreted from stromal cells play crucial roles in interaction with carcinoma cells and regulating tumor progression. In human breast carcinoma tissues, the expression of CCL5 and CCR3 is significantly correlated with aggressive phenotype, and patients with positive CCL5 and CCR3 but negative CCR1 and CCR5 have a higher risk of recurrence. These findings suggest that the CCL5-CCR3 axis may contribute to a worse prognosis in breast cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Tian Zheng, Mingyao Sun, Lanzai Liu, Yanfen Lan, Lihua Wang, Fan Lin
Summary: The study found that GPR116 is significantly upregulated in gastric cancer tissues and is positively correlated with tumor staging and invasion, high GPR116 expression is associated with poor overall survival in gastric cancer patients, and GPR116 overexpression is an independent prognostic indicator for poor outcomes in gastric cancer patients.
Article
Oncology
Ramona Erber, Sareetha Kailayangiri, Hanna Huebner, Matthias Ruebner, Arndt Hartmann, Lothar Haeberle, Julia Meyer, Simon Voelkl, Andreas Mackensen, Laura Landgraf, Carol Geppert, Ruediger Schulz-Wendtland, Matthias W. Beckmann, Peter A. Fasching, Nicole Farwick, Claudia Rossig, Paul Gass
Summary: The study found that GD2 is expressed in more than 50% of breast cancer cases, with the highest frequency in hormone receptor-positive tumors. However, GD2 expression was not significantly associated with patient outcome.
Article
Oncology
Wei Wen, Baohong Jiang, Xi Cao, Liming Xie, Xiaoli Zhang, Yuehua Li, Rongfang He
Summary: Our study found that low CRIM1 expression predicts poor prognosis in breast cancer and CRIM1 could potentially serve as a treatment target or prognostic marker. We observed downregulation of CRIM1 in various subtypes of breast cancer, particularly in triple-negative breast cancers. The expression of CRIM1 was positively correlated with ER and PR status, while negatively correlated with HER-2 expression. We also found associations between CRIM1 expression and clinicopathological characteristics of breast cancer, as well as immune infiltration patterns. Further research is needed to fully understand the prognostic value of CRIM1 in breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Liyu Cao, Cong Zhang, Qingqing Wu, Zhenzhen Bai, Jing Chen
Summary: Colorectal cancer (CRC) is the third leading cause of cancer-related death globally. The study found that YAP expression in CRC tissues is associated with histological differentiation, lymph node metastasis, and Duke's stage, promoting cell proliferation and inhibiting apoptosis. Additionally, upregulated YAP expression in CRC tissues correlates with tumor progression and poor prognosis.
Article
Oncology
Abrar I. Aljohani, Michael S. Toss, Sasagu Kurozumi, Chitra Joseph, Mohammed A. Aleskandarany, Islam M. Miligy, Rokaya El Ansari, Nigel P. Mongan, Ian O. Ellis, Andrew R. Green, Emad A. Rakha
BREAST CANCER RESEARCH AND TREATMENT
(2020)
Article
Oncology
Yousif A. Kariri, Chitra Joseph, Sasagu Kurozumi, Michael S. Toss, Mansour Alsaleem, Sara Raafat, Nigel P. Mongan, Mohammed A. Aleskandarany, Andrew R. Green, Emad A. Rakha
BREAST CANCER RESEARCH AND TREATMENT
(2020)
Article
Pathology
Somaia Elsheikh, Ilias Kouzoukakis, Catherine Fielden, Wei Li, Shaimaa Elsaid Lashin, Nadia Khair, Teresa Pereira Raposo, Wakkas Fadhil, Philip Rudland, Mohammed Aleskandarany, Poulam Patel, Mohamed El--Tanani, Mohammad Ilyas
Summary: Ran is an overexpressed poor prognostic marker in malignant melanoma. It promotes cell motility through upregulation of the oncogene c-Met, potentially leading to metastasis.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Smarakan Sneha, Simon C. Baker, Andrew Green, Sarah Storr, Radhika Aiyappa, Stewart Martin, Klaus Pors
Summary: Advances in treatment strategies for breast cancer face challenges in achieving selective treatment with limited side effects; The CYP family of enzymes play important roles in cancer cell proliferation, cell signaling, and drug metabolism, impacting treatment outcomes; Understanding CYP expression and its role in metabolizing steroid hormones and xenobiotics is crucial for the pathogenesis of breast cancer.
Review
Pathology
C. van Dooijeweert, P. J. van Diest, I. O. Ellis
Summary: Histologic grading is a simple and cost-effective method to assess tumor behavior in invasive breast cancer, with important prognostic value. Properly performed histologic grading is crucial for guiding treatment decisions in breast cancer patients.
Article
Oncology
Brendah K. Masisi, Rokaya El Ansari, Lutfi Alfarsi, Madeleine L. Craze, Natasha Jewa, Andrew Oldfield, Hayley Cheung, Michael Toss, Emad A. Rakha, Andrew R. Green
Summary: This study aimed to evaluate the expression and prognostic significance of glutaminase in luminal breast cancer. It was found that GLS plays a key role in the biological function of luminal BC, particularly in the early non-invasive stage, which could be used as a potential biomarker to predict disease progression and as a target for inhibition. Further validation and functional assessments are needed to confirm these observations and explore their specific roles.
Article
Oncology
Karuna Mittal, Jaspreet Kaur, Shaligram Sharma, Nivya Sharma, Guanhao Wei, Ishita Choudhary, Precious Imhansi-Jacob, Nagini Maganti, Shrikant Pawar, Padmashree Rida, Michael S. Toss, Mohammed Aleskandarany, Emiel A. Janssen, Havard Soiland, Meenakshi Gupta, Michelle D. Reid, Emad A. Rakha, Ritu Aneja
Summary: Hypoxia promotes centrosome amplification (CA) by upregulating PLK4 via HIF1 alpha. High levels of HIF1A and PLK4 are associated with poor overall survival in breast cancer and PDAC patients, indicating the significance of HIF1 alpha and PLK4 in prognosis. The findings suggest that HIF1 alpha-induced CA through direct upregulation of PLK4 could serve as a potential risk stratification marker and therapeutic target for CA-rich cancers.
MOLECULAR CANCER RESEARCH
(2022)
Article
Genetics & Heredity
Esther Danenberg, Helen Bardwell, Vito R. T. Zanotelli, Elena Provenzano, Suet-Feung Chin, Oscar M. Rueda, Andrew Green, Emad Rakha, Samuel Aparicio, Ian O. Ellis, Bernd Bodenmiller, Carlos Caldas, H. Raza Ali
Summary: Imaging mass cytometry profiling of 693 breast tumors revealed 10 recurrent tumor microenvironment spatial structures, associated with genomic profiles and outcomes. These multicellular structures within the TME, varying in vascular content, stromal activation, and leukocyte composition, could improve patient stratification and link spatial organization to local TME function.
Article
Cell Biology
Islam M. Miligy, Michael S. Toss, Kylie L. Gorringe, Ian O. Ellis, Andrew R. Green, Emad A. Rakha
Summary: High AURKA expression is associated with aggressiveness features in DCIS and may be a predictive marker for DCIS progression to invasive disease.
Article
Biochemistry & Molecular Biology
Qi Xu, Jaspreet Kaur, Dennis Wylie, Karuna Mittal, Hongxiao Li, Rishab Kolachina, Mohammed Aleskandarany, Michael S. Toss, Andrew R. Green, Jianchen Yang, Thomas E. Yankeelov, Shristi Bhattarai, Emiel A. M. Janssen, Jun Kong, Emad A. Rakha, Jeanne Kowalski, Ritu Aneja
Summary: This study explores the intratumoral heterogeneity (ITH) in triple-negative breast cancer (TNBC) by evaluating gene expression and imaging differences within the same tumor. The results show extensive intertumoral heterogeneity and regional ITH in gene expression and image-derived features in TNBC. Concerns are raised regarding gene expression based TNBC subtyping.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Ian O. Ellis, Emad A. Rakha, Gary M. Tse, Puay Hoon Tan
Summary: The International Collaboration on Cancer Reporting (ICCR) has developed an international dataset for breast cancer pathology reporting, aiming to provide a unified approach worldwide. The dataset includes essential and optional data items based on a critical review and discussion of current evidence. The process concludes with international public consultation and publication on the ICCR website to promote high-quality, standardised pathology reporting globally.
Article
Oncology
Yousif A. Kariri, Chitra Joseph, Mansour A. Alsaleem, Khloud A. Elsharawy, Sami Alsaeed, Michael S. Toss, Nigel P. Mongan, Andrew R. Green, Emad A. Rakha
Summary: Breast cancer exhibits genetic and clinical heterogeneity. This study evaluates the prognostic and biological value of Cell Division Cycle Associated 5 (CDCA5) in breast cancer. The results demonstrate that CDCA5 plays an important role in breast cancer development and metastasis, and could be used as a potential biomarker for disease progression.
Article
Economics
Ahmed Rakha, Hansi Hettiarachchi, Dina Rady, Mohamed Medhat Gaber, Emad Rakha, Mohammed M. Abdelsamea
Summary: This study aims to assess the economic impacts of COVID-19 in the UK using AI and past economic crisis data to predict future impacts. By analyzing macroeconomic indicators and industry performance data, it predicts -8.5% GDP growth in 2021 compared to pre-pandemic levels, with no quarterly GDP drops after Q1 2021.
Meeting Abstract
Oncology
Yousif Ahmad Kariri, Chitra Joseph, Mansour Alsaleem, Abrar Aljohani, Sami Alsaeed, Pavan Lakshmi Narasimha, Nigel P. Mongan, Ian O. Ellis, Mohammed Aleskandarany, Andrew R. Green, Emad A. Rakha
BREAST CANCER RESEARCH AND TREATMENT
(2020)