Article
Biology
John C. O'Donnell, Erin M. Purvis, Kaila V. T. Helm, Dayo O. Adewole, Qunzhou Zhang, Anh D. Le, D. Kacy Cullen
Summary: The Tissue-Engineered Rostral Migratory Stream (TE-RMS) developed by O'Donnell et al. uses astrocyte-like cells derived from adult gingival stem cells to facilitate directed migration of immature neurons and redirect neuroblast migration in athymic rat brains, offering a promising new approach to neuroregenerative medicine.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nobuhiro Kurabayashi, Kazuki Fujii, Yuta Otobe, Shingo Hiroki, Masaharu Hiratsuka, Hikari Yoshitane, Yasuhiro Kazuki, Keizo Takao
Summary: Through studying the TcMAC21 mouse model, we found that it exhibits similar brain developmental abnormalities as individuals with Down syndrome (DS), making it a valuable model for investigating the causes of intellectual disability in DS individuals.
Article
Biochemistry & Molecular Biology
Dimitrios Troumpoukis, Andreas Rafail Vasileiou, Nikistratos Siskos, Electra Stylianopoulou, Petros Ypsilantis, George Skavdis, Maria E. Grigoriou, Igor Jakovcevski, Fabio Di Domenico
Summary: In this study, the expression of Abracl in the embryonic brain was characterized using double immunofluorescence. The results showed that Abracl protein had a broader expression domain compared to mRNA, including proliferating cells, post-mitotic cells, and migrating interneurons.
Article
Neurosciences
Joseph Cichon, Andrzej Z. Wasilczuk, Loren L. Looger, Diego Contreras, Max B. Kelz, Alex Proekt
Summary: This study demonstrates that ketamine can cause a switch in the active population of excitatory neurons in the cortical layers, which leads to impairments in sensory processing and dissociative-like state. These findings provide insights into how the brain can become disconnected from the environment while maintaining internal subjective experiences.
NATURE NEUROSCIENCE
(2023)
Article
Cell Biology
Maijia Liao, Alex D. Bird, Hermann Cuntz, Jonathon Howard
Summary: This study found that the subtree size distribution of neurons follows power laws, indicating scale invariance as a characteristic of optimal morphology.
Review
Multidisciplinary Sciences
Liqun Luo
Summary: While individual neurons are the building blocks of the nervous system, they function by collaborating in neuronal circuits with specific patterns of synaptic connectivity. Understanding how these circuits assemble and evolve can help bridge the gap between individual neuron biology and brain function, leading to insights into neural computations and behavior.
Article
Cell Biology
Greta Limoni, Sahana Murthy, Denis Jabaudon, Alexandre Dayer, Mathieu Niquille
Summary: Deep-layer inhibitory interneurons (INs) in the mammalian cerebral cortex control the laminar allocation of 5-HT receptor 3a-expressing (HTR3A(+)) cortical INs (hlNs) by secreting Semaphorin3A (SEMA3A).
Article
Neurosciences
Nicoletta Kessaris, Myrto Denaxa
Summary: Inhibition in the mammalian cerebral cortex is regulated by a small population of diverse GABAergic interneurons. These local neurons play a crucial role in the formation and function of cortical circuits. Recent findings and new technologies are advancing our understanding of the diversity and development of inhibitory neurons. This knowledge is essential for stem cell therapy and correcting human disorders involving inhibitory dysfunction.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Review
Cell Biology
Melanie V. Brady, Flora M. Vaccarino
Summary: Human neurodevelopment has historically been complex to decipher, but utilizing organoid systems provides a unique opportunity to model human development and disease, shedding light on the intricacies of neural biology.
Article
Biochemistry & Molecular Biology
Fabiola Pacheco Valencia, Amanda F. Marino, Christos Noutsos, Kinning Poon
Summary: Prenatal exposure to a high-fat diet increases hypothalamic neurogenesis events in embryos and programs the offspring to be prone to obesity. This study investigates the effects of oleic and palmitic acids, abundant in a high-fat diet, on the hypothalamic neuronal transcriptome and how these changes affect neurogenesis events. The results show that oleic acid stimulates proliferation and palmitic acid stimulates apoptosis in hypothalamic neurons, with both fatty acids impacting migration. Potential signaling pathways affected by these fatty acids are also uncovered.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Behavioral Sciences
Carmela Matrone, Gabriella Ferretti
Summary: Autism spectrum disorder (ASD) is a pervasive disorder characterized by difficulties in social communication and repetitive behaviors. The causes of ASD are still not fully understood despite numerous hypotheses and research efforts. This review highlights the role of SEMA3A in neurodevelopment and its potential as a target for identifying unique patterns of ASD and predicting the prognosis of affected individuals.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemical Research Methods
Fikri Birey, Sergiu P. Pasca
Summary: The article presents protocols for monitoring the migration of GABAergic interneurons and network activity in forebrain assembloids. Through high-resolution imaging and analysis of neuronal migration, as well as calcium imaging of network activity, the functional characteristics of forebrain assembloids can be understood.
Article
Mathematics, Applied
Jean-Philippe Thivierge, Eloise Giraud, Michael Lynn, Annie Theberge Charbonneau
Summary: This paper proposes a new class of structured reservoir models that incorporate a diversity of cell types and their known connections. Experimental results show that the model has two distinct dynamical regimes and can be used to relay and generate chaotic Lorenz attractors.
Article
Multidisciplinary Sciences
Weipang Chang, Andrea Pedroni, Maria Bertuzzi, Caghan Kizil, Andras Simon, Konstantinos Ampatzis
Summary: The study shows that physical exercise can activate neurogenesis in the spinal cord of adult zebrafish through cholinergic neurotransmission and a reduction of GABA(A) receptors. The researchers also found that functional recovery after spinal cord injury can be promoted by stimulating cholinergic receptors and interfering with GABAergic signaling. The findings suggest a model for activity-dependent neurogenesis in the adult zebrafish spinal cord during homeostasis and regeneration.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Ana Gonzalez-Ramos, Eliska Waloschkova, Apostolos Mikroulis, Zaal Kokaia, Johan Bengzon, Marco Ledri, My Andersson, Merab Kokaia
Summary: This study demonstrates the potential for regulating human neuronal network activity by transplanting light-sensitive GABAergic interneurons. It provides a new avenue for controlling neurological disorders through precise temporal modulation of network excitability.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Melissa Barber, William D. Andrews, Fani Memi, Phillip Gardener, Daniel Ciantar, Mathew Tata, Christiana Ruhrberg, John G. Parnavelas
Article
Endocrinology & Metabolism
Sasha R. Howard, Roberto Oleari, Ariel Poliandri, Vasiliki Chantzara, Alessandro Fantin, Gerard Ruiz-Babot, Louise A. Metherell, Claudia P. Cabrera, Michael R. Barnes, Karoliina Wehkalampi, Leonardo Guasti, Christiana Ruhrberg, Anna Cariboni, Leo Dunkel
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Article
Multidisciplinary Sciences
Mathew Tata, Christiana Ruhrberg
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Multidisciplinary Sciences
James T. Brash, Christiana Ruhrberg, Alessandro Fantin
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Developmental Biology
Rachael Lumb, Mathew Tata, Xiangjun Xu, Andrew Joyce, Ceilidh Marchant, Natasha Harvey, Christiana Ruhrberg, Quenten Schwarz
Article
Multidisciplinary Sciences
Alice Plein, Alessandro Fantin, Laura Denti, Jeffrey W. Pollard, Christiana Ruhrberg
Article
Developmental Biology
Roberto Oleari, Alessia Caramello, Sara Campinoti, Antonella Lettieri, Elena Ioannou, Alyssa Paganoni, Alessandro Fantin, Anna Cariboni, Christiana Ruhrberg
Letter
Cardiac & Cardiovascular Systems
James T. Brash, Rebecca L. Bolton, Victoria S. Rashbrook, Laura Denti, Yoshiaki Kubota, Christiana Ruhrberg
CIRCULATION RESEARCH
(2020)
Article
Medicine, Research & Experimental
Raphael F. P. Castellan, Milena Vitiello, Martina Vidmar, Steven Johnstone, Dominga Iacobazzi, David Mellis, Benjamin Cathcart, Adrian Thomson, Christiana Ruhrberg, Massimo Caputo, David E. Newby, Gillian A. Gray, Andrew H. Baker, Andrea Caporali, Marco Meloni
Review
Peripheral Vascular Disease
Daniyal J. Jafree, David A. Long, Peter J. Scambler, Christiana Ruhrberg
Summary: Lymphatic vessels play critical roles in both health and disease, and research in this field is rapidly evolving. Recent studies have revealed new cellular mechanisms and diverse cell lineages involved in the formation of organ lymphatic vasculature.
Review
Peripheral Vascular Disease
Giovanni Canu, Christiana Ruhrberg
Summary: Hematopoiesis in vertebrate embryos involves multiple stages, including primitive and definitive hematopoiesis, with a shift in cell identity achieved through endothelial-to-hematopoietic transition. This process generates a variety of blood cells in the fetus and adult, with hematopoietic stem cells playing a crucial role in sustaining adult hematopoiesis. Recent studies have provided insights into the molecular mechanisms driving the hemato-endothelial transcription program for EHT, as well as the use of human pluripotent stem cells for modeling fetal hematopoiesis and regenerative medicine applications.
Article
Cell Biology
Alessandro Fantin, Carlotta Tacconi, Emanuela Villa, Elena Ceccacci, Laura Denti, Christiana Ruhrberg
Summary: This study found that KIT is crucial for transient definitive hematopoiesis in the fetal liver during mouse embryo development, but dispensable for the process of yolk sac endothelial-to-hematopoietic transition.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Elena Ceccacci, Emanuela Villa, Fabio Santoro, Saverio Minucci, Christiana Ruhrberg, Alessandro Fantin
Summary: We generated a scRNA-seq dataset from a whole mouse E12.5 liver, including all liver cell populations, to obtain a refined single cell landscape of haematopoiesis. Our findings confirm previous reports on the timing of liver colonisation by haematopoietic progenitors and the emergence of differentiated lineages, and provide further molecular characterisation. Additionally, we discovered a foetal intermediate haemoglobin profile and a previously unidentified population of primitive erythroid cells in the foetal liver.
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2023)
Article
Developmental Biology
Lynda Erskine, Urielle Francois, Laura Denti, Andy Joyce, Miguel Tillo, Freyja Bruce, Neil Vargesson, Christiana Ruhrberg
Meeting Abstract
Physiology
A. Fantin, A. Lampropoulou, V. Senatore, J. T. Brash, C. Prahst, C. A. Lange, S. E. Liyanage, C. Raimondi, J. W. Bainbridge, H. G. Augustin, C. Ruhrberg
JOURNAL OF VASCULAR RESEARCH
(2017)