Article
Neurosciences
Ahmed M. Radwan, Stefan Sunaert, Kurt Schilling, Maxime Descoteaux, Bennett A. Landman, Mathieu Vandenbulcke, Tom Theys, Patrick Dupont, Louise Emsell
Summary: The virtual dissection of white matter using diffusion MRI tractography has poor reproducibility, but this study provides a comprehensive description of white matter anatomy using a reproducible automated subject-specific parcellation-based approach with probabilistic CSD tractography. The study demonstrates high inter-session similarity and provides a WM atlas that can be useful for mapping white matter fasciculi in healthy adults.
Article
Clinical Neurology
Hebel Urquia-Osorio, Luciana R. Pimentel-Silva, Thiago Junqueira Ribeiro Rezende, Eimy Almendares-Bonilla, Clarissa L. Yasuda, Luis Concha, Fernando Cendes
Summary: This study evaluated WM diffusion tensor imaging (DTI) metrics in focal epilepsies and identified distinctive patterns of microstructural abnormalities. The findings showed widespread WM diffusion abnormalities in patients with TLE-HS compared to other focal epilepsies. In addition, the study highlighted the potential of superficial-WM analysis for better understanding the biological mechanisms of focal epilepsies and aiding in the diagnosis of subtle FCDs.
Article
Neurosciences
Thomas W. Owen, Jane de Tisi, Sjoerd B. Vos, Gavin P. Winston, John S. Duncan, Yujiang Wang, Peter N. Taylor
Summary: This study examined the relationship between epilepsy duration and white matter alterations using the Mahalanobis distance measure, finding significant negative associations for two limbic tracts in left-TLE patients and positive associations in both left and right-TLE cohorts. The multivariate approach provided more robust results compared to traditional univariate analyses, suggesting the importance of considering both frameworks in future studies for a complete understanding of epilepsy progression.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Lorna Bryant, Emilie T. McKinnon, James A. Taylor, Jens H. Jensen, Leonardo Bonilha, Christophe de Bezenac, Barbara A. K. Kreilkamp, Guleed Adan, Udo C. Wieshmann, Shubhabrata Biswas, Anthony G. Marson, Simon S. Keller
Summary: This study utilized FBI and FBWM to evaluate the diffusion properties of white matter tracts in patients with epilepsy. It was found that patients with chronic epilepsy had a widespread distribution of extra-axonal diffusivity, and those with refractory epilepsy exhibited significantly greater markers of extra-axonal diffusivity compared to nonrefractory epilepsy patients. These findings suggest that extra-axonal diffusivity alterations may serve as biomarkers of neuroinflammatory processes or reduced axonal density in epilepsy.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Elizabeth Huber, Aviv Mezer, Jason D. Yeatman
Summary: Diffusion MRI and quantitative MRI measurements were used to study changes in white matter during an 8-week intensive reading intervention, revealing that mean 'extra-axonal' diffusivity in white matter was inversely related to intervention time, while model estimated axonal water fraction, overall diffusion kurtosis, and T1 relaxation time showed no significant change. These results suggest that rapid changes in diffusion properties may reflect phenomena other than widespread changes in myelin density.
Article
Neurosciences
Natalia Del Campo, Owen Phillips, Francoise Ory-Magne, Christine Brefel-Courbon, Monique Galitzky, Claire Thalamas, Katherine L. Narr, Shantanu Joshi, Manpreet K. Singh, Patrice Peran, Anne Pavy-LeTraon, Olivier Rascol
Summary: Multiple system atrophy (MSA) is a rare neurodegenerative disorder characterized by widespread accumulation of alpha-synuclein, primarily in oligodendrocytes. Whole brain deep and superficial white matter diffusivity abnormalities were observed in MSA patients but not in Parkinson's disease (PD) patients. These abnormalities were associated with motor and cognitive functions in MSA patients.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Michiel Cottaar, Matteo Bastiani, Nikhil Boddu, Matthew F. Glasser, Suzanne Haber, David C. van Essen, Stamatios N. Sotiropoulos, Saad Jbabdi
Summary: Many brain imaging studies measure structural connectivity with diffusion tractography, but biases in the data can limit accuracy. A new algorithm reduces these biases by modeling fiber density and orientation.
Article
Neurosciences
Qiuting Wen, Shannon L. Risacher, Linhui Xie, Junjie Li, Jaroslaw Harezlak, Martin R. Farlow, Frederick W. Unverzagt, Sujuan Gao, Liana G. Apostolova, Andrew J. Saykin, Yu-Chien Wu
Summary: The study explored the spatial pattern of tau-white matter (WM) associations across the whole brain and found a distinct spatial pattern resembling the typical propagation of tau pathology in Alzheimer's disease (AD). The association between tau and WM degeneration highlights the important role of WM alterations in the AD pathological cascade.
Article
Multidisciplinary Sciences
Sian Wilson, Maximilian Pietsch, Lucilio Cordero-Grande, Anthony N. Price, Jana Hutter, Jiaxin Xiao, Laura McCabe, Mary A. Rutherford, Emer J. Hughes, Serena J. Counsell, Jacques-Donald Tournier, Tomoki Arichi, Joseph V. Hajnal, A. David Edwards, Daan Christiaens, Jonathan O'Muircheartaigh
Summary: A study characterizing the in utero maturation of white matter microstructure in human fetal brains using high-resolution MRI data identified unique maturational trends in different white matter bundles and regions, suggesting potential insights into connectivity abnormalities associated with preterm birth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lei Wei, Xiaonan Du, Zidong Yang, Ming Ding, Baofeng Yang, Ji Wang, Shasha Long, Zhongwei Qiao, Yonghui Jiang, Yi Wang, He Wang
Summary: This study investigated the local and global alterations of white matter in patients with Angelman syndrome (AS). The results showed that AS patients had diminished connectivity in the brain and reduced network efficiency compared to healthy controls.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Multidisciplinary Sciences
Roey Schurr, Aviv A. Mezer
Summary: The study developed a method based on Nissl staining technique to quantify the structure and orientation of axons, applicable to various datasets. Utilizing structure tensor analysis, fine details of axonal architecture can be extracted effectively.
Article
Clinical Neurology
Ali H. Palejwala, Nicholas B. Dadario, Isabella M. Young, Kyle O'Connor, Robert G. Briggs, Andrew K. Conner, Daniel L. O'Donoghue, Michael E. Sughrue
Summary: The medial occipital lobe is highly interconnected, supporting both visual processing and nonvisual functions such as language and memory. The research findings can be used to guide multimodal navigation of white matter lesions to prevent neurological deficits.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Jelle Veraart, Erika P. Raven, Luke J. Edwards, Nikolaus Weiskopf, Derek K. Jones
Summary: This study introduces the noninvasive quantification of axonal morphology using diffusion-weighted MRI techniques, with a focus on the effective MR axon radius. It evaluates the repeatability and reproducibility of this method in the whole brain, aiming to further develop the effective MR axon radius as a neuroimaging biomarker.
HUMAN BRAIN MAPPING
(2021)
Article
Geriatrics & Gerontology
Emma L. Ducca, Gabriela T. Gomez, Priya Palta, Kevin J. Sullivan, Clifford R. Jack, David S. Knopman, Rebecca F. Gottesman, Jeremy Walston, B. Gwen Windham, Keenan A. Walker
Summary: The study found a strong association between cerebral white matter structure and current and future frailty. Specifically, white matter hyperintensity volume was significantly associated with frailty. However, measures of white matter microstructure were not generally associated with progression from nonfrail to frail status.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ricardo Rios-Carrillo, Alonso Ramirez-Manzanares, Hiram Luna-Munguia, Mirelta Regalado, Luis Concha
Summary: Diffusion-weighted magnetic resonance imaging (DW-MRI) is a non-invasive technique sensitive to microstructural geometry in neural tissue and useful for detecting neuropathology. Tensor-valued diffusion encoding schemes (b-tensor) enrich the microstructural data obtained from DW-MRI. This study explores the application of machine learning in analyzing b-tensor encoding data to detect histopathology and neurodegeneration.
Letter
Psychiatry
Peter Giacobbe, Enoch Ng, Daniel M. Blumberger, Zafiris J. Daskalakis, Jonathan Downar, Carla Garcia, Clement Hamani, Nir Lipsman, Fidel Vila-Rodriguez, Mark Watling
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2021)
Article
Medicine, Research & Experimental
Yoshihiro Noda, Yuliya Knyahnytska, Reza Zomorrodi, Jonathan Downar, Tarek K. Rajji, Zafiris J. Daskalakis, Daniel M. Blumberger
Summary: The study aimed to explore the relationships among baseline heart rate variability (HRV), age, clinical outcomes, and executive function following Magnetic Seizure Therapy (MST) in patients with treatment-resistant depression (TRD). Results indicated that baseline RMSSD was correlated with baseline HAM-D-24 and the Mazes Test, suggesting that HRV may serve as a state biomarker of depression and executive function impairment. Additionally, baseline vagally mediated resting cardiac activity did not predict the outcome of depression but may mediate executive function improvements following MST.
Article
Geriatrics & Gerontology
Abhishek Jaywant, Katharine Dunlop, Lindsay W. Victoria, Lauren Oberlin, Charles J. Lynch, Matteo Respino, Amy Kuceyeski, Matthew Scult, Matthew J. Hoptman, Conor Liston, Michael W. O'Dell, George S. Alexopoulos, Roy H. Perlis, Faith M. Gunning
Summary: The relationship between WMH and cognitive functioning in older adults was investigated. The study found that the disruption to white matter fiber tracts from WMH and its impact on specific brain networks were associated with delayed recall, highlighting the importance of network-level structural and functional alterations in resting state networks for memory in older adults.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychology, Clinical
Lindsey R. Yessick, Robyn A. Jackowich, Shannon M. Coyle, Tim Salomons, Caroline F. Pukall
Summary: This study examines the association between low self-efficacy, heightened perceived stress, and dyspareunia during COVID-19. The findings indicate that self-efficacy declines during the pandemic, with individuals experiencing dyspareunia reporting lower self-efficacy. While stress levels are greater for those with dyspareunia, both groups show reductions in stress over time. Lower stress levels are associated with increased self-efficacy.
JOURNAL OF SEX & MARITAL THERAPY
(2022)
Article
Neurosciences
Batu Kaya, Paul Geha, Ivan de Araujo, Iacopo Cioffi, Massieh Moayedi
Summary: This study is the first to delineate the neuroanatomical circuit from the central amygdala (CeA) to the trigeminal motor nucleus (5M) in humans. The findings provide important insights into the functional role of jaw muscle circuitry in humans and its relevance to related disorders.
HUMAN BRAIN MAPPING
(2023)
Editorial Material
Neurosciences
T. V. Salomons, G. D. Iannetti
Summary: This article discusses the controversy surrounding whether fetuses can feel pain in the Mississippi case that led to the overturning of Roe vs Wade. The authors argue that critical biological evidence used by the state was misinterpreted and that the state's argument conflated pain and nociception.
NATURE NEUROSCIENCE
(2022)
Article
Anesthesiology
Lindsey R. Yessick, Justine Tanguay, Wiebke Gandhi, Richard Harrison, Ruxandra Dinu, Bhismadev Chakrabarti, Emma Borg, Tim V. Salomons
Summary: Due to the subjectivity of pain, it is difficult to accurately judge others' pain. This study found that participants were more influenced by pain indicators they perceived as objective. Additionally, facial expressions had the least impact on observers' judgements of pain.
EUROPEAN JOURNAL OF PAIN
(2023)
Review
Anesthesiology
Greig R. R. Adams, Wiebke Gandhi, Richard Harrison, Carien M. M. van Reekum, Desmond Wood-Anderson, Ian Gilron, Tim V. V. Salomons
Summary: Central sensitization (CS) refers to increased pain responsiveness due to sensitization of neurons in the central nervous system. This review aimed to investigate whether self-report questionnaires linked with CS are associated with enhanced nociceptive responses or measure sensitivity in a broader sense (i.e., emotional responses).
Review
Clinical Neurology
Stephanie Park, Rex Park, Duncan Westwood, Massieh Moayedi, James S. Khan
Summary: Peripheral magnetic stimulation (PMS) shows promise in managing postoperative pain, as evidenced by positive effects on pain scores in several studies. However, more high-quality trials are needed to confirm its benefits, as the current evidence is limited by heterogeneity and low-quality studies. Overall, PMS appears to be more efficacious than sham or no intervention in the perioperative period, but further research is required.
Editorial Material
Neurosciences
Natalie C. W. Ho, Katharine Dunlop
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Neurosciences
Matthew A. Cormie, Batu Kaya, Georgia E. Hadjis, Pedram Mouseli, Massieh Moayedi
Summary: The insula and the cingulate are key brain regions involved in processing affective, cognitive, and interoceptive stimuli. Using ultra-high field 7T diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI), this study investigated the structural connectivity (SC) and functional connectivity (FC) between insula and cingulate subregions. The findings suggest strong connections between posterior INS and posterior MCC, and a potential mediating structure between the anterior insula and anterior mid-cingulate cortex.
Letter
Anesthesiology
Massieh Moayedi
Review
Anesthesiology
Elad Dana, Cody Tran, Evgeny Osokin, Duncan Westwood, Massieh Moayedi, Priyancee Sabhaya, James S. Khan
Summary: This study provides a systematic review of the effects of peripheral magnetic stimulation (PMS) in the treatment of chronic peripheral neuropathic pain. The results are mixed, with some studies showing benefits of PMS while others show no significant differences. PMS has a significant effect in reducing pain scores in the short term, but its efficacy in the long term is limited. Further high-quality studies are needed to establish the effectiveness and safety of PMS.
Article
Neurosciences
Richard Harrison, Wiebke Gandhi, Carien M. van Reekum, Tim Salomons
Summary: This study investigated the association between whole-brain connectivity of the periaqueductal grey (PAG), a core modulatory region, and conditioned pain modulation (CPM) and endogenous pain modulation. The findings showed that CPM was associated with heightened connectivity between the PAG and key regions involved in pain processing and inhibition. These results may serve as brain-based biomarkers for vulnerability or resilience to pain.
Article
Neurosciences
Lindsey R. Yessick, Tim Salomons
Summary: Learned helplessness, which develops with prolonged exposure to uncontrollable stressors, is highly relevant to individuals living with pain or other poorly controlled chronic diseases. This study has developed a helplessness scale specific to chronic conditions, addressing the limitations of previous scales in conceptualizing control constructs. The results suggest that the three-factor CDHS is a psychometrically sound measure of helplessness in individuals with chronic pain.