Article
Radiology, Nuclear Medicine & Medical Imaging
Fabian Riedel, Benedikt Schaefgen, Hans-Peter Sinn, Manuel Feisst, Andre Hennigs, Sarah Hug, Angela Binnig, Christina Gomez, Aba Harcos, Anne Stieber, Hans-Ulrich Kauczor, Christof Sohn, Michael Golatta, Antonia Glaeser, Joerg Heil
Summary: Axillary ultrasound alone is not accurate enough to identify or exclude axillary metastatic disease in patients with early breast cancer, and systematic application of previously recommended diagnostic criteria did not improve its performance.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Maria Escala-Garcia, Sander Canisius, Renske Keeman, Jonathan Beesley, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Marina Bermisheva, Stig E. Bojesen, Manjeet K. Bolla, Hermann Brenner, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Fergus J. Couch, Kamila Czene, Mary B. Daly, Joe Dennis, Peter Devilee, Thilo Dork, Alison M. Dunning, Douglas F. Easton, Arif B. Ekici, A. Heather Eliassen, Peter A. Fasching, Henrik Flyger, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Juergen Geisler, Graham G. Giles, Mervi Grip, Melanie Guendert, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Jaana M. Hartikainen, Bernadette A. M. Heemskerk-Gerritsen, Antoinette Hollestelle, Reiner Hoppe, John L. Hopper, David J. Hunter, William Jacot, Anna Jakubowska, Esther M. John, Audrey Y. Jung, Rudolf Kaaks, Elza Khusnutdinova, Linetta B. Koppert, Peter Kraft, Vessela N. Kristensen, Allison W. Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Robert N. Luben, Jan Lubinski, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Dimitrios Mavroudis, Taru A. Muranen, Heli Nevanlinna, Andrew F. Olshan, Hakan Olsson, Tjoung-Won Park-Simon, Alpa V. Patel, Paolo Peterlongo, Paul D. P. Pharoah, Kevin Punie, Paolo Radice, Gad Rennert, Hedy S. Rennert, Atocha Romero, Rebecca Roylance, Thomas Ruediger, Matthias Ruebner, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Christopher Scott, Melissa C. Southey, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, Lauren R. Teras, Emilie Thomas, Ian Tomlinson, Melissa A. Troester, Celine M. Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Kyriaki Michailidou, Georgia Chenevix-Trench, Thomas Bachelot, Marjanka K. Schmidt
Summary: Two germline variants on chromosome 1 were significantly associated with breast cancer-specific survival, however, validation in a smaller replication dataset was not successful. Larger replication studies are needed to confirm the identified associations.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Tima Davidson, Nagham Shehade, Ella Nissan, Miri Sklair-Levy, Simona Ben-Haim, Iris Barshack, Douglas Zippel, Ariel Halevy, Bar Chikman
Summary: PET/CT plays a crucial role in evaluating axillary lymph nodes and distant metastases in newly diagnosed breast cancer patients, helping to confirm tumor location and size, and guiding clinical diagnosis and treatment decisions.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Oncology
Katrin Almstedt, Lisa Krauthauser, Franziska Kappenberg, Daniel-Christoph Wagner, Anne-Sophie Heimes, Marco J. J. Battista, Katharina Anic, Slavomir Krajnak, Antje Lebrecht, Roxana Schwab, Walburgis Brenner, Wolfgang Weikel, Joerg Rahnenfuehrer, Jan G. G. Hengstler, Wilfried Roth, Annette Hasenburg, Kathrin Stewen, Marcus Schmidt
Summary: This study investigated the differences in HER2 expression levels between primary tumors and distant metastases in HER2-negative breast cancer patients. The results showed relevant discordance of HER2-low status between primary tumors and their corresponding distant metastases. Significant HER2 discordance rates were observed between different metastatic sites and molecular subtypes. These findings highlight the importance of evaluating potentially therapy-relevant discordance rates between a primary tumor and corresponding distant metastases.
Article
Health Care Sciences & Services
Hua Ni, Joerg Kumbrink, Doris Mayr, Alina Seiler, Friederike Hagemann, Tom Degenhardt, Sabine Sagebiel, Rachel Wuerstlein, Ronald Kates, Nadia Harbeck, Tanja K. Eggersmann
Summary: Molecular factors driving metastasis in premenopausal patients with HR+/HER2- EBC remain largely unknown. This study identified gene signatures and single-gene markers associated with distant metastasis in this patient population, potentially applicable in future clinical practice. These markers may provide important prognostic information for patient outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
M. Luke Marinovich, Elizabeth Wylie, William Lotter, Helen Lund, Andrew Waddell, Carolyn Madeley, Gavin Pereira, Nehmat Houssami
Summary: In this study, the accuracy of artificial intelligence (AI) was compared with radiologists in breast cancer screening. The AI algorithm showed a lower AUC compared to radiologists. However, AI detected interval cancers that were missed by radiologists.
Article
Medicine, General & Internal
Hong Pan, Hui Wang, Mengjia Qian, Xinrui Mao, Guojian Shi, Ge Ma, Muxin Yu, Hui Xie, Lijun Ling, Qiang Ding, Kai Zhang, Shui Wang, Wenbin Zhou
Summary: This cohort study examined the survival of breast cancer patients with distant lymph node metastases compared to ipsilateral supraclavicular lymph node metastases and other stage IV breast cancer. The results suggest that DLNM may be a regional disease with similar survival outcomes to N3c disease, indicating the need for reassessment of the role of lymph node metastases in breast cancer and consideration of aggressive locoregional therapies for DLNM patients.
Review
Oncology
Valerio Di Paola, Giorgio Mazzotta, Vincenza Pignatelli, Enida Bufi, Anna D'Angelo, Marco Conti, Camilla Panico, Vincenzo Fiorentino, Francesco Pierconti, Fleur Kilburn-Toppin, Paolo Belli, Riccardo Manfredi
Summary: Breast cancer is a common cancer in women, and metastatic breast cancer is the leading cause of death from all cancers in women. Accurate staging of breast cancer is crucial for personalized treatment and prognosis. Imaging modalities, such as ultrasound and MRI, play an important role in the diagnosis of breast cancer. MRI is an accurate and reproducible technique for assessing lymph node status. Radiological assessment of lymph nodes must be accurate to avoid misdiagnosis and unnecessary surgeries.
Article
Oncology
Jiansong Fan, Lei Zhang, Tianxu Lv, Yuan Liu, Heng Sun, Kai Miao, Chunjuan Jiang, Lihua Li, Xiang Pan
Summary: An artificial intelligence system was developed to recognize lymph node and distant tumor metastases on whole-slide images of primary breast cancer, which is essential for future treatment and patient survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Sven Jacob, Vindi Jurinovic, Christopher Lampert, Elise Pretzsch, Joerg Kumbrink, Jens Neumann, Ren Haoyu, Bernhard W. Renz, Thomas Kirchner, Markus O. Guba, Jens Werner, Martin K. Angele, Florian Boesch
Summary: Chronic inflammation may enhance local tumor growth and immune related gene sets were found to be differentially expressed in CRC patients with liver or peritoneal metastases. Liver metastases formation may be associated with TLR-associated pathways, while high expression of FOXP3+ tumor infiltrating lymphocytes in M0 seemed to prevent metastases to a certain extent. These findings provide a foundation for further research on the underlying mechanisms of organotropism in metastases.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Zhen Lu Yang, Yi Qi Hu, Jia Huang, Chen Ao Zhan, Min Xiong Zhou, Xiao Yong Zhang, Hui Ting Zhang, Li Ming Xia, Tao Ai
Summary: Although rs-EPI DWI has inferior lesion visibility compared to DCE-MRI, it can detect about 90% of breast lesions identified by DCE-MRI and has comparable diagnostic capacity to that of DCE-MRI in distinguishing breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Wen-Fang Tang, Min Wu, Hua Bao, Yang Xu, Jie-Shan Lin, Yi Liang, Yu Zhang, Xiang-Peng Chu, Zhen-Bin Qiu, Jian Su, Jia-Tao Zhang, Chao Zhang, Fang-Ping Xu, Jing-Hua Chen, Rui Fu, Ying Chen, Tao Yang, Qing-Ke Chen, Ting-Ting Wu, Xue Wu, Yang Shao, Jian-Tao Zheng, Zhi Xie, Zhi-Yi Lv, Song Dong, Yi-Long Wu, Wen-Zhao Zhong
Summary: Whole-exome sequencing of primary tumors and metastases from 47 lung cancer patients revealed metastasis-selected genetic alterations. Statistical tools and mathematical models were used to analyze metastatic timing and evolutionary origins, shedding light on potential drivers of lung cancer metastases.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Genetics & Heredity
Yentl Lambrechts, Abhishek D. Garg, Giuseppe Floris, Kevin Punie, Patrick Neven, Ines Nevelsteen, Jannes Govaerts, Francois Richard, Annouschka Laenen, Christine Desmedt, Hans Wildiers, Sigrid Hatse
Summary: There is an urgent need for new and improved biomarker modalities to estimate the risk of recurrence in breast cancer patients. This study provides proof of concept that various liquid biopsy read-outs could be used to build a multi-modal biomarker model that can distinguish between early metastasizing and non-metastasizing patients.
GENES AND IMMUNITY
(2023)
Article
Gastroenterology & Hepatology
Gregor A. Stavrou, Axel Stang, Dimitri A. Raptis, Erik Schadde, Martin Zeile, Roland Bruning, Kim C. Wagner, Tessa M. Huber, Karl J. Oldhafer
Summary: This study aimed to compare sensitivity, specificity, and diagnostic accuracy in the detection of colorectal liver metastases between imaging and intraoperative assessment. The results showed that lesion detection accuracy is severely impaired for lesions smaller than 5mm, intraoperative ultrasound is not affected by lesion size, and CEIOUS can improve intraoperative decision-making.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Gary J. R. Cook
Summary: Bone metastases are a common spread site in advanced breast cancer, and imaging plays a crucial role in staging, treatment response assessment, and patient management. Traditional imaging methods include radiographs, computed tomography, and bone scans, while recent advancements in molecular and hybrid imaging techniques have provided a more comprehensive understanding of the abnormal biology associated with bone metastases. These new methods allow the analysis of the bone microenvironment and tumor cell characteristics using specific tracers, leading to more sensitive and accurate detection of bone metastases as well as earlier assessment of treatment response.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tong Li, Darren Lockie, Michelle Clemson, Nehmat Houssami
Summary: This study compared the secondary outcomes of digital breast tomosynthesis (DBT) and digital mammography (DM) screening. The results showed that DBT detected more benign and malignant lesions compared to DM, and generally required more procedures.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2023)
Review
Oncology
Dorsa Banihashemi, Meagan E. Brennan
Summary: This study aimed to evaluate the impact of breast awareness on breast cancer outcomes in women at low risk of breast cancer who have not reached the age for mammographic screening. After screening the literature, no studies exclusively evaluating the effect of breast awareness in young women were found. Limited evidence of the benefit of breast awareness was found in mixed-age cohorts, including some younger women.
Article
Computer Science, Information Systems
Yves Saint James Aquino, Wendy A. Rogers, Annette Braunack-Mayer, Helen Frazer, Khin Than Win, Nehmat Houssami, Christopher Degeling, Christopher Semsarian, Stacy M. Carter
Summary: This study examines the issue of deskilling due to healthcare artificial intelligence (AI) from the perspective of professional stakeholders involved in the development and regulation of AI. The findings reveal diverse views on the extent of AI-enabled automation in healthcare work, the impact of AI on clinical skills, and the different models of healthcare work. The study highlights the importance of considering the perspectives of various stakeholders in decision-making regarding AI development and deployment in healthcare.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Letter
Public, Environmental & Occupational Health
Brooke Nickel, Hankiz Dolan, Nehmat Houssami, Erin Cvejic, Meagan Brennan, Jolyn Hersch, Melanie Dorrington, Angela Verde, Lisa Vaccaro, Kirsten McCaffery
Summary: This study examined factors associated with women's intentions for supplemental screening after receiving notification of dense breasts. The results showed that women with higher levels of breast cancer worry, private health insurance, a family history of breast cancer, and previous mammography screenings were more likely to have intentions for supplemental screening. Understanding these factors is important for health systems considering widespread notification of dense breasts and discussing the benefits and harms of supplemental screening.
JOURNAL OF MEDICAL SCREENING
(2023)
Review
Oncology
Tong Li, Brooke Nickel, Preston Ngo, Kathleen McFadden, Meagan Brennan, M. Luke Marinovich, Nehmat Houssami
Summary: This systematic review examines the impact of the COVID-19 pandemic on breast cancer screening and diagnosis. The findings show a significant reduction in screening volumes and the number of diagnosed breast cancers during the pandemic, as well as an increase in the proportion of advanced stage cancer at diagnosis.
Article
Biochemistry & Molecular Biology
Gisella Figlioli, Amandine Billaud, Thomas U. Ahearn, Natalia N. Antonenkova, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Marinus J. Blok, Natalia Bogdanova, Bernardo Bonanni, Barbara Burwinkel, Nicola J. Camp, Archie Campbell, Jose E. Castelao, Melissa H. Cessna, Stephen J. Chanock, Kamila Czene, Peter Devilee, Thilo Doerk, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Anna Gonzalez-Neira, Felix Grassmann, Pascal Guenel, Melanie Gundert, Andreas Hadjisavvas, Eric Hahnen, Per Hall, Ute Hamann, Patricia A. Harrington, Wei He, Peter Hillemanns, Antoinette Hollestelle, Maartje J. Hooning, Reiner Hoppe, Anthony Howell, Keith Humphreys, Agnes Jager, Anna Jakubowska, Elza K. Khusnutdinova, Yon-Dschun Ko, Vessela N. Kristensen, Annika Lindblom, Jolanta Lissowska, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Dimitrios Mavroudis, William G. Newman, Nadia Obi, Mihalis Panayiotidis, Muhammad U. Rashid, Valerie Rhenius, Matti A. Rookus, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Mitul Shah, Reijo Sironen, Melissa C. Southey, Maija Suvanto, Rob A. E. M. Tollenaar, Ian Tomlinson, Therese Truong, Lizet E. van der Kolk, Elke M. van Veen, Barbara Wappenschmidt, Xiaohong R. Yang, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Michael Lush, Kyriaki Michailidou, Paul D. P. Pharoah, Qin Wang, Muriel A. Adank, Marjanka K. Schmidt, Irene L. Andrulis, Jenny Chang-Claude, Heli Nevanlinna, Georgia Chenevix-Trench, D. Gareth Evans, Roger L. Milne, Paolo Radice, Paolo Peterlongo
Summary: Evidence from the BRIDGES study suggests that germline protein truncating variants (PTVs) in FANCM are associated with increased risk of ER-negative and triple-negative breast cancer (TNBC), particularly for those with a family history. This study further investigates the association between FANCM missense variants (MVs) and breast cancer risk using the BRIDGES study, analyzing a total of 689 MVs. The results indicate that FANCM MVs may be low/moderate risk factors for ER-negative and TNBC subtypes of breast cancer.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Environmental Sciences
Tanvi Pandya, Zixuan Liu, Hankiz Dolan, Jolyn Hersch, Meagan Brennan, Nehmat Houssami, Brooke Nickel
Summary: This study examined women's responses and intentions if notified that they had dense breasts. The results showed that half of the women would feel a little anxious, while 29.5% would not feel anxious. The most common responses were to consult their doctor for information/advice and considering supplemental screening.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Editorial Material
Oncology
Alberto Stefano Tagliafico, Nehmat Houssami
Article
Ethics
Yves Saint James Aquino, Stacy M. Carter, Nehmat Houssami, Annette Braunack-Mayer, Khin Than Win, Chris Degeling, Lei Wang, Wendy A. Rogers
Summary: This study examines strategies to mitigate algorithmic bias in healthcare AI and investigates the question of responsibility for bias. The findings reveal divergent views on bias as a problem, strategies to mitigate bias, and whether to include sociocultural identifiers in AI development. The study suggests interdisciplinary collaboration, tailored engagement activities, empirical studies, participatory methods, and increased diversity and inclusion as potential responses.
JOURNAL OF MEDICAL ETHICS
(2023)
Article
Public, Environmental & Occupational Health
Brooke Nickel, Josephine Armiger, Christobel Saunders, Wendy Vincent, Rachael H. Dodd, Anthea Temple, Nalini Bhola, Angela Verde, Nehmat Houssami
Summary: This study aimed to explore current knowledge, understanding and experience of potentially modifiable risk factors for breast cancer, and views on current and future communication strategies for this information and related interventions. The findings showed limited general knowledge of risk factors for breast cancer, particularly in relation to modifiable factors such as alcohol consumption and postmenopausal obesity. However, women overwhelmingly believed that information on modifiable risk factors for breast cancer should be communicated more widely.
Article
Medicine, General & Internal
M. Luke Marinovich, Elizabeth Wylie, William Lotter, Helen Lund, Andrew Waddell, Carolyn Madeley, Gavin Pereira, Nehmat Houssami
Summary: In this study, the accuracy of artificial intelligence (AI) was compared with radiologists in breast cancer screening. The AI algorithm showed a lower AUC compared to radiologists. However, AI detected interval cancers that were missed by radiologists.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Cozzi, Giovanni Di Leo, Nehmat Houssami, Fiona J. Gilbert, Thomas H. Helbich, Marina Alvarez Benito, Corinne Balleyguier, Massimo Bazzocchi, Peter Bult, Massimo Calabrese, Julia Camps Herrero, Francesco Cartia, Enrico Cassano, Paola Clauser, Marcos de Lima F. Docema, Catherine Depretto, Valeria Dominelli, Gabor Forrai, Rossano Girometti, Steven E. Harms, Sarah Hilborne, Raffaele Ienzi, Marc B. I. Lobbes, Claudio Losio, Ritse M. Mann, Stefania Montemezzi, Inge-Marie Obdeijn, Umit A. Ozcan, Federica Pediconi, Katja Pinker, Heike Preibsch, Jose L. Raya Povedano, Carolina Rossi Saccarelli, Daniela Sacchetto, Gianfranco P. Scaperrotta, Margrethe Schlooz, Botond K. Szabo, Donna B. Taylor, Ozden S. Ulus, Mireille Van Goethem, Jeroen Veltman, Stefanie Weigel, Evelyn Wenkel, Chiara Zuiani, Francesco Sardanelli
Summary: This study aimed to investigate the mastectomy and reoperation rates in breast cancer patients who underwent MRI for screening or diagnostic purposes. The results showed that patients who had MRI for screening had higher mastectomy rates and lower reoperation rates compared to those who had MRI for diagnostic purposes.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
M. E. Brennan, K. Bell, G. Hamid, J. Gilchrist, J. Gillingham
Summary: Shame can be experienced in various clinical settings during breast cancer treatment, from the scrutiny of the naked body to comments from healthcare professionals. This study collected anonymous stories from individuals with a lived experience of breast cancer and identified themes related to shame experiences. The findings highlight the profound impact of shame and emphasize the need for strategies to support patients and educate healthcare professionals in order to reduce harm associated with cancer treatment.