The Response of Young and Adult Rats to the Riboflavin Supplementation

The aim of this article was to study the response of young and adult rats on the supplementation of diet with riboflavin. Twenty-four young and adult normotensives (Wistar) male rats, subdivided into two groups: treated (10mg riboflavin/Kg of body weight) and control (receiving vehicle) were daily evaluated for physical and behavioural aspects. Systolic blood pressure was determined twice a week and liver toxicity was investigated it the end of treatment. Data were evaluated using one-way ANOVA and p<0.05 was significant. There were no changes on general health aspects of the treated rats; however, the supplementation provoked a significant (p<0.05) systolic blood pressure reduction.