Review
Oncology
Tingting Yang, Lihua Kang, Dan Li, Yanqiu Song
Summary: Immunotherapy is a promising treatment for advanced breast cancer, particularly for triple-negative and HER2+ breast cancers. Monoclonal antibodies like trastuzumab, pertuzumab, and T-DM1 have proven effective in treating HER2+ breast cancers and have improved patient survival. Immune checkpoint inhibitors targeting PD-1/PD-L1 have also shown benefits in clinical trials. Adoptive T-cell immunotherapies and tumor vaccines are new approaches that require further study.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Santiago Moragon, Cristina Hernando, Maria Teresa Martinez-Martinez, Marta Tapia, Belen Ortega-Morillo, Ana Lluch, Begona Bermejo, Juan Miguel Cejalvo
Summary: The aim of this review is to study the role of immune response in HER2+ breast cancer, summarize the interaction between the tumor microenvironment and anti-HER2 targeted therapies, and explore the implementation of immune modulators in clinical practice. Understanding the biological aspects of immune response is crucial for developing new treatment strategies.
Article
Immunology
Danilo Pellin, Natalie Claudio, Zihan Guo, Tahereh Ziglari, Ferdinando Pucci
Summary: Lymph nodes are crucial lymphoid organs that play a key role in monitoring tissues. Sentinel lymph nodes are the first to initiate an immune response against cancerous cells. Sub-capsular sinus macrophages (SSMs) have been found to possess anti-tumor activity by capturing tumor-derived extracellular vesicles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hannah L. Chung, Huong T. Le-Petross, Jessica W. T. Leung
Summary: Metastatic lymph node involvement in breast cancer plays a crucial role in determining disease stage and prognosis. Neoadjuvant systemic treatment is increasingly used as initial therapy. Imaging and image-guided interventions are essential for lymph node assessment and treatment decision-making.
Article
Surgery
Xuefei Wang, Guochao Zhang, Zhichao Zuo, Qingli Zhu, Shafei Wu, Yidong Zhou, Feng Mao, Yan Lin, Songjie Shen, Xiaohui Zhang, Xue Qin, Cunli Yan, Xiaoying Ma, Yue Shi, Qiang Sun
Summary: This retrospective study found an association between SLN positive rate and non-SLN metastasis in breast cancer, with SLN-PR > 0.333 being a potential risk factor for non-SLN metastasis. The results provide valuable reference for guiding adjuvant treatment in breast cancer patients.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Cell Biology
Carlotta Tacconi, Catharina D. Commerford, Lothar C. Dieterich, Simon Schwager, Yuliang He, Kristian Ikenberg, Ekaterina Friebel, Burkhard Becher, Sonia Tugues, Michael Detmar
Summary: This study shows that CD169(+) lymph node macrophages play a protective role in breast cancer metastasis, and their expansion is linked to B cell expansion in tumor-draining lymph nodes. Depletion of these macrophages increases metastatic burden, highlighting the caution needed in targeting tumor-associated macrophages to avoid unintended consequences in tumor-draining lymph nodes.
Article
Multidisciplinary Sciences
Sean M. Hacking, Kara-Lynne Leonard, Dongling Wu, Mara Banks, Theresa Graves, Lijuan Wang, Evgeny Yakirevich, Yihong Wang
Summary: The use of sentinel lymph node biopsy (SLNB) in patients with microinvasive breast cancer (MIBC) has been debated. This study evaluated clinical and histological features to predict disease free survival (DFS) and factors influencing clinical decision making in MIBC patients. SLNB was found to be associated with mastectomy, high nuclear grade, and negativity for ER and HER-2. However, SLNB did not impact DFS in this study.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Zhen Huang, Zhe Wu, Quan-qing Zou, Yu-jie Xie, Li-hui Li, Yan-ping Huang, Feng-ming Wu, Dong Huang, Yin-hua Pan, Jian-rong Yang
Summary: This study aimed to investigate the risk factors of non-sentinel lymph node metastasis in breast cancer patients with 1-2 sentinel lymph node macrometastases undergoing total mastectomy. The results showed that tumor size and ratio of sentinel lymph node macrometastases were independent risk factors for non-sentinel lymph node metastasis. The incidence of non-sentinel lymph node metastasis could be reduced to 17.1% for patients with tumor size ≤ 22 mm and ratio of sentinel lymph node macrometastases ≤ 0.33.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Suzanne B. Coopey
Summary: Patients with contralateral axillary disease without distant metastasis are often treated more aggressively than other Stage IV patients. However, their treatment outcomes are more similar to patients with ipsilateral supraclavicular disease and other locally advanced breast cancers.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qiaoyun Hou, Shuohua Chen, Qi An, Boya Li, Yan Fu, Yongzhang Luo
Summary: The study confirms plasma Hsp90 alpha as a biomarker for breast cancer, providing insights into its prognostic value across different clinical stages, and suggests that eHsp90 alpha plays a role in promoting lymphangiogenesis in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Paolo Izzo, Claudia De Intinis, Simone Sibio, Luigi Basso, Andrea Polistena, Raimondo Gabriele, Massimo Codacci-Pisanelli, Luciano Izzo, Sara Izzo
Summary: This study proposed new techniques to prevent complications of sentinel lymph node biopsy and presented initial data from our experience. The identification rates of sentinel lymph node detection using radioactive tracers and the magnetic tracer technology (Sentimag) were 88.9% and 89.5% respectively.
Article
Radiology, Nuclear Medicine & Medical Imaging
Manus J. Donahue, Paula M. C. Donahue, R. Sky Jones, Maria Garza, Chelsea Lee, Niral J. Patel, Andrea Cooper, Jill B. De Vis, Ingrid Meszoely, Rachelle Crescenzi
Summary: This study investigates whether in vivo imaging with CEST-Dixon can distinguish lymph nodes with metastatic involvement from those without. The results suggest that CEST-Dixon can detect a unique microenvironment in metastatic lymph nodes and has the potential for non-invasive mapping of lymph node metastasis in vivo.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Oncology
Zhao Bi, Jia-Jian Chen, Peng-Chen Liu, Peng Chen, Wei-Li Wang, Yan-Bing Liu, Chun-Jian Wang, Peng-Fei Qiu, Qing Lv, Jiong Wu, Yong-Sheng Wang
Summary: This study developed a predictive model based on a multi-center retrospective database to accurately predict whether HR+/HER2- patients can undergo genomic tests. Through multivariate logistic regression analysis, imaging abnormal nodes, the number of positive SLNs, the number of negative SLNs, pathological tumor stage, and lympho-vascular invasion were identified as independent predictors for patients having <= 3 total metastatic ALNs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hongtao Duan, Jiawei Zhang, Guanxin Zhang, Xingmeng Zhu, Wenjia Wang
Summary: The aim of this study was to develop a nomogram based on elastography for the prediction of the risk of non-SLN metastasis in early-stage breast cancer patients with 1 or 2 positive SLNs in China. The nomogram showed good discrimination and performance in predicting NSLN metastasis, and could be considered as an ancillary tool to help selectively exempt patients from ALND.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Lei Liu, Yaoxin Lin, Guozheng Li, Lei Zhang, Xin Zhang, Jiale Wu, Xinheng Wang, Yumei Yang, Shouping Xu
Summary: This study developed a preoperative prediction model based on a nomogram to assist in selecting proper surgical procedures for T1-2 breast cancer patients with only one sentinel lymph node (SLN) metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nuffel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stephanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwe, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frederic Amant, Katrien Vandecasteele, Hannelore G. Denys
Summary: The PRIMMO study conducted a phase II trial on patients with pretreated persistent/recurrent/metastatic cervical or endometrial cancer. The study found that pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail had modest but durable antitumor activity, with acceptable but not negligible toxicity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Acoustics
C. Landolfo, T. Bourne, W. Froyman, B. Van Calster, J. Ceusters, A. C. Testa, L. Wynants, P. Sladkevicius, C. Van Holsbeke, E. Domali, R. Fruscio, E. Epstein, D. Franchi, M. J. Kudla, V. Chiappa, J. L. Alcazar, F. P. G. Leone, F. Buonomo, M. E. Coccia, S. Guerriero, N. Deo, L. Jokubkiene, L. Savelli, D. Fischerova, A. Czekierdowski, J. Kaijser, A. Coosemans, G. Scambia, I. Vergote, D. Timmerman, L. Valentin
Summary: This study validated the use of modified benign simple descriptors (BDs) to exclude malignancy in most women with adnexal masses, and proposed a two-step strategy using the ADNEX model to estimate the risk of malignancy. The modified BDs were applicable to 37% of tumors, 99.3% of which were benign. The two-step strategy showed an AUC of 0.94.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
E. A. F. Dancet, L. Ameye, W. Sermeus, M. Welkenhuysen, K. T. Zondervan, C. De Cicco, V Mijatovic, A. Schreurs, D. Timmerman, T. M. D'Hooghe
Summary: European patients seek more patient-centred healthcare by crossing borders. This study validated the ENDOCARE questionnaire in nine different languages and demonstrated its benchmark potential. Significant between-country variance in case-mix-adjusted overall and dimensional patient-centredness scores explained 3-9% of the total variance in patient-centredness across 10 European countries. Compared to the least patient-centred country, endometriosis care in Denmark, Italy, and Belgium was more patient-centred.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Health Care Sciences & Services
Alexander Pate, Richard D. Riley, Gary S. Collins, Maarten van Smeden, Ben Van Calster, Joie Ensor, Glen P. Martin
Summary: Multinomial logistic regression models are used to predict the risk of a categorical outcome with more than two categories. Researchers need to ensure that the number of participants is appropriate relative to the number of events and predictor variables for each category. This study proposes three criteria to determine the minimum required sample size, aiming to minimize overfitting, difference between observed and adjusted R-2 Nagelkerke, and ensure accurate estimation of overall risk. The criteria were evaluated through simulation study and applied to a worked example, with code provided for implementation in R and Stata.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2023)
Letter
Multidisciplinary Sciences
Ben Van Calster
Letter
Acoustics
R. Heremans, T. van den Bosch, P. Sladkevicius, M. A. Pascual, J. L. Alcazar, D. Timmerman, L. Valentin
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Health Care Sciences & Services
Anne A. H. de Hond, Vaibhavi B. B. Shah, Ilse M. J. Kant, Ben Van Calster, Ewout W. Steyerberg, Tina Hernandez-Boussard
Summary: The generalizability of predictive algorithms is crucial for their application in clinical practice. This article provides an overview of three types of generalizability, namely temporal, geographical, and domain generalizability, based on existing literature. These types of generalizability are associated with their respective goals, methodology, and stakeholders.
NPJ DIGITAL MEDICINE
(2023)
Letter
Medical Laboratory Technology
Margot van Riel, Yan Zhao, Tatjana Jatsenko, Lore Lannoo, Dirk Timmerman, Joris R. Vermeesch
CLINICAL CHEMISTRY
(2023)
Article
Oncology
Liselore Loverix, Ignace Vergote, Pieter Busschaert, Adriaan Vanderstichele, Tom Venken, Bram Boeckx, Philipp Harter, Hilde Brems, Els Van Nieuwenhuysen, Sandro Pignata, Thais Baert, Antonio Gonzalez-Martin, Sileny Han, Christian Marth, Patrick Neven, Nicoletta Colombo, Patrick Berteloot, Johanna Maeenpaeae, Siel Olbrecht, Tina Laga, Erwin Sablon, Isabelle Ray-Coquard, Eric Pujade-Lauraine, Diether Lambrechts, Toon Van Gorp
Summary: The Leuven HRD test and Myriad HRD test have similar predictive value for PFS and OS in HRD+ patients, and there is a robust correlation between the two tests.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
I. Vergote, E. Van Nieuwenhuysen, A. Casado, A. Laenen, D. Lorusso, E. I. Braicu, E. Guerra-Alia, P. Zola, P. Wimberger, P. R. Debruyne, E. Falco, A. Ferrero, M. Z. Muallem, J. Kerger, E. Garcia-Martinez, S. Pignata, J. Sehouli, T. Van Gorp, C. Gennigens, M. J. Rubio
Summary: This study aimed to establish the role of nintedanib in first-line recurrent/metastatic cervical cancer. The results showed that nintedanib improved the progression-free survival compared to the carboplatin-paclitaxel group. The nintedanib group had a longer median overall survival and a higher RECIST response rate.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lori M. Strachowski, Priyanka Jha, Catherine H. Phillips, Misty M. Blanchette Porter, Wouter Froyman, Phyllis Glanc, Yang Guo, Maitray D. Patel, Caroline Reinhold, Elizabeth J. Suh-Burgmann, Dirk Timmerman, Rochelle F. Andreotti
Summary: The Ovarian-Adnexal Reporting and Data System (O-RADS) US is a standardized scoring system for ovarian and adnexal lesions, providing risk stratification and management guidance. The latest update includes additional morphologic features and emphasizes the use of MRI for further evaluation.
Letter
Computer Science, Artificial Intelligence
Paula Dhiman, Rebecca Whittle, Ben Van Calster, Marzyeh Ghassemi, Xiaoxuan Liu, Melissa D. McCradden, Karel G. M. Moons, Richard D. Riley, Gary S. Collins
NATURE MACHINE INTELLIGENCE
(2023)
Meeting Abstract
Oncology
Kathleen N. Moore, Antoine Angelergues, Gottfried E. Konecny, Susana N. Banerjee, Sandro Pignata, Nicoletta Colombo, John William Moroney, Casey Cosgrove, Jung-Yun Lee, Andrzej Roszak, Shani Breuer, Jacqueline Maria Tromp, Diana Bello-Roufai, Lucy Gilbert, Rowan Miller, Tashanna K. N. Myers, Yuemei Wang, Anna Berkenblit, Domenica Lorusso, Toon Van Gorp
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Ashleigh Ledger, Jolien Ceusters, Lil Valentin, Antonia Testa, Caroline Van Holsbeke, Dorella Franchi, Tom Bourne, Wouter Froyman, Dirk Timmerman, Ben Van Calster
Summary: Assessing the malignancy risk of ovarian tumors is crucial for selecting appropriate management. In this study, six algorithms were compared to estimate the probabilities of different types of ovarian tumors. The models developed showed good performance, but individual probability estimates varied substantially.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Obstetrics & Gynecology
Teska Schuurman, Ji-Ying Song, Vera Wolters, Marieke van de Ven, Nienke van Trommel, Ina Beerendonk, Frederic Amant, Christianne Lok
Summary: This study found that chemotherapy can cause damage to the maternal ovaries during pregnancy, and the extent of this damage depends on the type of chemotherapy and the duration of exposure. Short-term exposure leads to more severe damage, but it might be temporary. Chemotherapy also results in the loss of primordial follicles and DNA damage, with paclitaxel causing the least damage.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)