Article
Biochemistry & Molecular Biology
Qiao-Yun Li, Yi-Wen Duan, Yao-Hui Zhou, Shao-Xia Chen, Yong-Yong Li, Ying Zang
Summary: The study reveals the involvement of Piezo1 and NLRP3 in the pain-processing role of the anterior cingulate cortex in peripheral nerve injury. It suggests that NLRP3 may be a key factor in causing Piezo1 upregulation, leading to an imbalance in ACC excitation and inhibition and facilitating spinal pain transmission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Thomas Prevot, Etienne Sibille
Summary: Cognitive dysfunctions are a common occurrence in depression, other psychiatric disorders, and aging, potentially linked to altered GABA activity, specifically involving a decrease in the function of SST+ GABA neurons, leading to cognitive impairments.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
Maria L. Serradas, Valentin Stein, Anne-Kathrin Gellner
Summary: Chronic stress is a major risk factor for mental illnesses and cognitive deficiencies. This study establishes a connection between chronic social defeat stress and impaired motor learning abilities in mice. Structural changes in the interneuronal circuits of the primary motor cortex were observed, suggesting a role in controlling excitatory output and spine dynamics.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Yiwen Duan, Qiaoyun Li, Yaohui Zhou, Shaoxia Chen, Yongyong Li, Ying Zang
Summary: The hyperexcitability of the anterior cingulate cortex (ACC) is associated with the development of chronic pain. Disinhibition of the ACC, which may be caused by dysfunction of inhibitory parvalbumin (PV)-expressing interneurons (PV-INs), is one of the key factors contributing to ACC hyperexcitation. However, the molecular mechanism underlying ACC PV-INs injury is still unclear. This study demonstrates that nerve injury induces an imbalance in the excitatory and inhibitory activity of the ACC. The upregulation of tumor necrosis factor-alpha (TNF-alpha) in the ACC after nerve injury activates necroptosis and contributes to PV-INs damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Miao Li, David Cabrera-Garcia, Michael C. Salling, Edmund Au, Guang Yang, Neil L. Harrison
Summary: The prefrontal cortex (PFC) is crucial for behavior control, especially vulnerable to the impact of alcohol. Alcohol can dose-dependently alter the activity of SST INs in the PFC, leading to disinhibition and potential enhanced activity in other neurons.
Article
Biology
Hannah Twarkowski, Victor Steininger, Min Jae Kim, Amar Sahay
Summary: Memories encoded in the DG-CA3 circuit of the hippocampus play a crucial role in memory consolidation. By enhancing the neural circuitry between the CA1 and DG regions, the formation and maintenance of context-associated neuronal ensembles are facilitated, leading to improved long-term contextual fear memory. These findings provide important insights into the neural mechanisms of memory consolidation.
Article
Biology
Shu Liu, Heung Yan Wong, Li Xie, Zafar Iqbal, Zhuogui Lei, Zhongqi Fu, Yuk Yan Lam, Aruna Surendran Ramkrishnan, Ying Li
Summary: Background schema is formed through the neural circuit between the anterior cingulate cortex (ACC) and hippocampus (HPC). The recruitment of CA1-ACC projection neurons decreases gradually while ACC neurons show a peak of excitation in the middle stage of schema establishment. Activation of CA1 astrocytes disrupts the development of memory schema and inhibits the assimilation of new information.
Article
Neurosciences
Emma C. Utagawa, David G. Moreno, Kristian T. Schafernak, Nicoleta C. Arva, Michael H. Malek-Ahmadi, Elliott J. Mufson, Sylvia E. Perez
Summary: The study revealed the impact of trisomy 21 on postnatal cortical development, including alterations in neuronal migration, neurogenesis, and cellular lamination, which may contribute to cognitive impairment.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Neurosciences
Dwight F. Newton, Hyunjung Oh, Rammohan Shukla, Keith Misquitta, Corey Fee, Mounira Banasr, Etienne Sibille
Summary: This study investigated the transcriptomic effects of chronic stress on microcircuit cell types in the medial prefrontal cortex of mice. The results showed changes in behavior, dysregulation of gene expression, and reorganization of synaptic connections across different cell types, suggesting a shift in the regulation of cortical excitation-inhibition balance.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Weida Shen, Zijing Li, Yejiao Tang, Pufan Han, Feng Zhu, Jingyin Dong, Tianyu Ma, Kai Zhao, Xin Zhang, Yicheng Xie, Ling-Hui Zeng
Summary: It has been demonstrated that activation of hippocampal SOM-INs can influence excitatory synaptic transmission by activating astrocytic GABA(B)Rs, thereby modulating neuronal network activity.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Neurosciences
Chiwoo Lee, Jihae Oh, Jae-Hyung Lee, Bong-Kiun Kaang, Hyoung-Gon Ko
Summary: Itch is a distinct sensation that triggers a specific emotional and scratching response. The anterior cingulate cortex (ACC) has been associated with itch sensation, but its exact role in processing pruritic inputs is unclear. This study used in vivo calcium imaging to observe the reaction of ACC neurons in free-moving mice to pruritogenic histamine. The overall activity of itch-responsive neurons promptly decreased after the scratching response, suggesting that the ACC does not directly elicit the feeling of itchiness.
Article
Clinical Neurology
Mikael Tiger, Martin Garde, Amane Tateno, Granville J. Matheson, Takeshi Sakayori, Tsuyoshi Nogami, Hiroki Moriya, Katarina Varnas, Ryosuke Arakawa, Yoshiro Okubo
Summary: This study investigated the effect of Electroconvulsive therapy (ECT) on 5-HT1B receptor binding in patients with major depressive episodes. The results showed a significant increase in 5-HT1B receptor binding in the hippocampus after ECT, with strong correlations between changes in receptor binding and agitation scores on the Hamilton Depression Rating Scale.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemical Research Methods
Frank Mazza, Alexandre Guet-McCreight, Taufik A. Valiante, John D. Griffiths, Etay Hay
Summary: By simulating the activity of human cortical microcircuits and EEG signals, researchers found that individuals with depression showed increased frequency and power in their EEG, which can serve as biomarkers for different subtypes of depression and non-invasively monitor cortical inhibition modulation.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Neurosciences
Da-Yu Zhu, Ting-Ting Cao, Hong-Wei Fan, Ming-Zhe Zhang, Hao-Kai Duan, Jing Li, Xia-Jing Zhang, Yun-Qing Li, Pan Wang, Tao Chen
Summary: Chronic pain disrupts the balance between excitation and inhibition in the sensory cortex, leading to the development of pain hypersensitivity.
Article
Cardiac & Cardiovascular Systems
Hideaki Inazumi, Koichiro Kuwahara, Yasuaki Nakagawa, Yoshihiro Kuwabara, Takuro Numaga-Tomita, Toshihide Kashihara, Tsutomu Nakada, Nagomi Kurebayashi, Miku Oya, Miki Nonaka, Masami Sugihara, Hideyuki Kinoshita, Kenji Moriuchi, Hiromu Yanagisawa, Toshio Nishikimi, Hirohiko Motoki, Mitsuhiko Yamada, Sachio Morimoto, Kinya Otsu, Richard M. Mortensen, Kazuwa Nakao, Takeshi Kimura
Summary: NRSF is a transcriptional repressor that suppresses the reactivation of fetal cardiac gene program and maintains cardiac integrity. This study reveals that NRSF regulates ventricular function by controlling the expression of G alpha(o) gene, and excessive expression of G alpha(o) leads to cardiac dysfunction. Additionally, G alpha(o) plays a critical role in cardiac Ca2+ homeostasis and systolic function.
CIRCULATION RESEARCH
(2022)