Journal
BRAIN RESEARCH
Volume 1705, Issue -, Pages 24-31Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2018.09.034
Keywords
Brain development; Cortex; Hippocampus; Mowat-Wilson syndrome
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Funding
- Russian Scientific Foundation [15-14-10021]
- Russian Science Foundation [15-14-10021] Funding Source: Russian Science Foundation
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Zeb2 (Sip1, Zfhx1b) is a transcription factor that plays essential role in neuronal development. Sip1 mutation in humans was shown to cause Mowat-Wilson syndrome, a syndromic form of Hirschprung's disease. Affected individuals exhibit multiple severe neurodevelopmental defects. Zeb2 can act as both transcriptional repressor and activator. It controls expression of a wide number of genes that regulate various aspects of neuronal development. This review addresses the molecular pathways acting downstream of Zeb2 that cause brain development disorders.
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