Article
Surgery
Ayat Elsherif, Mary Freyvogel Ramirez, Edwina C. Moore, Jill R. Dietz, Chao Tu, Stephanie A. Valente
Summary: The risk of recurrence after mastectomy for DCIS is low and appears to be unrelated to margin status or the use of radiation therapy.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Biology
Naoko Shimizu, Miyako Myojin, Motoshi Tamura, Noriaki Nishiyama, Katsushige Yamashiro, Yuichi Yuyama, Yutaka Okazaki, Yasuhiro Suzuki, Masato Takahashi
Summary: The study indicates that boost RT can independently decrease the risk of IBTR in margin-free IDC with DCIS component. Additionally, LRFS rates differ significantly between age groups, with younger patients having lower rates.
JOURNAL OF RADIATION RESEARCH
(2022)
Editorial Material
Oncology
Lindsey R. R. Fauveau, Tuoc N. N. Dao, Lucy B. B. Wallace, Mufaddal K. K. Mamawala, Ala Obaid, Anthony C. C. Waddimba, Michael D. D. Grant
Summary: This study analyzed the factors associated with positive surgical margins in patients with DCIS following BCS, focusing on histologic grade and ER status. The results showed that tumor size and ER negativity were significantly associated with positive margins, suggesting that modifying the surgical approach could reduce the risk of positive margins in patients with large-sized ER negative DCIS.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Matthew F. Gong, William T. Li, Sumail Bhogal, Brittany Royes, Tanya Heim, Maria Silvaggio, Marcus Malek, Rajeev Dhupar, Stella J. Lee, Richard L. McGough, Kurt R. Weiss
Summary: Soft tissue sarcomas (STS) are rare malignant tumors associated with poor outcomes and high local recurrence rates. Indocyanine green (ICG) has shown efficacy for intraoperative margin assessment in breast and gastrointestinal cancers. This study presents an ongoing clinical study implementing ICG intraoperative margin assessment in patients with STS. ICG margins matched permanent pathology margins in 56% of patients, with 22% sensitivity and 89% specificity. Larger sample sizes are needed to further evaluate the optimal dosage, timing, and impact on different histological subtypes of STS.
Article
Otorhinolaryngology
Kenric Tam, Shan Huang, Laith Mukdad, Yazeed Alhiyari, Jeffrey Krane, Ramesh Shori, Oscar Stafsudd, Maie St. John
Summary: Obtaining negative surgical cancer margins is crucial for long-term survival in oral cavity squamous cell carcinoma patients. The use of dynamic optical contrast imaging (DOCI) provides a real-time intraoperative tool that can quickly and accurately distinguish cancer from healthy tissues, improving surgical outcomes and overall survival.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Joshua Kong, Sudeshna Bandyopadhyay, Wei Chen, Faisal Al-Mufarrej, Lydia Choi, Mary A. Kosir
Summary: Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer with a poor survival rate. Intraoperative frozen section analysis (FSA) can decrease the number of positive margins in IBC patients undergoing modified radical mastectomy (MRM), potentially reducing the need for re-operation, allowing immediate wound closure, and preventing delays in adjuvant radiation therapy.
Article
Pharmacology & Pharmacy
W. -D. Lin, L. -N. Ye, Z. -S. Song, K. -P. Wang, Y. -F. Feng, C. -Y. Pan
Summary: This study conducted a systematic review on surgical margins in HCC patients. The results showed that a wide surgical margin significantly improves patient prognosis, and predicting the progression of MVI in liver cancer can help with preoperative decision-making.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Dermatology
Wei Chen, Zhen-ru Liu, Yuan Zhou, Meng-xi Liu, Xiao-qing Wang, Da-guang Wang
Summary: This study investigates the diagnostic value of dermoscopy in defining the tumor margin of basal cell carcinoma (BCC) and determines the appropriate surgical margin. The results show that dermoscopy is superior to visual inspection in defining the tumor margin of BCC and can guide the delineation of surgical margin.
DERMATOLOGIC THERAPY
(2022)
Article
Surgery
Biqi Zhang, Grace C. Lee, Motaz Qadan, Zhi Ven Fong, Mari Mino-Kenudson, Vikram Desphande, Giuseppe Malleo, Laura Maggino, Giovanni Marchegiani, Roberto Salvia, Aldo Scarpa, Claudio Luchini, Lucia De Gregorio, Cristina R. Ferrone, Andrew L. Warshaw, Keith D. Lillemoe, Claudio Bassi, Carlos Fernandez-del Castillo
Summary: Complete, tumor-free resection at the pancreatic neck, achieved either en-bloc or non-en-bloc, is associated with improved survival in pancreatic ductal adenocarcinoma patients, without increased perioperative morbidity or mortality.
Review
Biochemical Research Methods
Ghayathri Balasundaram, Christoph Krafft, Ruochong Zhang, Kapil Dev, Renzhe Bi, Mohesh Moothanchery, Juwrgen Popp, Malini Olivo
Summary: Breast conserving surgery is popular but incomplete tumor removal may require reoperation. Biophotonic technologies are evolving to be an intraoperative tool for assessing breast cancer surgical margins.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Oncology
Yasunori Minami, Tomohiro Minami, Kazuomi Ueshima, Yukinobu Yagyu, Masakatsu Tsurusaki, Takuya Okada, Masatoshi Hori, Masatoshi Kudo, Takamichi Murakami
Summary: The study evaluated the clinical feasibility of CT/MRI fusion application for ablative margin assessment in radiofrequency ablation for hepatocellular carcinoma. The overlay fused imaging technology showed high accuracy in evaluating HCC ablative margins, which could be crucial in preventing local tumor progressions due to initial misjudgments.
Review
Otorhinolaryngology
Ye Beibei, Yang Rong, Yan Yunfei, Zhang Wenchao
Summary: The status of surgical margins is closely related to the prognosis of laryngeal carcinoma, with patients with positive margins showing higher rates of recurrence and metastasis. Patients with abnormal molecular margin results post-surgery also require special attention, and further large sample studies are needed to establish molecular margin detection markers.
ENT-EAR NOSE & THROAT JOURNAL
(2021)
Article
Otorhinolaryngology
James Fowler, Yael Campanile, Andrew Warner, Francisco Laxague, Naif Fnais, Kevin Fung, Adrian Mendez, Danielle MacNeil, John Yoo, David Palma, Anthony Nichols
Summary: The study found that in head and neck surgery, patients with margins greater than 1 mm had similar local recurrence and overall survival rates compared to patients with margins greater than 5 mm, while patients with margins less than 1 mm showed worse survival outcomes.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Peter A. Brennan, Flavia Dylgjeri, Ricardo D. Coletta, Gururaj Arakeri, Alexander M. Goodson
Summary: There are various prognostic indicators used to predict tumor recurrence and overall prognosis in oral squamous cell carcinoma (OSCC), with the width of excision margins being an important factor. However, there is still conflicting data in the literature about the ideal margin width for this cancer.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zengjie Wu, Qing Lin, Haibo Wang, Guanqun Wang, Guangming Fu, Tiantian Bian
Summary: The study developed a radiomics nomogram based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to accurately differentiate between ductal carcinoma in situ with microinvasion (DCISM) and pure ductal carcinoma in situ (DCIS) breast cancer. The radiomics signature and nomogram model showed better performance in calibration and validation compared to the clinical factor model, indicating good potential for clinical utility.
ACADEMIC RADIOLOGY
(2023)
