Article
Oncology
Dang Van Nguyen, Sang-Won Kim, Young-Taek Oh, O. Kyu Noh, Yongsik Jung, Mison Chun, Dae Sung Yoon
Summary: Young women undergoing breast conserving therapy have a higher risk of local recurrence compared to mastectomy alone. Despite aggressive salvage treatments, those with local recurrence after breast conserving therapy have poor prognosis. Novel systemic treatments are needed to improve outcomes for young women with breast cancer undergoing breast conserving therapy.
Review
Oncology
Ju-Chun Chien, Wen-Shan Liu, Wei-Tzu Huang, Liang-Chung Shih, Wen-Chung Liu, Yu-Chia Chen, Kang-Ju Chou, Yow-Ling Shiue, Pei-Chin Lin
Summary: This study compares the treatment outcomes for young women with ductal carcinoma in situ (DCIS) using different methods. The study found that adjuvant radiotherapy following breast conserving surgery significantly reduces the risk of ipsilateral breast tumor recurrence in young DCIS women. However, the benefit is less robust in extremely young patients and with long-term follow-ups. Total mastectomy yields the lowest ipsilateral breast tumor recurrence rate, but there is no conclusive evidence for survival outcomes.
Article
Oncology
Charles E. Leonard, Shannon P. Tole, Michelle P. Turner, John P. Bennett, Kathryn T. Howell, Dennis L. Carter
Summary: This study aimed to investigate the risk stratification of DCIS population in APBI treatment using the 12-gene Breast DCIS Score assay, which showed a significant association between the DCIS Score result and local recurrence. However, no significant association was found between clinicopathologic factors and locoregional recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Priyanka Narayan, Caroline E. Kostrzewa, Zhigang Zhang, Diana A. Roth O'Brien, Boris A. Mueller, John J. Cuaron, Amy J. Xu, Michael B. Bernstein, Beryl McCormick, Simon N. Powell, Atif J. Khan, Hannah Y. Wen, Lior Z. Braunstein
Summary: This study aimed to investigate the recurrence and survival outcomes of a rare subtype of breast cancer, metaplastic breast carcinoma (MBC). It was found that appropriately treated MBC patients had similar recurrence and survival rates compared to non-MBC patients, and chemotherapy and radiotherapy may help reduce the differences.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Surgery
Laura Dominici, Jiani Hu, Yue Zheng, Hee Jeong Kim, Tari A. King, Kathryn J. Ruddy, Rulla M. Tamimi, Jeffrey Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Ellen Warner, Julia S. Wong, Ann H. Partridge, Shoshana M. Rosenberg
Summary: This study found that local therapy in young breast cancer survivors is persistently associated with poorer scores in multiple QOL domains, particularly among those treated with mastectomy and radiotherapy, irrespective of breast reconstruction. Socioeconomic stressors also appear to play a role.
Article
Oncology
Ishita Chen, Astrid M. Botty Van den Bruele, Erin F. Gillespie, Boris A. Mueller, Amy J. Xu, John Cuaron, Atif J. Khan, Beryl McCormick, Oren Cahlon, Simon N. Powell, Hiram Cody, Lior Z. Braunstein
Summary: This study evaluated the safety and efficacy of repeat breast conservation using a novel radiotherapy regimen as salvage therapy for recurrent breast cancer. With a median follow-up of 23.5 months, the study found excellent local control with low toxicity rates. Further research with longer follow-up in larger cohorts is needed to determine the long-term outcomes of this treatment approach.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Jan Haussmann, Wilfried Budach, Vratislav Strnad, Stefanie Corradini, David Krug, Livia Schmidt, Balint Tamaskovics, Edwin Boelke, Ioannis Simiantonakis, Kai Kammers, Christiane Matuschek
Summary: This meta-analysis compares the treatment outcomes of partial-breast radiotherapy and whole-breast radiotherapy after breast-conserving surgery in early-stage breast cancer. The results suggest that partial-breast radiotherapy may result in a slightly higher risk of local recurrence compared to whole-breast radiotherapy, but does not increase the risk of distant relapse.
Article
Oncology
Kai-yun You, Zhuo-fei Bi, Yu-jia Ma, Yong-lin Mao, Wei-liang Zou, Yi-min Liu, He-rui Yao
Summary: This study compared survival rates between mastectomy and BCS plus adjuvant radiotherapy in patients with DCIS, finding no significant difference in local recurrence and disease-free survival rates between the two groups. Factors such as tumor grade and age were significantly associated with LRFS and DFS rates, with mastectomy potentially offering better outcomes in patients with grade III tumors.
Article
Oncology
Brady S. Laughlin, Ronik S. Bhangoo, Joshua R. Niska, Cameron S. Thorpe, Marlene E. Girardo, Justin D. Anderson, Heidi E. Kosiorek, Lisa A. McGee, William F. Hartsell, John H. Chang, Carl J. Rossi, Henry K. Tsai, Isabelle J. Choi, Carlos E. Vargas
Summary: Proton therapy is well-tolerated and effective in achieving loco-regional control for breast cancer patients with isolated local-regional recurrence after mastectomy without prior radiotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Anne S. Reiner, Gordon P. Watt, Esther M. John, Charles F. Lynch, Jennifer D. Brooks, Lene Mellemkjaer, John D. Boice, Julia A. Knight, Patrick Concannon, Susan A. Smith, Xiaolin Liang, Meghan Woods, Roy Shore, Kathleen E. Malone, Leslie Bernstein, Jonine L. Bernstein
Summary: There was no evidence that radiation therapy further increased second primary contralateral breast cancer (CBC) risk in young women with first primary breast cancer who were current smokers or had smoking history.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Editorial Material
Medicine, General & Internal
Ha Young Woo, Hyun-Soo Kim
Summary: Papillary squamous cell carcinoma (PSCC) is a rare and aggressive type of cervical carcinoma. We present a rare case of recurrent PSCC in a young woman, which rapidly progressed within a short period.
Article
Multidisciplinary Sciences
Jeongmin Lee, Bong Joo Kang, Sung Hun Kim
Summary: This study aimed to investigate the imaging characteristics and detectability of early and late recurrent breast cancer in patients who underwent breast-conservation therapy (BCT) using mammography, ultrasonography, and breast magnetic resonance imaging (MRI). The results showed that postoperative breast MRI had significantly higher detectability for recurrent lesions compared to mammography and ultrasound.
Article
Medicine, General & Internal
Zhi-Hong Sun, Chuang Chen, Xin-Wen Kuang, Jun-Long Song, Sheng-Rong Sun, Wei-Xing Wang
Summary: This study found that, compared to mastectomy, breast-conserving therapy (BCT) can provide better breast cancer-specific survival and overall survival benefits in young white patients under 40 with early-stage breast cancer, especially in the 36 to 40 years age group.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen-zhen Ding, Sisi Liu, Fangyi Liu, Zhigang Cheng, Xiaoling Yu, Zhi-yu Han, Jie Yu, Ping Liang
Summary: This study found that using the MF method can accurately and conveniently assess the shortest ablation margin quadrant. LTP tends to occur in the shortest ablation margin quadrant, but dissociated-type LTP and LTPs after 24 months do not, suggesting that these types of LTP may not be related to ablation.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Yang Li, Su Lu, Yuhan Zhang, Shuaibing Wang, Hong Liu
Summary: The study found that the rates of local recurrence and regional recurrence in young breast cancer patients showed a downward trend, and the proportion of early-stage breast cancer increased. HR-/HER2+ tumors were significantly associated with higher rates of local recurrence in young patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Laura F. C. Fransen, Thijs H. J. B. Janssen, Martijn Aarnoudse, Grard A. P. Nieuwenhuijzen, Misha D. P. Luyer
Summary: This study aimed to compare the effects of direct oral feeding (DOF) to standard of care in patients who underwent minimally invasive esophagectomy (MIE). The results showed that DOF resulted in faster functional recovery and lower 30-day postoperative complication rate compared to conventional fasting.
Article
Surgery
Sanne-Marije Hazen, Tania Sluckin, Geerard Beets, Roel Hompes, Pieter Tanis, Miranda Kusters
Summary: There is significant variation among Dutch colorectal surgeons in the assessment and treatment of lateral lymph nodes in rectal cancer patients, highlighting the need for further research and international guidelines.
ACTA CHIRURGICA BELGICA
(2023)
Article
Gastroenterology & Hepatology
Thijs H. J. B. Janssen, Laura F. C. Fransen, Fanny F. B. M. Heesakkers, Annemarie C. P. Dolmans-Zwartjes, Krishna Moorthy, Grard A. P. Nieuwenhuijzen, Misha D. P. Luyer
Summary: This study investigated the impact of prehabilitation on postoperative outcomes in patients undergoing minimally invasive esophagectomy. The results showed that prehabilitation led to a shorter hospital stay, reduced ICU readmission rate, and clinically relevant improvement in postoperative recovery and morbidity rate.
DISEASES OF THE ESOPHAGUS
(2022)
Article
Oncology
S. H. J. Ketelaers, R. G. Orsini, G. A. P. Nieuwenhuijzen, H. J. T. Rutten, J. W. A. Burger, J. G. Bloemen
Summary: This study focused on the outcomes of diverting ostomy in elderly patients with advanced rectal cancer after low anterior resection (LAR). The results showed that most elderly patients successfully reversed their ostomy with limited complications, but there is still a risk of non-reversal and ostomy recreation over time.
Article
Surgery
Eva L. K. Voogt, Stefi Nordkamp, Desley M. G. van Zoggel, Alette W. Daniels-Gooszen, Grard A. P. Nieuwenhuijzen, Johanne G. Bloemen, Geert-Jan Creemers, Jeltsje S. Cnossen, Gesina van Lijnschoten, Jacobus W. A. Burger, Harm J. T. Rutten, Joost Nederend
Summary: This study investigated the agreement between magnetic resonance tumour regression grade (mrTRG) and pathological regression grade (pTRG) in patients with locally recurrent rectal cancer (LRRC). The reproducibility of mrTRG was found to be limited among radiologists and the agreement with pTRG was low. However, a shorter interval between MRI and surgery improved the agreement and if assessed by a dedicated radiologist, mrTRG could predict good responders.
Article
Oncology
Delal Akdeniz, Iris Kramer, Carolien H. M. van Deurzen, Bernadette A. M. Heemskerk-Gerritsen, Michael Schaapveld, Pieter J. Westenend, Adri C. Voogd, Agnes Jager, Ewout W. Steyerberg, Stefan Sleijfer, Marjanka K. Schmidt, Maartje J. Hooning
Summary: Lobular and lobular mixed primary breast cancer histology are associated with modestly increased risk of contralateral breast cancer (CBC), and personalized risk assessment needs to consider the histology of the primary cancer as well as the impact of systemic therapy.
Article
Oncology
Josianne C. H. B. M. Luijten, Pauline A. J. Vissers, Julie Geerts, Valery E. P. Lemmens, Richard van Hillegersberg, Laurens Beerepoot, Janneke E. W. Walraven, Wouter Curvers, Francine E. M. Voncken, Maurice van der Sangen, Rob H. A. Verhoeven, Grard A. P. Nieuwenhuijzen
Summary: This study investigates national practice variation in the proportion of oesophageal or gastric cancer patients being discussed during an expert Multidisciplinary team meeting (MDTM). The results show significant variation among hospitals and regions regarding the proportion of patients discussed during an expert MDTM, indicating a correlation between the likelihood of being discussed and the diagnosing hospital for patients with oesophageal or gastric cancer.
Article
Oncology
Lonneke A. van Tuijl, Maartje Basten, Kuan-Yu Pan, Roel Vermeulen, Luetzen Portengen, Alexander de Graeff, Joost Dekker, Mirjam I. Geerlings, Adriaan Hoogendoorn, Femke Lamers, Adri C. Voogd, Jessica Abell, Philip Awadalla, Aartjan T. F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Trynke R. de Jong, Melanie R. Keats, Almar A. L. Kok, Steinar Krokstad, Flora E. van Leeuwen, Annemarie I. Luik, Nolwenn Noisel, N. Charlotte Onland-Moret, Yves Payette, Brenda W. J. H. Penninx, Ina Rissanen, Annelieke M. Roest, Rikje Ruiter, Robert A. Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Emma L. Twait, Alison Teyhan, W. M. Monique Verschuren, Kimberly D. van der Willik, Judith G. M. Rosmalen, Adelita V. Ranchor
Summary: A meta-analysis of individual participant data from 18 cohorts found no associations between depression or anxiety and most types of cancer, except for lung cancer and smoking-related cancers. The associations with lung and smoking-related cancers were attenuated when adjusting for known risk factors.
Article
Oncology
Cas de Jongh, Lianne Triemstra, Arjen van der Veen, Lodewijk AA. Brosens, Grard AP. Nieuwenhuijzen, Jan HMB. Stoot, Wobbe O. de Steur, Jelle P. Ruurda, Richard van Hillegersberg
Summary: This study assessed the quality of gastric cancer surgery using a photo-scoring method and implemented quality control measures during the LOGICA trial. The results showed that high radicality and nodal yield were indicators of good quality D2-gastrectomy. However, the photo-scoring method used in the study needs further improvement.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eline L. van der Veer, Joost Lameijer, Angela M. P. Coolen, Adriana M. J. Bluekens, Joost Nederend, Maaike Gielens, Adri Voogd, Lucien Duijm
Summary: This study aimed to investigate the prevalence, causes, and consequences of delayed breast cancer diagnosis in the screening population. The results showed that a primary diagnostic delay in breast cancer diagnosis resulted in less favorable tumor characteristics and a higher rate of mastectomy compared to no delay in diagnosis and a delay in diagnostic work-up after recall.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Surgery
Stefi Nordkamp, Jan M. van Rees, Kim van den Berg, David M. Mens, Davy M. J. Creemers, Heike M. U. Peulen, Geert-Jan Creemers, Grard A. P. Nieuwenhuijzen, Jip L. Tolenaar, Johanne G. Bloemen, Joost Rothbarth, Harm J. T. Rutten, Cornelis Verhoef, Jacobus W. A. Burger
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Stefi Nordkamp, Floor Piqeur, Kim van den Berg, Jip L. Tolenaar, Irene E. G. van Hellemond, Geert-Jan Creemers, Mark Roef, Gesina van Lijnschoten, Jeltsje S. Cnossen, Grard A. P. Nieuwenhuijzen, Johanne G. Bloemen, Lien Coolen, Joost Nederend, Heike M. U. Peulen, Harm J. T. Rutten, Jacobus W. A. Burger
Summary: This study aimed to evaluate the oncological outcomes of patients with locally recurrent rectal cancer with a pCR, and compare them with patients without a pCR. Patients with a pCR had superior oncological outcomes. A watch-and-wait approach may be considered in highly selected patients to improve quality of life without compromising oncological outcomes.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Anouk Hiensch, Elles Steenhagen, Jonna K. van Vulpen, Jelle P. Ruurda, Grard A. P. Nieuwenhuijzen, Ewout A. Kouwenhoven, Richard P. R. Groenendijk, Donald L. van der Peet, Camiel Rosman, Bas P. L. Wijnhoven, Mark I. van Berge Henegouwen, Hanneke W. M. van Laarhoven, Richard van Hillegersberg, Peter D. Siersema, Anne M. May
Article
Oncology
Yuwei Wang, Annegien Broeks, Daniele Giardiello, Michael Hauptmann, Katarzyna Jozwiak, Esther A. Koop, Mark Opdam, Sabine Siesling, Gabe S. Sonke, Nikolas Stathonikos, Natalie D. ter Hoeve, Elsken van der Wall, Carolien H. M. van Deurzen, Paul J. van Diest, Adri C. Voogd, Willem Vreuls, Sabine C. Linn, Gwen M. H. E. Dackus, Marjanka K. Schmidt
Summary: This study validated the reliability of the PREDICT breast cancer prognostic model and assessed its clinical utility in young women with node-negative breast cancer. The results showed that PREDICT was not reliable in predicting outcomes for this patient subset and further updates are needed.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristien B. I. M. Keymeulen, Sandra M. E. Geurts, Loes F. S. Kooreman, Lucien E. M. Duijm, Sanne Engelen, Sigrid Vanwetswinkel, Ernest Luiten, Sabine Siesling, Adri C. Voogd, Vivianne C. G. Tjan-Heijnen
Summary: Breast MRI at primary DCIS diagnosis can detect additional synchronous cDCIS and cIBC, and is associated with a higher rate of metachronous cDCIS without decreasing the rate of metachronous cIBC. This finding is most evident in younger patients.
EUROPEAN RADIOLOGY
(2023)
