Article
Engineering, Biomedical
Milan Decuyper, Stijn Bonte, Karel Deblaere, Roel Van Holen
Summary: This study presents an automatic pipeline for segmenting gliomas based on pre-operative MRIs and accurately predicting important molecular markers like grade, IDH mutation, and 1p19q co-deletion. The method utilizes a 3D U-Net for segmentation and a CNN for classification, achieving high performance in both segmentation and classification tasks. The network was trained on a large dataset, handling missing labels and demonstrating robustness on independent validation datasets.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2021)
Article
Oncology
Xinzhuang Wang, Quan Yang, Nan Liu, Qilong Bian, Ming Gao, Xu Hou
Summary: TXNDC12 is significantly upregulated in gliomas, predicting poor prognosis for patients and correlating with the local immune microenvironment of tumors.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Oncology
Wanzun Lin, Xianxin Qiu, Pian Sun, Yuling Ye, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: While successful clinical trials of immunotherapy have shown promising strategies for many cancers, its application in glioma has lagged behind compared to other cancers. This study focused on the molecular alterations affecting therapeutic response in lower-grade glioma (LGG) and characterized the immunological phenotypes with different molecular subtypes to improve our understanding and application of immunotherapies in LGG. The research collected data from 1,052 patients, stratified them into three genetic subgroups, and discovered distinct immunological tumor microenvironments associated with IDH mutations and 1p/19q codeletions in LGG, ultimately leading to the construction of an immune-related prognostic signature that predicts overall survival time in LGG.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Andreas Stadlbauer, Stefan Oberndorfer, Gertraud Heinz, Max Zimmermann, Thomas M. Kinfe, Arnd Doerfler, Michael Buchfelder, Natalia Kremenevski, Franz Marhold
Summary: Anaplastic gliomas (AG) are aggressive primary brain tumors that affect young adults. This study found that physiological MRI biomarkers can help detect pathophysiological changes before radiological recurrence of IDH-mutated AG, with intensifying hypoxia and upregulation of neovascularization activity preceding recurrence. These findings may lead to the development of new MRI imaging modalities and tailored therapy options for recurrent AG patients.
Article
Clinical Neurology
Gabrielle Metz, Dasantha Jayamanne, Helen Wheeler, Matthew Wong, Raymond Cook, Nicholas Little, Jonathon Parkinson, Marina Kastelan, Chris Brown, Michael Back
Summary: This study assessed the tumor volume reduction in patients with IDH-mutated anaplastic glioma (IDHmutAG) of the insular cortex treated with IMRT. The results showed that IMRT can significantly reduce tumor volume, and residual disease volume does not have a significant negative impact on relapse-free survival.
Article
Clinical Neurology
Jin Zhu, Li-Bo Hu, Ya-Peng Zhao, Yu-Qi Zhang
Summary: This study demonstrates that patients with lower EYA4 expression in LGG have a more favorable prognosis. Patients in the oligoastrocytoma and oligodendroglioma groups exhibit lower EYA4 expression and longer survival. Patients with IDH1 mutations and 1p19q co-deletion show downregulated EYA4 expression and better prognosis.
WORLD NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Qiuyi Jiang, Xinzhuang Wang, Quan Yang, Hong Zhang, Xiaoxiong Wang
Summary: The study identified an abnormal upregulation of TMEM2 in high-grade glioma, which is closely related to patient prognosis. Molecular subtype classification can affect patient survival, with altered tumor microenvironment and cell redistribution in the high TMEM2-expressing subtype.
DNA AND CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
L. Eric Huang
Summary: CDKN2A/B homozygous deletion is associated with poor prognosis in glioma, but the new CNS WHO classification has upgraded IDH-mutant astrocytoma to grade IV, even without the histological features of glioblastoma. Understanding the mechanism of how IDH mutation and intact tumor-suppressor genes interact can improve therapeutics.
Article
Clinical Neurology
Yannick Braun, Katharina Filipski, Simon Bernatz, Peter Baumgarten, Bastian Roller, Jenny Zinke, Pia S. Zeiner, Elena Ilina, Christian Senft, Michael W. Ronellenfitsch, Karl H. Plate, Oliver Baehr, Elke Hattingen, Joachim P. Steinbach, Michel Mittelbronn, Patrick N. Harter
Summary: This study aims to characterize metabolic features in different molecular subgroups of gliomas, focusing on the impact of metabolic alterations on patient outcomes. Results showed that DNA methylation patterns of metabolic genes can distinguish between IDHmut and IDHwt gliomas, and mitochondrial DNA copy number and immune cell content analysis can predict patient survival under anti-angiogenic therapy. Genomic signatures related to metabolism could indicate specific tumor subgroups with metabolic vulnerabilities.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Oncology
Weilun Fu, Wenjing Wang, Hao Li, Yuming Jiao, Jiancong Weng, Ran Huo, Zihan Yan, Jie Wang, Hongyuan Xu, Shuo Wang, Jiangfei Wang, Dexi Chen, Yong Cao, Jizong Zhao
Summary: This study used mass cytometry to analyze immune cells in AG patients, demonstrating tumor-driven immune changes and the predominant immune cells in the AG immune microenvironment. The immune milieu in AAmut showed more immunosuppressive characteristics compared to AOD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yanyu Zhang, Yuan Xie, Liqun He, Jiefu Tang, Qiyuan He, Qingze Cao, Langjun Cui, Wei Guo, Kai Hua, Anna Dimberg, Liang Wang, Lei Zhang
Summary: This study found that in IDH-mutated LGGs, most TAMs expressed M1 activation markers CD86 and TNF, with some TAMs co-expressing both M1 and M2-related markers. Higher levels of TAMs expressing M2-related markers were observed in 1p/19q non-codeletion IDH-mutated LGGs compared to 1p/19q codeletion LGGs. Inhibition of M-CSF and TGF beta 1 signaling decreased tumor growth and modulated TAM phenotype in a glioma mouse model, indicating a potential role of these proteins in regulating TAM phenotype in glioma.
Article
Spectroscopy
Zhiyan Sun, Xianhao Wu, Rui Tao, Tianyao Zhang, Xing Liu, Jiangfei Wang, Haibin Wan, Shaowen Zheng, Xiaoyan Zhao, Zhaohui Zhang, Pei Yang
Summary: This study established a predictive model for IDH mutation status in gliomas based on terahertz spectroscopy data. The results showed that gliomas with different IDH mutation status have distinct terahertz spectral features, indicating the potential of terahertz spectroscopy as a new approach for predicting IDH mutation status in gliomas.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Cell Biology
Mengli Zhang, Huaichao Zhang, Minjie Fu, Jingwen Zhang, Cheng Zhang, Yingying Lv, Fengfeng Fan, Jinsen Zhang, Hao Xu, Dan Ye, Hui Yang, Wei Hua, Ying Mao
Summary: B7H3 expression is significantly decreased in IDH-mutated gliomas, possibly due to the accumulation of 2-HG and enhanced activity of the IDH1-R132H mutant. Inhibition of autophagy can block the degradation of B7H3 in glioma cells, while IDH1-R132H glioma cells exhibit a more active autophagy flux.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Johan M. Kros, Elisabeth Rushing, Aime L. Uwimana, Aurelio Hernandez-Lain, Alex Michotte, Maysa Al-Hussaini, Franck Bielle, Christian Mawrin, Gianluca Marucci, C. Mircea S. Tesileanu, Roger Stupp, Brigitta Baumert, Martin van den Bent, Pim J. French, Thierry Gorlia
Summary: The histologic parameters, especially the mitotic count, provide additional prognostic value in IDH mutant astrocytomas. The mitotic count significantly affects the PFS and marginally the OS. Furthermore, the mitotic count also affects the PFS of tumors with CDKN2A/B homozygous deletion.
Article
Oncology
Kee Kiat Yeo, Sanda Alexandrescu, Jennifer A. Cotter, Jayne Vogelzang, Varun Bhave, Marilyn M. Li, Jianling Ji, Jamal K. Benhamida, Marc K. Rosenblum, Tejus A. Bale, Nancy Bouvier, Kristiyana Kaneva, Tom Rosenberg, Mary-Jane Lim Fat, Hia Ghosh, Migdalia Martinez, Dolly Aguilera, Amy Smith, Stewart Goldman, Eli L. Diamond, Igor Gavrilovic, Tobey J. MacDonald, Matthew D. Wood, Kellie J. Nazemi, Ai Lien Truong, Andrew Cluster, Keith L. Ligon, Kristina Cole, Wenya Linda Bi, Ashley S. Margol, Matthias A. Karajannis, Karen D. Wright
Summary: This study found that a subset of pediatric gliomas is driven by IDH1/2 mutations, with a higher rate among adolescents. The majority of patients underwent upfront observant management without adjuvant therapy. The findings suggest that the natural history of pediatric IDH1/2-mutant glioma may be similar to that of adults.
Article
Clinical Neurology
Yuichi Nagata, Kazuhito Takeuchi, Hiroo Sasaki, Akihiro Mizuno, Hideyuki Harada, Kuniaki Tanahashi, Yoshio Araki, Ryuta Saito
Summary: A novel dural closure technique using collagen matrix for sellar reconstruction in extended endonasal transsphenoidal surgery (eTSS) may be an effective option to prevent postoperative cerebrospinal fluid leakage.
NEUROLOGIA MEDICO-CHIRURGICA
(2022)
Article
Multidisciplinary Sciences
Shinsuke Muraoka, Reiya Takagi, Yoshio Araki, Kenji Uda, Masaki Sumitomo, Sho Okamoto, Masahiro Nishihori, Takashi Izumi, Masanori Nakamura, Ryuta Saito
Summary: This study aimed to analyze postoperative flow characteristics and elucidate the cause of ischemic complications related to the perforating branch using computational fluid dynamics. The results indicated that flow stagnation may lead to ischemic complications, but balloon test occlusion did not reflect the influence of bypass blood flow. Therefore, utilizing CFD analysis for surgical strategy decision-making can be helpful in preventing ischemic complications in patients with giant aneurysms.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Takayuki Awaya, Yusuke Nishimura, Kaoru Eguchi, Yoshitaka Nagashima, Ryo Ando, Sho Akahori, Satoshi Yoshikawa, Shoichi Haimoto, Masahito Hara, Masakazu Takayasu, Ryuta Saito
Summary: This study retrospectively compared the radiological and clinical outcomes of two different surgical techniques (LSPSL and ULBD) for treating LCS. ULBD showed better outcomes in terms of recurrence prevention, preservation of the facet joints, and less blood loss.
WORLD NEUROSURGERY
(2022)
Review
Clinical Neurology
Kazuya Motomura, Fumiharu Ohka, Kosuke Aoki, Ryuta Saito
Summary: Surgical resection is crucial for treating gliomas, with a wider extent of resection associated with better clinical outcomes. Recurrence is common, but supratotal resection techniques can improve survival rates for patients with gliomas.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Junya Yamaguchi, Shoichi Haimoto, Fumiharu Ohka, Masakazu Takayasu, Ryuta Saito
Summary: The study of genetic alterations and molecular biology in CNS tumors has greatly improved prognosis estimation and tumor categorization. The updated 2021 WHO classification includes diagnostic genes, molecules, pathways, and histological findings, which can be used for diagnosis and the development of targeted therapies. Intramedullary spinal cord tumors are rare and challenging to treat, but their genetic characteristics are gradually being revealed. This review describes the major changes in the new 2021 WHO classification and provides an overview of the clinical features and genetic alterations of intramedullary spinal cord tumors.
Article
Biology
Sosuke Kageyama, Atsuhiro Nakagawa, Tomohiro Kawaguchi, Kiyonobu Ohtani, Toshiki Endo, Manabu Kyan, Tetsuya Kusunoki, Yoshiteru Shimoda, Shin-Ichiro Osawa, Masayuki Kanamori, Niizuma Kuniyasu, Teiji Tominaga
Summary: A new actuator-driven pulsed water jet device (ADPJ) was developed to achieve maximal lesion dissection with minimal risk of structural damage. This study proposed a simple experimental method using spectrophotometry to evaluate the degree of tissue dispersion in a wet field.
BMC RESEARCH NOTES
(2022)
Article
Oncology
Atsushi Natsume, Yoshiki Arakawa, Yoshitaka Narita, Kazuhiko Sugiyama, Nobuhiro Hata, Yoshihiro Muragaki, Naoki Shinojima, Toshihiro Kumabe, Ryuta Saito, Kazuya Motomura, Yohei Mineharu, Yasuji Miyakita, Fumiyuki Yamasaki, Yuko Matsushita, Koichi Ichimura, Kazumi Ito, Masaya Tachibana, Yasuyuki Kakurai, Naoko Okamoto, Takashi Asahi, Soichiro Nishijima, Tomoyuki Yamaguchi, Hiroshi Tsubouchi, Hideo Nakamura, Ryo Nishikawa
Summary: DS-1001, an oral brain-penetrant mutant IDH1 selective inhibitor, demonstrated good tolerability and brain distribution in patients with recurrent/progressive IDH1-mutant glioma. It showed efficacy in tumor response and further studies are ongoing to evaluate its effectiveness in other types of gliomas.
Correction
Biology
Sosuke Kageyama, Atsuhiro Nakagawa, Tomohiro Kawaguchi, Kiyonobu Ohtani, Toshiki Endo, Manabu Kyan, Tetsuya Kusunoki, Yoshiteru Shimoda, Shin-Ichiro Osawa, Masayuki Kanamori, Kuniyasu Niizuma, Teiji Tominaga
BMC RESEARCH NOTES
(2022)
Article
Medicine, Research & Experimental
Takafumi Tanei, Satoshi Maesawa, Yusuke Nishimura, Yoshitaka Nagashima, Tomotaka Ishizaki, Masahiko Ando, Yachiyo Kuwatsuka, Atsushi Hashizume, Shimon Kurasawa, Ryuta Saito
Summary: This study aims to investigate the effectiveness of new spinal cord stimulation (SCS) patterns without paresthesia compared to conventional tonic stimulation for neuropathic pain. A randomized clinical trial will be conducted to compare pain improvement between different stimulation patterns in participants. The study also aims to evaluate the relationship between causative disease and pain improvement, as well as long-term effects and adverse events related to the study.
Article
Clinical Neurology
Yuto Shingai, Masayuki Kanamori, Yoshiteru Shimoda, Shingo Kayano, Hitoshi Nemoto, Shunji Mugikura, Ryuta Saito, Teiji Tominaga
Summary: This study evaluated the usefulness of preoperative simulation of the occipital transtentorial approach (OTA) for lesions in the pineal region, dorsal brainstem, and supracerebellar region. The simulation, including the cerebellar tentorium, helped in determining safe incisions and guiding surgical procedures.
NEUROSURGICAL REVIEW
(2023)
Article
Clinical Neurology
Hiroo Sasaki, Kazuhito Takeuchi, Yuichi Nagata, Kuniaki Tanahashi, Akihiro Mizuno, Hideyuki Harada, Yugo Kishida, Tadashi Watanabe, Tetsuya Nagatani, Ryuta Saito
Summary: This study found that bilateral preservation of primary superior hypophyseal artery (pSHA) Ib is associated with preserved postoperative anterior pituitary function in craniopharyngioma surgery, but may have little effect on the occurrence of diabetes insipidus (DI) postoperatively.
ACTA NEUROCHIRURGICA
(2023)
Article
Medicine, Research & Experimental
Miki Hashida, Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Toshiaki Taoka, Hisashi Kawai, Ryuta Saito
Summary: The literature mainly focuses on the study of giant tumefactive perivascular spaces, Virchow-Robin spaces, and other intracranial structures, reviewing and discussing the normal data, dilatation, and disease-related information of these structures.
NAGOYA JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Ichiyo Shibahara, Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Sumito Sato, Takuichiro Hide, Teiji Tominaga, Toshihiro Kumabe
Summary: The parietooccipital fissure is an important anatomical landmark for understanding the infiltrating architecture of posterior medial temporal gliomas.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Yoshiki Kawamura, Satoshi Maesawa, Shingo Numoto, Ryuta Saito, Tetsushi Yoshikawa, Akihisa Okumura
Summary: This study performed virological analysis on a patient with temporal lobe epilepsy and mesial temporal sclerosis after febrile status epilepticus caused by human herpesvirus 6 infection. Surgical treatment was necessary for the patient, and no viral DNA was detected in the resected brain tissues.
Article
Clinical Neurology
Kazuhito Takeuchi, Yuichi Nagata, Kuniaki Tanahashi, Yoshio Araki, Akihiro Mizuno, Hiroo Sasaki, Hideyuki Harada, Keishi Ito, Ryuta Saito
Summary: This study evaluated the efficacy and safety of endoscopic transcylinder removal of supratentorial cerebral cavernous malformations (CMs) using a novel wet-field technique. The results showed that this method is safe and effective, achieving complete or subtotal resection of the lesions.
ACTA NEUROCHIRURGICA
(2022)