Article
Neurosciences
Feifei Zhang, Song Wang, Yang Feng, Kun Qin, Huiru Li, Baolin Wu, Zhiyun Jia, Qiyong Gong
Summary: The study highlights the potential risk of exercise dependence (EXD) due to excessive exercise and the role of stress in its onset and development. The findings suggest that gray matter volume (GMV) in specific brain regions may mediate the relationship between stress and EXD, even after controlling for various factors such as sex, age, and psychological conditions.
HUMAN BRAIN MAPPING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qihao Zhang, Chaofan Sui, Junghun Cho, Linfeng Yang, Tao Chen, Bin Guo, Kelly McCabe Gillen, Jing Li, Lingfei Guo, Yi Wang
Summary: The objective of this study was to analyze the different brain oxygen metabolism statuses in preeclampsia using magnetic resonance imaging and investigate the factors that affect cerebral oxygen metabolism in preeclampsia. By studying 49 women with preeclampsia, 22 pregnant healthy controls, and 40 non-pregnant healthy controls, it was found that the preeclampsia group had significantly higher brain oxygen extraction fraction (OEF) values compared to the control groups.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Neurosciences
Jiayan Liu, Yahui Lei, Yuyao Diao, Yamei Lu, Xingbo Teng, Qingting Chen, Lian Liu, Jingxiang Zhong
Summary: This study investigates the morphological alterations in gray matter volume (GMV) in form-deprivation myopia (FDM) rats using voxel-based morphometry (VBM) method. The results show that compared to the normal controls, the FDM group exhibits significantly decreased GMVs in the left primary visual cortex, left secondary visual cortex, right subiculum, right cornu ammonis, right entorhinal cortex, and bilateral molecular layer of the cerebellum, while significantly increased GMVs were found in the right dentate gyrus, parasubiculum, and olfactory bulb.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Xinyue Zhang, Jun Zhou, Mengyuan Guo, Shirui Cheng, Yilin Chen, Nannan Jiang, Xinling Li, Shengjie Hu, Zilei Tian, Zhengjie Li, Fang Zeng
Summary: This study comprehensively summarizes and meta-analyzes voxel-based morphometric neuroimaging studies of migraine. The findings reveal gray matter alterations in multiple brain regions in migraine patients, which may be a consequence of repeated migraine attacks.
JOURNAL OF NEUROLOGY
(2023)
Article
Neuroimaging
Xiaoxi Ji, Hui Wang, Minwei Zhu, Yingjie He, Hong Zhang, Xiaoguang Chen, Wenpeng Gao, Yili Fu
Summary: The study revealed bilateral loss in the pons and left part of the midbrain in patients with mild Alzheimer's disease (AD-M) compared to the normal control group. There was also greater loss in the left midbrain in the AD-M group compared to those with very mild AD (AD-VM). This is the first VBM study providing evidence of early brainstem alterations in Alzheimer's disease.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Geriatrics & Gerontology
Wei-Ling Chen, Yukiko Nishita, Akinori Nakamura, Takashi Kato, Takeshi Nakagawa, Shu Zhang, Hiroshi Shimokata, Rei Otsuka, Kuan-Pin Su, Hidenori Arai
Summary: This study found a positive correlation between hemoglobin concentration and hippocampal volume in middle-aged and older adults, highlighting the importance of monitoring hemoglobin concentration to decrease the possibility of neurodegeneration.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Review
Clinical Neurology
Alessandro Miola, Nicola Meda, Giulia Perini, Fabio Sambataro
Summary: Around one-third of patients with major depressive disorder do not see significant improvement in their symptoms even after adequate treatment with two different antidepressant medications. This condition, known as treatment-resistant depression (TRD), severely impacts the quality of life of millions of people worldwide, leading to long-lasting interpersonal problems and social costs. A systematic review of neuroimaging studies indicates that frontal, cerebellar, and brainstem functions may be involved in the pathophysiology of TRD, although the heterogeneity and limitations of the available literature restrict the generalizability of the findings.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Clinical Neurology
Hernan C. Kulsgaard, Jose I. Orlando, Mariana Bendersky, Juan P. Princich, Luis S. R. Manzanera, Alberto Vargas, Silvia Kochen, Ignacio Larrabide
Summary: The study proposed to refine the findings of single subject VBM using SVM technique, which successfully reduced the false positive detections while maintaining the true positive findings. This method has the potential to assist radiologists and clinicians in manual analysis and increase the usability of SS-VBM for image reading.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Computer Science, Interdisciplinary Applications
Gabriel Solana-Lavalle, Roberto Rosas-Romero
Summary: This study proposes a new method for classifying 3-D MRI scans as an assisting tool for Parkinson's disease diagnosis, using separate experiments for men and women due to gender differences in disease prevalence. High detection performance was achieved, with men showing 99.01% accuracy and women showing 96.97% accuracy in classification experiments, highlighting the effectiveness of the proposed approach.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Clinical Neurology
Gregor Broessner, Isabel Ellerbrock, Mareike M. Menz, Florian Frank, Michael Verius, Christian Gaser, Arne May
Summary: Voxel-based morphometry (VBM) is a widely used tool to study brain plasticity, development, and disease, but the source of T-1 signal changes is not fully understood. This study found significant gray matter volume changes in pain processing areas following pain stimulation, yet similar changes were observed in a control group without pain input. The results highlight the need for further research and control groups in longitudinal imaging studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Francina Hartmann, Julia Reinhardt, Christoph Stippich, Sabine Krumm
Summary: Voxel-based morphometry (VBM) is a method used to assess grey matter volumes in the brain, and the quality of MRI and data preprocessing steps can affect the results. This study found a lack of standardized protocols and that manual correction of voxel misclassification had minimal impact on Alzheimer's disease research.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Antonio Del Casale, Stefano Ferracuti, Andrea Steven Barbetti, Paride Bargagna, Paolo Zega, Alessia Iannuccelli, Federico Caggese, Teodolinda Zoppi, Gabriele Pasquale De Luca, Giovanna Parmigiani, Isabella Berardelli, Maurizio Pompili
Summary: In this meta-analysis, researchers investigated the grey matter changes in patients with posttraumatic stress disorder (PTSD) compared to trauma-exposed individuals without clinical PTSD. The results showed a significant reduction in grey matter volume in a large left-sided cluster extending from the parahippocampal gyrus to the uncus, including the amygdala, in PTSD patients. These findings suggest that these volumetric reductions may be a major structural correlate of PTSD and contribute to symptom expression.
NEUROPSYCHOBIOLOGY
(2022)
Article
Anatomy & Morphology
Stephanie Seidenbecher, Maria Schoene, Joern Kaufmann, Kolja Schiltz, Bernhard Bogerts, Thomas Frodl
Summary: The present study examined the structural brain characteristics in two healthy samples differing only in their propensity for aggressive behavior, revealing brain structural differences between the two groups in frontal and parietal brain areas critical for emotion processing/inhibition and empathy processes.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Clinical Neurology
Yang Yang, Wei Liang, Yongjun Wang, Dechang Peng, Liang Gong, Na Wang, Zhongjie Huang, Weikang Yang
Summary: The study aimed to investigate the pattern of volume changes in neurofunctional hippocampal subfields in patients with insomnia and their associations with risk of development of insomnia. Results showed that hippocampal volume atrophy in specific neurofunctional subfields was not only associated with insomnia but also a significant risk factor predicting the development of insomnia. The study also developed a practical and visual competing risk-nomogram tool for individual prediction of insomnia risk with high accuracy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Feifei Zhang, Hongsheng Xie, Song Wang, Fei Li, Qiyong Gong, Zhiyun Jia
Summary: This study found that the volume of the right orbitofrontal cortex was negatively correlated with exercise addiction. The function of the right orbitofrontal cortex played an indirect role in exercise addiction and affected it through its volume. The volume of the right orbitofrontal cortex mediated the relationship between ability motivation and exercise addiction.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Mark Mikkelsen, Peter B. Barker, Pallab K. Bhattacharyya, Maiken K. Brix, Pieter F. Buur, Kim M. Cecil, Kimberly L. Chan, David Y. -T. Chen, Alexander R. Craven, Koen Cuypers, Michael Dacko, Niall W. Duncan, Ulrike Dydak, David A. Edmondson, Gabriele Ende, Lars Ersland, Fei Gao, Ian Greenhouse, Ashley D. Harris, Naying He, Stefanie Heba, Nigel Hoggard, Tun-Wei Hsu, Jacobus F. A. Jansen, Alayar Kangarlu, Thomas Lange, R. Marc Lebel, Yan Li, Chien-Yuan E. Lin, Jy-Kang Liou, Jiing-Feng Lirng, Feng Liu, Ruoyun Maq, Celine Maes, Marta Moreno-Ortega, Scott O. Murray, Sean Noah, Ralph Noeske, Michael D. Noseworthy, Georg Oeltzschner, James J. Prisciandaro, Nicolaas A. J. Puts, Timothy P. L. Roberts, Markus Sack, Napapon Sailasuta, Muhammad G. Saleh, Michael-Paul Schallmo, Nicholas Simard, Stephan P. Swinnen, Martin Tegenthoff, Peter Truong, Guangbin Wang, Iain D. Wilkinson, Hans-Joerg Wittsack, Hongmin Xu, Fuhua Yan, Chencheng Zhang, Vadim Zipunnikov, Helge J. Zoellner, Richard A. E. Edden
Article
Neurosciences
Margot Thiaucourt, Polina Shabes, Natalie Schloss, Markus Sack, Ulf Baumgaertner, Christian Schmahl, Gabriele Ende
Article
Psychiatry
Sarah V. Biedermann, Traute Demirakca, Alexander Sartorius, Matthias K. Auer, Gabriele Ende, Fabrice Berna
PSYCHIATRY RESEARCH
(2017)
Article
Neurosciences
Christian Paret, Jenny Zaehringer, Matthias Ruf, Martin Fungisai Gerchen, Stephanie Mall, Talma Hendler, Christian Schmahl, Gabriele Ende
HUMAN BRAIN MAPPING
(2018)
Letter
Genetics & Heredity
Fabian Streit, Jens Treutlein, Ulrich Frischknecht, Derik Hermann, Karl Mann, Falk Kiefer, Markus Sack, Alisha S. M. Hall, Josef Frank, Stephanie H. Witt, Jerome C. Foo, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Markus M. Noethen, Wolfgang H. Sommer, Rainer Spanagel, Marcella Rietschel, Gabriele Ende
PSYCHIATRIC GENETICS
(2018)
Article
Behavioral Sciences
Jenny Zaehringer, Christian Schmahl, Gabriele Ende, Christian Paret
BEHAVIORAL NEUROSCIENCE
(2018)
Article
Clinical Neurology
Alexander Sartorius, Traute Demirakca, Andreas Boehringer, Christian Clemm von Hohenberg, Suna Su Aksay, Jan Malte Bumb, Laura Kranaster, Thomas Nickl-Jockschat, Michael Groezinger, Philipp A. Thomann, Robert Christian Wolf, Peter Zwanzger, Udo Dannlowski, Ronny Redlich, Maxim Zavorotnyy, Rebecca Zoellner, Isabel Methfessel, Matthias Besse, David Zilles, Gabriele Ende
Article
Neurosciences
Mark Mikkelsen, Daniel L. Rimbault, Peter B. Barker, Pallab K. Bhattacharyya, Maiken K. Brix, Pieter F. Buur, Kim M. Cecil, Kimberly L. Chan, David Y-T Chen, Alexander R. Craven, Koen Cuypers, Michael Dacko, Niall W. Duncan, Ulrike Dydak, David A. Edmondson, Gabriele Ende, Lars Ersland, Megan A. Forbes, Fei Gao, Ian Greenhouse, Ashley D. Harris, Naying He, Stefanie Heba, Nigel Hoggard, Tun-Wei Hsu, Jacobus F. A. Jansen, Alayar Kangarlu, Thomas Lange, R. Marc Lebel, Yan Li, Chien-Yuan E. Lin, Jy-Kang Liou, Jiing-Feng Lirng, Feng Liu, Joanna R. Long, Ruoyun Ma, Celine Maes, Marta Moreno-Ortega, Scott O. Murray, Sean Noah, Ralph Noeske, Michael D. Noseworthy, Georg Oeltzschner, Eric C. Porges, James J. Prisciandaro, Nicolaas A. J. Puts, Timothy P. L. Roberts, Markus Sack, Napapon Sailasuta, Muhammad G. Saleh, Michael-Paul Schallmo, Nicholas Simard, Diederick Stoffers, Stephan P. Swinnen, Martin Tegenthoff, Peter Truong, Guangbin Wang, Iain D. Wilkinsons, Hans-Joerg Wittsack, Adam J. Woods, Hongmin Xu, Fuhua Yan, Chencheng Zhang, Vadim Zipunnikov, Helge J. Zoellner, Richard A. E. Edden
Article
Psychiatry
Annegret Krause-Utz, Ezgi Erol, Athina Brousianou, Sylvia Cackowski, Christian Paret, Gabriele Ende, Bernet Elzinga
BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
(2019)
Meeting Abstract
Psychology, Biological
Jenny Zaehringer, Christine Jennen-Steinmetz, Christian Schmahl, Gabriele Ende, Christian Paret
Article
Psychiatry
Sylvia Cackowski, Annegret Krause-Utz, Julia Van Eijk, Katrin Klohr, Stephanie Daffner, Esther Sobanski, Gabriele Ende
BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
(2017)
Meeting Abstract
Neurosciences
Christian Paret, Jenny Zaehringer, Matthias Ruf, Gabriele Ende, Christian Schmahl
NEUROPSYCHOPHARMACOLOGY
(2017)
Meeting Abstract
Clinical Neurology
G. Ende
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2017)
Meeting Abstract
Neurosciences
Christian Paret, Gabriele Ende, Jenny Zahringer, Matthias Ruf, Christian Schmahl
BIOLOGICAL PSYCHIATRY
(2017)
Article
Substance Abuse
Ulrich Frischknecht, Derik Hermann, Nuran Tunc-Skarka, Guo-Ying Wang, Markus Sack, Julia van Eijk, Traute Demirakca, Claudia Falfan-Melgoza, Bertram Krumm, Sandra Dieter, Rainer Spanagel, Falk Kiefer, Karl F. Mann, Wolfgang H. Sommer, Gabriele Ende, Wolfgang Weber-Fahr
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2017)