Article
Oncology
Ji Young You, Eun Sook Lee, Siew Kuan Lim, Youngmee Kwon, So-Youn Jung
Summary: According to the study, performing sentinel lymph node biopsy (SLNB) without axillary lymph node dissection (ALND) may be a reasonable treatment option for patients with positive lymph nodes after breast cancer surgery. There was no significant difference in the loco-regional recurrence rates between SLNB with ALND and SLNB alone.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Peiyong Li, Ciqiu Yang, Junsheng Zhang, Yitian Chen, Xiaoqi Zhang, Minting Liang, Na Huang, Yilin Chen, Kun Wang
Summary: Sentinel lymph node biopsy can provide survival results equivalent to axillary lymph node dissection for patients with cN0 and T1-2 breast cancer; however, whether it can be performed on patients with T3-4c breast cancer is still controversial.
Article
Oncology
Ian Campbell, Neil Wetzig, Owen Ung, David Espinoza, Gelareh Farshid, John Collins, James Kollias, Val Gebski, Rebecca Mister, R. John Simes, Martin R. Stockler, Grantley Gill
Summary: For early breast cancer patients who are clinically node-negative, sentinel node-based management (SNBM) is the international standard of care. In the SNAC1 study, we report the rates of axillary recurrence, overall survival, and breast cancer-specific survival at 10 years.
Article
Oncology
Jing Si, Rong Guo, Huan Pan, Xiang Lu, Zhiqin Guo, Chao Han, Li Xue, Dan Xing, Wanxin Wu, Caiping Chen
Summary: The aim of this study was to determine whether breast cancer patients with mastectomy and false-negative frozen section in sentinel lymph node biopsy (SLNB) could forgo axillary lymph node dissection (ALND). The study found that SLNB and axillary radiation therapy could effectively replace ALND in selected patients who met specific criteria.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Gilles Houvenaeghel, Monique Cohen, Pedro Raro, Jeremy De Troyer, Pierre Gimbergues, Christine Tunon de Lara, Vivien Ceccato, Veronique Vaini-Cowen, Christelle Faure-Virelizier, Frederic Marchal, Tristan Gauthier, Eva Jouve, Pierrick Theret, Claudia Regis, Philippe Gabelle, Julia Pernaut, Francesco Del Piano, Gauthier D'Halluin, Stephane Lantheaume, Emile Darai, Bassoodeo Beedassy, Caroline Dhainaut-Speyer, Xavier Martin, Sophie Girard, Richard Villet, Emilie Monrigal, Theophile Hoyek, Jean-Francois Le Brun, Pierre-Emmanuel Colombo, Agnes Tallet, Jean-Marie Boher
Summary: The study analyzed the treatment and pathological results of patients included in the SERC trial, a multicenter randomized non-inferiority phase-3 trial comparing completion axillary lymph node dissection (cALND) with sentinel lymph node biopsy alone in breast cancer patients. Patients with one or two involved sentinel nodes by micro- or macro-metastases may not require cALND, but further research is needed for those with more than two involved nodes.
Article
Oncology
Anna C. Beck, Monica Morrow
Summary: Although sentinel lymph node biopsy is the preferred method for axillary staging and therapeutic for limited nodal disease, axillary lymph node dissection is still necessary in certain cases and for maintaining local control with heavy axillary tumor burden. Knowledge of the number of involved axillary nodes, obtained through axillary lymph node dissection, is also needed for tailored systemic therapies. Ongoing trials will explore the possibility of radiotherapy as a replacement for axillary lymph node dissection in certain circumstances.
Article
Oncology
Zhao Bi, Jia-Jian Chen, Peng-Chen Liu, Peng Chen, Wei-Li Wang, Yan-Bing Liu, Chun-Jian Wang, Peng-Fei Qiu, Qing Lv, Jiong Wu, Yong-Sheng Wang
Summary: This study developed a predictive model based on a multi-center retrospective database to accurately predict whether HR+/HER2- patients can undergo genomic tests. Through multivariate logistic regression analysis, imaging abnormal nodes, the number of positive SLNs, the number of negative SLNs, pathological tumor stage, and lympho-vascular invasion were identified as independent predictors for patients having <= 3 total metastatic ALNs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jennifer Q. Zhang, Giacomo Montagna, Varadan Sevilimedu, Kelly Abbate, Jillian Charyn, Babak Mehrara, Monica Morrow, Andrea Barrio
Summary: This study evaluates the effect of axillary lymph node dissection (ALND) on quality of life (QOL) in breast cancer patients. The results show that QOL scores initially decrease after ALND but improve by 6 months post-surgery. Decreases in QOL were independent of arm volume. Patients with worse QOL were more likely to seek lymphedema therapy, although the effect of therapy on QOL remains unknown.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Y. Andersson, L. Bergkvist, J. Frisell, J. de Boniface
Summary: The SENOMIC trial found that omitting axillary lymph node dissection in patients with breast cancer and sentinel node micrometastases had excellent 3-year event-free survival rates. However, patients who underwent mastectomy had worse tumor characteristics and higher risk of recurrence, especially without adjuvant radiotherapy. Long-term follow-up and enrollment of mastectomy patients are crucial.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
Qiufan Zheng, Hanjia Luo, Wen Xia, Qianyi Lu, Kuikui Jiang, Ruoxi Hong, Fei Xu, Shusen Wang
Summary: This study found significant differences in overall survival and breast cancer-specific survival between SLNB and ALND, with SLNB showing a slight survival advantage.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Review
Surgery
Nur Amalina Che Bakri, Richard M. Kwasnicki, Naairah Khan, Omar Ghandour, Alice Lee, Yasmin Grant, Aleksander Dawidziuk, Ara Darzi, Hutan Ashrafian, Daniel R. Leff
Summary: This study evaluated the impact of axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) on upper limb morbidity in breast cancer patients. The results showed that ALND patients had higher prevalence of lymphedema, pain, reduced strength, and range of motion compared with SLNB patients. These findings support the continued de-escalation of axillary surgery.
Article
Oncology
Matilda Appelgren, Helena Sackey, Yvonne Wengstrom, Karin Johansson, Johan Ahlgren, Yvette Andersson, Leif Bergkvist, Jan Frisell, Dan Lundstedt, Lisa Ryden, Malin Sund, Sara Alkner, Birgitte Vrou Offersen, Tove Filtenborg Tvedskov, Peer Christiansen, Jana de Boniface
Summary: This report evaluates the impact of axillary lymph node dissection (ALND) on health related quality of life (HRQoL) and patient-reported arm morbidity one year after breast cancer surgery. The study found that ALND did not have a negative impact on HRQoL and could reduce arm morbidity in patients.
Article
Oncology
Toralf Reimer
Summary: The local treatment of axilla in early breast cancer patients without clinically evident lymph node metastases is a subject of debate. Various prospective randomized surgical trials are currently being conducted to evaluate the safety of omitting sentinel lymph node biopsy in upfront breast-conserving surgery and neoadjuvant setting. These trials aim to determine whether it is possible to make therapeutic decisions without pathologic evaluation of nodal status. Additionally, ongoing trials are investigating the possibility of de-escalating surgery based on the response to neoadjuvant systemic therapy.
Article
Oncology
Maria Cristina Leonardi, Camilla Arrobbio, Sara Gandini, Stefania Volpe, Francesca Colombo, Eliana La Rocca, Viviana Galimberti, Sabrina Kahler-Ribeiro-Fontana, Cristiana Fodor, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Emilia Montagna, Marco Colleoni, Giovanni Mazzarol, Laura Lavinia Travaini, Mattia Zaffaroni, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: This study aimed to evaluate the rate of positive non-sentinel lymph nodes in breast cancer patients after neoadjuvant systemic therapy following positive sentinel lymph node biopsy. Positive non-SLNs were found in 62.3% of cases and were significantly associated with older age, clinically positive lymph nodes, SLN extracapsular extension, and a higher ratio of positive SLNs/total SLNs. ECE and higher nodal ratio were independent predictors of III axillary level positivity.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Isaac Cebrecos, Eduard Mension, Inmaculada Alonso, Helena Castillo, Esther Sanfeliu, Sergi Vidal-Sicart, Sergi Ganau, Maria Vidal, Francesco Schettini
Summary: In early stage breast cancer patients without lymph node metastasis, the presence of positive sentinel lymph nodes after primary systemic treatment directs axillary lymph node dissection. This study aimed to identify factors associated with non-sentinel lymph node involvement and develop a predictive score. The results showed that non-sentinel lymph node involvement was infrequent (22.2%) and associated with progesterone receptor levels and macrometastatic sentinel lymph nodes. The developed predictive score accurately predicted the absence of non-sentinel lymph node involvement, suggesting that unnecessary axillary lymph node dissection could be safely avoided in most patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Rachel Woodford, Daniel Brungs, Carly Leighton, Peter Grimison, Katrin M. Sjoquist, Therese Becker, Samuel Robinson, Val Gebski, Kate Wilson, Lorraine Chantrill, Morteza Aghmesheh
Summary: This study demonstrates the feasibility and potential efficacy of combination therapy with capecitabine and nab-paclitaxel as a second-line treatment for ABTC, warranting further assessment in formal phase II or III trials. The treatment was generally well tolerated, with encouraging disease control rates and survival outcomes.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Dickon Hayne, Jeremy Grummet, David Espinoza, Steve P. McCombie, Venu Chalasani, Kate S. Ford, Mark Frydenberg, Peter Gilling, Barbara Gordon, Cynthia Hawks, Alex Konstantatos, Andrew J. Martin, Anthony Nixon, Colin O'Brien, Manish Patel, Shomik Sengupta, Shekib Shahbaz, Shalini Subramaniam, Scott Williams, Henry H. Woo, Martin R. Stockler, Ian D. Davis, Nick Buchan
Summary: The study found that the addition of inhaled methoxyflurane did not improve pain scores at 15 min after TRUSB, but it did lead to improvements in patient-reported discomfort, overall experience, and willingness to undergo repeat biopsies.
Article
Oncology
Paul A. Cohen, Penelope M. Webb, Madeleine King, Andreas Obermair, Val Gebski, Phyllis Butow, Rachael Morton, Wanda Lawson, Patsy Yates, Rachel Campbell, Tarek Meniawy, Michelle McMullen, Andrew Dean, Jeffrey Goh, Orla McNally, Linda Mileshkin, Philip Beale, Rhonda Beach, Jane Hill, Cyril Dixon, Sue Hegarty, Jim Codde, Angela Ives, Yeh Chen Lee, Alison Brand, Anne Mellon, Sanela Bilic, Isobel Black, Stephanie Jeffares, Michael Friedlander
Summary: The study aims to evaluate the emotional wellbeing, acceptability, safety, and cost effectiveness of nurse-led telehealth follow-up for women with ovarian cancer. It is hypothesized that this telehealth follow-up model will improve emotional wellbeing, increase patient satisfaction, identify patients with psychological distress, and be cost-effective. The results are expected to be published in 2025, 24 months after the last participant is enrolled.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Pediatrics
Ju Lee Oei, Vishal Kapadia, Yacov Rabi, Ola Didrik Saugstad, Denise Rook, Marijn J. Vermeulen, Nuria Boronat, Valerie Thamrin, William Tarnow-Mordi, John Smyth, Ian M. Wright, Kei Lui, Johannes B. van Goudoever, Val Gebski, Maximo Vento
Summary: In this study, resuscitation with lower or higher initial FiO2 was not associated with the risk of death or disability at 2 years in infants under 32 weeks gestation. However, the wide confidence intervals indicate that conclusive evidence is lacking, and larger randomized studies are urgently needed to further investigate the potential benefits or harms of different initial FiO2 levels on infant outcomes.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Oncology
Martin R. Stockler, Andrew J. Martin, Ian D. Davis, Haryana M. Dhillon, Stephen D. Begbie, Kim N. Chi, Simon Chowdhury, Xanthi Coskinas, Mark Frydenberg, Wendy E. Hague, Lisa G. Horvath, Anthony M. Joshua, Nicola J. Lawrence, Gavin M. Marx, John McCaffrey, Ray McDermott, Margaret McJannett, Scott A. North, Francis Parnis, Wendy R. Parulekar, David W. Pook, M. Neil Reaume, Shahneen Sandhu, Alvin Tan, Thean Hsiang Tan, Alastair Thomson, Francisco Vera-Badillo, Scott G. Williams, Diana G. Winter, Sonia Yip, Alison Y. Zhang, Robert R. Zielinski, Christopher J. Sweeney
Summary: Enzalutamide improves overall survival in metastatic, hormone-sensitive prostate cancer, but has limited effects on health-related quality of life.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Fiona Chionh, Val Gebski, Sheren J. Al-Obaidi, Jennifer K. Mooi, Maressa A. Bruhn, Chee K. Lee, Anderly C. Chueh, David S. Williams, Andrew J. Weickhardt, Kate Wilson, Andrew M. Scott, John Simes, Jennifer E. Hardingham, Timothy J. Price, John M. Mariadason, Niall C. Tebbutt
Summary: The study found that SNPs in the VEGF-A and VEGFR2 genes may have predictive value for treatment outcomes and the development of hypertension in patients with colorectal cancer.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
K. E. Francis, S. Kim, M. Friedlander, V Gebski, I Ray-Coquard, A. Clamp, R. T. Penson, A. Oza, T. Perri, T. Huzarski, C. Martin-Lorente, S. C. Cecere, N. Colombo, B. Ataseven, K. Fujiwara, G. Sonke, I Vergote, E. Pujade-Lauraine, J-W Kim, C. K. Lee
Summary: Using data from the SOLO2 trial, this study evaluated the impact of dose alterations on survival outcomes of olaparib treatment and identified baseline characteristics associated with dose alteration.
ANNALS OF ONCOLOGY
(2022)
Review
Oncology
Katrin M. Sjoquist, Andrew Martin, Nick Pavlakis, David Goldstein, Eric Tsobanis, Daniel Moses, Richard Maher, Wendy Hague, Val Gebski, Martin R. Stockler, R. John Simes
Summary: This study assessed the value of central review in evaluating PFS times in phase 2 clinical trials and found that it supported the reliability of trial results and conclusions.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Neville F. Hacker, Ellen L. Barlow, Glenn McNally, Stephen Morrell, Val Gebski, Andreas Obermair
Summary: Vulvar cancer is a rare disease that often leads to body image issues due to its treatment. Chronic lower limb lymphedema is a common problem after the removal of groin lymph nodes. The status of these nodes is crucial for prognosis, and most patients require groin dissection. A pilot study on 32 patients showed promising results for serial ultrasonography as a potential alternative to groin dissection in selected patients. The study achieved a high sensitivity and specificity in detecting positive nodes, supporting the need for further research on this approach.
Article
Health Care Sciences & Services
Rachel Campbell, Madeleine T. King, Martin R. Stockler, Yeh Chen Lee, Felicia T. Roncolato, Michael L. Friedlander
Summary: Patient-reported outcomes (PROs) are important in assessing symptoms and treatment effects in ovarian cancer. Well-validated PRO measures can be used in clinical trials to guide improvements in clinical practice and health policy. In clinical practice, PRO assessments can help monitor symptoms and facilitate communication between patients and their clinicians.
PATIENT-RELATED OUTCOME MEASURES
(2023)
Article
Health Care Sciences & Services
Ann Livingstone, Kirsten Howard, Alexander M. Menzies, Georgina V. Long, Martin R. Stockler, Rachael L. Morton
Summary: This study aimed to quantify adult preferences for adjuvant immunotherapy for resected melanoma and the influence of varying levels of key attributes and baseline characteristics. The study found that 70% of respondents chose adjuvant immunotherapy over no adjuvant immunotherapy, preferring treatment that improved efficacy and safety. The importance of this study is rated 8 out of 10.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2023)
Meeting Abstract
Oncology
Danka Zebic, Martin Stockler, Andrew Martin, Farzana Pashankar, Ben Tran, Danish Mazhar, Robert Huddart, Matthew Wheater, Euan Walpole, Elaine Dunwoodie, Darren Feldman, Alison Birtle, Amanda Stevanovic, David Wyld, Fritha Hanning, Peter Grimison
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Sharon Nahm, Andrew Martin, Martin Stockler, Belinda Kiely
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Bruce Mann, Allison Rose, Janemary Hughes, Anita R. Skandarajah, Anand Murugasu, Andrew John Spillane, Boon Hui Chua, Nicholas Zdenkowski, Helen Braggett, Heath Badger, Renee Eggins, Val Gebski, Allan Park, Kaley Schwartz, Arlene Mou, John Collins
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
J. Buteau, A. Martin, L. Emmett, A. Iravani, S. Sandhu, A. M. Joshua, R. J. Francis, A. Y. Zhang, A. M. Scott, S. Lee, A. Azad, M. McJannett, M. R. Stockler, S. Williams, I. D. Davis, M. S. Hofman
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)