Article
Biochemistry & Molecular Biology
Qinghan Ren, Guoquan Zhang, Ruiting Yan, Dezheng Zhou, Li Huang, Qianwen Zhang, Wen Li, Guowei Huang, Zhenshu Li, Jing Yan
Summary: Research has shown that folate deficiency in either parents can affect the biological functions of neural cells in offspring. This deficiency can impair the methionine cycle and lead to damage to the central nervous system. The study found that parental folate deficiency caused apoptosis of neural cells in neonatal rats, with the greatest effect seen when both parents were deficient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Ratajczak, Natalia Glatzel-Plucinska, Katarzyna Ratajczak-Wielgomas, Katarzyna Nowinska, Sylwia Borska
Summary: Resveratrol may have anticarcinogenic effects by inhibiting human pancreatic cancer cell proliferation and affecting the levels of Bcl-2 proteins. However, its activity is specific to each tested cell line, with the most significant changes observed in the mitoxantrone-resistant cells.
Article
Biochemistry & Molecular Biology
Yu-Kai Huang, Kun-Che Chang, Chia-Yang Li, Ann-Shung Lieu, Chih-Lung Lin
Summary: This study investigated the role of AKR1B1 in glioma cell proliferation and apoptosis signaling. AKR1B1 expression was measured in different cell lines and tissues. The effects of AKR1B1 overexpression or knockdown, as well as p38 MAPK activation and inhibition, were evaluated. AKR1B1 was found to regulate glioma cell proliferation through the activation of p38 MAPK and apoptosis signaling. Therefore, AKR1B1 may be a potential therapeutic target for glioma therapy.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Immunology
Shuling Zhang, Ning Liu, Mingxing Ma, Hai Huang, Mike Handley, Xueli Bai, Fengping Shan
Summary: The study demonstrated that MENK regulates the biological behavior of lung cancer cells by enhancing apoptosis and immunogenicity while promoting NK cell-driven tumor immunity, potentially inhibiting the proliferation of lung cancer cells through the activation of key signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Boglarka Balogh, Gergely Szarka, Adam J. Tengolics, Gyula Hoffmann, Bela Volgyi, Tamas Kovacs-Oller
Summary: The study found that exposure to LED light increased levels of major apoptosis-related markers and activated microglial cells and Caspase-3, suggesting that overuse of unfiltered direct LED light can have detrimental effects on human retina.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Jialin Wang, Mengjun Zhang, Xin Huang, Haodi Yue
Summary: This study investigates the potential of a novel nanomaterial, PEI-Pt NCs, as an antitumor agent in osteosarcoma. The research findings demonstrate that PEI-Pt NCs can enter osteosarcoma cells, hinder cell migration and proliferation, and promote cell apoptosis by modulating the BAX-Bcl-2/Caspase 3/PARP axis.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Chunfeng Wang, Na Wang, Na Li, Qiuying Yu, Fangyu Wang
Summary: The combination of resveratrol and vitamin E had a significant inhibitory effect on colorectal cancer cells, promoting cell apoptosis and altering the expression of apoptosis-related proteins. This study demonstrates the positive synergy of resveratrol and vitamin E in inhibiting cancer cell growth and proliferation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Abdullah Aslan, Seda Beyaz, Ozlem Gok, Gozde Parlak, Muhammed Ismail Can, Can Ali Agca, Ibrahim Hanifi Ozercan, Akif Evren Parlak
Summary: This study aimed to investigate whether royal jelly can prevent fluoride-induced brain tissue damage and explore the underlying molecular mechanisms. The results showed that royal jelly prevented brain tissue damage caused by fluoride through its antioxidant activities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Parasitology
Shanming Hu, Yanan Wang, Zhengmao Xu, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Jinlin Zhou
Summary: The study found that the transcription levels of the RhBax gene in ticks increase significantly at all developmental stages, while the transcription levels of both RhBcl-2 and RhBax increase more significantly in the female salivary glands. Inhibiting RhBcl-2 expression significantly inhibited tick feeding, while interference with RhBax had no effect on tick feeding.
PARASITES & VECTORS
(2021)
Article
Chemistry, Medicinal
Dawon Bae, Prakash Chaudhary, Jae-Hui Been, Jaya Gautam, Jisu Lee, Sajita Shah, Euijung Kim, Hyunji Lee, Tae-gyu Nam, Byeong-Seon Jeong, Jung-Ae Kim
Summary: A series of 3-arylidene-4,6-dimethyl-5-hydroxy-7-azaoxindole compounds with various functional groups were synthesized and evaluated for their antitumor activity. Compound 6-15, containing a quinoline moiety, exhibited stronger cytotoxicity than sunitinib against multiple cancer cell lines. However, it showed weaker inhibitory activity against receptor tyrosine kinases compared to sunitinib. Compound 6-15 suppressed the expression of Gas6, the ligand of Axl, and demonstrated promising anticancer effects both in vitro and in vivo.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Ka-Na Lin, Wei Zhao, Shi-Ying Huang, Hao Li
Summary: The study revealed that GSPE inhibits the proliferation of HL-60/ADR cells through induction of apoptosis in a dose-dependent manner via the Bax/Bcl-2 caspase-3/9 signaling pathway.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Z. Ahmed, Fahd A. Nasr, Wajhul Qamar, Omar M. Noman, Javed Masood Khan, Abdullah A. Al-Mishari, Ali S. Alqahtani
Summary: The study showed that janerin inhibits THP-1 cell proliferation in a dose-dependent manner by causing cell cycle arrest at the G2/M phase. Additionally, janerin promotes THP-1 cell death through apoptosis induction, which involves upregulation of pro-apoptotic markers and downregulation of anti-apoptotic marker. Furthermore, janerin treatment leads to the activation of P38-MAPK and ERK1/2 signaling pathways, suggesting its potential as a therapeutic agent for leukemia.
Article
Agriculture, Dairy & Animal Science
Reshma S. Raj, D. N. Das, S. Mondal, M. Ashokan, Lakshmi Narasimha Thota, T. Karuthadurai, Nikhil Kumar J. Tej, Kerekoppa P. Ramesha
Summary: This study aimed to analyze the expression of pro-apoptotic BAX and anti-apoptotic BCL-2 genes on lactation performance in Bos indicus and HF crossbred cows during early lactation. The results showed that BCL-2 gene promotes milk production while BAX gene opposes milk production. Bos indicus cows are more sensitive to apoptosis compared to HF crossbreds.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pavel Tregub, Natalia Malinovskaya, Elena Hilazheva, Andrey Morgun, Vladimir Kulikov
Summary: In this study, we aimed to investigate the effects of hypercapnia, alone or in combination with hypoxia, on the activation of signaling pathways related to cell apoptosis. The degree of apoptosis was evaluated in both in vivo and in vitro ischemic models. The results showed that hypercapnic component can reduce apoptosis in the ischemic penumbra, decrease the levels of caspase-3, AIF, and Bax, and increase the level of Bcl-2.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Kaiming Li, Mark F. van Delft, Grant Dewson
Summary: Apoptotic cell death plays important roles in physiological and pathological processes, especially in cancer therapy and neurodegenerative diseases. Inhibitors of apoptosis have emerged as a potential strategy to combat pathological cell loss, serving as important research tools due to their mechanisms of action, advantages, and limitations.
