Article
Multidisciplinary Sciences
G. Allan Johnson, Yuqi Tian, David G. Ashbrook, Gary P. Cofer, James J. Cook, James C. Gee, Adam Hall, Kathryn Hornburg, Catherine C. Kaczorowski, Yi Qi, Fang-Cheng Yeh, Nian Wang, Leonard E. White, Robert W. Williams
Summary: We have developed workflows to align 3D magnetic resonance histology (MRH) of the mouse brain with light sheet microscopy (LSM) and 3D delineations of the same specimen. The result is a high-dimensional integrated volume with registration (HiDiver) with alignment precision better than 50 μm. HiDiver is being used in quantitative studies of the impact of gene variants and aging on mouse brain cytoarchitecture and connectomics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Young-Eun Hwang, Young-Bo Kim, Young-Don Son
Summary: The study found that the language-related fiber pathways in the human brain, such as SLF and AF, are connected to regions such as the prefrontal cortex, inferior parietal cortex, and temporal cortex, forming language-related circuits.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jaeho Kang, Dong Ah Lee, Ho-Joon Lee, Kang Min Park
Summary: There were no differences in limbic structure volumes between patients with TGA and healthy controls, but the radius of the limbic covariance network was significantly larger in TGA patients. Patients with recurrent TGA events showed alterations in various graph theory parameters compared to those with a single event.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Ahmed Radwan, Lisa Decraene, Patrick Dupont, Nicolas Leenaerts, Cristina Simon-Martinez, Katrijn Klingels, Els Ortibus, Hilde Feys, Stefan Sunaert, Jeroen Blommaert, Lisa Mailleux
Summary: This study explored the structural brain connectomes in children with spastic unilateral cerebral palsy (uCP) and its relationship to sensory-motor function using graph theory. The results showed a hyperconnectivity pattern in the CDGM-lesion group compared to the PWM-lesion group, with higher clustering coefficient, characteristic path length, and local efficiency. The CST-wiring pattern was found to be the strongest predictor for motor function. The findings highlight the potential of structural connectomics in understanding disease severity and brain development in children with uCP.
HUMAN BRAIN MAPPING
(2023)
Review
Oncology
Onur Tanglay, Nicholas B. Dadario, Elizabeth H. N. Chong, Si Jie Tang, Isabella M. Young, Michael E. Sughrue
Summary: Advances in our understanding of brain structure and function have been made through improved mapping of the brain connectome. By utilizing different statistical techniques and non-invasive imaging modalities, the brain can be represented as a graph of interconnected nodes. This graph theory approach provides additional information on important inter-individual network properties and functionally eloquent brain regions.
Article
Neurosciences
Kristoffer J. Albers, Karen S. Ambrosen, Matthew G. Liptrot, Tim B. Dyrby, Mikkel N. Schmidt, Morten Morup
Summary: This study proposes a framework for quantitative evaluation of brain parcellations via statistical prediction of connectomics data, revealing substantial differences in parcellation structures that characterize functional and structural connectivity. The choice of fine-grained and coarse representations used by existing atlases is crucial, with resolution being more critical than exact border location of parcels.
Article
Neurosciences
Sami Obaid, Francois Rheault, Manon Edde, Guido Guberman, Etienne St-Onge, Jasmeen Sidhu, Alain Bouthillier, Alessandro Daducci, Jimmy Ghaziri, Michel W. Bojanowski, Dang K. Nguyen, Maxime Descoteaux
Summary: Operculo-insular epilepsy (OIE) is a condition that can mimic temporal and extratemporal epilepsies and often involves increased connectivity strength between certain brain regions. The study proposed a cutting-edge method that revealed widespread connectivity alterations in the OIE group, indicating a diffuse epileptic network within the brain. Graph theoretic analyses showed higher connectivity within insular subregions of OIE patients compared to those with temporal lobe epilepsy.
Article
Computer Science, Artificial Intelligence
Anca Radulescu, Johan Nakuci, Simone Evans, Sarah Muldoon
Summary: The interplay between neuronal network connectivity and neuron dynamics is complex and poorly understood. Previous studies have shown that certain topological features of complex quadratic networks (CQNs) can be used to classify network topology. This study applies CQN modeling to real-world brain networks and shows that CQNs are more sensitive than traditional measures at capturing individual differences in the human connectome. Furthermore, features of the equi-M sets can differentiate between male and female connectomes.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Andre Obenaus, Eli Kinney-Lang, Amandine Jullienne, Elizabeth Haddad, Kara M. M. Wendel, A. Duke Shereen, Ana Solodkin, Jeffrey F. F. Dunn, Tallie Z. Z. Baram
Summary: Previous neuroimaging techniques have struggled to accurately delineate the boundaries of the amygdaloid complex, specifically the basolateral nucleus (BLA), due to poor contrast. This study presents a novel diffusion tensor imaging (DTI) approach that enhances contrast, allowing for precise measurement and validation of BLA volumes using histological and cellular-identity techniques. The principles utilized in this study can be applied to other brain regions and various species.
Article
Computer Science, Artificial Intelligence
Yuanjing Feng, Jiahao Song, Wenxuan Yan, Jingqiang Wang, Changchen Zhao, Qingrun Zeng
Summary: This study used a new method to investigate the white matter microstructure changes in the brain of professional chess players and found significant differences in diffusion characteristics in the thalamofrontal tracts and left superior longitudinal fasciculus. The changes in brain structures of professional chess players are mainly related to cognitive aspects such as learning and memory, and studying this cognitive mechanism is of great significance.
IEEE TRANSACTIONS ON COGNITIVE AND DEVELOPMENTAL SYSTEMS
(2021)
Article
Neurosciences
Scott Trinkle, Sean Foxley, Gregg Wildenberg, Narayanan Kasthuri, Patrick La Riviere
Summary: Diffusion MRI tractography is a noninvasive method for measuring the structural connectome in humans, but recent studies have shown limitations due to local uncertainties in fiber orientations. Geometry plays a larger role in determining the topology of graphs produced by tractography compared to neural tracers, underestimating weights at long distances and affecting the placement of network hubs. The role of spatial embedding in modular structure and network efficiency is explored in both modalities, with geometric biases inherent in tractography quantified for future validation efforts.
Article
Neurosciences
Jianzhong He, Fan Zhang, Guoqiang Xie, Shun Yao, Yuanjing Feng, Dhiego C. A. Bastos, Yogesh Rathi, Nikos Makris, Ron Kikinis, Alexandra J. Golby, Lauren J. O'Donnell
Summary: This study compared four tractography methods and found that UKF-2T and iFOD1 produce the best results for RGVP reconstruction. The iFOD1 method can more accurately estimate the percentage of decussating fibers, while the UKF-2T method produces reconstructed RGVPs that better correspond to known anatomy.
HUMAN BRAIN MAPPING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pasquale Borrelli, Giovanni Savini, Carlo Cavaliere, Fulvia Palesi, Maria Grazia Bruzzone, Domenico Aquino, Laura Biagi, Paolo Bosco, Irene Carne, Stefania Ferraro, Giovanni Giulietti, Antonio Napolitano, Anna Nigri, Luigi Pavone, Alice Pirastru, Alberto Redolfi, Fabrizio Tagliavini, Michela Tosetti, Marco Salvatore, Claudia A. M. Gandini Wheeler-Kingshott, Marco Aiello, RIN Neuroimaging Network
Summary: This study investigates the reproducibility and variability of topological metrics derived from structural connectomes in the clinical context. The data from the Italian Neuroscience and Neurorehabilitation Network initiative were used to obtain normative values and examine the reproducibility and variability across different centers. The results show significant differences among the centers.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Jeong-Min Shim, Young-Bo Kim, Chang-Ki Kang
Summary: This study introduced a new compressed sensing averaging (CSA) technique for reducing blurring and ringing artifacts in images, analyzed image quality parameters, and found that ringing artifacts become more prominent with smaller sampling lines in CSA techniques.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Biomedical
Aliesha Danielle O'Raw, Nikolai Rakhilin, Nian Wang, Jennifer McKey, Gary Cofer, Robert B. J. Anderson, Blanche Capel, G. Allan Johnson, Xiling Shen
Summary: The study produced a comprehensive peripheral nerve atlas of the entire mouse PNS using diffusion tensor magnetic resonance imaging (DT-MRI) and high-speed compressed sensing techniques. The atlas mapped PNS innervation and fiber network in multiple organs at a resolution of 70 μm, providing unprecedented information on the neural circuitry throughout the body. This high-resolution nerve atlas could potentially guide future neuromodulation therapies and studies on neural circuits involved in homeostasis and disease.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nian Wang, Anthony J. Mirando, Gary Cofer, Yi Qi, Matthew J. Hilton, G. Allan Johnson
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Lauren M. Slosky, Yushi Bai, Krisztian Toth, Caroline Ray, Lauren K. Rochelle, Alexandra Badea, Rahul Chandrasekhar, Vladimir M. Pogorelov, Dennis M. Abraham, Namratha Atluri, Satyamaheshwar Peddibhotla, Michael P. Hedrick, Paul Hershberger, Patrick Maloney, Hong Yuan, Zibo Li, William C. Wetsel, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron
Article
Physics, Multidisciplinary
Robert J. Anderson, Christopher M. Long, Evan D. Calabrese, Scott H. Robertson, G. Allan Johnson, Gary P. Cofer, Richard J. O'Brien, Alexandra Badea
FRONTIERS IN PHYSICS
(2020)
Article
Neurosciences
Nian Wang, Leonard E. White, Yi Qi, Gary Cofer, G. Allan Johnson
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandra Badea, Robert Schmalzigaug, Woojoo Kim, Pamela Bonner, Umer Ahmed, G. Allan Johnson, Gary Cofer, Mark Foster, Robert J. Anderson, Cristian Badea, Richard T. Premont
Summary: GIT1-KO mice exhibit neuroimaging phenotypes such as microcephaly and altered cortical layering, with a decrease in neuron density in cortical layer V. High field MRM revealed reduced white matter volume, particularly in the anterior commissure, in GIT1-KO mice. The basal ganglia appeared enlarged in GIT1-KO mice, suggesting a vulnerability to addiction.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Engineering, Biomedical
Aliesha Danielle O'Raw, Nikolai Rakhilin, Nian Wang, Jennifer McKey, Gary Cofer, Robert B. J. Anderson, Blanche Capel, G. Allan Johnson, Xiling Shen
Summary: The study produced a comprehensive peripheral nerve atlas of the entire mouse PNS using diffusion tensor magnetic resonance imaging (DT-MRI) and high-speed compressed sensing techniques. The atlas mapped PNS innervation and fiber network in multiple organs at a resolution of 70 μm, providing unprecedented information on the neural circuitry throughout the body. This high-resolution nerve atlas could potentially guide future neuromodulation therapies and studies on neural circuits involved in homeostasis and disease.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Orthopedics
Qi Zhao, Rees P. Ridout, Jikai Shen, Nian Wang
Summary: The study found that the direction and strength of diffusion gradients have significant influences on diffusion tensor imaging and fiber tracking in various connective tissues of the knee joint. Ligaments showed higher FA values compared to other tissues, while MD was less sensitive to angular resolution. Fiber tracking failed at low angular resolution or high b values, and measurements of fiber length and volume were highly dependent on angular resolution and b value.
Article
Multidisciplinary Sciences
K. Saidas Nair, Chitrangda Srivastava, Robert V. Brown, Swanand Koli, Helene Choquet, Hong Soon Kang, Yien-Ming Kuo, Sara A. Grimm, Caleb Sutherland, Alexandra Badea, G. Allan Johnson, Yin Zhao, Jie Yin, Kyoko Okamoto, Graham Clark, Terete Borras, Gulab Zode, Krishnakumar Kizhatil, Subhabrata Chakrabarti, Simon W. M. John, Eric Jorgenson, Anton M. Jetten
Summary: Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. The authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular pressure, and as a glaucoma risk gene.
NATURE COMMUNICATIONS
(2021)
Letter
Cardiac & Cardiovascular Systems
Zhiyun Yu, Xin Zhou, Ziyi Liu, Victor Pastrana-Gomez, Yu Liu, Minzhe Guo, Lei Tian, Timothy J. Nelson, Nian Wang, Seema Mital, David Chitayat, Joseph C. Wu, Marlene Rabinovitch, Sean M. Wu, Michael P. Snyder, Yifei Miao, Mingxia Gu
CIRCULATION RESEARCH
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Nian Wang, Qiuting Wen
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Stephanie Crater, Surendra Maharjan, Yi Qi, Qi Zhao, Gary Cofer, James C. Cook, G. Allan Johnson, Nian Wang
Summary: Diffusion MRI has been widely used to study tissue microstructure and structural connectivity. This study focuses on acquiring high quality dMRI datasets of mouse brains and investigating the effects of three important parameters on the resulting connectome.
Article
Neurosciences
Ali Mahzarnia, Jacques A. Stout, Robert J. Anderson, Hae Sol Moon, Zay Yar Han, Kate Beck, Jeffrey N. Browndyke, David B. Dunson, Kim G. Johnson, Richard J. O'Brien, Alexandra Badea
Summary: This study reveals vulnerable brain networks associated with Alzheimer's disease (AD) using a sample consisting of individuals with the risk genotype APOE4. Through sparse canonical correlation analysis and sparse regression predictive models, accurate predictions can be made for genotype, family risk factor for AD, and age. Additionally, the inclusion of cognitive metrics in the risk factor improves the prediction of age in individuals with cognitive impairment.
Review
Radiology, Nuclear Medicine & Medical Imaging
Jose G. Raya, Alejandra Duarte, Nian Wang, Valentina Mazzoli, Diego Jaramillo, Andrew M. M. Blamire, Olaf Dietrich
Summary: Diffusion-weighted imaging (DWI) is a well-established MRI technique for investigating tissue microstructure. Musculoskeletal tissues, with their highly ordered structure, are an ideal application for DWI. However, there are specific challenges in acquiring DWI data for musculoskeletal applications. This review provides an overview of the technical aspects of DWI acquisition and discusses its applications in various musculoskeletal tissues.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Nian Wang, Robert J. Anderson, David G. Ashbrook, Vivek Gopalakrishnan, Youngser Park, Carey E. Priebe, Yi Qi, Rick Laoprasert, Joshua T. Vogelstein, Robert W. Williams, G. Allan Johnson
Meeting Abstract
Ophthalmology
Saidas Nair, Chitrangda Srivastava, Swanand Koli, Hong Soon Kang, Yien-Ming Kuo, Helene Choquet, Alexandra Badea, Eric Jorgenson, Anton Jetten
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
