Article
Cell Biology
Kevin Roarty
Summary: In this article, Pfannenstein and Macara demonstrate that intercalation within the terminal end bud is controlled by the tight junction organizing protein ZO-1 and dynamic actin cytoskeletal rearrangements to drive ductal elongation.
DEVELOPMENTAL CELL
(2023)
Review
Endocrinology & Metabolism
Haim Werner
Summary: This review article examines the significant role of the breast and ovarian cancer susceptibility gene (BRCA1) in tumor development and its emerging role as a regulator of various endocrine and metabolic axes. The study reveals the relationship between BRCA1 and a number of hormones, as well as the correlation between BRCA1 mutations and metabolic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Pascal Pujol, Kevin Yauy, Amandine Coffy, Nicolas Duforet-Frebourg, Sana Gabteni, Jean-Pierre Daures, Frederique Penault Llorca, Frederic Thomas, Kevin Hughes, Clare Turnbull, Virginie Galibert, Chloe Rideau, Carole Corsini, Laetitia Collet, Benoit You, David Genevieve, Nicolas Philippe
Summary: The meta-analysis revealed a higher prevalence of gBRCA2 in unselected breast cancer patients. Additionally, the majority of tumors in breast cancer patients with gBRCA are estrogen receptor-positive.
Article
Multidisciplinary Sciences
Makoto Habara, Yuki Sato, Takahiro Goshima, Masashi Sakurai, Hiroyuki Imai, Hideyuki Shimizu, Yuta Katayama, Shunsuke Hanaki, Takahiro Masaki, Masahiro Morimoto, Sayaka Nishikawa, Tatsuya Toyama, Midori Shimada
Summary: FKBP52 is associated with poor prognosis of ERα-positive breast cancer, stabilizes ERα, and promotes breast cancer cell proliferation, while FKBP51 reduces the stability of ERα. FKBP51 is more abundantly expressed in normal tissues than in cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Jiahao Chen, Jingxin Liu, Pengguihang Zeng, Cai Zhao, Xinyi Liu, Jun Sun, Jia Wang, Peihang Fang, Wenjie Chen, Junjun Ding
Summary: Estrogen (E2) and BRCA1 deficiency synergistically induce DNA damage in breast cancer cells, possibly involving transcriptional activation of ER genes and changes in DNA damage distribution.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Manuela Santarosa, Davide Baldazzi, Michela Armellin, Roberta Maestro
Summary: Germline inactivating mutations in the BRCA1 gene increase the lifetime risk of ovarian and breast cancer. The role of miRNAs and their networks in mediating BRCA1 functions and the potential mechanism of how BRCA1 inactivation contributes to the specific phenotype of triple-negative breast cancer (TNBC) were investigated. The miR-29:DNA methyltransferase network was found to control hormone receptor expression through the methylation level of HR genes, suggesting its involvement in the receptor-negative phenotype of BRCA1 dysfunctional tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Tarja Rajalahti, Eivind Aadland, Geir Kate Resaland, Sigmund Alfred Anderssen, Olav Martin Kvalheim
Summary: Physical activity is associated with a favorable cardiometabolic pattern, including increased HDL and decreased triglycerides, while adiposity is inversely related to this pattern. These associations remain strong after adjustment, with lipoproteins explaining more of the variation in adiposity compared to PA.
Article
Plant Sciences
Sahar Sedaghat, Badii Gaaliche, Majid Rahemi, Hamid Zare, Moslem Jafari
Summary: This study evaluated the enzyme activity and physiochemical changes of terminal buds of rain-fed fig during the dormant season. The results showed that the buds were metabolically active with a short dormant period under rain-fed conditions.
HORTICULTURAL PLANT JOURNAL
(2022)
Article
Chemistry, Medicinal
Sky Price, Sophie G. Bender, Rachel Yahn, Nicholas A. Till, Sophia Varady, Rebecca Lyn LaLonde
Summary: The report highlights the potential of Selective Estrogen Receptor Modulators (SERMs) in breast cancer treatment, presenting an unexplored tamoxifen substitution pattern with favorable pharmacodynamics mimicking raloxifene.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Multidisciplinary Sciences
Takahiro Masaki, Makoto Habara, Yuki Sato, Takahiro Goshima, Keisuke Maeda, Shunsuke Hanaki, Midori Shimada
Summary: The study reveals that calcineurin regulates the stability and activity of ER-alpha in breast cancer cells by modulating its phosphorylation at Ser 294 and Ser 118 positions. The expression of the calcineurin A-alpha gene (PPP3CA) is associated with poor prognosis in ER-alpha-positive breast cancer patients, suggesting calcineurin as a promising target for therapies in ER-alpha-positive breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Mostafa A. Aboouf, Julia Armbruster, Markus Thiersch, Franco Guscetti, Glen Kristiansen, Peter Schraml, Anne Bicker, Ruben Petry, Thomas Hankeln, Max Gassmann, Thomas A. Gorr
Summary: The expression of myoglobin is associated with better prognosis in breast cancer patients, but its role in mammary tumorigenesis is unclear. Through CRISPR/Cas9 technology, we generated myoglobin-deficient breast cancer cell lines and found that loss of myoglobin increased cell survival and expression of cell cyclins, as well as enhanced cell migration and invasion under hypoxia. In human invasive mammary ductal carcinoma tissues, myoglobin levels were positively correlated with apoptotic markers, and myoglobin expression was associated with a positive prognostic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Dahae Lee, Young-Mi Kim, Young-Won Chin, Ki Sung Kang
Summary: This study demonstrated that schisandrol A has estrogen-like effects by inducing the expression of ER alpha through the PI3K/AKT and ERK signaling pathways, promoting the proliferation of MCF-7 cells. The effects of schisandrol A were more significant compared to E2 and could be mitigated by the ER antagonist ICI.
Article
Biochemistry & Molecular Biology
Paulina Kobylka, Malgorzata Kucinska, Jacek Kujawski, Dawid Lazewski, Marcin Wierzchowski, Marek Murias
Summary: Resveratrol, a plant-derived phytoalexin, has pleiotropic biological activities, particularly anticancer and chemopreventive properties. It interacts with estrogen receptors and functions as a mixed agonist/antagonist. The hydroxyl groups are crucial for its cytotoxic and antioxidative activities. Through experiments and computational simulations, specific analogues of resveratrol were found to act as selective estrogen receptor modulators.
Article
Chemistry, Medicinal
Lilan Xin, Jian Min, Hebing Hu, Yuanyuan Li, Chuanqian Du, Baohua Xie, Yan Cheng, Xiaofei Deng, Xiangping Deng, Kang Shen, Jian Huang, Chun -Chi Chen, Rey-Ting Guo, Chune Dong, Hai -Bing Zhou
Summary: In this study, a novel class of dual-targeting selective estrogen receptor degraders (SERDs) based on a three-dimensional oxabicycloheptene sulfonamide (OBHSA) scaffold equipped with aromatase inhibitor (AI) activity were identified. These compounds showed excellent ERa degradation activity, ARO inhibitory activity, and antiproliferative activity against drug-resistant breast cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Laura Leite-Almeida, Manuela Morato, Dina Cosme, Joana Afonso, Jose C. Areias, Antonio Guerra, Alberto Caldas Afonso, Antonio Albino-Teixeira, Teresa Sousa, Liane Correia-Costa
Summary: Physical activity benefits nonoverweight children by increasing NO bioavailability, while it enhances systemic antioxidant capacity and insulin sensitivity in overweight/obese children.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)