Journal
BRAIN RESEARCH BULLETIN
Volume 83, Issue 5, Pages 266-271Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2010.06.014
Keywords
Gypenosides; Neuroprotection; Neurotoxicity; Substantia nigra; Parkinson s disease
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Funding
- China Postdoctoral Science Foundation [20080431369]
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Oxidative injury has been implicated in the etiology of Parkinson s disease (PD) Gypenosides (GPs) the saponins extract derived from the Gynostemma pentaphyllum has various bioactivities In this study GPs was investigated for its neuroprotective effects on the 1-methyl-4-phenylpyridinium ion (MPP+)-induced oxidative injury of dopaminergic neurons in primary nigral culture It was found that GPs pretreatment cotreatment or posttreatment significantly and dose-dependently attenuated MPP+-induced oxidative damage reduction of dopamine uptake loss of tyrosine hydrolase (TH)-immunopositive neurons and degeneration of TH-immunopositive neurites However the preventive effect of GPs was more potential than its therapeutical effect Most importantly the neuroprotective effect of GPs may be attributed to GPs-induced strengthened antioxidation as manifested by significantly increased glutathione content and enhanced activity of glutathione peroxidase catalyze and superoxide dismutase in nigral culture The neuroprotective effects of GPs are specific for dopaminergic neurons and it may have therapeutic potential in the treatment of PD (C) 2010 Elsevier Inc All rights reserved
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