Review
Hematology
Jeremy W. Jacobs, Cristina A. Figueroa Villalba, Garrett S. Booth, Jennifer S. Woo, Laura D. Stephens, Brian D. Adkins
Summary: Paroxysmal cold hemoglobinuria (PCH) is a rare autoimmune hemolytic anemia that is often overlooked and challenging to diagnose due to the complicated testing methods required. A systematic review of reported cases revealed that PCH most commonly occurs in children with a preceding viral infection, and corticosteroid use is frequent but potentially ineffective. The presence of complement and absence of IgG bound to red blood cells is the most common DAT result, although other findings were observed in a third of cases.
Article
Immunology
Kylie Alcorn, John Gerrard, Tara Cochrane, Rikki Graham, Amy Jennison, Peter J. Irwin, Amanda D. Barbosa
Summary: This study reports the first detection of Candidatus Mycoplasma haemohominis infection in an Australian patient exhibiting persistent fever, hemolytic anemia, and pancytopenia. New and emerging diagnostic approaches, including whole genome sequencing and PCR, were used to confirm the pathogen. This highlights the need for further investigations on the epidemiology of Candidatus Mycoplasma haemohominis in Australia.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Elodie Descloux, Oleg Mediannikov, Ann-Claire Gourinat, Julien Colot, Martine Chauvet, Isabelle Mermoud, Denise Desoutter, Cecile Cazorla, Elise Klement-Frutos, Luca Antonini, Anthony Levasseur, Vincent Bossi, Bernard Davoust, Audrey Merlet, Marie-Amelie Goujart, Malik Oedin, Fabrice Brescia, Sylvie Laumond, Pierre-Edouard Fournier, Didier Raoult
Summary: The study identified hemotropic mycoplasmas in the blood of a patient in New Caledonia and found infection in 15 patients. Interestingly, bats and biting flies were identified as potential vectors for the bacterium's transmission.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Immunology
Katharina Ginter, Dalia Melina Ahsan, Mojca Bizjak, Karoline Krause, Marcus Maurer, Sabine Altrichter, Dorothea Terhorst-Molawi
Summary: The study found that only a very small number of ColdU patients have detectable cryoproteins. Both retrospective analysis and prospective study supported this conclusion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mojca Bizjak, Mitja Kosnik, Dorothea Terhorst-Molawi, Dejan Dinevski, Marcus Maurer
Summary: This study found that cold urticaria patients with cold agglutinins and cryoglobulins are associated with the course and possibly the pathogenesis of their disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zhengrui Xiao, Irina Murakhovskaya
Summary: AIHA is a rare autoimmune disorder characterized by the destruction of red blood cells mediated by autoantibodies, presenting challenges in treatment. Traditional first-line therapies have associated adverse effects and treatment failures, with high rates of relapse. Some patients are refractory to available treatments, leading to the importance of novel therapies.
Review
Hematology
Sigbjorn Berentsen
Summary: Significant progress has been made in the treatment of CAD in recent decades, with recommendations mainly based on nonrandomized trials and personal experience due to the lack of comparative trials. Individualized treatment options tailored to patients' symptoms and disease characteristics are crucial to avoid ineffective therapies.
Editorial Material
Hematology
V. Koneti Rao
Summary: In this study, Kumar et al describe a group of 24 children with Evans syndrome who exhibit an immune dysregulation characterized by increased circulating cTfh cells, chronic T-cell activation/exhaustion, and decreased naive CD4(+) T cells and CSMB cells.
Article
Hematology
Alexander Roeth, Jon Fryzek, Xiaohui Jiang, Heidi Reichert, Parija Patel, Jun Su, Jaime Morales Arias, Catherine M. Broome
Summary: Patients with cold agglutinin disease showed evidence of persistent chronic hemolysis, healthcare resource utilization, and thromboembolism risk year round, with no significant differences between summer and winter.
Article
Immunology
Yifan Zhu, Yingying Luo, Ling Li, Xinyi Jiang, Yi Du, Jing Wang, Huilin Li, Haiyan Gu, Daiying Li, Heng Tang, Houbing Qin, Changdi Xu, Yan Liu, Deyu Zhao, Yun Guo, Feng Liu
Summary: This study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from children with MPP and found that the progression of MPP is associated with the host immune response, especially the intrinsic immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Anne Recker, Shivani Patel, Conner Baus, Robert Wittler, Melissa Jefferson, Paul Teran, Adam McClure
Summary: A previously healthy 14-year-old boy developed symptoms of right-sided neck pain, tachycardia, diffuse rash, and fevers. After initial treatment, his symptoms improved but worsened during follow-up, leading to admission to the pediatric critical care services.
Article
Hematology
Alexander Roeth, Sigbjorn Berentsen, Wilma Barcellini, Shirley D'Sa, Bernd Jilma, Marc Michel, Ilene C. Weitz, Masaki Yamaguchi, Jun-ichi Nishimura, Josephine M. Vos, Michael Storek, Nancy Wong, Parija Patel, Xiaoyu Jiang, Deepthi S. Vagge, Marek Wardecki, Frank Shafer, Michelle Lee, Catherine M. Broome
Summary: Sutimlimab, a humanized monoclonal antibody, shows potential as an important advancement in the treatment of cold agglutinin disease (CAD) by selectively inhibiting the classical complement pathway and rapidly halting hemolysis.
Article
Medicine, General & Internal
Chang Ho Kim, Jaehee Lee
Summary: Parapneumonic effusions are common complications of Mycoplasma pneumoniae infection, affecting approximately 20-25% of adult patients. Pleural fluid analysis typically shows mononuclear leukocyte predominance and elevated ADA activity, similar to tuberculous pleural effusion. Differential diagnosis between MPPE and TPE relies on the levels of ADA and serum inflammatory biomarkers. Early diagnosis of MP infection can be achieved through positive IgM and PCR results, guiding the selection of appropriate antibiotic treatment based on local antibiotic resistance data.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Microbiology
Roger Dumke
Summary: This review summarizes the typing methods for Mycoplasma pneumoniae and Mycoplasma genitalium, including their application in different studies, and presents the current knowledge regarding the association of typing data with the clinical characteristics of infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Federica Plano, Salvatrice Mancuso, Giulia Maria Camarda, Maria Giulia Butera, Giuseppe Sucato, Giuseppe Alecci, Ada Maria Florena, Salvatore Perrone, Sergio Mario Siragusa
Summary: This article reports a challenging case of mixed AIHA and adenopathy, which was difficult to diagnose due to low hemoglobin values and refractory response to standard therapies. Lymph node biopsy confirmed the diagnosis of MCD, leading to successful treatment with siltuximab, an anti-IL-6 monoclonal antibody. This case highlights the diagnostic challenges of MCD and presents the first case of response to siltuximab in relieving mixed AIHA after rituximab failure.
Review
Medicine, General & Internal
Mohammad T. Abuawwad, Mohammad J. J. Taha, Luai Abu-Ismail, Warda A. Alrubasy, Shams Khalid Sameer, Ibrahim T. Abuawwad, Yaqeen Al-Bustanji, Abdulqadir J. Nashwan
Summary: ABO and Rh blood grouping systems are non-modifiable risk factors that influence the susceptibility, severity, and outcomes of COVID-19 infection. This review examines the associations between blood types and COVID-19 globally, aiming to provide insights for clinical practice. The results suggest that blood type O offers protection against infection, while blood type A is associated with a higher risk of exacerbation. Rh positive individuals are more prone to severe infection and complications. However, further investigation is needed due to conflicting findings reported by some studies.
FRONTIERS IN MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Nour Shaheen, Ahmed Shaheen, Abdelraouf Ramadan, Abdulqadir J. Nashwan
Summary: Pulse field ablation (PFA) is a safe and effective treatment for atrial fibrillation, with short procedure time, high isolation rate, low recurrence rate, and high safety.
HEALTH SCIENCE REPORTS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Sarya Swed, Haidara Bohsas, Hidar Alibrahim, Kirellos Said Abbas, Bisher Sawaf, Yazan Khair Eldien Jabban, Amr Farwati, Mohammed Najdat Seijari, Mohamed Elsayed, Abdulqadir J. Nashwan, Basel Abdelazeem
Article
Infectious Diseases
Huzaifa Ahmad Cheema, Rustam Shariq Mujtaba, Amna Siddiqui, Laiba Imran Vohra, Abia Shahid, Jaffer Shah, Abdulqadir J. Nashwan, Natasha Howard
Summary: Dengue outbreaks have been a recurring issue in Singapore since 1901, affecting mainly children and with a recent shift in dominant strains. The country is also grappling with the COVID-19 pandemic, with a significant number of cases reported. Singapore has implemented various policies and interventions, but more efforts are needed to address the dual threat of dengue and COVID-19. International collaboration, digitization, and research on dengue transmission in affected countries are crucial in combating the diseases.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, General & Internal
Khalid Ahmed, Yasamin Abdu, Sief Khasawneh, Ahmed Shukri, Ehab Adam, Salma Mustafa, Mohammad Affas, Mohamed Izham Mohamed Ibrahim, Abdullah Al Zayed, Mohamed A. Yassin
Summary: In this study, the effect of intermittent fasting on the clinical and hematological parameters of individuals with sickle cell disease was investigated. The results showed that intermittent fasting does not appear to influence the rate of occurrence of severe vaso-occlusive crisis or hemolytic crisis in patients with sickle cell disease, but significant differences were found in platelet count, reticulocyte count, and creatinine level. The statistical and clinical significance of these findings needs to be confirmed in studies with a larger sample size.
FRONTIERS IN MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Huzaifa Ahmad Cheema, Saleha Azeem, Abdullah Ejaz, Faiza Khan, Anza Muhammad, Abia Shahid, Abdulqadir J. Nashwan, Muhammad Haisum Maqsood, Sourbha S. Dani, Robert J. Mentz, Marat Fudim, Gregg C. Fonarow
CLINICAL CARDIOLOGY
(2023)
Article
Nursing
Abdulqadir J. Nashwan, Suzan Gharib, Majdi Alhadidi, Ayman Mohamed El-Ashry, Asma Alamgir, Mohammed Al-Hassan, Mahmoud Abdelwahab Khedr, Shaimaa Dawood, Bassema Abufarsakh
Summary: This narrative review explores the transformative impact of Artificial Intelligence (AI) in mental health nursing, particularly in enhancing psychiatric patient care. AI technologies offer new strategies for early detection, risk assessment, and improving treatment adherence in mental health. They also support remote patient monitoring and clinical decision-making. The development of virtual mental health assistants and AI-enhanced therapeutic interventions are also discussed. These technological advancements reshape nurse-patient interactions, ensuring personalized, efficient, and high-quality care.
ISSUES IN MENTAL HEALTH NURSING
(2023)
Article
Health Policy & Services
Mohammad Abo Jalghef, Nidal Eshah, Islam Al-Oweidat, Abdulqadir J. Nashwan
Summary: This study examined the performance-based training needs of middle-level nursing managers in Jordanian governmental hospitals. The findings highlighted the need for training in various managerial competencies, and identified the impact of experience and work unit characteristics on training needs.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2023)
Article
Medicine, General & Internal
Abdulqadir J. Nashwan, Sarah H. Osman, Leena A. Mohamedahmed
Summary: Sudan's conflict has resulted in displacement, poverty, and the breakdown of social services due to colonial-era policies and resource competition. The power struggle between the Sudanese Army Forces and paramilitary Rapid Support Forces further worsens the humanitarian crisis by undermining health services and infrastructure. It is crucial for national and international organizations to coordinate a response, providing emergency healthcare, rebuilding infrastructure, and supporting healthcare workers.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Daniel A. Nnate, Abdulqadir J. Nashwan
Summary: This paper critiques theoretical frameworks for breaking bad news in clinical settings and highlights the lack of evidence available to guide nursing practice in managing the emotional burden of breaking bad news. The concept of emotional intelligence is introduced and the impact of delivering bad news on the psychological well-being of healthcare workers is outlined. Various models for delivering bad news in clinical practice are presented to emphasize the lack of evidence for mitigating the burden associated with breaking bad news. The key components of emotional intelligence are highlighted to increase awareness among nurses and enable them to improve their interpersonal skills to mitigate the impact of breaking bad news.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
E. Fradelos, I. V. Papathanasiou, F. Tzavella, P. Maggoulia, A. J. Nashwan, V. Alikari
Summary: This study aimed to investigate the stigmatization of health professionals during the second wave of the pandemic. A total of 279 health professionals who treated COVID-19 patients in two public hospitals in Attica participated in this cross-sectional study. The Stigma Towards Healthcare Providers Working with COVID-19 Patients Scale (S19-HCPs) was used for data collection. The results showed that health professionals experience high levels of infection fear, while women experience stigmatization more than men. Employee education and years of work are positive predictors of willingness to care for patients with COVID-19. The scale is considered a reliable tool for studying the stigmatization of health professionals. Rating: 8 out of 10.
ARCHIVES OF HELLENIC MEDICINE
(2023)
Article
Clinical Neurology
Milad Shenno, Almonzer Al-Qiami, Ismail A. Ibrahim, Lojin Elhaw, Abdulqadir J. Nashwan
Summary: This report presents a rare case of a 19-year-old male with bilateral periventricular nodular heterotopia (PVNH) and an intra-axial pontine lesion. Unlike the common diffuse midline glioma, the patient's condition is more favorable, and the lesion is suspected to be a pilocytic astrocytoma. The final diagnosis was made based on clinical evaluation and various medical diagnostic tests, and management and follow-up were initiated.
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2024)
Article
Medicine, General & Internal
Bassem Al Hariri, Ahmad Taher Alharafsheh, Muad Abdi Hassan, Abdulqadir J. Nashwan, Mohamed Gaafar Mohamedali, Hatem Mabrouk Abusriwil
Summary: Hemothorax is a rare and potentially fatal condition characterized by pleural effusion with high hematocrit. Common causes include trauma, surgery, and medication. Anticoagulation is an important treatment strategy for thromboembolic events, and DOACs have shown to be as effective as VKAs with lower risk of hemorrhage. However, in some cases, DOACs may lead to more severe bleeding complications.
CLINICAL CASE REPORTS
(2023)
Letter
Health Policy & Services
Abdulqadir J. Nashwan
Review
Hematology
Abdulqadir J. Nashwan, Mohamed A. Yassin
Summary: Chronic kidney disease is a global health concern, and iron overload is a common complication in CKD patients. Deferasirox has emerged as a promising treatment option, but its use presents challenges such as cost and potential side effects, and more research is needed to confirm its efficacy and safety.
JOURNAL OF BLOOD MEDICINE
(2023)
