Review
Medicine, General & Internal
Sidar Copur, Atalay Demiray, Mehmet Kanbay
Summary: Increased serum uric acid levels are associated with metabolic diseases such as hypertension, gout, fatty liver, chronic kidney disease, and cardiovascular diseases. Research has identified potential mechanisms involving oxidative stress, inflammation, and apoptosis in the role of uric acid.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Lu Zhang, Chi Zhang, Ze-Nan Zhuang, Chu-Xin Li, Pei Pan, Cheng Zhang, Xian-Zheng Zhang
Summary: The study introduces a novel nanoenzyme with excellent inflammation targeting and uric acid degrading properties for the treatment of gout and hyperuricemia, showing great promise in effectively and safely addressing these conditions.
SCIENCE CHINA-CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Massimo Bortolotti, Letizia Polito, Maria Giulia Battelli, Andrea Bolognesi
Summary: Human xanthine oxidoreductase (XOR) is a versatile enzyme with various activities, including purine catabolism, production of reactive oxygen species, generation of nitric oxide, and NADH oxidase activity. These activities contribute to metabolism of compounds and play a key role in inflammatory defense.
Article
Medicine, General & Internal
Rodney G. Bowden, Kathleen A. Richardson, Luke T. Richardson
Summary: This large cross-sectional study found an association between hyperuricemia and MetS. Even when controlling for other risk factors, hyperuricemia remained independently associated with MetS. These results suggest a need for a better understanding of the role of uric acid in MetS.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yannan Zhang, Huanzhen Zhang, Shengzhong Rong, Cailing Bian, Yuexin Yang, Hongzhi Pan
Summary: This study used a metabolomics approach to explore the molecular mechanism of uric acid in the development of MetS. Results showed significant alterations in 20 metabolites in both MetS and MetS & HUA patients, with MetS patients exhibiting a more severe metabolic disorder. Pathway analysis revealed perturbed metabolic pathways in both groups, contributing to a better understanding of MetS progression.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Melanie Reijrink, Stefanie A. De Boer, Anniek M. Van Roon, Riemer H. J. A. Slart, Bernadette O. Fernandez, Martin Feelisch, Hiddo J. L. Heerspink, Harry Van Goor, Jan-Luuk Hillebrands, Douwe J. Mulder
Summary: The study found a positive correlation between plasma nitrate and vegetable intake, and a negative correlation between nitrate and HOMA-IR, BMI, GGT, and CRP. After 26 weeks of linagliptin treatment with stable vegetable intake, there were no significant changes in nitrate and nitrite, TFT, adipokines, and CRP.
Article
Biochemistry & Molecular Biology
Xingxing Zhang, Xin Wu, Gengsheng Xiao, Gongliang Liu, Hao Dong, Rui Liu, Qun Lu
Summary: This study found that phenolamide extract (PAE) from apricot bee pollen has a significant weight loss effect on obese mice fed a high-fat diet. PAE can reduce weight gain and lipid accumulation, improve glucose tolerance, reduce insulin resistance, and improve lipid metabolism. In addition, PAE can regulate the gut microbiota and metabolites. This study suggests that PAE can be used as a functional dietary supplement to alleviate HFD-induced obesity.
Article
Medicine, General & Internal
Xinwen Yu, Fei Sun, Jie Ming, Shengru Liang, Wencheng Zhang, Li Wang, Qiaoyue Li, Qian Xu, Lei Shi, Bin Gao, Qiuhe Ji
Summary: The levels of serum uric acid (UA) and the ratio of high-density lipoprotein cholesterol (HDL-C) to UA were found to be significantly correlated with the components of metabolic syndrome (MetS) in nondiabetic men, particularly with waist circumference and triglyceride. The ratio of UA to HDL-C can serve as a reliable marker for identifying high-risk populations for MetS in nondiabetic men, especially in younger adults.
POSTGRADUATE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Li Liu, Yuhan Shao, Xiaojing Li, Jianping Sun, Dongming Xing
Summary: The study found that alanine aminotransferase (ALT) and serum uric acid (SUA) were associated with metabolic syndrome (MetS), and the combined elevation of ALT and SUA levels increased the risk of developing MetS and its components.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Endocrinology & Metabolism
Shuai Zheng, Min Shen, Yu Qian, Shushu Li, Yang Chen, Hemin Jiang, Hui Lv, Doudou Chen, Ruiling Zhao, Xuqin Zheng, Min Sun, Tao Yang, Yun Shi, Qi Fu
Summary: This study aimed to evaluate the roles of GDF-15, adiponectin, and GDF-15/adiponectin ratio as biomarkers for detecting metabolic syndrome. The results suggest that the G/A ratio and adiponectin are potential biomarkers for detecting metabolic syndrome in women and men, respectively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Analytical
Fangying Shi, Jie Zhou, Yonglei Wu, Xufang Hu, Qionghong Xie, Chunhui Deng, Nianrong Sun
Summary: In this study, a novel matrix based on metal oxide hierarchical heterojunctions is proposed for extracting urine metabolic fingerprints, enabling accurate diagnosis and prognosis evaluation of primary nephrotic syndrome. Additionally, a high-confidence marker panel for PNS diagnosis is constructed, shedding light on mechanism exploration and pathway analysis. This work drives the application of metabolomics toward precision medicine.
ANALYTICAL CHEMISTRY
(2022)
Article
Genetics & Heredity
Aecio A. Braga, Raul H. Bortolin, Magda E. Graciano-Saldarriaga, Thiago D. C. Hirata, Alvaro Cerda, Renata C. C. de Freitas, Hui T. Lin-Wang, Jessica B. Borges, Joao I. D. Franca, Laureane N. Masi, Rui Curi, Tania C. Pithon-Curi, Marcelo F. Sampaio, Lara R. Castro, Gisele M. Bastos, Rosario D. C. Hirata, Mario H. Hirata
Summary: This study aimed to explore the association of circulating miRNAs with obesity, metabolic alterations, and inflammation in patients with MetS. Seven miRNAs were found to be dysregulated in MetS patients, with miR-421 being associated with a high risk of MetS, insulin resistance, and hypertension. Circulating miR-421 may serve as a potential biomarker for insulin resistance, metabolic dysregulation, and inflammatory status in MetS patients.
Review
Physiology
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi
Summary: Hyperuricemia, characterized by elevated serum uric acid levels, is linked to the development of cardiometabolic disorders through induction of endothelial dysfunction. The mechanism involves interference with insulin signaling and reduced NO availability, leading to endothelial insulin resistance. This can result in impaired endothelial function, NO-dependent vasodilation, and systemic insulin resistance, which can potentially be improved with UA-lowering drugs.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jie Zhang, Wenyan Sun, Fei Gao, Jie Lu, Kelei Li, Yijun Xu, Yushuang Li, Changgui Li, Ying Chen
Summary: This study aimed to explore the relationship between the changes in SUA level and free glucocorticoids and inflammatory factors in acute and remission stages of gouty arthritis. A total of 50 acute gout patients were included in a prospective study. Results showed that SUA levels were significantly reduced during the acute flare, while 24-hour fractional excretion of uric acid and 24-hour urinary uric acid excretion increased significantly. The percent change in SUA was associated with changes in 24-hour fractional excretion of uric acid and C-reactive protein, while the percent change in 24-hour urinary uric acid excretion was associated with changes in 24-hour urinary free cortisol, interleukin 1 beta, and interleukin 6.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Katie E. Cohen, Boran Katunaric, Mary E. Schulz, Gopika SenthilKumar, Micaela S. Young, James E. Mace, Julie K. Freed
Summary: This study found that chronic administration of exogenous adiponectin can restore nitric oxide as the mediator of flow-induced dilation in arterioles from patients with coronary artery disease. The Adiponectin Receptor 1 (AdipoR1) plays a critical role in adiponectin-induced NO signaling during shear. Additionally, osmotin, a plant-derived protein, showed similar effects to adiponectin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Beatriz Piantoni Goncalves, Tamires Flauzino, Claudia Junko Inoue, Jaqueline Costa Castardo de Paula, Talita Cristina Galvao, Camila Cataldi de Alcantara, Paula Kikuchi Miyazaki, Lucilene Rosa, Silva Westmore, Marcell Alysson Batisti Lozovoy, Edna Maria Vissoci Reiche, Andrea Name Colado Simao
Summary: The study evaluated the IL6 genetic variants and their association with inflammatory bowel diseases (IBDs), disease activity, and response to TNF-alpha inhibitors. The G/C haplotype was associated with susceptibility to UC and endoscopic activity of CD. However, these IL6 variants did not predict the response to TNF-alpha inhibitor therapy.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Oncology
P. L. Micheletti, J. Carla-da-Silva, T. B. Scandolara, R. Kern, V. D. Alves, J. Malanowski, V. J. Victorino, A. C. S. A. Herrera, D. Rech, J. A. O. Souza, A. N. C. Simao, C. Panis, I. Dichi
Summary: This study examined markers of cardiac damage, inflammatory markers, and lipid profiles in breast cancer patients undergoing different chemotherapy regimens. The results showed that different drugs induced specific changes in the biomarkers, which could be associated with cardiac toxicity.
JOURNAL OF CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Nicole Perugini Stadtlober, Tamires Flauzino, Lorena Flor da Rosa Franchi Santos, Tatiana Mayumi Veiga Iriyoda, Neide Tomimura Costa, Marcell Alysson Batisti Lozovoy, Isaias Dichi, Edna Maria Vissoci Reiche, Andrea Name Colado Simao
Summary: The study evaluated the association of rs2232365 and rs3761548 FOXP3 variants with SLE susceptibility, autoantibodies, disease activity, and nephritis, finding that certain genotypes and haplotypes were linked to these aspects of the disease. The data suggest that the G/C haplotype may be protective against SLE, while the presence of allele A of these variants could contribute to autoimmunity, disease activity, and LN.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Ligia Aparecida Trintin Cannarella, Naiara Lourenco Mari, Camila Cataldi Alcantara, Tatiana Mayumi Veiga Iryioda, Neide Tomimura Costa, Sayonara Rangel Oliveira, Marcell Alysson Batisti Lozovoy, Edna Maria Vissoci Reiche, Isaias Dichi, Andrea Name Colado Simao
Summary: The study indicated that probiotics have beneficial effects on inflammation and oxidative stress in RA patients, including reducing white blood cell count and inflammatory cytokine levels, and improving oxidative/nitrosative stress markers.
Article
Immunology
Nicole Perugini Stadtlober, Tamires Flauzino, Lorena Flor da Rosa Franchi Santos, Tatiana Mayumi Veiga Iriyoda, Neide Tomimura Costa, Marcell Alysson Batisti Lozovoy, Edna Maria Vissoci Reiche, Andrea Name Colado Simao
Summary: The study showed that certain TGFB1 variants are associated with SLE susceptibility and disease activity, with the TGFB1 + 869 CC genotype linked to decreased C4 levels and TGF-beta 1 levels. Additionally, patients with the TGFB1 + 869 TC and CC genotypes had lower TGF-beta 1 levels compared to those with the TT genotype when positive for anti-dsDNA.
Article
Medicine, Research & Experimental
Ana Lucia Cruz Furstenberger Lehmann, Daniela Frizon Alfieri, Maria Caroline Martins de Araujo, Emanuelle Roberto Trevisani, Maisa Rocha Nagao, Francisco Spessatto Pesente, Jair Roberto Gelinski, Leonardo Bodner de Freitas, Tamires Flauzino, Marcio Francisco Lehmann, Marcell Alysson Batisti Lozovoy, Jose Wander Bregano, Andrea Name Colado Simao, Michael Maes, Edna Maria Vissoci Reiche
Summary: This study evaluated the prognostic validity of a combination of clinical, imaging, and laboratory biomarkers in predicting 1-year mortality of IS, finding that non-survivors showed significant differences in multiple indicators including IS severity, carotid intima-media thickness, coagulation factors, and inflammatory factors.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Tatiana Mayumi Veiga Iriyoda, Tamires Flauzino, Neide Tomimura Costa, Marcell Alysson Batisti Lozovoy, Edna Maria Vissoci Reiche, Andrea Name Colado Simao
Summary: The study evaluated the association between TGFB1 gene variants and susceptibility, disease activity, and other factors in rheumatoid arthritis (RA) patients. The findings suggest that the TGFB1 + 869 T > C and -509 C > T variants are not associated with RA susceptibility but can predict disease activity in different patient subgroups. Additionally, the interaction between the TGFB1 + 869 T > C variant and autoantibodies may modulate TGF-beta 1 plasma levels in RA patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Taylon Felipe Silva, Manoela Daiele Goncalves, Virginia Marcia Concato, Bruna Taciane da Silva Bortoleti, Fernanda Tomiotto-Pellissier, Raquel Arruda Sanfelice, Ana Carolina Jacob Rodrigues, Mariana Barbosa Detoni, Andrea Name Colado Simao, Luiz Antonio Custodio, Tania Longo Mazzuco, Idessania Nazareth da Costa, Milena Menegazzo Miranda-Sapla, Wander Rogerio Pavanelli, Ivete Conchon-Costa
Summary: The study found that peripheral blood mononuclear cells (PBMC) from diabetic patients are more susceptible to L. amazonensis infection and fail to control the infection over time due to an inability to generate effector microbicidal molecules, which results in oxidative stress and dysregulated inflammatory response.
IMMUNOLOGY LETTERS
(2021)
Article
Endocrinology & Metabolism
Ana Lucia Cruz Furstenberger Lehmann, Daniela Frizon Alfieri, Maria Caroline Martins de Araujo, Emanuelle Roberto Trevisani, Maisa Rocha Nagao, Francisco Spessatto Pesente, Jair Roberto Gelinski, Leonardo Bodner de Freitas, Tamires Flauzino, Marcio Francisco Lehmann, Marcell Alysson Batisti Lozovoy, Jose Wander Bregano, Andrea Name Colado Simao, Michael Maes, Edna Maria Vissoci Reiche
Summary: This study highlights that poor prognosis in IS patients is related to carotid stenosis, type 2 diabetes mellitus, and NIHSS, while short-term mortality is closely associated with cIMT, NIHSS, and age. High values of cIMT and NIHSS at admission strongly predict short-term functional impairment as well as mortality three months after IS.
METABOLIC BRAIN DISEASE
(2021)
Article
Nutrition & Dietetics
Elis C. S. Fatel, Flavia T. Rosa, Daniela F. Alfieri, Tamires Flauzino, Bruna M. Scavuzzi, Marcell A. B. Lozovoy, Tatiana M. V. Iriyoda, Andrea N. C. Simao, Isaias Dichi
Summary: The study indicates that consuming cranberry juice in conjunction with fish oil supplementation can reduce disease activity and inflammatory markers in people with rheumatoid arthritis.
Article
Multidisciplinary Sciences
Paulo Sergio da Silva Santos, Bernardo da Fonseca Orcina, Rafael Rahal Guaragna Machado, Fabiano Vieira Vilhena, Lucas Marques da Costa Alves, Mariana Schutzer Ragghianti Zangrando, Rodrigo Cardoso de Oliveira, Mariana Quirino Silveira Soares, Andrea Name Colado Simao, Emilene Cristine Izu Nakamura Pietro, Juliana Pescinelli Garcia Kuroda, Ivanilda Aparecida de Almeida Benjamim, Danielle Bastos Araujo, Sergio Hiroshi Toma, Lourival Flor, Koiti Araki, Edison Luiz Durigon
Summary: The study found that using a mouthwash containing a compound with antiviral effects against SARS-CoV-2 may reduce symptoms and spread of infection in patients, helping to shorten hospital stay.
SCIENTIFIC REPORTS
(2021)
Letter
Otorhinolaryngology
Bernardo da Fonseca Orcina, Emilene Cristine Izu Nakamura Pietro, Juliana Pescinelli Garcia Kuroda, Lucas Marques da Costa Alves, Mariana Schutzer Ragghianti Zangrando, Rodrigo Cardoso de Oliveira, Andrea Name Colado Simao, Fabiano Vieira Vilhena, Paulo Sergio da Silva Santos
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Caroline Martins de Araujo, Daniela Frizon Alfieri, Ana Lucia Cruz Furstenberger Lehmann, Tamires Flauzino Luz, Emmanuelle Roberto Trevisani, Maisa Rocha Nagao, Leonardo Bodner de Freitas, Andrea Name Colado Simao, Edna Maria Vissoci Reiche
Summary: This study aimed to investigate the association between cellular adhesion molecules (CAMs) and acute ischemic stroke (IS), as well as to identify biomarkers for predicting short-term mortality after IS. The results showed that a combination of baseline IS severity and soluble vascular cellular adhesion molecule 1 (sVCAM-1) levels could early predict the prognosis of IS patients. Additionally, this study suggests that VCAM-1 might be a potential target for therapeutic strategies in IS.
METABOLIC BRAIN DISEASE
(2023)
Article
Developmental Biology
Fernanda Mithie Ogo, Glaucia Eloisa Munhoz Lion Siervo, Ana Maria Praxedes, Henrique Rodrigues Vieira, Suellen Ribeiro da Silva Scarton, Ana Tereza Guimaraes Bitencourt, Arielle Cristina Arena, Andrea Name Colado Simao, Marina Trevizan Guerra, Paulo Cesar de Freitas Mathias, Glaura Scantamburlo Alves Fernandes
Summary: This study aimed to evaluate the impact of maternal exposure to continuous light during pregnancy on the adult reproductive system in female offspring. The results showed that continuous light exposure during the intrauterine period resulted in reduced LH levels and increased progesterone levels, uterine injuries, increased number of endometrial glands, and reduced antioxidant enzyme activity in the uterus of female offspring.
BIRTH DEFECTS RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Fernanda Mithie Ogo, Glaucia Eloisa Munhoz Lion Siervo, Ana Maria Praxedes de Moraes, Katia Gama de Barros Machado, Suellen Ribeiro da Silva Scarton, Ana Tereza Bittencourt Guimaraes, Alessandra Lourenco Cecchini, Andrea Name Colado Simao, Paulo Cezar de Freitas Mathias, Glaura Scantamburlo Alves Fernandes
Summary: Exposure of pregnant rats to constant light during gestation was found to impair the reproductive system of male offspring in adulthood, leading to decreased testosterone levels, epididymal weight, sperm count, and histopathological damage in the testes.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)