Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 115, Issue 1, Pages 145-150Publisher
SPRINGER
DOI: 10.1007/s10549-008-0045-y
Keywords
BARD1; Breast cancer; Polymorphisms; Cys557Ser
Categories
Funding
- NHMRC [145684, 288704]
- National Breast Cancer Foundation
- National Health and Medical Research Council (NHMRC)
- Queensland Cancer Fund
- Cancer Councils of New South Wales, Victoria, Tasmania, South Australia
- Cancer Foundation of Western Australia
- National Health and Medical Research Council
- Victorian Health Promotion Foundation
- New South Wales Cancer Council
- Peter MacCallum Cancer Institute
- Inkster-Ross Memorial Fund
- National Institute of Health
- Cancer Family Registry for Breast Cancer Study [CA 69638]
- National Cancer Institute [RFA CA-95-003]
- Fox Chase Cancer Center
- Huntsman Cancer Institute
- Columbia University
- Northern California Cancer Center
- Cancer Care Ontario
- University of Melbourne
- NHMRC Senior Principal Research Fellowship
- NHMRC Australian Fellow
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BARD1 was first identified as a BRCA1-interacting protein with tumour-suppressor functions. Some association studies suggested that the BARD1 Cys557Ser variant might be associated with increased risk of breast cancer, but the evidence remains uncertain. We found that the BARD1 Cys557Ser variant was carried by 50 of 1,136 cases (4.4%) and 30 of 623 controls (5.0%) from the population-based Australian Breast Cancer Family Study, 14 of 324 (4.3%) cases from the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), and 30 of 760 controls (4.0%) from the Australian Ovarian Cancer Study. Case-control comparisons showed no evidence that the variant frequency differed by case-control status (P a parts per thousand yen 0.3). Segregation analysis of 14 kConFab variant-carrying families containing 157 genotyped individuals provided no evidence of segregation with disease. We conclude that the BARD1 Cys557Ser variant is not associated with breast cancer risk.
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