Article
Toxicology
Xiaowei Wang, Dan Guan, Dafei Wang, Hanting Liu, Yanling Wu, Weida Gong, Mulong Du, Haiyan Chu, Jing Qian, Zhengdong Zhang
Summary: The study revealed the crucial regulatory role of m(6)A modification genes in gastric cancer (GC) development, with the SNP rs9906944 C > T in IGF2BP1 significantly associated with a decreased risk of GC. Higher expression of IGF2BP1 was linked to poorer overall survival in GC patients.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Toxicology
Hanting Liu, Jingjing Gu, Yu Jin, Qi Yuan, Gaoxiang Ma, Mulong Du, Yuqiu Ge, Chao Qin, Qiang Lv, Guangbo Fu, Meilin Wang, Haiyan Chu, Lin Yuan, Zhengdong Zhang
Summary: The study investigated the association between genetic variants in m(6)A-switches and bladder cancer risk, identifying a significant effect of a specific SNP in the SOD2 gene on reducing bladder cancer risk. It was also found that SOD2 may regulate its expression through an m(6)A-hnRNP C dependent mechanism, playing a crucial role in suppressing bladder cancer cell growth and invasion.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Oncology
Angela N. Giaquinto, Hyuna Sung, Kimberly D. Miller, Joan L. Kramer, Lisa A. Newman, Adair Minihan, Ahmedin Jemal, Rebecca L. Siegel
Summary: This article provides an update on female breast cancer statistics in the United States, including data on incidence, mortality, survival, and mammography screening. It shows that breast cancer incidence rates have increased over the past few decades, driven by localized-stage and hormone receptor-positive disease. However, breast cancer mortality rates have been steadily declining since 1989, although at a slower pace in recent years. Despite lower incidence rates, there remains a racial disparity in breast cancer mortality, with higher rates among Black women compared to White women.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Toxicology
Zhichao Han, Jingjing Gu, Junyi Xin, Hanting Liu, Yanling Wu, Mulong Du, Haiyan Chu, Yadong Liu, Zhengdong Zhang
Summary: This study investigated the association between genetic variants in the choline metabolism pathway and bladder cancer susceptibility. The results showed that the C allele of rs6810830 in ENPP6 was a significant protective allele for bladder cancer. Additionally, the study found that the expression of ENPP6 was decreased in bladder tumors and high expression was associated with worse overall survival in bladder cancer patients.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Genetics & Heredity
Xi Wang, Zheng Guo, Huanhuan Zhu, Junyi Xin, Lin Yuan, Chao Qin, Meilin Wang, Zhengdong Zhang, Yunyan Wang, Haiyan Chu
Summary: The study suggests that the rs978416 G>A SNP in RBFOX3 may be associated with bladder cancer predisposition in the Chinese population and could potentially serve as a novel biomarker for bladder cancer risk. The protective effect of rs978416 was more significant in the subgroup of low grade and non-muscle invasive bladder cancer. Additionally, RBFOX3 mRNA expression was found to be decreased in bladder tumor tissues.
Article
Toxicology
Yujuan Zhang, Guoquan Tao, Ping Liu, Kai Lu, Zhichao Han, Hanting Liu, Mulong Du, Meilin Wang, Haiyan Chu, Zhengdong Zhang
Summary: The study revealed that genetic variants in NuRD complex subunits encoding genes are associated with gastric cancer risk, with an increase in the number of favorable alleles of specific SNPs linked to lower risk. Specific SNPs in GATAD2A were significantly correlated with mRNA expression levels, and patients with higher expression levels of GATAD2A or CHD4 mRNA had more advantageous overall survival.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Pat W. Whitworth, Peter D. Beitsch, Rakesh Patel, Barry Rosen, Gia Compagnoni, Paul L. Baron, Rache Simmons, Eric A. Brown, Linsey Gold, Dennis Holmes, Linda Ann Smith, Michael Kinney, Ian Grady, Patricia Clark, Karen Barbosa, Samuel Lyons, Lee Riley, Cynara Coomer, Lisa Curcio, Antonio Ruiz, Sadia Khan, Heather MacDonald, Kevin Hughes, Mary Kay Hardwick, Brandie Heald, Sandra B. Munro, Sarah M. Nielsen, Edward D. Esplin
Summary: This study examines the implications of universal testing for patients with breast cancer and finds that germline genetic testing informs clinical decision-making and provides access to targeted treatments and clinical trials for all patients with breast cancer.
Article
Microbiology
Zahra Salehi, Masoomeh Shams-Ghahfarokhi, Mehdi Razzaghi-Abyaneh
Summary: The study identified BT2, ITS, and TEF-1 alpha as suitable genes for MLST, with the most prevalent STs found among Trichophyton interdigitale. Two new genotypes, XXVII and XXVIII, were introduced for T. interdigitale and T. mentagrophytes. The most informative locus was TEF-1 alpha, and the phylogenetic tree revealed a new topological pattern confirming the evolution from geophilic to anthropophilic and zoophilic genera.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soma Saeidi, Su-Jung Kim, Yanymee N. Guillen-Quispe, Achanta Sri Venkata Jagadeesh, Hyeong-Jun Han, Seung Hyeon Kim, Xiancai Zhong, Juan-Yu Piao, Seong-Jin Kim, Joon Jeong, Yun Jin Shin, Yoon Jin Cha, Han-Byoel Lee, Wonshik Han, Sang-Hyun Min, Wang Tian, Hiroshi Kitamura, Young-Joon Surh
Summary: Pin1 is frequently overexpressed in various types of malignancy, including triple-negative breast cancer, and plays a role in stabilizing and activating Nrf2 by competing with Keap1 for Nrf2 binding, thus promoting breast cancer progression. Through its interaction with phosphorylated Nrf2 and Keap1 residues, Pin1 alters the stability and function of Nrf2, leading to the accumulation of Nrf2 in the nucleus and contributing to breast cancer development and progression.
Review
Medicine, General & Internal
Bailey A. Martin-Giacalone, P. Adam Weinstein, Sharon E. Plon, Philip J. Lupo
Summary: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children, with little known about its etiology. Studies have identified factors such as environmental exposures and genetic predisposition that contribute to RMS incidence. Research has focused on age at diagnosis, biological sex, geographic location, parental exposures, birth and perinatal characteristics, childhood exposures, as well as RMS predisposition syndromes and associated genes. Future directions aim to advance understanding of RMS origin for novel therapies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Maria Escala-Garcia, Sander Canisius, Renske Keeman, Jonathan Beesley, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Marina Bermisheva, Stig E. Bojesen, Manjeet K. Bolla, Hermann Brenner, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Fergus J. Couch, Kamila Czene, Mary B. Daly, Joe Dennis, Peter Devilee, Thilo Dork, Alison M. Dunning, Douglas F. Easton, Arif B. Ekici, A. Heather Eliassen, Peter A. Fasching, Henrik Flyger, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Juergen Geisler, Graham G. Giles, Mervi Grip, Melanie Guendert, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Jaana M. Hartikainen, Bernadette A. M. Heemskerk-Gerritsen, Antoinette Hollestelle, Reiner Hoppe, John L. Hopper, David J. Hunter, William Jacot, Anna Jakubowska, Esther M. John, Audrey Y. Jung, Rudolf Kaaks, Elza Khusnutdinova, Linetta B. Koppert, Peter Kraft, Vessela N. Kristensen, Allison W. Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Robert N. Luben, Jan Lubinski, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Dimitrios Mavroudis, Taru A. Muranen, Heli Nevanlinna, Andrew F. Olshan, Hakan Olsson, Tjoung-Won Park-Simon, Alpa V. Patel, Paolo Peterlongo, Paul D. P. Pharoah, Kevin Punie, Paolo Radice, Gad Rennert, Hedy S. Rennert, Atocha Romero, Rebecca Roylance, Thomas Ruediger, Matthias Ruebner, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Christopher Scott, Melissa C. Southey, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, Lauren R. Teras, Emilie Thomas, Ian Tomlinson, Melissa A. Troester, Celine M. Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Kyriaki Michailidou, Georgia Chenevix-Trench, Thomas Bachelot, Marjanka K. Schmidt
Summary: Two germline variants on chromosome 1 were significantly associated with breast cancer-specific survival, however, validation in a smaller replication dataset was not successful. Larger replication studies are needed to confirm the identified associations.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Qian Wang, Zeynep H. Gumus, Cristina Colarossi, Lorenzo Memeo, Xintong Wang, Chung Yin Kong, Paolo Boffetta
Summary: This article reviews research on the epidemiology, risk factors, genetic susceptibility, molecular pathology, and early detection of small cell lung cancer (SCLC). It summarizes the changing incidences of SCLC globally and in the United States, discusses the established risk factor of tobacco smoking, and highlights the importance of tobacco control. The review also explores genetic susceptibility, molecular pathology, and the limited utility of low-dose computed tomography screening in SCLC, as well as promising blood-based molecular biomarkers for early detection.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Adrienne G. Waks, Dewey Kim, Esha Jain, Craig Snow, Gregory J. Kirkner, Shoshana M. Rosenberg, Coyin Oh, Philip D. Poorvu, Kathryn J. Ruddy, Rulla M. Tamimi, Jeffrey Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Elena F. Brachtel, Ellen Warner, Laura C. Collins, Ann H. Partridge, Nikhil Wagle
Summary: The study identified significant differences in somatic alterations of three genes (PIK3CA, GATA3, and ARID1A) in young versus older women with luminal A breast cancer. Additionally, a portion of young women with breast cancer carried pathogenic germline variants, with BRCA1/2 mutations being the most common. Further investigation into these genetic differences may help improve treatment options for young patients with breast cancer.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Marzhan A. Aitmagambetova, Gaziza A. Smagulova, Rustem R. Tuhvatshin, Azhar N. Zheksenova, Ainur Amanzholkyzy
Summary: The aim of this study was to determine the BRCA1 and BRCA2 gene mutation polymorphisms in patients with breast cancer in Kazakhstan and investigate their clinical, histopathological and prognostic characteristics. The results showed a high prevalence of breast cancer in Kazakhstan, with BRCA1 and BRCA2 gene mutations being significant factors. The findings of this study have important implications for the prevention and treatment of breast cancer.
Review
Medicine, General & Internal
Wenji Xu, Yao Zhong, Haihui Yang, Yuhan Gong, Jun Dao, Liping Bao
Summary: The meta-analysis confirms a significant association between the rs4784227-CASC16 polymorphism and breast cancer risk, suggesting that this genetic variant may serve as a new therapeutic strategy for breast cancer.
Article
Oncology
Jennifer L. Caswell-Jin, Maryam N. Shafaee, Lan Xiao, Mina Liu, Esther M. John, Melissa L. Bondy, Allison W. Kurian
Summary: Using insurance claims data, this study examined the changes in breast cancer incidence and treatment methods during the COVID-19 pandemic. While there were dramatic shifts in breast cancer incidence and treatment methods in the early months of the pandemic, these changes were not sustained over time, with only modest alterations in breast cancer management persisting.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Lauren C. Peres, Christelle Colin-Leitzinger, Sweta Sinha, Jeffrey R. Marks, Jose R. Conejo-Garcia, Anthony J. Alberg, Elisa Bandera, Andrew Berchuck, Melissa L. Bondy, Brock C. Christensen, Michele L. Cote, Jennifer Anne Doherty, Patricia G. Moorman, Edward S. Peters, Carlos Moran Segura, Jonathan Nguyen, Ann G. Schwartz, Paul D. Terry, Christopher M. Wilson, Brooke L. Fridley, Joellen M. Schildkraut
Summary: This study found that tumor-infiltrating lymphocytes confer a survival benefit among patients with ovarian cancer, but little work has been conducted in racially diverse cohorts. Non-Hispanic Black women may not experience the same survival benefit as Non-Hispanic White women with high-grade serous ovarian carcinoma (HGSOC).
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Maryam Nemati Shafaee, Leonardo Roberto Silva, Susana Ramalho, Maira Teixeira Doria, Rodrigo De Andrade Natal, Victor Cabello, Livia Cons, Marina Pavanello, Luiz Carlos Zeferino, Max S. Mano, Rudinei Diogo Marques Linck, Leticia Souza Batista, Estela Pantarotto Pedro, Bruno Henrique De Paula, Gustavo Zuca-Matthes, Emily Podany, Shalini Makawita, Kelsey Ann Stewart, Spiridon Tsavachidis, Rull Tamimi, Melissa Bondy, Logan Debord, Matthew Ellis, Jose Bines, Cesar Cabello
Summary: This study compared the outcomes of patients with breast cancer using public health systems in Harris County (Texas, USA) and Southeast Brazil, finding that treatment delay does not affect treatment outcomes in both regions. Timely screening and diagnosis of breast cancer are crucial for these populations.
Article
Oncology
Kyle M. Walsh, Corey Neff, Melissa L. Bondy, Carol Kruchko, Jason T. Huse, Christopher Amos, Jill S. Barnholtz-Sloan, Quinn T. Ostrom
Summary: The incidence and outcomes of glioma differ in association with the geographic origins of Hispanic communities, with predominantly Mexican/Central American-origin counties at reduced risk and predominantly Caribbean-origin counties at greater risk. Higher incidence and improved survival are associated with European admixture in Hispanic patients.
Article
Medicine, General & Internal
Manali I. Patel, Jacqueline M. Ferguson, Eida Castro, Cristina D. Pereira-Estremera, Guillermo N. Armaiz-Pena, Ysabel Duron, Fay Hlubocky, Analynn Infantado, Bles Nuqui, Donna Julian, Nii Nortey, Alexandra Steck, Melissa Bondy, Shail Maingi
Summary: This survey of US adults with cancer found that the COVID-19 pandemic was associated with treatment delays and adverse social and economic effects among Black and Latinx adults.
Article
Oncology
Maryam Nemati Shafaee, Kristina Goutsouliak, Heather Lin, Therese B. Bevers, Angelica Gutierrez-Barrera, Melissa Bondy, Banu Arun
Summary: This study demonstrates for the first time that aromatase inhibitors reduce the risk of contralateral breast cancer in BRCA mutation carriers. This finding, different from previous studies on tamoxifen, has important clinical implications for chemoprevention.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Shinichi Namba, Yuki Saito, Yasunori Kogure, Tatsuo Masuda, Melissa L. Bondy, Puya Gharahkhani, Ines Gockel, Dominik Heider, Axel Hillmer, Janusz Jankowski, Stuart MacGregor, Carlo Maj, Beatrice Melin, Quinn T. Ostrom, Claire Palles, Johannes Schumacher, Ian Tomlinson, David C. Whiteman, Yukinori Okada, Keisuke Kataoka
Summary: Aggregation of genome-wide common risk variants can measure genetic susceptibility to cancer. Our results suggest that common germline cancer risk variants are associated with earlier cancer onset and lower burden of somatic alterations.
Article
Oncology
Joellen M. M. Schildkraut, Courtney Johnson, Lauren F. F. Dempsey, Bo Qin, Paul Terry, Maxwell Akonde, Edward S. S. Peters, Hannah Mandle, Michele L. L. Cote, Lauren Peres, Patricia Moorman, Ann G. G. Schwartz, Michael Epstein, Jeffrey Marks, Melissa Bondy, Andrew B. B. Lawson, Anthony J. J. Alberg, Elisa V. V. Bandera
Summary: This study describes the likely multi-factorial causes for the survival disparity among Black women with epithelial ovarian cancer (EOC). The African American Cancer Epidemiology Study (AACES) is the largest cohort of Black women with EOC, and the results show that the five-year overall survival rate of AACES participants is lower compared to Black women in the Surveillance Epidemiology and End Results (SEER) registry and white women in SEER. A significant proportion of women in AACES have low levels of household income, education, and insurance coverage.
CANCER CAUSES & CONTROL
(2023)
Article
Environmental Sciences
S. M. Samon, D. Rohlman, L. Tidwell, P. D. Hoffman, A. O. Oluyomi, C. Walker, M. Bondy, K. A. Anderson
Summary: Hurricane Harvey caused catastrophic flooding in Houston, Texas, resulting in increased concern about chemical exposure from flood waters and industrial emissions. This study used silicone wristbands as personal passive samplers to assess immediate exposure to endocrine-disrupting chemicals (EDCs) and identify factors associated with higher exposure concentrations. The results showed that living in areas with a high Area Deprivation Index, identifying as Black/African American or Latino, and residing in specific Houston neighborhoods were linked to increased exposure to EDCs, indicating racial/ethnic and socioeconomic injustices. Further research is needed to identify direct sources of EDCs and develop effective exposure mitigation strategies.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Sara Lindstrom, Lu Wang, Helian Feng, Arunabha Majumdar, Sijia Huo, James Macdonald, Tabitha Harrison, Constance Turman, Hongjie Chen, Nicholas Mancuso, Theo Bammler, Steve Gallinger, Stephen B. Gruber, Marc J. Gunter, Loic Le Marchand, Victor Moreno, Kenneth Offit, Immaculata De Vivo, Tracy A. O'Mara, Amanda B. Spurdle, Ian Tomlinson, Rebecca Fitzgerald, Puya Gharahkhani, Ines Gockel, Janusz Jankowski, Stuart Macgregor, Johannes Schumacher, Jill Barnholtz-Sloan, Melissa L. Bondy, Richard S. Houlston, Robert B. Jenkins, Beatrice Melin, Margaret Wrensch, Paul Brennan, David C. Christiani, Mattias Johansson, James Mckay, Melinda C. Aldrich, Christopher Amos, Maria Teresa Landi, Adonina Tardon, D. Timothy Bishop, Florence Demenais, Alisa M. Goldstein, Mark M. Iles, Peter A. Kanetsky, Matthew H. Law, Laufey T. Amundadottir, Rachael Stolzenberg-Solomon, Brian M. Wolpin, Alison Klein, Gloria Petersen, Harvey Risch, Stephen J. Chanock, Mark P. Purdue, Ghislaine Scelo, Paul Pharoah, Siddhartha Kar, Rayjean J. Hung, Bogdan Pasaniuc, Peter Kraft
Summary: This study quantified the shared genetic contribution to risk of different cancers and identified novel cancer susceptibility loci using data from 12 cancer genome-wide association studies. The results suggest that some genetic risk variants are shared among cancers, but most of cancer heritability is specific to certain tissues. Cross-disease analysis allows for increased statistical power and the identification of new susceptibility regions. Future studies are likely to discover additional regions associated with the risk of multiple cancer types.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Multidisciplinary Sciences
Dong-Joo Choi, Georgina Armstrong, Brittney Lozzi, Prashanth Vijayaraghavan, Sharon E. Plon, Terence C. Wong, Eric Boerwinkle, Donna M. Muzny, Hsiao-Chi Chen, Richard A. Gibbs, Quinn T. Ostrom, Beatrice Melin, Benjamin Deneen, Melissa L. Bondy, Matthew N. Bainbridge
Summary: This study conducted comprehensive surveillance of the genomic landscape of familial glioma and identified significant enrichment of rare deleterious variants in seven genes, with HERC2 being the most significantly enriched gene. Rare noncoding variants that may affect transcription factor binding sites or cause cryptic splicing were also found. Additionally, validation experiments revealed the significant impacts of DMBT1, HP1BP3, and ZCH7B3 genes on proliferation.
Article
Public, Environmental & Occupational Health
Andrew B. Lawson, Joanne Kim, Courtney Johnson, Theresa Hastert, Elisa V. Bandera, Anthony J. Alberg, Paul Terry, Maxwell Akonde, Hannah Mandle, Michele L. Cote, Melissa Bondy, Jeffrey Marks, Lauren Peres, Kendra L. Ratnapradipa, Yao Xin, Joellen Schildkraut, Edward S. Peters
Summary: This study assessed the impact of deprivation and segregation indices on the survival of self-identified Black women diagnosed with ovarian cancer. The results showed that high socioeconomic status-related indices were associated with increased survival, while the index of concentration at the extremes-race had no significant impact on overall survival. The study highlights the importance of area-level economic indices and urbanization index in the survival of Black women with ovarian cancer.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Samantha M. Samon, Michael Barton, Kim Anderson, Abiodun Oluyomi, Melissa Bondy, Georgina Armstrong, Diana Rohlman
Summary: The feedback of research results for community and individual level exposure assessment data should adhere to key principles such as accessibility, distinguishing known from unknown information, respecting community knowledge and history, and setting participant expectations.
Article
Oncology
Courtney E. Johnson, Anthony J. Alberg, Elisa V. Bandera, Lauren C. Peres, Maxwell Akonde, Lindsay J. Collin, Michele L. Cote, Theresa A. Hastert, James R. Hebert, Edward S. Peters, Bonnie Qin, Paul Terry, Ann G. Schwartz, Melissa Bondy, Michael P. Epstein, Hannah B. Mandle, Jeffrey R. Marks, Andrew B. Lawson, Joellen M. Schildkraut
Summary: An association was found between an inflammation-related risk score and worse overall survival among Black women with ovarian cancer. This association was also influenced by inflammation-related dietary exposures.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Rowland Pettit, Jinyoung Byun, Younghun Han, Quinn Ostrom, Cristian Coarfa, Melissa Bondy, Christopher Amos
Summary: Using Mendelian randomization analysis, we identified several heritable traits associated with the risk of lung cancer development. These effects vary based on histologic subtype and conditional third trait exposures, providing valuable insights for lung cancer research.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
