Article
Clinical Neurology
Takashi Tsuboi, Joshua K. Wong, Robert S. Eisinger, Lela Okromelidze, Mathew R. Burns, Adolfo Ramirez-Zamora, Leonardo Almeida, Aparna Wagle Shukla, Kelly D. Foote, Michael S. Okun, Sanjeet S. Grewal, Erik H. Middlebrooks
Summary: The optimal targets for deep brain stimulation in essential tremor and dystonic tremor remain unknown. This study suggests that DBS targeting the ventral intermediate nucleus/ventralis oralis posterior nucleus border and ventral intermediate nucleus region may be a reasonable treatment option for medication-refractory dystonic tremor and essential tremor patients. Our findings highlight the involvement of cerebello-thalamo-cortical and basal ganglia-thalamo-cortical networks in the pathophysiology of dystonic tremor.
Article
Neurosciences
Kaijia Yu, Zhiwei Ren, Tao Yu, Xueyuan Wang, Yongsheng Hu, Song Guo, Jianyu Li, Yongjie Li
Summary: The study investigated the potential of using 3T QSM to delineate the ANT in the human brain, finding that QSM can clearly visualize the ANT and may be suitable for DBS surgery targeting. The morphology and location of the ANT were found to be highly variable among patients in the AC-PC system.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Robert E. Gross, Robert S. Fisher, Michael R. Sperling, Jonathon E. Giftakis, Paul H. Stypulkowski
Summary: This study analyzed the relationship between DBS lead locations and clinical outcomes, finding that subjects with good bilateral lead placements based on defined targets were more likely to be clinical responders. Specific sites within the ANT may be associated with superior clinical outcomes, highlighting the importance of continuing to evaluate these relationships to optimize DBS therapy.
Article
Clinical Neurology
Erik H. Middlebrooks, Ayushi Jain, Lela Okromelidze, Chen Lin, Erin M. Westerhold, Chad A. O'Steen, Anthony L. Ritaccio, Alfredo Quinones-Hinojosa, William O. Tatum, Sanjeet S. Grewal
Summary: The study showed that high-frequency stimulation (HFS) and low-frequency stimulation (LFS) in deep brain stimulation (DBS) for epilepsy treatment produce significant differences in local and downstream network effects, particularly displaying opposing effects within the limbic network and default mode network (DMN).
Article
Neuroimaging
Erik H. Middlebrooks, Lela Okromelidze, Joshua K. Wong, Robert S. Eisinger, Mathew R. Burns, Ayushi Jain, Hsin-Pin Lin, Jun Yu, Enrico Opri, Andreas Horn, Lukas L. Goede, Kelly D. Foote, Michael S. Okun, Alfredo Quinones-Hinojosa, Ryan J. Uitti, Sanjeet S. Grewal, Takashi Tsuboi
Summary: This study found a correlation between structural connectivity and treatment outcomes in DBS for tremor patients, suggesting the potential for structural connectivity to predict contralateral tremor improvement. The predictive feature map showed the anatomical course of the DRTT, with all analyzed sweet spots overlapping this predictive tract.
NEUROIMAGE-CLINICAL
(2021)
Article
Multidisciplinary Sciences
Federico Bruno, Alessia Catalucci, Marco Varrassi, Francesco Arrigoni, Patrizia Sucapane, Davide Cerone, Francesca Pistoia, Silvia Torlone, Emanuele Tommasino, Luca De Santis, Antonio Barile, Alessandro Ricci, Carmine Marini, Alessandra Splendiani, Carlo Masciocchi
Summary: Direct targeting in MRgFUS thalamotomy showed better accuracy compared to indirect targeting, especially on RL and AP coordinates. The agreement between measurements was higher for tractography along the AP and SI planes and lower along the RL planes. Indirect atlas-based targeting remains a valid approach for MRgFUS thalamotomy.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Tariq Parker, Ashley L. B. Raghu, James J. FitzGerald, Alexander L. Green, Tipu Z. Aziz
Summary: Dual thalamo-pallidal stimulation demonstrates great flexibility and efficacy in managing complex movement disorders, but also has limitations.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Laila Terzic, Angela Voegtle, Amr Farahat, Nanna Hartong, Imke Galazky, Slawomir J. Nasuto, Adriano de Oliveira Andrade, Robert T. Knight, Richard B. Ivry, Juergen Voges, Lars Buentjen, Catherine M. Sweeney-Reed
Summary: The study investigated the impact of VIM stimulation on motor sequence learning, showing beneficial effects of VIM-DBS on motor sequence learning in ET patients, particularly with lateral VIM electrode location.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Hao Yan, Xueyuan Wang, Xiaohua Zhang, Liang Qiao, Runshi Gao, Duanyu Ni, Wei Shu, Cuiping Xu, Liankun Ren, Tao Yu
Summary: By studying the surgical outcome of deep brain stimulation (DBS) of different target nuclei for patients with refractory epilepsy, we aimed to explore a clinically feasible target nucleus selection strategy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Mathematics, Applied
Erik T. K. Mau, Michael Rosenblum
Summary: Collective synchronization in a large population of self-sustained units can be observed in both natural and engineered systems. In this paper, the authors focus on studying pulsatile control to manipulate the level of synchrony. By quantifying this level using the entropy of the phase distribution, the researchers investigate the effect of pulses of realistic shape on the synchronization. The results show that the change in entropy is related to the properties of individual units and the state of the population.
Article
Clinical Neurology
Clemens Neudorfer, Daniel Kroneberg, Bassam Al-Fatly, Lukas Goede, Dorothee Kuebler, Katharina Faust, Ursula van Rienen, Anna Tietze, Thomas Picht, Todd M. Herrington, Erik H. Middlebrooks, Andrea Kuhn, Gerd-Helge Schneider, Andreas Horn
Summary: Using FGATIR sequences, this study identified a thalamic hypointensity as a potential visual marker for deep brain stimulation (DBS). By analyzing 65 patients with essential tremor, the clinical utility of the hypointensity marker was validated, and it was found to predict the clinical outcome of DBS treatment.
ANNALS OF NEUROLOGY
(2022)
Review
Clinical Neurology
Adeel Ilyas, Kathryn M. Snyder, Tessy M. Thomas, Nitin Tandon
Summary: This study reviewed seven studies on ANT DBS and found that 56% of patients were considered responders at an average follow-up of 2.3 years post-DBS. The active contacts of responders were found to be 1.6 mm anterior compared to nonresponders and were adjacent to the MTT.
JOURNAL OF NEUROSURGERY
(2022)
Review
Clinical Neurology
Davide Paoli, Russell Mills, Una Brechany, Nicola Pavese, Claire Nicholson
Summary: This study reviewed the application of double-targeting strategy in the treatment of patients with mixed tremor and dystonia and reported a case series of nine patients at our center. The results showed that the double-targeting strategy achieved significant and durable improvement in controlling tremor and dystonia, and demonstrated good efficacy in improving quality of life.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Adeel Ilyas, Kathryn M. Snyder, Sandipan Pati, Nitin Tandon
Summary: This study aimed to quantify the association between active contact location and outcomes of CM DBS, indicating that success of CM DBS is related to active contact location, with the optimal location found to be at the dorsal border of the CM.
Article
Multidisciplinary Sciences
Antoine Collomb-Clerc, Maelle C. M. Gueguen, Lorella Minotti, Philippe Kahane, Vincent Navarro, Fabrice Bartolomei, Romain Carron, Jean Regis, Stephan Chabardes, Stefano Palminteri, Julien Bastin
Summary: This study analyzed intra-thalamic electrophysiological recordings from human participants during a reinforcement learning task. The results showed that the thalamus is involved in estimating expected value and signaling reward prediction errors during reward-based and punishment-based learning. The study also revealed the neural mechanisms underlying action inhibition in punishment avoidance learning.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Youssef El Ouadih, Guillaume Coll, Betty Jean, Aurelien Coste, Remi Chaix, Laurent Sakka, Jean-Jacques Lemaire
Summary: This article reports a case of brainstem compression due to delayed migration of a pipeline embolization device (PED), highlighting the importance of technical issues and the role of surgery in cases of vascular compression of the lower brainstem.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Letter
Rehabilitation
Benedicte Pontier, Anna Sontheimer, Jerome Coste, Youssef El Ouadih, Anne-Marie Briancon, Guilhem Millet, Eric Pantera, Catherine Sarret, Jean-Jacques Lemaire
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Neurosciences
Anna Sontheimer, Benedicte Pontier, Beatrice Claise, Carine Chassain, Jerome Coste, Jean-Jacques Lemaire
Summary: Chronic disorders of consciousness, including unresponsive wakefulness syndrome and minimally conscious state, lack clear definition of their anatomo-functional correlates. A study using resting-state functional MRI revealed disrupted functional connectivity between subcortical structures and cortical networks in chronic DOC patients, with implications for the mesocircuit model and potential therapeutic implications.
Article
Clinical Neurology
R. Kardous, H. Joly, B. Giordana, L. Stefanini, A. Mulliez, C. Giordana, J-J Lemaire, D. Fontaine
Summary: This study investigated changes in impulsivity following subthalamic nucleus deep brain stimulation in Parkinson's disease patients, finding an increase in dysfunctional impulsivity while functional impulsivity remained unchanged. The increase in dysfunctional impulsivity may be influenced by the location of the electrode in the ventral part of the subthalamic nucleus.
Article
Oncology
Angeline Ginzac, Guillaume Dupic, Lucie Brun, Ioana Molnar, Melanie Casile, Xavier Durando, Pierre Verrelle, Jean-Jacques Lemaire, Toufic Khalil, Julian Biau
Summary: BackgroundSurgery is a crucial treatment for brain metastases, but postoperative stereotactic radiosurgery (SRT) comes with risks. Preoperative SRT is proposed as an alternative to reduce risks, and the STEP trial is the first prospective study in Europe to assess its effectiveness.
Article
Biotechnology & Applied Microbiology
Frederic Chapelle, Lucie Manciet, Bruno Pereira, Anna Sontheimer, Jerome Coste, Youssef El Ouadih, Ruxandra Cimpeanu, Dimitri Gouot, Yuri Lapusta, Beatrice Claise, Valerie Sautou, Yassine Bouattour, Ana Marques, Adrien Wohrer, Jean-Jacques Lemaire
Summary: The findings highlight the impact of hemisphere coupling and electrode stiffness on electrode deformations, as well as differences in deformations based on tissue layers, electrode type, and hemisphere-brain-shift effect. These results provide valuable insights for the development of intracerebral electrode design and surgical procedures.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Medicine, General & Internal
Jean-Jacques Lemaire, Remi Chaix, Anna Sontheimer, Jerome Coste, Marie-Anne Cousseau, Charlene Dubois, Melanie San Juan, Christelle Massa, Sandrine Raynaud, Alexandra Usclade, Benedicte Pontier, Youssef El Ouadih, Kamel Abdelouahab, Luca Maggiani, Francois Berry
Summary: Risk-taking behaviors among adult bedridden patients in neurosurgery are frequent but often overlooked. Studies have shown that patients may lack awareness of these behaviors, leading to uncontrollable risks, highlighting the importance of technological solutions in prevention.
FRONTIERS IN MEDICINE
(2021)
Article
Computer Science, Cybernetics
S. Kirchhofer, T. Chateau, C. Bouzgarrou, J. -J Lemaire
Summary: The article explores the estimation of hand joint coordinates from EMG data, presenting a new dataset, neural network models, and experimental study results, which serve as a foundation for future prosthetic control solutions.
CYBERNETICS AND SYSTEMS
(2022)
Review
Clinical Neurology
J-J Lemaire, B. Pontier, R. Chaix, Y. El Ouadih, T. Khalil, D. Sinardet, V Achim, A. Postelnicu, J. Coste, V Germain, C. Sarret, A. Sontheimer
Summary: This article reviews the medical aspects of consciousness, including the behavioral dimension, phenotypic descriptors, relative consciousness, neural correlates, and related disorders. Consciousness is relative and specific to each individual. Modern functional exploration techniques contribute to the understanding of consciousness disorders. Neural correlates include wakefulness pathways and cortico-subcortical circuitry. Deep brain structures and cortices can be segregated into overlapping networks. This review is important for understanding and treating consciousness disorders.
Review
Biotechnology & Applied Microbiology
Yassine Bouattour, Valerie Sautou, Rodayna Hmede, Youssef El Ouadhi, Dimitri Gouot, Philip Chennell, Yuri Lapusta, Frederic Chapelle, Jean-Jacques Lemaire
Summary: Brain surrogates are becoming increasingly important in the medical field, being used for education, training, and evaluating medical devices. They have specific and accurate mechanical and biophysical properties, and can complement numeric models.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Marine Lottin, Alexandre Escande, Luc Bauchet, Marie Albert-Thananayagam, Mael Barthoulot, Matthieu Peyre, Mathieu Boone, Sonia Zouaoui, Jacques Guyotat, Guillaume Penchet, Johan Pallud, Henry Dufour, Evelyne Emery, Michel Lefranc, Sebastien Freppel, Houman Namaki, Edouard Gueye, Jean-Jacques Lemaire, Bertrand Muckensturm, Robin Srour, Stephane Derrey, Apolline Monfilliette, Jean-Marc Constans, Claude-Alain Maurage, Bruno Chauffert, Nicolas Penel
Summary: This retrospective study analyzed the clinical outcomes of 88 patients with intracranial solitary fibrous tumours (iSFTs). Gross tumour resection was found to be beneficial for prognosis and reduced local recurrence without impacting overall survival. High-grade tumours were associated with poorer progression-free survival and local recurrence-free survival. More than 40% of patients experienced local recurrence and were mostly treated with surgery and radiotherapy. The first relapse was a turning point in iSFT evolution, with shorter recurrence intervals over time. Managing repeated recurrence and disseminated disease remains challenging and local techniques should be considered.
Article
Oncology
Youssef El Ouadih, Bruno Pereira, Julian Biau, Beatrice Claise, Remi Chaix, Pierre Verrelle, Toufik Khalil, Xavier Durando, Jean-Jacques Lemaire
Summary: This study focused on investigating the mechanisms of tumor cell spreading and MRI abnormalities in the brain adjacent to the tumor. The researchers analyzed MRI characteristics, such as apparent diffusion coefficient (ADC), fractional anisotropy (FA), and number of fibers, in patients with GBM and metastasis, as well as healthy individuals. The results showed that GBM volumes were larger than metastasis volumes, and ADC was higher in metastasis.