Article
Anatomy & Morphology
William W. Graves, Jeremy Purcell, David Rothlein, Donald J. Bolger, Miriam Rosenberg-Lee, Ryan Staples
Summary: The study found that phonological and orthographic representations are primarily associated with the supramarginal gyrus, while semantic representations are primarily associated with the angular gyrus. De-correlating constituent representations of complex cognitive processes by careful selection of stimuli, representational formats, and analysis techniques is a promising approach for enhancing our understanding of brain structure-function relationships.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Neurosciences
Jeffrey M. Kenzie, Deepthi Rajashekar, Bradley G. Goodyear, Sean P. Dukelow
Summary: Around 50% of stroke patients have deficits in proprioception, but our understanding of the neurological mechanisms behind these deficits is limited. This study used resting-state functional magnetic resonance imaging (fMRI) to investigate changes in functional brain networks associated with proprioception deficits in stroke patients. The results showed reduced connectivity in specific brain regions, including the supplementary motor area and the supramarginal gyrus, in stroke patients compared to healthy controls. Functional connectivity of these regions, as well as the primary somatosensory cortex and the parietal opercular area, was significantly associated with proprioceptive function. The parietal lobe of the lesioned hemisphere was identified as an important node for proprioception after stroke, and evaluating the functional connectivity of this region could help predict recovery. The study also identified potential targets for therapeutic neurostimulation to aid in stroke recovery.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
M. B. Reed, T. Vanicek, R. Seiger, M. Klobl, B. Spurny, P. Handschuh, V Ritter, J. Unterholzner, G. M. Godbersen, G. Gryglewski, C. Kraus, D. Winkler, A. Hahn, R. Lanzenberger
Summary: The study illustrates that SSRIs may facilitate relearning by modulating brain region activation in humans. The left angular gyrus is identified as a crucial component for correct memory retrieval, with activation depending on both stimulus and time. Escitalopram is shown to improve performance after relearning, regardless of the task content.
Article
Neurosciences
Gina F. Humphreys, JeYoung Jung, Matthew A. Lambon Ralph
Summary: This study revealed the different roles of lateral parietal cortex (LPC) in episodic memory retrieval and semantic memory retrieval from a functional and connectivity perspective. The findings showed that ventral LPC was positively activated during episodic retrieval but not during semantic memory retrieval, while dorsal LPC was activated in various tasks and positively correlated with task difficulty. Furthermore, a gradient of connectivity along the dorsal-ventral and anterior-posterior axis was found in the angular gyrus (AG).
Article
Behavioral Sciences
Min Wang, Ping Yang, Tingting Zhang, Wenjuan Li, Junjun Zhang, Zhenlan Jin, Ling Li
Summary: This study used EEG and fMRI methods to investigate the neural response underlying WM guidance in a visual search task. The findings suggest that information held in WM enhances early object discrimination during attentional selection, and the left SMG/IPL may play a critical role in mediating goal-directed processing under WM biases in human visual attention.
Article
Neurosciences
Zhiyao Gao, Li Zheng, Rocco Chiou, Andre Gouws, Katya Krieger-Redwood, Xiuyi Wang, Dominika Varga, Matthew A. Lambon Ralph, Jonathan Smallwood, Elizabeth Jefferies
Summary: The study found that semantic and non-semantic demands led to both similar and distinct neural responses across control-related networks. While the difficulty of both semantic and working memory decisions could be decoded in both the semantic control network and multiple-demand network, there was no shared neural coding of cognitive demands in the semantic control network regions.
Article
Neurosciences
Mengting Fang, Aidas Aglinskas, Yichen Li, Stefano Anzellotti
Summary: The selectivity of perceptual brain regions is a fundamental principle of organization, and the occipitotemporal cortex in humans is divided into areas that preferentially respond to faces, bodies, artifacts, and scenes. However, combining information about objects from different categories is necessary for a coherent understanding of the world. This study used fMRI and artificial neural networks to investigate the interactions between brain regions in male and female subjects and found that the angular gyrus is statistically dependent on multiple category-selective regions. The combination of scenes and other categories suggests that scenes provide a context for integrating information about the world. Additional analyses revealed that multicategory information is encoded in multiple distinct brain regions rather than a single centralized location.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Cory Shain, Alexander Paunov, Xuanyi Chen, Benjamin Lipkin, Evelina Fedorenko
Summary: Language comprehension and theory of mind (ToM) are related during development and language use. However, neural evidence on the relationship between language and ToM is mixed. This study examines the response of the language network to verbal and nonverbal ToM tasks using fMRI. The results show that the differences in brain activation between language and ToM are largely due to linguistic confounds, arguing against cognitive and neural overlap.
Article
Neuroimaging
Maximilian Maywald, Oliver Pogarell, Susanne Levai, Marco Paolini, Nadja Tschentscher, Boris Stephan Rauchmann, Daniela Krause, Sophia Stoecllein, Stephan Goerigk, Lukas Roell, Birgit Ertl-Wagner, Boris Papazov, Daniel Keeser, Susanne Karch, Agnieszka Chrobok
Summary: This study investigated the differences in neural correlates between patients with persistent postural-perceptual dizziness (PPPD) and anxiety disorders (ANX). The findings showed that PPPD patients had higher neural responses in the vestibulo-spatial network compared to ANX patients, while their responses in the anxiety network were similar. Additionally, the control group exhibited stronger activation in visual processing areas.
NEUROIMAGE-CLINICAL
(2023)
Article
Anatomy & Morphology
Astrid Graessner, Emiliano Zaccarella, Gesa Hartwigsen
Summary: This study demonstrates the existence of different nodes in the brain during semantic composition, with functional contributions depending on the type of compositional process under analysis.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Psychiatry
Lukas Uhlmann, Mareike Pazen, Bianca M. van Kemenade, Tilo Kircher, Benjamin Straube
Summary: The study found that disturbances in self-other distinction in schizophrenia spectrum disorders are particularly driven by agency, while self-other distinction based on hand identity might be spared.
SCHIZOPHRENIA BULLETIN
(2021)
Review
Clinical Neurology
Sarah Houben, Megane Homa, Zehra Yilmaz, Karelle Leroy, Jean-Pierre Brion, Kunie Ando
Summary: AHN plays a critical role in sustaining hippocampal functions such as learning and memory, and impaired AHN in AD patients may contribute to cognitive deficits. NFTs and amyloid plaques are key neuropathological hallmarks of AD, with abnormal tau protein accumulation impacting AHN. Further research is needed to fully understand the relationship between tau pathology and AHN.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Taylor J. J. Bosch, Kelene A. A. Fercho, Reuven Hanna, Jamie L. L. Scholl, Austin Rallis, Lee A. A. Baugh
Summary: The study investigates the neural mechanisms underlying advanced tool use abilities in humans. Previous research has identified a unique brain region, the left anterior supramarginal gyrus (aSMG), which is consistently active during tool use action observation. This region is crucial for integrating semantic and technical information to form action plans with tools. However, the impact of tool use motor learning on aSMG activation and connectivity with other brain regions remains unknown.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Francesco Neri, Stefano F. Cappa, Lucia Mencarelli, Davide Momi, Emiliano Santarnecchi, Simone Rossi
Summary: This study investigated the recruitment of brain networks during story recollection process using an ecological fMRI free recall task. The results showed that free recall enhanced the activity of brain networks such as language, left executive control, default mode, and precuneus. The recruitment of the anterior angular gyrus may serve as a marker for optimal functioning in the recall process.
Article
Geriatrics & Gerontology
Sara Isernia, Valeria Blasi, Gisella Baglio, Monia Cabinio, Pietro Cecconi, Federica Rossetto, Marta Cazzoli, Francesco Blasi, Chiara Bruckmann, Fabrizio Giunco, Sandro Sorbi, Mario Clerici, Francesca Baglio
Summary: The study found that depression plays a crucial role in mediating the relationship between cortical thickness and frailty, while cognitive level showed no significant impact. Handgrip weakness was identified as an early key indicator of frailty in the cohort.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Yapei Xie, Zhilei Xu, Mingrui Xia, Jin Liu, Xiaojing Shou, Zaixu Cui, Xuhong Liao, Yong He
Summary: This study uncovers consistent alterations in brain network dynamics in individuals with Autism Spectrum Disorder (ASD) and identifies transcriptomic signatures associated with these changes, providing further insights into the biological basis of this disorder.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Congying Chu, Haoran Guan, Sangma Xie, Yanpei Wang, Jie Luo, Gai Zhao, Zhiying Pan, Mingming Hu, Weiwei Men, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Yong He, Lingzhong Fan, Qi Dong, Sha Tao
Summary: School-age children often undergo ongoing brain development. Diffusion tensor imaging is commonly used to assess white matter properties during this period. However, there is a lack of standardized diffusion tensor templates for school-age children. In this study, researchers established the school-age children diffusion tensor (SACT) template and found that it showed higher spatial normalization accuracy and inter-subject coherence compared to adult templates. The SACT template could contribute to future studies on white matter development.
NEUROSCIENCE BULLETIN
(2022)
Article
Multidisciplinary Sciences
Yunman Xia, Mingrui Xia, Jin Liu, Xuhong Liao, Tianyuan Lei, Xinyu Liang, Tengda Zhao, Ziyi Shi, Lianglong Sun, Xiaodan Chen, Weiwei Men, Yanpei Wang, Zhiying Pan, Jie Luo, Siya Peng, Menglu Chen, Lei Hao, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Gaolang Gong, Sha Tao, Qi Dong, Yong He
Summary: This study utilizes longitudinal functional magnetic resonance imaging data to uncover significant changes in the primary-to-transmodal gradient in the brain network during childhood to adolescence. These gradient changes are linked to cognitive growth, topological reorganization, and gene expression profiles.
Article
Neuroimaging
Zhiyuan Fan, Zhen Fan, Tianming Qiu, Liuxun Hu, Yuan Shi, Yunman Xia, Xiaoyi Sun, Yingjun Liu, Sichen Li, Mingrui Xia, Wei Zhu
Summary: The study found that there are differences in the topological organization of functional brain connectomes between patients with right-sided unilateral hearing loss (RUHL) and left-sided unilateral hearing loss (LUHL), indicating different pathophysiological mechanisms between the two conditions.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Neurosciences
Siyang Li, Yali Chen, Peng Ren, Zhipeng Li, Jun Zhang, Xia Liang
Summary: This study conducted graph-theoretical analyses on resting-state fMRI data to search for the neural correlates of consciousness (NCC) candidates. The results found these regions to be located in the prefrontal and temporoparietal cortices and related to the sustained existence of conscious content. The study also revealed two recurring brain states, one dominated by NCC regions and the other primarily composed of sensory/motor regions. Additionally, the study found that NCC was modulated by the loss of consciousness induced by propofol anesthesia.
HUMAN BRAIN MAPPING
(2023)
Article
Oncology
Hongbo Bao, Peng Ren, Liye Yi, Zhonghua Lv, Wencai Ding, Chenlong Li, Siyang Li, Zhipeng Li, Xue Yang, Xia Liang, Peng Liang
Summary: Increasing evidence suggests that the location of gliomas is associated with their cellular origin, molecular alterations, and genetic profile. This research aimed to elucidate the mechanisms underlying the tumor location preference in glioblastoma multiforme (GBM) and lower-grade glioma (LGG), and to use glioma location features to predict prognosis. MRI images from patients with GBM and LGG were analyzed, and the correlation between glioma distribution and gene expression in healthy brains was investigated. Transcriptomic differences in tumor tissue from preferred and non-preferred sites were also evaluated. Additionally, tumor anatomical localization was quantitatively characterized, and its relationship with overall survival was explored. Finally, a support vector machine was employed to build a survival prediction model for GBM patients. The findings revealed distinct location preferences for GBMs and LGGs, and identified specific gene activation patterns and anatomical distance metrics that could predict GBM 1-year survival status. These results provide new insights into tumor anatomical localization and have important implications for individualized therapy and prognosis prediction.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Neurosciences
Mingrui Xia, Yong He
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Zilong Zeng, Tengda Zhao, Lianglong Sun, Yihe Zhang, Mingrui Xia, Xuhong Liao, Jiaying Zhang, Dinggang Shen, Li Wang, Yong He
Summary: In this study, a new 3D mixed-scale asymmetric convolutional segmentation network (3D-MASNet) was proposed for tissue segmentation of 6-month-old infant brain MRI images. Compared to traditional single-scale symmetric convolutions, this approach demonstrated better accuracy and achieved the best performance in the evaluation.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Peng Ren, Wencai Ding, Siyang Li, Guiyou Liu, Meng Luo, Wenyang Zhou, Rui Cheng, Yiqun Li, Pingping Wang, Zhipeng Li, Lifen Yao, Qinghua Jiang, Xia Liang, Alzheimers Dis Neuroimaging Initiat
Summary: The study investigates the functional dysconnectivity of the nucleus basalis of Meynert (NbM) in Alzheimer's disease (AD) and its transcriptional correlates. The results reveal that NbM dysconnectivity is associated with specific gene expression abnormalities related to protein and immune functions, cholinergic receptors, immune, vascular and energy metabolism functions. These dysconnectivity-correlated gene sets contribute to preclinical amyloid-beta change and MCI onset age, highlighting their potential role in the early pathology of AD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Lei Wang, Qing Ma, Xiaoyi Sun, Zhilei Xu, Jiaying Zhang, Xuhong Liao, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Mingrui Xia, Yihe Zhang
Summary: This study conducted frequency-resolved connectome analysis on a large sample of MDD patients and healthy controls, revealing significant frequency-dependent connectome alterations in MDD. These alterations mainly occur in the left parietal, temporal, precentral, and fusiform cortices, as well as bilateral precuneus. Additionally, the connectome alteration in the high frequency band (0.16-0.24 Hz) is significantly associated with illness duration.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Wencai C. Ding, Peng Ren, Liye Yi, Yao F. Si, Fan L. Yang, Zhipeng Li, Hongbo L. Bao, Shi W. Yan, Xinyu Zhang, Siyang Li, Xia Liang, Lifen Yao
Summary: This study investigated cortical and subcortical microstructural changes in frontotemporal lobar degeneration (FTLD) subtypes, finding that patients with FTLD showed alterations in cortical mean diffusivity and cortical thinning. Anomalies in subcortical white matter diffusion were widely distributed across the frontotemporal and parietal areas. Different patterns of cortical and subcortical microstructural abnormalities were observed in the different FTLD subtypes, which correlated with disease severity and language functions.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Junling Wang, Lianglong Sun, Lili Chen, Junyan Sun, Yapei Xie, Dezheng Tian, Linlin Gao, Dongling Zhang, Mingrui Xia, Tao Wu
Summary: Neuroimaging studies have shown that dysfunction of the amygdala plays a crucial role in the non-motor symptoms of Parkinson's disease. However, the specific relationship between amygdala subregions and these symptoms has not been well-defined. Using resting-state functional MRI, researchers found that the amygdala subregions in Parkinson's disease exhibited altered functional connectivity, particularly with the frontal, temporal, insular cortex, and putamen. Each subregion also displayed distinct hypoconnectivity with different limbic systems, and this hypoconnectivity was associated with various non-motor symptoms such as emotion, pain, olfaction, cognition, and sleepiness. These findings provide new insights into the pathogenesis of non-motor symptoms in Parkinson's disease.
NPJ PARKINSONS DISEASE
(2023)
Correction
Neurosciences
Junling Wang, Lianglong Sun, Lili Chen, Junyan Sun, Yapei Xie, Dezheng Tian, Linlin Gao, Dongling Zhang, Mingrui Xia, Tao Wu
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Yuxing Hao, Huashuai Xu, Mingrui Xia, Chenwei Yan, Yunge Zhang, Dongyue Zhou, Tommi Karkkainen, Lisa D. Nickerson, Huanjie Li, Fengyu Cong
Summary: This study proposes an effective and powerful harmonisation strategy based on dual-projection (DP) theory of independent component analysis (ICA) to remove scanner/site effects while preserving signals of interest. The method shows superior performance compared to GLM-based and conventional ICA harmonisation methods in both simulation and real datasets.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
