Journal
BRAIN RESEARCH BULLETIN
Volume 93, Issue -, Pages 47-56Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2012.11.004
Keywords
Extrasynaptic AMPA receptors; AMPAR trafficking; AMPAR subunits; Dorsal horn; Inflammatory pain
Categories
Funding
- State Fund Fundamental Research (DFFD) [F46.2/001]
- National Academy of Sciences of Ukraine (NASU)
- NASU Grant for Young Scientists
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Extrasynaptic AMPA receptors (AMPARs) are widely expressed in the brain, spinal cord and periphery. These receptors are critically involved in activity-dependent synaptic transmission and changes in their functioning are causally linked to multiple neuropathologies in the central nervous system (CNS). However, most studies in this field have been concentrated on elucidating synaptic AMPAR functioning, leaving a possible involvement of an extrasynaptic pool of AMPARs in normal and pathological signaling open for consideration. Here, we review the present evidence for extrasynaptic AMPAR function in the dorsal horn neurons of the spinal cord, linking these receptors to neurotransmission and non-synaptic signaling in this part of the CNS. In addition, we summarize current knowledge about the role of extrasynaptic AMPARs in the development and maintenance of pain states during inflammation. This knowledge potentially suggests the development of alternative therapies to prevent and/or treat inflammatory pain. (C) 2012 Elsevier Inc. All rights reserved.
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